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1 s, each of which is postsynaptic to a single inner hair cell.
2 axons and their sensory endings beneath each inner hair cell.
3 ed from a single synaptic ribbon in a single inner hair cell.
4 are similar to those of developing cochlear inner hair cells.
5 channels at the synaptic ribbons of auditory inner hair cells.
6 outer hair cells more severely affected than inner hair cells.
7 1.3 channels and Ca(2+) homeostasis in mouse inner hair cells.
8 elease of glutamate at the ribbon synapse of inner hair cells.
9 th in transfected HEK293T cells and in mouse inner hair cells.
10 subtle structural changes in and surrounding inner hair cells.
11 ganglion cells and outer hair cells but not inner hair cells.
12 kout mice, the stereocilia were thickened in inner hair cells.
13 akes transient direct synaptic contacts with inner hair cells.
14 being higher in outer hair cells (OHCs) than inner hair cells.
15 responsible for encoding the SK channels of inner hair cells.
16 heir significance for Ca(v)1.3 regulation in inner hair cells.
17 litudes but no difference in degeneration of inner hair cells.
18 re extensive between supporting cells around inner hair cells.
19 Ca(2+) influx at presynaptic active zones in inner hair cells.
20 of fast activating outward current from the inner hair cells.
21 fibers terminating onto the afferents to the inner hair cells.
22 chanical signal, which is then transduced by inner hair cells.
23 characterized BK channel expression in mouse inner hair cells.
24 lls and to a small increase in the number of inner hair cells.
25 rows of outer hair cells and a single row of inner hair cells.
26 ture of the SGNs and their synapses with the inner hair cells.
27 I SGNs that synapse on the modiolar side of inner hair cells.
28 cells prevented the functional maturation of inner hair cells.
29 icted to the cell apical region) in cochlear inner hair cells.
30 (+) efflux, and subsequent depolarization of inner hair cells.
31 or normal calcium currents and exocytosis in inner hair cells.
32 erformed intracellular recordings from mouse inner hair cells across the lifespan and show that effer
34 ereocilia of outer hair cells (OHCs) but not inner hair cells and affects interactions of stereocilia
35 Nevertheless, BK channels are present in inner hair cells and encode a fast activating outward cu
38 a novel function of BK channels in mammalian inner hair cells and provide a framework for future rese
39 ablation caused duplication of FGF8-positive inner hair cells and reduction of outer hair cells witho
40 ria for: (i) presynaptic disorders affecting inner hair cells and ribbon synapses; (ii) postsynaptic
41 crodissected immature (postnatal days 10-13) inner hair cells and spiral ganglion cells but not outer
42 onset of spontaneous correlated activity in inner hair cells and spiral ganglion neurons, which begi
44 bundle, structural aberrations in outer and inner hair cells and stria vascularis defects, leading t
45 ll differentiation and an over production of inner hair cells and that these effects are likely media
46 occur in the synapses between the cochlea's inner hair cells and the auditory nerve, effectively sev
47 e first time, successful transduction of all inner hair cells and the majority of outer hair cells in
48 fate mapping shows this region gives rise to inner hair cells and their associated inner phalangeal c
50 that form a boundary between a single row of inner hair cells and three rows of outer hair cells (OHC
51 ed region of the cochlea in which one row of inner hair cells and three rows of outer hair cells are
52 sional finite-element methods, we modeled an inner hair-cell and an outer hair-cell stereocilia bundl
53 or-image duplications of tunnel of Corti and inner hair cells, and expressing ectopic vestibular-like
54 r cells, with the former being comparable to inner hair cells, and the latter comparable to OHCs, bas
56 t displacement value, which implies that the inner hair cells are more sensitive to V(BM) than to BM
60 lends support to the recent hypothesis that inner hair cells are stimulated by a net flow, in additi
62 rves, a measure of the tuning of the sensory inner hair cells, are also sharply tuned, but the thresh
66 fespan and show that efferent innervation of inner hair cells arises in parallel with the loss of aff
67 ng is in outer hair cells at the apex and in inner hair cells as well as spiral ganglion neurons at t
69 rders that result from noise-induced loss of Inner Hair Cell - Auditory Nerve synaptic connections.
70 of synaptic ribbons associated with loss of Inner Hair Cell - Auditory Nerve synaptic connections.
73 d at the presynaptic ribbon synapse of adult inner hair cells both in wild-type and CaBP4(-/-) mice a
74 yosin-XVa and is disrupted in Myo15(sh2/sh2) inner hair cells, but not in Myo15(sh2/sh2) outer hair c
75 outer hair cells, whereas innervation of the inner hair cells by type I spiral ganglion neurons was n
78 urther suggest that in the cochlea, neuronal-inner hair cell connections may dynamically reshape as p
79 ordings showed that ANFs contacting the same inner hair cell could have different SRs, with no correl
82 e transient cochlear efferent innervation to inner hair cells during the critical period before the o
84 feedback loop that is positioned to regulate inner hair cell excitability and refine maturation of th
85 is a form of hearing loss in which cochlear inner hair cells fail to correctly encode or transmit ac
87 at embryonic day (E)14.5, beginning with the inner hair cells, Fgf20 expression precedes hair cell di
88 endent inactivation is marginally greater in inner hair cells from CaBP4(-/-) than from wild-type mic
89 most sensitive range, is absent in outer and inner hair cells from homozygous Snell's waltzer mutant
91 o synaptic vesicle recycling in the auditory inner hair cells from the organ of Corti and to investig
93 s suggest that the effective stimulus to the inner hair cell hair bundles results not from a simple O
94 m the modiolar face and/or basal pole of the inner hair cell have larger ribbons and smaller receptor
97 sly, in both naked and Damaraland mole rats, inner hair cell (IHC) afferent ribbon density was reduce
98 Spatial magnitude and phase profiles for inner hair cell (IHC) depolarization throughout the chin
99 pends on the transfer characteristics of the inner hair cell (IHC) ribbon synapse and its multiple co
100 riggering of neurotransmitter release at the inner hair cell (IHC) ribbon synapses by Ca(2)(+) entry
101 heminodes relative to excitatory input from inner hair cell (IHC) ribbon synapses continued until ap
103 g loss (ARHL) is associated with the loss of inner hair cell (IHC) ribbon synapses, lower hearing sen
109 dynamics in a phenomenological model of the inner hair cell (IHC)-auditory nerve (AN) synapse succes
117 taneous whole-cell recordings from mammalian inner hair cells (IHCs) and auditory nerve fiber termina
118 n at birth, with gradual localization to the inner hair cells (IHCs) and its supporting cells, inner
119 y (P) 2, the efferent arbors associated with inner hair cells (IHCs) and outer hair cells (OHCs) disp
120 ntains two types of mechanotransducer cells, inner hair cells (IHCs) and outer hair cells (OHCs).
121 ation and maintenance of stereocilia in both inner hair cells (IHCs) and outer hair cells (OHCs).
123 ntiation of afferent ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGN
124 t cell types but remained relatively high in inner hair cells (IHCs) and to a lesser extent in IHC su
125 ceive auditory information from the cochlear inner hair cells (IHCs) and transmit that information to
126 input from several ribbons, whereas cochlear inner hair cells (IHCs) are contacted by several individ
140 (BK) current is prominent, and in mammalian inner hair cells (IHCs) displays unusual properties.
143 ion of Ca(2+)SIGNIFICANCE STATEMENT Auditory inner hair cells (IHCs) encode sounds into nerve impulse
145 ing whole-cell voltage-clamp recordings from inner hair cells (IHCs) in acutely excised apical turns
150 s and prevented the normal synaptogenesis in inner hair cells (IHCs) in the newly identified mouse mu
151 ory system, spontaneous activity of cochlear inner hair cells (IHCs) is initiated by the release of A
153 The systematically varying innervation of inner hair cells (IHCs) of the cochlea provides a model
155 nsory epithelium and then diverge to contact inner hair cells (IHCs) or outer hair cells (OHCs), resp
156 opment before the onset of hearing, cochlear inner hair cells (IHCs) present spontaneous Ca(2+) actio
157 OHCs) in the mature mammalian cochlea and on inner hair cells (IHCs) prior to the onset of hearing.
158 onset of hearing at postnatal day 12, mouse inner hair cells (IHCs) produce spontaneous and evoked a
159 TRACT: Just before the onset of hearing, the inner hair cells (IHCs) receive inhibitory efferent inpu
165 k Ca(2+) and Ba(2+) currents of mature du/du inner hair cells (IHCs) were reduced by 30-40%, respecti
166 ogical membrane properties of mouse cochlear inner hair cells (IHCs) were studied from just after ter
168 + entry and exocytosis were studied in mouse inner hair cells (IHCs) which, together with the afferen
170 ed by cochlear hair cells, preferentially in inner hair cells (IHCs), and was lacking from the postsy
171 cient mice, outer hair cells (OHCs), but not inner hair cells (IHCs), began to lose their third row o
172 on-type active zones (AZs) of mouse auditory inner hair cells (IHCs), but its modes and molecular reg
173 (AAV1) leads to transgene expression in only inner hair cells (IHCs), despite broader viral uptake.
174 s affecting the afferent dendrites under the inner hair cells (IHCs), however, little is known about
175 periodically release ATP, which depolarizes inner hair cells (IHCs), leading to bursts of action pot
176 diate neurotransmitter release from auditory inner hair cells (IHCs), pancreatic insulin secretion, a
177 f spiral ganglion neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses,
180 Similar to the primary sensory receptor, the inner hair cells (IHCs), the mature functional character
181 sensitivity of the synaptic machinery allow inner hair cells (IHCs), the primary auditory receptors,
182 (2+) current (I(Ca)) in prehearing and adult inner hair cells (IHCs), the primary sensory receptors o
184 natal day 7 (P7), before the primary sensory inner hair cells (IHCs), which become competent at about
185 s calcium action potentials are generated by inner hair cells (IHCs), which form the primary sensory
186 potential (AP) activity in immature sensory inner hair cells (IHCs), which is crucial for the refine
187 ction potential activity in immature sensory inner hair cells (IHCs), which is crucial for the refine
188 ltaC mouse), MYO7A is severely diminished in inner hair cells (IHCs), while expression in outer hair
196 rt provided by their peripheral targets, the inner hair cells (IHCs): following ototoxic drugs or aco
198 of glutamatergic transmission from cochlear inner hair cells in mice lacking the vesicular glutamate
200 terns around ribbons from serial sections of inner hair cells in the cat, and compared data from low
203 d progressive degeneration of both outer and inner hair cells in the organ of Corti, following two re
204 f pre- and post-synaptic markers on cochlear inner hair cells, in guinea pigs surviving from 1 day to
205 ysical maturation, growth and innervation of inner hair cells; in contrast, it is required only for t
207 rthermore, transmitter secretion of cochlear inner hair cells is compromised in mice lacking otoferli
210 nstrate that an Fgf8 signal arising from the inner hair cells is the key component in an inductive pa
216 the endogenous release of glutamate from the inner hair cells may increase the strength of efferent i
217 hat CRFR1 has a developmental role affecting inner hair cell morphology and afferent and efferent syn
218 age than low-frequency cells; high-frequency inner hair cells must have a low Ca(2+) buffer capacity
219 tory nucleus.SIGNIFICANCE STATEMENT Cochlear inner hair cells of altricial mammals display spontaneou
222 ere we present voltage-clamp recordings from inner hair cells of the C57BL/6J mouse model of age-rela
223 nces in afferent neurons and, in the case of inner hair cells of the cochlea, vulnerability to damage
227 ral ganglion cells, but not with the loss of inner hair cells or a reduced thickness of the stria vas
228 pparatus in the inner ear and is composed of inner hair cells, outer hair cells, and highly specializ
241 Overexpression of twinfilin 2 in cochlear inner hair cells resulted in a significant reduction of
243 he mechanical responses of hair bundles from inner hair cells revealed a characteristic resonance and
244 ical recordings from postnatal (P) days P8-9 inner hair cells revealed ACh-gated currents in alpha10(
247 y neuropathy owing to disordered function of inner hair cell ribbon synapses (temperature-sensitive a
249 the compound action potentials, a measure of inner hair cell sensitivity, are significantly elevated.
250 that make simple one-to-one connections with inner hair cell sensory receptors, it has an elaborate o
252 POINTS: Spontaneous activity of the sensory inner hair cells shapes maturation of the developing asc
253 ir role in this regard, Ca(v)1.3 channels in inner hair cells show little Ca(2+)-dependent inactivati
254 ter gene results in binaural transduction of inner hair cells, spiral ganglion neurons and vestibular
255 neurons originating in the brainstem inhibit inner hair cell spontaneous activity and may further ref
256 ed by conspicuous elongations and fusions of inner hair cell stereocilia and progressive degeneration
257 labeled mouse cochleas, we demonstrated that inner hair cell stereocilia developed in specific stages
260 hich manifests with shortening and fusion of inner hair cells stereocilia and progressive degeneratio
262 the tectorial membrane directly overlies the inner hair cell stereociliary bundles, these data provid
263 mice suggest roles for the ALC in regulating inner hair cell stereociliary growth and differentiation
264 with Otoa mutations is caused by a defect in inner hair cell stimulation, and reveal the limbal attac
265 e inner ear, mainly outer hair cells (OHCs), inner hair cells, stria vascularis, spiral ganglia, and
267 The results were observed first in afferent inner hair cell synapse of type I neurites, followed by
269 in and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availabili
271 function follows a conserved mechanism where inner hair cell synapses are lost, termed cochlear synap
272 hannels and the exocytosis calcium sensor at inner hair cell synapses changes along the mammalian coc
273 on of AMPKalpha in OHCs, reduced the loss of inner hair cell synaptic ribbons and OHCs, and protected
274 nduced hearing loss by mediating the loss of inner hair cell synaptic ribbons and outer hair cells.
275 a(2+) currents and membrane capacitance from inner hair cells that clarin-1 is not essential for form
276 use they extend a peripheral axon beyond the inner hair cells that subsequently makes a distinct 90 d
278 ry epithelium after death (especially of the inner hair cells), the tectorial membrane appeared to be
281 ontaneously release ATP, which causes nearby inner hair cells to depolarize and release glutamate, tr
282 95% of the cochlear nerve and contact single inner hair cells to provide acoustic analysis as we know
283 nously released ATP in the cochlea activates inner hair cells to trigger bursts of action potentials
284 lecules at the afferent synapses of cochlear inner hair cells to trigger exocytosis of neurotransmitt
286 earing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the b
287 ential to maintain synaptic Ca(2+) influx in inner hair cells via fueling Ca(2+)-ATPases to avoid an
289 primary sensory fibers innervating a single inner hair cell, we quantified the sizes of presynaptic
290 channel alpha and beta subunits in mammalian inner hair cells, we analyzed the morphology, physiology
293 mycin injections (from P8 to P16), surviving inner hair cells were evident at P16 but absent by P19,
297 t send a single dendrite to contact a single inner hair cell, whereas unmyelinated type II afferents
298 ling synchronizes the output of neighbouring inner hair cells, which may help refine tonotopic maps i
299 in background have selective degeneration of inner hair cells while outer hair cells remain structura
300 ochondrial NADH in outer hair cells, but not inner hair cells, within minutes of administration.