ライフサイエンスコーパス: inositol

1 Inositol 1, 4, 5-trisphosphate (IP(3)) binding at the N-

2 Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks

3 We demonstrated that inositol 1,3,4,5-tetrakisphosphate (IP4), the product of

4 An inositol 1,4,5-triphosphate (IP3) receptor inhibitor pre

5 role for either ryanodine receptor (RyR) or inositol 1,4,5-triphosphate receptor (IP(3)R) dysfunctio

6 ptor 2 (RyR2)-mediated Ca2+ oscillations and inositol 1,4,5-triphosphate receptor (IP3R)-induced cyto

7 Calcium-mediated signaling through inositol 1,4,5-triphosphate receptors (IP(3)Rs) is essen

8 the PLC/IP3/PKC/ERK pathway (phospholipase C/inositol 1,4,5-triphosphate/protein kinase C/extracellul

9 s also were reduced by selectively buffering inositol 1,4,5-trisphosphate (InsP(3)) within the nucleu

10 tal opening; [Ca(2+) ](cyt) oscillation; and inositol 1,4,5-trisphosphate (InsP3) production.

11 We propose that inositol 1,4,5-trisphosphate (IP(3) )-dependent Ca(2+) s

12 eration, and Inpp5a overexpression decreases inositol 1,4,5-trisphosphate (IP(3)) levels and ameliora

13 The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs)

14 (VGCC) and mobilization of Ca(2+) from both inositol 1,4,5-trisphosphate (IP(3))-sensitive stores an

15 nic M3 receptors, or by direct activation of inositol 1,4,5-trisphosphate (IP3) receptors by photolys

16 T-cell activation releases inositol 1,4,5-trisphosphate (IP3), inducing cytoplasmic

17 ition of the phospholipase C gamma 2 (PLCG2)/inositol 1,4,5-trisphosphate (IP3)/Ca(2+)/protein kinase

18 In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphor

19 (2+)-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P(3)] are imp

20 2+)-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)].

21 hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrop

22 ggers PLC-mediated hydrolysis of PIP(2) into inositol 1,4,5-trisphosphate and diacylglycerol, which a

23 escent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-trisphosphate biosensor GFP-PLCdelta1-PH

24 ce of extracellular Ca(2+), and that the PLC-inositol 1,4,5-trisphosphate pathway, which controls the

25 (i)) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+)-

26 ng a proteomics approach, we identify type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R1) as a spe

27 n genes encoding the neuronal isoform of the inositol 1,4,5-trisphosphate receptor (ITPR1) and genes

28 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

29 The type 3 inositol 1,4,5-trisphosphate receptor (ITPR3) is the pri

30 sed from these organelles through a channel, inositol 1,4,5-trisphosphate receptor (TbIP(3)R), which

31 , voltage-dependent Ca(2+) channels, and the inositol 1,4,5-trisphosphate receptor as well as the N-m

32 co/ER Ca(2+) ATPase, ryanodine receptor, and inositol 1,4,5-trisphosphate receptor channel in various

33 R Ca(2+) ATPase, ER Ca(2+) release channels, inositol 1,4,5-trisphosphate receptor channel, ryanodine

34 phate receptor (ITPR1) and genes involved in inositol 1,4,5-trisphosphate receptor degradation (ERLIN

35 ubiquitinated endoplasmic reticulum protein inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), wh

36 tically, we showed that HAX-1 interacts with inositol 1,4,5-trisphosphate receptor-1 (InsP3R1) in the

37 Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are end

38 pled receptors stimulates Ca(2+) release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs), engagi

39 ted by intracellular calcium release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs).

40 Activated inositol 1,4,5-trisphosphate receptors are then rapidly

41 iquitin E3 ligase gene RNF170, which targets inositol 1,4,5-trisphosphate receptors for degradation,

42 reticulum membrane (ryanodine receptors and inositol 1,4,5-trisphosphate receptors) of isolated card

43 release from the nucleoplasmic reticulum by inositol 1,4,5-trisphosphate receptors.

44 Our findings highlight inositol 1,4,5-trisphosphate signaling as a candidate ke

45 to the cytoplasm is controlled by binding of inositol 1,4,5-trisphosphate to its receptor.

46 onse to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors

47 steoclast (OC) differentiation by modulating inositol 1,4,5-trisphosphate-mediated calcium oscillatio

48 Furthermore, we report the INPP1/inositol 1,4-bisphosphate complex which illuminates key

49 hich 4,6-di-O-(methoxy-diethyleneglycol)-myo-inositol-1,2,3,5-tetrakis(phosphate), (OEG(2))(2)-IP4, d

50 butes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and

51 ough metabolism of phytate and production of inositol-1,4,5-trisphosphate (InsP(3)).

52 ed morphology and express IP3R3, which is an inositol-1,4,5-trisphosphate receptor constitutively exp

53 IRE1alpha determined the distribution of inositol-1,4,5-trisphosphate receptors at MAMs by operat

54 vely, these results support the concept that inositol-1,4,5-trisphosphate type 3 receptor signaling i

55 cted by inhibition of the production of IP3 (inositol-1,4,5-trisphosphate) by phospholipase-C and acc

56 of the second messengers, diacylglycerol and inositol-1,4,5-trisphosphate.

57 pha-Manp-1 -> P-(O -> 6)-alpha-Manp-(1 -> 2)-Inositol-1-P-(O -> 1)-phytoceramide of Candida albicans

58 determined by measuring A7r5 cell line D-myo-inositol-1-phosphate accumulation).

59 Furthermore, inositol-1-phosphate release into the medium occurred up

60 idylinositol (LPI) into monoacylglycerol and inositol-1-phosphate.

61 ethoxybenzyl-1,2:4,5-di-O-isopropylidene-myo-inositol 11.

62 ogical inhibitors wortmannin, a phosphatidyl inositol 3-kinase inhibitor, and leupeptin plus E64 (inh

63 Downstream inositol 3-phosphate (IP(3)) signaling appeared to be un

64 In an astrocyte-specific inositol 3-phosphate receptor type-2 knockout mouse, nea

65 erpinning their resemblance to physiological inositol 3-phosphate receptor type-2-independent Ca(2+)

66 The phosphatidyl-inositol-3 kinases (PI3K) pathway regulates a variety of

67 1 (IGF-1) signalling (IIS) via phosphatidyl inositol-3-kinase (PI3K), phosphoinositide-dependent kin

68 Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase

69 (SOCS1) and Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP-1) and therefore could pl

70 Concomitantly, SH2 domain-containing inositol 5-phosphatase 1 (SHIP1) was recruited to the gH

71 Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), ch

72 conditions that result from mutations of the inositol 5-phosphatase oculocerebrorenal syndrome of Low

73 denophostin 2 by d-chiro-inositol in d-chiro-inositol adenophostin 4 increased the potency.

74 thoxy-benzyl-1,2:4,5-di-O-isopropylidene-myo-inositol allowed the preparation of 11.

75 1-MMP and TACE, to the glycosyl-phosphatidyl inositol anchor of prions to create a membrane-tethered,

76 ression of prostasin, a glycosylphosphatidyl inositol-anchored membrane protease, in blood samples fr

77 tilizations of the existing framework of myo-inositol and a regioselective esterification.

78 (as well as N-acetylaspartate, choline, myo-inositol and creatine) group contrasts from all individu

79 microbial activity, was synthesized from myo-inositol and dimethyl d-camphor acetal in 14 steps.

80 25 steps in an overall yield of 6% using myo-inositol and ethyl propiolate as the starting materials.

81 fivefold increases in specific titers of myo-inositol and glucaric acid, respectively.

82 ges are associated with altered cortical myo-inositol and glycine levels, suggesting sleep loss-induc

83 Comparison of inositol and/or pinitol pool in three types of transgeni

84 spartate, choline, glutamate, glutamine, myo-inositol, and total creatine).

85 ls PLC-generated IPs are rapidly recycled to inositol, and uncover the enzymology behind an alternati

86 Inositol availability, which regulates several phospholi

87 Anaerostipes hadrus that encodes a composite inositol catabolism-butyrate biosynthesis pathway, the p

88 (L-serine, L-leucine, glucose, fructose, myo-inositol, citric acid and 2, 3-hydroxypropanoic acid).Tw

89 tic InoAz analogues as inhibitors or MCRs of inositol-containing glycoconjugates in eukaryotic and my

90 bolic chemical reporters (MCRs) for labeling inositol-containing glycoconjugates in eukaryotic cells

91 Moreover, inositol depletion in strains lacking this interaction r

92 cess both enantiomers of 4,5-di-O-benzyl-myo-inositol, derived from the same set of starting material

93 ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations.

94 Inositol diphosphates (PP-IPs), also known as inositol p

95 palmitoleic acid, L-serine, oleic acid, myo-inositol, dodecanoic acid, L-methionine, hypoxanthine, p

96 GPC1 decreased stationary phase viability in inositol-free medium.

97 A1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from in

98 mbrane-associated protein], GPLD1 [phosphate inositol-glycan specific phospholipase D], APOE [apolipo

99 our understanding of the biological roles of inositol heptaphosphates (PP-InsP(5)) has greatly improv

100 n of highly phosphorylated inositols, mostly inositol hexakisphosphate (IP(6)), detected in HEK293 ce

101 hermore, binding of the host cell metabolite inositol hexakisphosphate (IP6) enhances dNTP import, wh

102 family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.

103 Myo-inositol hexakisphosphate (IP6) is a natural product kno

104 Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activa

105 e eukaryote-specific host signaling molecule inositol hexakisphosphate (IP6) is required for Lpg2603

106 We subsequently demonstrate that a myo-inositol hexakisphosphate (IP6) noncovalent adduct can s

107 tion, RNA binding, and the assembly cofactor inositol hexakisphosphate (IP6) synergize to generate im

108 Myo-inositol hexakisphosphate (IP6), is the main iron chelat

109 roles for stress-induced phosphorylation and inositol hexakisphosphate binding in specifying Gle1 fun

110 r phosphate homeostasis, here we knocked out inositol hexakisphosphate kinase (IP6K) 1 and IP6K2 to g

111 nserved in two human small-molecule kinases, inositol hexakisphosphate kinase (IP6K) and inositol pol

112 Accordingly, inositol hexakisphosphate kinase 1-2 (IP6K1-2) gene inac

113 zyl), N6-(p-nitrobenzyl) purine], to inhibit inositol hexakisphosphate kinases upstream of PPIP5Ks.

114 ular P(i) accumulated following knockdown of inositol hexakisphosphate kinases.

115 y showed that arrestin-3 can be activated by inositol-hexakisphosphate (IP(6)).

116 isiae, extracellular [Pi] is "sensed" by the inositol-hexakisphosphate kinase (IP6K) that synthesizes

117 ogen Ralstonia solanacearum, in complex with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA

118 SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formati

119 Inositol, hydroxyphenylpyruvate, citrulline, ornithine,

120 ural product mimic adenophostin 2 by d-chiro-inositol in d-chiro-inositol adenophostin 4 increased th

121 Azide-modified inositol (InoAz) analogues are valuable as inhibitors an

122 It is conceivable that inositol itself acts as a stress-ameliorator and/or as a

123 ally hydrolyze the hexakisphosphate ester of inositol known as phytic acid, are routinely added to th

124 that is not detectable by traditional [(3)H]-inositol labeling.

125 Additional metabolite changes including low inositol levels in response to high blood alcohol levels

126 The inositol lipid phosphatases PTEN and SHIP-1 play a cruci

127 A key molecule in this process is the inositol lipid PtdIns(4,5)P(2), which recruits numerous

128 Such selective manipulation of the inositol metabolic pathway may be one of the ways to com

129 n the levels of N-acetylaspartate (NAA), myo-inositol (mI), scyllo-inositol (sI), glycine, taurine, p

130 tions of total N-acetylaspartate (tNAA), myo-inositol (mI), total choline-containing compounds (tCho)

131 than the younger group were observed for myo-inositol (mIns) in DLPFC and hippocampus and total choli

132 A homozygous mutation in the inositol monophosphatase 1 (IMPA1) gene was recently ide

133 -induced signaling with Ca(2+) mobilization, inositol monophosphate (IP(1)) accumulation, extracellul

134 nvestigated their effects on KISS1R-mediated inositol monophosphate (IP1) and Ca2+ signaling in cell

135 coupling of the probe to substance P, while inositol monophosphate accumulation assays demonstrated

136 by an accumulation of highly phosphorylated inositols, mostly inositol hexakisphosphate (IP(6)), det

137 the seven carbon (7-C) sugar C-methyl-scyllo-inositol (mytilitol) in mussels and clams (Mytilus and R

138 ) has greatly improved, the functions of the inositol octaphosphates ((PP)(2)-InsP(4)) have remained

139 by feeding cells with either [(13)C(6)]-myo-inositol or [(13)C(6)]-D-glucose.

140 ression, in the absence of extracellular myo-inositol or other SMIT1 substrates, on fundamental funct

141 xpression of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitr

142 Conceivably, upregulation of myo-inositol oxygenase (MIOX) is associated with altered cel

143 phosphatase genes, including SH2-containing inositol phosphatase (Ship2).

144 I3K), or 5' Src homology 2 domain-containing inositol phosphatase 1 (SHIP1).

145 The results indicate that scaffolding of inositol phosphatase activity is critical for maintainin

146 An inactivating mutation (R258Q) in the Sac inositol phosphatase domain of synaptojanin 1 (SJ1/PARK2

147 IPIP27 scaffolds the inositol phosphatase oculocerebrorenal syndrome of Lowe

148 y, experiments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolo

149 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155,

150 nts of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from the non-pathogenic b

151 one rapidly increased intracellular cAMP and inositol phosphate accumulation, and altered phosphoryla

152 Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors

153 ase (IPMK), which synthesize multifunctional inositol phosphate cell signals.

154 , including analysis of PLCgamma(2)-mediated inositol phosphate formation, inositol phospholipid asse

155 due to the number of reactions and lipid and inositol phosphate intermediates involved makes it diffi

156 operties to assist the future development of inositol phosphate kinase inhibitors.

157 ation, and PLC activation by determining the inositol phosphate levels in brain lysates of animals pr

158 ting the potential of this method to dissect inositol phosphate metabolism and signalling.

159 evelopment for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and des

160 Human inositol phosphate multikinase (HsIPMK) critically contr

161 s competitive antagonists of ghrelin-induced inositol phosphate production and calcium mobilization.

162 gain-of-function activity through increased inositol phosphate production and the downstream activat

163 ive pathway through which microbiota-derived inositol phosphate regulates histone deacetylase 3 (HDAC

164 tors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-

165 tion studies, including radioligand binding, inositol phosphate, and toxicity assays, proved that we

166 ortant hypertension related pathways such as inositol phosphate-mediated signaling and calcineurin-NF

167 ween cytidine diphosphate-diacylglycerol and inositol-phosphate to yield phosphatidylinositol-phospha

168 The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophospha

169 myo-Inositol phosphates (IPs) are important bioactive molecu

170 Inositol phosphates (IPs) comprise a network of phosphor

171 ctosides (raffinose, stachyose, verbascose), inositol phosphates (IPs), trypsin inhibitors and lectin

172 Rpd3L complexes is inducibly up-regulated by inositol phosphates but involves interactions with a zin

173 Our results indicate that inositol phosphates stimulate HDAC activity and that the

174 M densities could be assigned to PA200-bound inositol phosphates, and we speculate regarding their fu

175 has been shown previously to be enhanced by inositol phosphates, which also bridge the catalytic dom

176 ma(2)-mediated inositol phosphate formation, inositol phospholipid assessments, fluorescence recovery

177 were needed for virus infection, whereas the inositol phospholipid-binding and F-actin-binding domain

178 Cytotoxic NLPs bind to glycosyl inositol phosphoryl ceramide (GIPC) sphingolipids that a

179 Study of the highly glycosylated glycosyl inositol phosphorylceramide (GIPC) sphingolipids has bee

180 A1 as a glucuronosyltransferase for glycosyl inositol phosphorylceramide (GIPC) sphingolipids in the

181 an Arabidopsis GIPC glucuronosyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLUCURONOSYLTRANSFERASE 1 (I

182 The plant sphingolipid biosynthetic enzyme, inositol phosphorylceramide synthase (IPCS), has been id

183 in fatty acids and dihydroxylated bases into inositol phosphorylceramides and GIPCs.

184 homeostasis, and we identified XPR1 as a key inositol polyphosphate (IP)-dependent regulator of this

185 Inositol polyphosphate 1-phosphatase (INPP1) is a protot

186 m its hydrolysis by the PI(3,4)P(2)-specific inositol polyphosphate 4-phosphatase 4A (INPP4A).

187 emically-induced dimerization to translocate inositol polyphosphate 5-phosphatase (Inp54p) to plasma

188 The inositol polyphosphate 5-phosphatase INPP5E localizes to

189 Mutations in OCRL encoding the inositol polyphosphate 5-phosphatase OCRL (Lowe oculocer

190 OCRL1 encodes an inositol polyphosphate 5-phosphatase which preferentiall

191 Therefore, tight regulation of inositol polyphosphate metabolism is essential for prope

192 results in an intracellular imbalance of the inositol polyphosphate metabolism.

193 at damage sites requires phosphorylation by inositol polyphosphate multikinase (IPMK) and promotes n

194 integrin beta1 concomitant with the loss of inositol polyphosphate multikinase (IPMK) in murine myoc

195 inositol hexakisphosphate kinase (IP6K) and inositol polyphosphate multikinase (IPMK), which synthes

196 Inositol polyphosphate multikinase is a metformin target

197 , we showed that depletion of IPMK, encoding inositol polyphosphate multikinase, promotes autophagy a

198 Multiple inositol polyphosphate phosphatases (MINPPs) are clade 2

199 and MA proteins incubated in the presence of inositol polyphosphate, we show a correlation between MA

200 s, we identified a functional null allele of inositol polyphosphate-5-phosphatase E (Inpp5e), ridge t

201 Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in

202 However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), c

203 y loss-of-function mutations in the multiple inositol-polyphosphate phosphatase 1 gene (MINPP1).

204 from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphat

205 Inositol polyphosphates are vital metabolic and secondar

206 red for potentiation of SMIT activity by myo-inositol preincubation.

207 transgenic plants suggests that plants whose inositol production remains uninterrupted under stress b

208 inase), vip1Delta (IP6 1-kinase), ddp1Delta (inositol pyrophosphatase), or kcs1Delta vip1Delta mutant

209 rophosphatase domain of Asp1, a bifunctional inositol pyrophosphate (IPP) kinase/pyrophosphatase that

210 comparatively uncharacterized member of the inositol pyrophosphate (PP-InsP) signaling family: 1,5-b

211 levated ATP levels are a hallmark of altered inositol pyrophosphate (PP-IP) synthesis, and basal ATP

212 se (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pen

213 cose-driven phosphate flush occurred despite inositol pyrophosphate depletion.

214 We hypothesized that strains with high inositol pyrophosphate levels will have an increased str

215 conclude that IP6K1 and -2 together control inositol pyrophosphate metabolism and thereby physiologi

216 onment, regulation of mRNA structure by this inositol pyrophosphate represents an epitranscriptomic c

217 of mRNA stability and P-body dynamics by the inositol pyrophosphate signaling molecule 5-InsP(7) (5-d

218 ular calcium oscillations, while other caged inositol pyrophosphates (3,5-(PP)(2)-InsP(4), 5-PP-InsP(

219 eostasis is subject to metabolite control by inositol pyrophosphates (IPPs), exerted through the 3'-p

220 s contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-In

221 Yeast cells unable to synthesize inositol pyrophosphates (PP-InsPs) are unable to induce

222 s of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challen

223 To verify whether inositol pyrophosphates also regulate mammalian cellular

224 Inositol pyrophosphates constitute a family of hyperphos

225 Inositol pyrophosphates have emerged as important regula

226 l types, basal P(i) efflux was stimulated by inositol pyrophosphates, and basal intracellular P(i) ac

227 nositol diphosphates (PP-IPs), also known as inositol pyrophosphates, are high-energy cellular signal

228 or 1 (XPR1) revealed that it is regulated by inositol pyrophosphates, which can bind to its SPX domai

229 to generate human HCT116 cells devoid of any inositol pyrophosphates.

230 code and is subject to metabolite control by inositol pyrophosphates.

231 Motor cortex total N-acetylaspartate to myo-inositol ratio (tNAA:mIns) significantly declined in pat

232 During ER stress, the inositol requiring enzyme 1alpha (IRE1alpha) endoribonuc

233 ), activating transcription factor-6 (ATF6), inositol requiring enzyme 1alpha (IRE1alpha), and their

234 Inositol Requiring Enzyme-1 (IRE1) is the most conserved

235 the membrane-associated RNA splicing factor, INOSITOL REQUIRING ENZYME1 (IRE1).

236 We found that Emapunil modulates the inositol requiring kinase 1alpha (IRE alpha)/X-box bindi

237 y hepatocytes of key cell stress regulators: inositol-requiring 1alpha (IRE1alpha) and X-box binding

238 The inositol-requiring 1alpha (IRE1alpha) is an ER stress se

239 The inositol-requiring enzyme (IRE1) is one ER stress sensor

240 The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream ta

241 ticulum (ER) membrane-resident stress sensor inositol-requiring enzyme 1 (IRE1) governs the most evol

242 ents pancreatic EIF2-alpha kinase (PERK) and inositol-requiring enzyme 1 (IRE1) have been reported to

243 Inositol-Requiring Enzyme 1 (IRE1) is an essential compo

244 KR-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), activated transcript

245 y, in which cells had elevated expression of inositol-requiring enzyme 1 (IRE1), NF-kappaB, and the i

246 One pathway is triggered by the inositol-requiring enzyme 1 (IRE1), which splices the X-

247 that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1alpha) and its substrat

248 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UP

249 Inhibition of the inositol-requiring enzyme 1/X-box binding protein 1 arm

250 Inositol-requiring enzyme 1[alpha] (IRE1[alpha])-X-box b

251 tis, our study demonstrates the induction of inositol-requiring enzyme 1alpha (IRE1alpha) and splicin

252 Here, we identified inositol-requiring enzyme 1alpha (IRE1alpha) as a critic

253 s) induces phosphorylation of the UPR sensor inositol-requiring enzyme 1alpha (IRE1alpha) in a SMAD2/

254 function of the dual kinase-endoribonuclease inositol-requiring enzyme 1alpha (IRE1alpha), a key comp

255 portant endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting

256 n of the endoplasmic reticulum stress marker inositol-requiring enzyme 1alpha were greater in FIT2 kn

257 nse (UPR); as evidenced by the activation of inositol-requiring enzyme 1alpha, protein kinase R-like

258 n of protective ER function was via the IRE (inositol-requiring enzyme)-1/XBP (X-box-binding protein)

259 e RNA-activated (PKR)-like ER kinase (PERK), inositol-requiring enzyme-1alpha (IRE1alpha), and activa

260 y activating signaling via sigma receptor 1, inositol-requiring enzyme-1alpha (IRE1alpha), and X-box

261 NOS) and S-nitrosylation of the endonuclease inositol-requiring protein 1alpha (IRE1alpha), culminati

262 d-chiro-Inositol ribophostin 10 was synthesized by coupling as b

263 d-chiro-Inositol ribophostin is the most potent small-molecule I

264 and positions of the phosphate groups in the inositol ring (with seven different PIPs being active in

265 d kinases that phosphorylate the 3-OH of the inositol ring of phosphoinositides, and deregulation of

266 scyllo-Inositol (SI) is a potential therapeutic for AD by direc

267 ylaspartate (NAA), myo-inositol (mI), scyllo-inositol (sI), glycine, taurine, phosphoethanolamine (PE

268 validated by rescuing the phenotype with myo-inositol supplemented media during differentiation of pa

269 rovide evidence for the existence of unknown inositol synthesis pathways in mammals, highlighting the

270 Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in A

271 entrations of neurochemicals choline and myo-inositol that were higher pretransplant compared with co

272 at a signaling system consisting of PLCbeta, inositol triphosphate (IP(3)), IP(3) receptors, and Ryan

273 XCR1 activation, as determined by assessing inositol triphosphate accumulation, intracellular calciu

274 ation in conjunction with stimulation of the inositol triphosphate receptor (IP3R).

275 of which are mediated by stimulation of the inositol triphosphate receptor 1 (INSP3R1).

276 lcium elevations during PIDs are mediated by inositol triphosphate receptor type 2-dependent (IP3R2-d

277 lar signal-regulated kinase 1/2, determining inositol triphosphate-dependent Ca2+ release from the en

278 activation of phospholipase C and opening of inositol trisphosphate (InsP3) receptors.

279 It is widely assumed that inositol trisphosphate (IP(3)) and ryanodine (Ry) recept

280 ge this idea and indicate that receptors for inositol trisphosphate (IP(3)) and ryanodine may be loca

281 Upon inositol trisphosphate (IP(3)) stimulation of non-excita

282 The 'building-block' model of inositol trisphosphate (IP(3))-mediated Ca(2+) liberatio

283 However, local inositol trisphosphate (IP(3))-mediated Ca(2+) signaling

284 rt mediated by TGFbeta-induced inhibition of inositol trisphosphate (IP3) production, leading to a de

285 We previously reported decreased inositol trisphosphate (IP3)-mediated Ca(2+) release fro

286 pholipase C to generate the second messenger inositol trisphosphate often evokes repetitive oscillati

287 PLC/inositol trisphosphate receptor (IP3R) and estrogen rece

288 ructures with the Ca2+ channel Orai1 and the inositol trisphosphate receptor (IP3R), thereby linking

289 xin on expression and function of the type 3 inositol trisphosphate receptor (ITPR3), because this is

290 ies, resulting in reduced phosphorylation of inositol trisphosphate receptor, which mediates endoplas

291 restricted membrane protein (LRMP, Jaw1) and inositol trisphosphate receptor-associated guanylate kin

292 red by release from stores most probably via inositol trisphosphate receptors.

293 e second messengers diacylglycerol and 1,4,5-inositol trisphosphate.

294 sm-related kinome RNAi screen, we identified inositol-trisphosphate 3-kinase B (ITPKB) as a critical

295 IP(3)R (Inositol-trisphosphate receptor) stimulation produced la

296 on of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter ju

297 5-Azido-5-deoxy-d-myo-inositol was inaccessible due to an unusual beta-elimina

298 ontal gyri (19 voxels, CCLAV = 0.05) and myo-inositol was reduced in the left cerebellum (34 voxels,

299 , 3-azido-3-deoxy- and 4-azido-4-deoxy-d-myo-inositol were efficiently synthesized.

300 rged osmolytes [(3) H]taurine and myo-[(3) H]inositol, without major impact on the simultaneously mea