ライフサイエンスコーパス: innate immunity

1 f interferons, a key component in vertebrate innate immunity.

2 et validation across species in the field of innate immunity.

3 the above modifiable risk factors influence innate immunity.

4 metalloproteinase 8, which is a regulator of innate immunity.

5 sophisticated and effective orchestrators of innate immunity.

6 to the role of the intestinal epithelium in innate immunity.

7 interface between liver sinusoidal cells and innate immunity.

8 to cell cycle arrest, genotoxic stress, and innate immunity.

9 including Rickettsia species, interact with innate immunity.

10 bitory Siglecs on host leukocytes, dampening innate immunity.

11 tion to facilitate RLR-mediated signaling of innate immunity.

12 a coordinated manner to suppress intestinal innate immunity.

13 role and mechanisms of SAMHD1 in suppressing innate immunity.

14 und repair and the concomitant activation of innate immunity.

15 interactions between influenza and the host innate immunity.

16 tionally powerful component of mammalian CNS innate immunity.

17 erived nucleic acids are crucial signals for innate immunity.

18 fect the migratory behavior of leukocytes in innate immunity.

19 aspergillosis correlates with impairments in innate immunity.

20 a role for group 3-like ILCs in endometrial innate immunity.

21 bination therapy and the macrophage-mediated innate immunity.

22 optosis, which plays a key role in mammalian innate immunity.

23 nctions to link erythrocyte homeostasis with innate immunity.

24 the acute phase response is a key element of innate immunity.

25 cyclic dinucleotide signalling in mammalian innate immunity.

26 he clearance of NETs, double-edged swords of innate immunity.

27 layed abnormal secretion of key mediators of innate immunity.

28 on, antiviral restriction, and regulation of innate immunity.

29 al utilization of LRRs modules in vertebrate innate immunity.

30 ll as PMK-1-independent factors critical for innate immunity.

31 of importance for complement recognition and innate immunity.

32 c acid chemical modification into organismal innate immunity.

33 ceptibility by altering soluble mediators of innate immunity.

34 leic acid sensors is a defining principle of innate immunity.

35 A)-activated protein kinase (PKR) related to innate immunity.

36 lso plays an important role in the antiviral innate immunity.

37 Neutrophils play a key role in innate immunity.

38 -inducible factor (HIF) in the regulation of innate immunity.

39 f viral genes and only occasionally activate innate immunity.

40 ne deaminases with functions in adaptive and innate immunity.

41 t (LRR)-containing proteins (NLRs) attenuate innate immunity.

42 are regarded as central regulators of plant innate immunity.

43 RS and is known to effectively suppress host innate immunity.

44 mycobacterial pathogenesis in the context of innate immunity.

45 eptor kinase pathways involved in growth and innate immunity.

46 their functional coordination in vertebrate innate immunity.

47 ulators of endothelial barrier functions and innate immunity.

48 ents and devise new therapeutics to modulate innate immunity.

49 not only escape, but further compromise host innate immunity.

50 on a large variety of genes associated with innate immunity.

51 demonstrate a suppression of cell-intrinsic innate immunity.

52 -circRNA and is essential for suppression of innate immunity.

53 RNA modification on human circRNAs inhibits innate immunity.

54 ables investigation solely in the context of innate immunity.

55 ay yield new insights into the regulation of innate immunity.

56 Macrophages are a key cell type in innate immunity.

57 e transcription, integration, and evasion of innate immunity.

58 peptides and underscores their importance in innate immunity.

59 is a primary player in ROS production during innate immunity.

60 lay a variety of recently described roles in innate immunity.

61 ce significantly compromised the endometrial innate immunity.

62 A (lncRNAs) that is important in controlling innate immunity.

63 directing downstream activation of IRF3 and innate immunity.

64 fective proviruses may trigger an element of innate immunity.

65 es mitochondrial homeostasis, thus affecting innate immunity.

66 ase of expression of several genes linked to innate immunity.

67 particularly those that interfere with plant innate immunity.

68 otein are present constitutively and enhance innate immunity.

69 velopment, significantly reduced endometrial innate immunity.

70 OTUD3 deficiency in mice results in enhanced innate immunity, a diminished viral load, and morbidity.

71 simultaneously upregulated and coreleased in innate immunity-activated primary human keratinocytes.

72 earlier study to elucidate how this altered innate immunity affects adaptive T cells.

73 In contrast, prevention of cell death and innate immunity after CI+Txp requires inhibition of both

74 (PRRs) sense microbial patterns and activate innate immunity against attempted microbial invasions.

75 that cellular m(6)A machinery regulates host innate immunity against hepatitis B and C viral infectio

76 eukaryotes they mediate protective roles in innate immunity against malignant, viral, and bacterial

77 opportunity for therapy without compromising innate immunity against pathogens.

78 oundation for understanding pathogenesis and innate immunity against SARS-CoV-2.

79 n, chronic ENDS vapor exposure downregulated innate immunity against viral pathogens in resident macr

80 ded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication

81 Regarding innate immunity, although SfAV-1a destroys most fat body

82 mimicking cellular RNA to avoid detection by innate immunity and (2) viral RNA m(6)A can serve as a t

83 killer (NK) cells and gammadelta T cells of innate immunity and alphabeta T cells of adaptive immuni

84 e lethality by promoting resistance to human innate immunity and antibiotics, enabling bacteria to pr

85 I was highly enriched for genes involved in innate immunity and apoptosis, and most transcript level

86 may serve as an extension or consequence of innate immunity and are shown to affect in vivo murine t

87 ecific defects in specific pathways, such as innate immunity and autophagy.

88 Myeloid cells are a vital component of innate immunity and comprise monocytes, macrophages, den

89 phibian host defense peptide modulates plant innate immunity and confers robust and reliable resistan

90 e the expression of target genes involved in innate immunity and cytokine signaling.

91 Identifying viral antagonists of innate immunity and determining if they contribute to pa

92 emerging evidence that interactions between innate immunity and diet affect human metabolic health a

93 lpha/beta hydrolase domain (ABH)-to suppress innate immunity and enhance colonization.

94 nctional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC.HA

95 However, the interplay between innate immunity and HIV/SIV is only poorly characterized

96 on-dependent antioxidation to modulate plant innate immunity and host susceptibility.

97 ish have emerged as an intermediate model of innate immunity and host-pathogen interactions to bridge

98 nding the intersection between nutrition and innate immunity and how potential nutritional, immune, a

99 ne-active peptides, naturally encountered in innate immunity and infection, could have important medi

100 Here, we show that caspase-6 mediates innate immunity and inflammasome activation.

101 ly upregulation of genes that play a role in innate immunity and inflammation and downregulation of g

102 ental data have identified the modulation of innate immunity and inflammation as plausible biological

103 recent advancements in our understanding of innate immunity and inflammation in AD onset and progres

104 E3 (TFE3), are emerging as key regulators of innate immunity and inflammation.

105 ch fatty acids lead to a state of heightened innate immunity and inflammation.

106 ch fatty acids lead to a state of heightened innate immunity and inflammation.

107 Both innate immunity and inflammatory disorders hinge on the

108 utbreak, supported by its potential to boost innate immunity and initial epidemiological analyses whi

109 egans utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron seq

110 The study of innate immunity and its link to inflammation and host de

111 s and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammator

112 categorized as a new adipokine cross-linking innate immunity and metabolic disorders including obesit

113 marize recent literature around the topic of innate immunity and mucosal hypoxia with a focus on tran

114 Macrophages are critical mediators of innate immunity and must be overcome for bacterial patho

115 t domain 8 (CARD8) protein is a component of innate immunity and overexpression of CARD8 mRNA was pre

116 ranscriptomic analysis revealed induction of innate immunity and phagocytotic pathways in presymptoma

117 Interferons are key components in the innate immunity and play crucial roles against viral inf

118 ndritic cells (DC) play an essential role in innate immunity and radiation-elicited immune responses.

119 re they act as critical rheostats to amplify innate immunity and regulate tissue damage.

120 mmunity and induction of programs related to innate immunity and response to danger signals triggered

121 Age-related impairments in innate immunity and suboptimal virus-specific T cell and

122 o be critical inducers of lung CXCL13, early innate immunity and the formation of protective lymphoid

123 endently associated with differences in both innate immunity and the stool microbiome in a biogeograp

124 st cells (MCs) are the initial responders of innate immunity and their degranulation contribute to va

125 ntially important and tractable link between innate immunity and thrombosis.

126 pportunities to study the systems biology of innate immunity and to determine how sustained ISG upreg

127 This process is fundamental to innate immunity and to inflammatory disease, including a

128 lowed the acquisition of STING into metazoan innate immunity, and determine the structure of a full-l

129 al microbiome and its correlations with host innate immunity, and host cytokine control, with the goa

130 Proteins associated with wound healing, innate immunity, and inflammation were significantly inc

131 will shed light on the origins of regulated innate immunity, and may have relevance to our understan

132 ance of cis-acting lncRNAs in TLR signaling, innate immunity, and pathophysiological inflammation.

133 sive inflammatory responses, upregulation of innate immunity, and promotion of tissue repairing mecha

134 a previously unrecognized role of lncRNAs in innate immunity, and suggest that Neat1 is a common medi

135 c host interactions that allow W to modulate innate immunity are incompletely understood.

136 f master regulators of metabolism to control innate immunity are less understood.

137 f animal physiology, yet roles in regulating innate immunity are relatively unexplored.

138 c functions, including skin desquamation and innate immunity, are hypothesized to contribute to AD pa

139 nce the intestinal epithelium contributes to innate immunity as a first line of defence, understandin

140 However, the evolution of innate immunity as a mechanism to prevent cancer and how

141 therapeutics by unveiling DNA damage-induced innate immunity as a novel target for cancer treatment.

142 (NLR) genes that are known to be involved in innate immunity, as well as those involved in terpene bi

143 ate the existence of functional anticipatory innate immunity at sites adjacent to infection that depe

144 Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autono

145 ic switch begins rapidly after activation of innate immunity, before the expression of markers of end

146 Inflammation is an essential aspect of innate immunity but also contributes to diverse human di

147 NK cells represent a cellular component of innate immunity but possess features of adaptive immunit

148 e circadian clock is known to regulate plant innate immunity but the underlying mechanism of this reg

149 et-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis

150 -cell reconstitution, but linked adaptive to innate immunity by enhancing the activation of donor-der

151 on, (2) pulmonary endothelium contributes to innate immunity by generating antimicrobial amyloids in

152 ficient for Vpr or Vpx alone, suppression of innate immunity by HIV/SIV is probably a key pathogenic

153 NS3-NS4A evades antiviral innate immunity by inactivating several proteins, includ

154 nding protein, is best known for its role in innate immunity by participation in cellular antiviral r

155 ment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circa

156 insic host defense immunity is a specialized innate immunity component to restrict viral infection.

157 ISG upregulation is essential for effective innate immunity, constitutive activation typically cause

158 in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to

159 However, to what degree innate immunity contributes to neurodegeneration as comp

160 everal genes involved in interferon-mediated innate immunity, cytokine signaling, and cellular defens

161 , trigger the SASP through activation of the innate immunity cytosolic DNA sensing cGAS-STING pathway

162 protein D (SP-D), a key factor in first-line innate immunity defense, removes influenza type A virus

163 ce significantly compromised the endometrial innate immunity, demonstrating an important role for inn

164 Both the gut microbiome and systemic innate immunity differ across biogeographically distinct

165 on determine infection outcome by triggering innate immunity, diminishing virulence, and, in many cas

166 ggest that PLA(2) and Cl(-) channels mediate innate immunity downstream of P2X7 receptors in human ma

167 he host oxidative burst and suppressing rice innate immunity during biotrophy.

168 pothesized that myeloid LKB1 plays a role in innate immunity during pneumonia.

169 hree DUSPs previously shown to have roles in innate immunity (DUSPs 1, 4, and 10) were expressed in p

170 he recruitment of cell types associated with innate immunity (e.g., monocytes/macrophages and neutrop

171 Natural killer (NK) cells are key innate immunity effectors that combat viral infections a

172 C-PUFA-containing lipids that participate in innate immunity, energy homeostasis, and brain developme

173 e granulocytic asthma highlighting defective innate immunity except for specific subsets characterize

174 atocytes injury, the recruitment of cells of innate immunity exerts a mechanistic role in disease pro

175 The human innate immunity factor apolipoprotein L-I (APOL1) protec

176 DEGs) defined three interconnected pathways (innate immunity, fatty acid biosynthesis and cholesterol

177 ibited persistent elevation of biomarkers of innate immunity for up to 2 weeks postintubation.

178 ulation to balance antiviral, metabolic, and innate immunity functions.

179 How innate immunity gave rise to adaptive immunity in verteb

180 t fat body cells by 7 days postinfection, so innate immunity gene transcripts apparently occur in rem

181 ur laboratory reported that knockout of some innate immunity genes was associated with increases in t

182 higher levels of transcripts of a cluster of innate immunity genes, including those encoding IFI16, I

183 ion of host mitochondrial, cytoskeletal, and innate immunity genes.

184 DAC4 to block upregulation of the cluster of innate immunity genes.

185 l oxidase 2, related to thyroid function and innate immunity) genes and, in the Amazon, the gene enco

186 ew, we have updated the mechanisms involving innate immunity-governed inflammatory cascades in the pa

187 ndings establish an unrecognized function of innate immunity governing both morphology and physiology

188 Hyperactivation of innate immunity has been implicated in the etiology of m

189 The discovery of TMEM173/STING-dependent innate immunity has recently provided guidance for the p

190 xide (NO) synthase, an important effector of innate immunity, has been previously described in the tr

191 As a marker of activation of innate immunity, high PCT levels affect clinical diagnos

192 asal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role

193 sed, uninfected (HUU) children, with altered innate immunity hypothesized to be a cause.

194 presentation, which may aid viral evasion of innate immunity.IMPORTANCE Human leukocyte antigens (HLA

195 insights into the PRRSV interference of the innate immunity.IMPORTANCE PRRSV infection elicits a mea

196 new roles for macrophage TRPV4 in regulating innate immunity in a mechanosensitive manner through the

197 more recent findings have shown the role of innate immunity in additional aspects of ACD, including

198 he complement system, a crucial component of innate immunity in AS, is unclear.

199 The dual role played by innate immunity in asthma pathogenesis offers multiple o

200 onal virus, supporting the potential role of innate immunity in driving the asynchronous circulation

201 ive immunity, indicating a critical role for innate immunity in endometrial control of C. trachomatis

202 e genetic and functional links of Pol III to innate immunity in humans remain largely unknown.

203 lysis confirmed differential upregulation of innate immunity in infants and natural killer cell netwo

204 -triggered immunity are two primary forms of innate immunity in land plants.

205 s the evolution of this field of research on innate immunity in obesity and metabolic perturbation, a

206 te that deficiency of TKFC leads to impaired innate immunity in response to viral illness, which may

207 e findings indicate a shift from adaptive to innate immunity in stressful situations.

208 expand our understanding of DNA sensing and innate immunity in T cells and may have relevance to the

209 disposing HLA molecules, and of adaptive and innate immunity in the development of tissue damage, hav

210 are well characterized, the role of GITR in innate immunity in the intestinal tissues has not been w

211 te to hepatic inflammation and activation of innate immunity in the liver.

212 early detection of viruses and in activating innate immunity in the respiratory mucosa, but there is

213 odifications that regulate both adaptive and innate immunity in the skin.

214 gy receptor that functions as a regulator of innate immunity, in sepsis.

215 hyperuricemia as an intrinsic suppressor of innate immunity, in which sUA modulates the capacity of

216 differential expression of genes related to innate immunity, including genes encoding cytokines, che

217 Viruses naturally engage innate immunity, induce antigen presentation, and mediat

218 Trained innate immunity, induced via modulation of mature myeloi

219 Macrophages show versatile functions in innate immunity, infectious diseases, and progression of

220 eiotropic functions, including regulation of innate immunity, inflammation, protein sorting, and chro

221 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected path

222 A critical facet of mammalian innate immunity involves the hosts' attempts to sequeste

223 Chronic activation of brain innate immunity is a prominent feature of Alzheimer's di

224 Innate immunity is associated with Alzheimer's disease(1

225 Counteracting innate immunity is essential for successful viral replic

226 Negative regulation of innate immunity is essential to avoid autoinflammation.

227 Although PARPi-induced innate immunity is highly desirable in human malignancie

228 Accurate regulation of innate immunity is necessary for the host to efficiently

229 ock as a potential strategy to suppress host innate immunity is not well understood.

230 n fruits than invertebrates, confirming that innate immunity is nutrient specific.

231 Seasonal variation in innate immunity is often attributed to either temporal e

232 A dogma of innate immunity is that neutrophils use G-protein-couple

233 Plant innate immunity is triggered via direct or indirect reco

234 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation

235 yet a strategy to control both, adaptive and innate immunity, is lacking.

236 unity confers immunological memory; and, (2) innate immunity lacks specificity.

237 accine triggered different components of the innate immunity, led to strong and persistent cellular r

238 fate-promoting mechanism while abrogating an innate immunity-linked, fate-suppressing mechanism.

239 es, including effects on the nervous system, innate immunity, microRNAs, and many disease-relevant pa

240 EBOV) and Marburg virus (MARV) modulate host innate immunity, MLAV VP35, VP40, and VP24 proteins were

241 Innate immunity most commonly relies on the endonuclease

242 Other viral proteins that counteract innate immunity negatively impact autophagy.

243 titers, reduced T and B cells, dysregulated innate immunity, neutrophil mobilization to the lungs an

244 nt role for oxygen metabolism and hypoxia in innate immunity of healthy tissue (physiologic hypoxia)

245 Innate immunity of LOAD patients is malfunctioning in ph

246 Human inborn errors of innate immunity often underlie infectious diseases.

247 Aging generally leads to exaggerated innate immunity, particularly in the form of elevated ne

248 Inhibition of the interleukin (IL)-1beta innate immunity pathway is associated with anti-inflamma

249 ntify gene expression profile differences in innate immunity pathways between low-quality and ideal k

250 n on the standard E. coli diet by activating innate immunity pathways that lead to bacterial avoidanc

251 ed that mutant ANP (mANP) activates multiple innate immunity pathways, including TNF-alpha, NF-kappaB

252 infection in primary T cells by upregulating innate immunity pathways.

253 ch suggests roles for pseudokinases in plant innate immunity, plant-fungal interactions, and bacteria

254 inflammatory signaling downstream of various innate immunity receptors.

255 )1-related (IFN-gamma and CXCL9/CXCL10), and innate immunity-related (nitric oxide synthase 2/inducib

256 Plant innate immunity relies on nucleotide binding leucine-ric

257 f SAMHD1 are required for its suppression of innate immunity remains unknown.

258 fungus Magnaporthe oryzae, terminating rice innate immunity requires a dynamic network of redox-resp

259 ts role in tumorigenesis, its crosstalk with innate immunity responses and its potential as an effect

260 n-mediated actin polymerization during plant innate immunity responses.

261 expected potential interface between GrB and innate immunity separate from the traditional role of Gr

262 gram-negative bacteria use to overcome host innate immunity, specifically the areas of nutritional i

263 brane receptors important for axon guidance, innate immunity, synapse development, and synaptic plast

264 c landscape refines SKN-1 activity away from innate immunity targets, which alleviates negative metab

265 , is designed to more effectively potentiate innate immunity than trastuzumab.

266 ing cascades function as central elements of innate immunity that control transcription of numerous p

267 Here we review inborn errors of innate immunity that have been recently discovered or cl

268 omplement proteins are ancient components of innate immunity that have emerged as crucial regulators

269 Acute inflammation is a key feature of innate immunity that initiates clearance and repair in i

270 TING) acts as a cytoplasmic signaling hub of innate immunity that is activated by host-derived or bac

271 ment of mice with an ATXN2 ASO also modified innate immunity, the complement system and lysosome/phag

272 While mitochondria play an important role in innate immunity, the relationship between mitochondrial

273 ously unsuspected link between inflammation, innate immunity, thrombosis, oxidative stress, and cardi

274 inflammatory differentiation and nutritional innate immunity through enhanced tryptophan degradation.

275 al program associated with the activation of innate immunity, through secretion of a cytokinome that

276 ukocytes, indicating a novel form of trained innate immunity (TII).

277 Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from ant

278 tant therapeutic implications for modulating innate immunity to combat Gram-negative bacterial infect

279 nterventions to enhance NAD levels may boost innate immunity to coronaviruses.

280 ising requirement for a key host mediator of innate immunity to DNA viruses in the life cycle of a sm

281 We conclude that innate immunity to HSV-1 is normally repressed in unstre

282 ng class of immunotherapeutics that activate innate immunity to increase tumour immunogenicity.

283 ude and intrinsic anti-microbial capacity of innate immunity to infection.

284 cemaker cells as neurons using components of innate immunity to interact with the microbial environme

285 Innate immunity to nucleic acids forms the backbone for

286 ressive tumor microenvironment and activates innate immunity to orchestrate adaptive immunity when sy

287 nd the literature support a working model of innate immunity to papillomaviruses involving the activa

288 ts of our studies support a working model of innate immunity to papillomaviruses, and the model provi

289 alpha (HIF-1alpha), a principal regulator of innate immunity to pathogens, is necessary for macrophag

290 get for treating periodontitis by harnessing innate immunity to regulate the oral microbiome.

291 ebrafish larvae, a powerful animal model for innate immunity, to measure leukocyte recruitment to dam

292 Similar increases occurred for innate immunity transcripts and their negative regulator

293 ILCs contribute significantly to endometrial innate immunity via an IFN-gamma-dependent effector mech

294 of the combinations could be stimulation of innate immunity via increased haemocyte numbers compared

295 was used in which several components of the innate immunity were degraded.

296 These in vitro and in vivo effects on innate immunity were not due to direct functions of the

297 IAV utilizes several tactics to evade host innate immunity, which include the evasion of antiviral

298 tury ago by Elie Metchnikoff, the "father of innate immunity," who is credited with discovering phago

299 itaconate and plays central roles in linking innate immunity with metabolism and in the biotechnologi

300 mechanism by which GM-CSF links adaptive to innate immunity within this tissue site have not been de