ライフサイエンスコーパス: inner medullary

1 in-regulated urea transporter protein in the inner medullary base, and Northern analysis showed no ch

2 In summary, AC6 expression determines inner medullary cAMP formation and AQP2 phosphorylation

3 re, AC6-deficient mice lacked dDAVP-promoted inner medullary cAMP formation and phosphorylation of se

4 reover, mice lacking AC6 had lower levels of inner medullary cAMP, reduced abundance of phosphorylate

5 lization of AQP2-4 in primary cultured renal inner medullary CD (IMCD) cells and how osmolality influ

6 tagonist PSB-0739 in primary cultures of rat inner medullary CD cells potentiated the expression of A

7 GPC protects inner medullary cells against the perturbing effects of

8 We demonstrate that renal inner medullary cells are able to efficiently repair hyp

9 As with adapted cells in culture, inner medullary cells in normal mice exhibit numerous DN

10 g organic osmolyte that accumulates in renal inner medullary cells in response to high NaCl and urea.

11 Renal inner medullary cells in vivo are normally exposed to a

12 ylates proteins in mIMCD3 cells and in renal inner medullary cells in vivo.

13 the hyperosmotic stress resistance of renal inner medullary cells is based not only on adaptations t

14 in the interstitial fluid surrounding renal inner medullary cells varies with operation of the renal

15 s (mediating salt and water absorption), and inner medullary cells, which mediate all three types of

16 ndant and relatively nonabundant proteins in inner medullary collecting duct (IMCD) altered in abunda

17 Mineralocorticoid receptors in the inner medullary collecting duct (IMCD) are protected fro

18 ssin increases the water permeability of the inner medullary collecting duct (IMCD) by inducing traff

19 Immunoblots using membrane fractions from inner medullary collecting duct (IMCD) cell suspensions

20 c phosphodiesterase (PDE5) activity in renal inner medullary collecting duct (IMCD) cells contributes

21 ANP-dependent cGMP accumulation by isolated inner medullary collecting duct (IMCD) cells from both S

22 We used primary cultivated inner medullary collecting duct (IMCD) cells from contro

23 ted protein (NRP) is found on the surface of inner medullary collecting duct (IMCD) cells in culture

24 Intercalated and inner medullary collecting duct (IMCD) cells of the kidn

25 the responsiveness of isolated glomeruil and inner medullary collecting duct (IMCD) cells to ANP and

26 ble contribution of COX-2 to the survival of inner medullary collecting duct (IMCD) cells under hyper

27 In inner medullary collecting duct (IMCD) cells, acid secre

28 ers branching morphogenesis and migration of inner medullary collecting duct (IMCD) cells, and suppor

29 Absorption of urea in the renal inner medullary collecting duct (IMCD) contributes to hy

30 ndance of the apical urea transporter of the inner medullary collecting duct (IMCD) is regulated in v

31 ated urea transporter (UT-A) in the terminal inner medullary collecting duct (IMCD) permits very high

32 Although the inner medullary collecting duct (IMCD) plays a major rol

33 is was investigated in isolated perfused rat inner medullary collecting duct (IMCD) segments using co

34 Urea permeability was measured in perfused inner medullary collecting duct (IMCD) subsegments from

35 ed cAMP levels in cell lysates prepared from inner medullary collecting duct (IMCD) suspensions.

36 lated phosphorylation events in isolated rat inner medullary collecting duct (IMCD) suspensions.

37 P regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the inser

38 Mice lacking the inner medullary collecting duct (IMCD) urea transporter

39 To investigate the role of inner medullary collecting duct (IMCD) urea transporters

40 insulin regulates NO production in the renal inner medullary collecting duct (IMCD), the segment with

41 We have reported the presence of an inner medullary collecting duct (IMCD)-specific enhancer

42 in (AVP) and hyperosmolality in rat terminal inner medullary collecting duct (IMCD).

43 of Henle and a less well defined role in the inner medullary collecting duct (IMCD).

44 id transepithelial urea transport across the inner medullary collecting duct (IMCD).

45 in transepithelial anion secretion by renal inner medullary collecting duct (IMCD, mIMCD-K2 cell lin

46 Proteomic analysis of Inner Medullary Collecting Duct (IMCD3) cells adapted to

47 other claudins, was initially identified in inner medullary collecting duct (IMCD3) cells by gene ar

48 to detect differentially expressed genes in inner medullary collecting duct (IMCD3) cells grown unde

49 STR3) and RHO, in three types of cilia, from inner medullary collecting duct (IMCD3) cells, hTERT-RPE

50 ted protein in response to osmotic stress in inner medullary collecting duct (IMCD3) cells.

51 In inner medullary collecting duct (IMCD3) epithelial cells

52 Murine kidney cells of the inner medullary collecting duct (mIMCD) were exposed to

53 We used a cultured murine cell model of the inner medullary collecting duct (mIMCD-3 cells) to exami

54 ation of a cultured murine cell model of the inner medullary collecting duct (mIMCD-3 cells) via tran

55 es Pax2 mRNA and protein expression in mouse inner medullary collecting duct (mIMCD3) cells, and its

56 In mouse inner medullary collecting duct (mIMCD3) cells, Dragon g

57 Vipar- and Vps33b-deficient mouse inner medullary collecting duct (mIMDC-3) cells expresse

58 d osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal ca

59 detect differentially expressed proteins in inner medullary collecting duct 3 (IMCD3) cells grown un

60 gic inhibition of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreas

61 transition zone of cilia in cultured murine inner medullary collecting duct 3 (mIMCD3) renal cells.

62 alpha (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 cells and show that PI

63 id transepithelial urea transport across the inner medullary collecting duct and plays a major role i

64 criptional targets of aldosterone in a mouse inner medullary collecting duct cell line and found that

65 311, Leu-322, and Leu-323, or Phe-340 in the inner medullary collecting duct cell line IMCD.

66 s of cystin expression are low, we generated inner medullary collecting duct cell lines that stably e

67 transiently overexpressed the constructs in inner medullary collecting duct cells (IMCD-3 cell line)

68 itutively in long term cultures of polarized inner medullary collecting duct cells (mIMCD-3).

69 70 superfamily that is up-regulated in renal inner medullary collecting duct cells (mIMCD3 cells) dur

70 ell cycle delay and apoptosis in mouse renal inner medullary collecting duct cells (mIMCD3) and incre

71 ugs individually and in combination on mouse inner medullary collecting duct cells (mIMCD3).

72 collecting ducts, and in cultured outer and inner medullary collecting duct cells (mOMCD1 and mIMCD3

73 ckout [DKO] mice) and in Pkd1 knockout mouse inner medullary collecting duct cells (Pkd1Bmal1KO mouse

74 carried out phosphoproteomic analysis of rat inner medullary collecting duct cells by using a combina

75 inally, patch-clamp studies in primary mouse inner medullary collecting duct cells did not detect ENa

76 ype intercalated cells, principal cells, and inner medullary collecting duct cells do not.

77 stimulated edn1 mRNA in acutely isolated rat inner medullary collecting duct cells ex vivo and ET-1 p

78 similar to cells lacking PC2, NEK8-depleted inner medullary collecting duct cells exhibited a defect

79 AngII-treated inner medullary collecting duct cells exhibited augmente

80 e call Thm1 and which encodes THM1) in mouse inner medullary collecting duct cells expressing an IFT8

81 Madin-Darby canine kidney cells and in mouse inner medullary collecting duct cells in isotonic medium

82 r, and genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of

83 A occurred in cortical, outer medullary, and inner medullary collecting duct cells in vitro.

84 In vivo, inner medullary collecting duct cells may regulate urea

85 escribed for the bradykinin B(2) receptor in inner medullary collecting duct cells of the kidney.

86 Furthermore, ptip null inner medullary collecting duct cells were sensitive to

87 by hypertonicity is isoform-specific, renal inner medullary collecting duct cells were stably transf

88 llecting duct cells (Pkd1Bmal1KO mouse renal inner medullary collecting duct cells).

89 ngII induced BdkrB2 mRNA expression in mouse inner medullary collecting duct cells, and this effect w

90 We find that in mouse inner medullary collecting duct cells, high NaCl increas

91 In cultured inner medullary collecting duct cells, HSP expression wa

92 lized retinal pigmented epithelial and mouse inner medullary collecting duct cells-3.

93 ated activation of potential target genes in inner medullary collecting duct cells.

94 expression through a p38 MAPKbeta pathway in inner medullary collecting duct cells.

95 a plasma membrane Cl(-) conductance in renal inner medullary collecting duct cells.

96 expression of this receptor in cultured rat inner medullary collecting duct cells.

97 Immunoblotting of proteins from rat kidney inner medullary collecting duct endosomes with CaR-speci

98 ubunit of Na/K-ATPase in cells of the murine inner medullary collecting duct line (IMCD3) by activati

99 lex regulatory circuitry in the cells of the inner medullary collecting duct linking two independent

100 nel subunit alpha (alpha-ENaC) gene in mouse inner medullary collecting duct mIMCD3 cells and mouse k

101 d represses the alpha-ENaC promoter in mouse inner medullary collecting duct mIMCD3 cells, and that a

102 n isolated renal collecting ducts, and in an inner medullary collecting duct mouse cell line.

103 egments from the proximal tubule through the inner medullary collecting duct of rat kidneys.

104 In the inner medullary collecting duct of the terminal nephron,

105 unique phosphoproteins were identified from inner medullary collecting duct samples treated short-te

106 Rat inner medullary collecting duct suspensions were incubat

107 Cells derived from the inner medullary collecting duct undergo in vitro branchi

108 tachment, apical membranes of cultured renal inner medullary collecting duct were biotinylated, the c

109 his study, we established stable IMCD (mouse inner medullary collecting duct) cell lines, in which FP

110 g and uniform in the epithelial cells of the inner medullary collecting duct, and in epithelial cells

111 NA knockdown of GDPD5 increases GPC in mouse inner medullary collecting duct-3 cells, and over expres

112 s and mislocalization of E-cadherin in mouse inner medullary collecting duct-3 renal tubular cells.

113 sm in the medullary thick ascending limb and inner medullary collecting duct.

114 s in murine ciliated epithelial cells of the inner medullary collecting duct.

115 of 25 TRs that are also expressed in native inner medullary collecting duct.

116 segments with the highest expression in the inner medullary collecting duct.

117 lates adenylyl cyclase activity in the renal inner medullary collecting duct.

118 ated adenylyl cyclase activity in the intact inner medullary collecting duct.

119 essin increases UT-A1 phosphorylation in rat inner medullary collecting duct; (3) UT-A protein abunda

120 ncreases the phosphorylation of UT-A1 in rat inner medullary collecting duct; (b) UT-A1 protein abund

121 timulates urea transport across rat terminal inner medullary collecting ducts (IMCD) by increasing th

122 We employed proteomic analysis of inner medullary collecting ducts (IMCD) from rats fed wi

123 dly increases urea transport in rat terminal inner medullary collecting ducts (IMCD).

124 Rat inner medullary collecting ducts (IMCD3s) possess a lumi

125 nduces a change in urea transport in initial inner medullary collecting ducts (IMCDs) which could con

126 In isolated inner medullary collecting ducts (IMCDs), vasopressin (0

127 hannel and may shed light on the function of inner medullary collecting ducts and polycystins.

128 staining of glomeruli, proximal tubules, or inner medullary collecting ducts was found.

129 the apical region of the principal cells of inner medullary collecting ducts.

130 We made use of primarily cultured rat renal inner medullary collecting-duct cells and microarray ana

131 ing ability of AQP3 null mice was due to the inner medullary collecting-duct water channel AQP4, AQP3

132 novel 3D cell culture model that uses mouse inner-medullary collecting duct (mIMCD3) cells to genera

133 -ATPase are up-regulated by hypertonicity in inner-medullary collecting duct cells adapted to survive

134 Although cultured inner-medullary collecting duct cells lacked the gamma s

135 Previous studies showed that renal inner medullary epithelial (IME) cells respond to hypert

136 that Pax2 expression in second-passage mouse inner-medullary epithelial cells is increased by a high

137 eins are induced by hyperosmolality in renal inner medullary (IM) cells, but their role for cell adap

138 Hypertonic stress induced in inner medullary (IMCD3) cells by addition of NaCl to the

139 Similarly, 24 h of dehydration increased inner medullary inositol, sorbitol, and betaine concentr

140 Further, the lower renal inner medullary interstitial NaCl concentration that occ

141 of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diure

142 th altered water balance, immunoblots of rat inner medullary membrane fractions were probed with rabb

143 reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in culture.

144 here were no significant differences in mean inner medullary Na(+) or Cl(-) concentrations between UT

145 o-Cys-1,d-Arg-8 vasopressin, which increases inner-medullary NaCl concentration, causes a 4-fold incr

146 Treatment with furosemide, which decreases inner-medullary NaCl, reduces inner-medullary Pax2 mRNA

147 Moreover, inner medullary Osp94 expression was increased during wa

148 hich decreases inner-medullary NaCl, reduces inner-medullary Pax2 mRNA and protein.

149 l concentration, causes a 4-fold increase in inner-medullary Pax2 protein.

150 lization of both AQP2 and pAQP2 in the renal inner medullary principal cells appeared more dispersed,

151 in urea transporter mRNA abundance in either inner medullary region.

152 significantly increased UT-A1 protein in the inner medullary tip after 7 d, whereas aldosterone reple

153 both membrane and vesicle fractions from the inner medullary tip of adrenalectomized rats.

154 rsed UT-A1 protein abundance increase in the inner medullary tip of adrenalectomized rats.

155 vesicle fraction proteins were isolated from inner medullary tip or base and Western analysis was per

156 s from the cortico-medullary boundary to the inner medullary tip.

157 Analysis of inner medullary tissue after water restriction revealed