ライフサイエンスコーパス: inositol 1,4,5-trisphosphate receptor

1 mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate receptor).

2 mily of intracellular Ca2+ release channels (inositol 1,4,5-trisphosphate receptors).

3 ontext of a structural homology model of the inositol 1,4,5-trisphosphate receptor.

4 Taxol increased binding of NCS-1 to the inositol 1,4,5-trisphosphate receptor.

5 ng protein), the ryanodine receptor, and the inositol 1,4,5-trisphosphate receptor.

6 e activity of the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor.

7 ive to inhibitors of the phospholipase C and inositol 1,4,5-trisphosphate receptor.

8 release from the nucleoplasmic reticulum by inositol 1,4,5-trisphosphate receptors.

9 reased pool of Ca2+ for positive feedback on inositol 1,4,5-trisphosphate receptors.

10 efficiently activated in DT40 cells lacking inositol 1,4,5-trisphosphate receptors.

11 kinase A-mediated phosphorylation of type II inositol 1,4,5-trisphosphate receptors.

12 and endoplasmic reticulum Ca(2+) release via inositol 1,4,5-trisphosphate receptors.

13 gated Ca(2+) channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors.

14 pase Cgamma to affect Ca(2+) release through inositol (1,4,5) trisphosphate receptors.

15 sed phosphorylation of the ER Ca(2+) channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG c

16 tically, we showed that HAX-1 interacts with inositol 1,4,5-trisphosphate receptor-1 (InsP3R1) in the

17 ly dependent on Ca2+ oscillation mediated by inositol 1,4,5-trisphosphate receptors 2 and 3 (ITPR2 an

18 Further, both inositol 1,4,5-trisphosphate receptor-3 and caveolin-1 w

19 Localization of Galpha(q/11), inositol 1,4,5-trisphosphate receptor-3, and phospholipa

20 s TRPC6, phospholipase Cbetas, Galpha(q/11), inositol 1,4,5-trisphosphate receptor-3, and syntaxin 3

21 lborate, a cell-permeant antagonist of D-myo-inositol 1,4,5-trisphosphate receptors, abrogates antige

22 attributed to changes in passive Ca2+ leak, inositol 1,4,5-trisphosphate receptor activity, or sensi

23 (8), two analogues of the superpotent 1D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophost

24 dium pump, the sodium/calcium exchanger, and inositol-1,4,5-trisphosphate receptors (all ankyrin-B-bi

25 strate that TAT-PS2-LP can interact with the inositol 1,4,5-trisphosphate receptor and activate Ca(2+

26 itol 1,4,5-trisphosphate, which binds to the inositol 1,4,5-trisphosphate receptor and gates the open

27 of intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor and ryanodine rece

28 protein that is required for localization of inositol 1,4,5-trisphosphate receptor and ryanodine rece

29 ) release from the endoplasmic reticulum via inositol 1,4,5-trisphosphate receptors and by Ca(2+) ent

30 t from diacylglycerol, endoplasmic reticulum inositol 1,4,5-trisphosphate receptors and Ca2+ stores.

31 arcoplasmic reticulum Ca(2+) release through inositol 1,4,5-trisphosphate receptors and extracellular

32 demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulates Ca2

33 the cooperative activity of Ca(2+)-regulated inositol 1,4,5-trisphosphate receptors and ryanodine rec

34 rin-B (-/-) mice display mis-localization of inositol 1,4,5-trisphosphate receptors and ryanodine rec

35 uggests that it results from potentiation of inositol 1,4,5-trisphosphate receptors and/or phospholip

36 use morulae occurs predominantly through the inositol 1,4,5-trisphosphate receptor, and that alterati

37 ryanodine receptors, increased expression of inositol-1,4,5-trisphosphate receptors, and differential

38 g the phospholipase C antagonist U73122, the inositol 1,4,5-trisphosphate receptor antagonist 2-amino

39 Activated inositol 1,4,5-trisphosphate receptors are then rapidly

40 oplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building

41 , voltage-dependent Ca(2+) channels, and the inositol 1,4,5-trisphosphate receptor as well as the N-m

42 striated distribution of both ryanodine and inositol 1,4,5-trisphosphate receptors as well as normal

43 ral transcriptional regulator TFII-I and the inositol 1,4,5-trisphosphate receptor-associated PKG sub

44 IRE1alpha determined the distribution of inositol-1,4,5-trisphosphate receptors at MAMs by operat

45 Hg, ECs generated low-frequency (~2 min(-1)) inositol 1,4,5-trisphosphate receptor-based Ca(2+) event

46 tors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity f

47 ch is blunted by internal store depletion or inositol 1,4,5-trisphosphate receptor blockade.

48 0, p < 0.001), whereas pretreatment with the inositol 1,4,5-trisphosphate receptor blocker xestospong

49 glutamate receptors; (ii) membrane-permeable inositol 1,4,5-trisphosphate receptor blockers 2-APB and

50 epletion of internal stores or inhibition of inositol 1,4,5-trisphosphate receptors but not by inhibi

51 d upon activation of phospholipase C and the inositol 1,4,5-trisphosphate receptor, but not upon extr

52 to demonstrate that sensitization of type 1 inositol (1,4,5)-trisphosphate receptors by mHtt, which

53 parks arise from the cooperative activity of inositol 1,4,5-trisphosphate receptor Ca(2+) channels (I

54 as blocked by inhibiting the phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+ signaling.

55 co/ER Ca(2+) ATPase, ryanodine receptor, and inositol 1,4,5-trisphosphate receptor channel in various

56 tributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms i

57 R Ca(2+) ATPase, ER Ca(2+) release channels, inositol 1,4,5-trisphosphate receptor channel, ryanodine

58 release events that arise from a cluster of inositol 1,4,5-trisphosphate receptor channels (IP(3)Rs)

59 ized releases of calcium through clusters of inositol 1,4,5-trisphosphate receptor channels constitut

60 They arise from clustered inositol 1,4,5-trisphosphate receptor/channels (IP3Rs),

61 estered in the endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors/channels (IP(3)Rs

62 physically with the N-terminal domain of the inositol 1,4,5-trisphosphate receptor, consistent with a

63 ed morphology and express IP3R3, which is an inositol-1,4,5-trisphosphate receptor constitutively exp

64 Importantly, ubiquitination of inositol 1,4,5-trisphosphate receptors correlates with s

65 phate receptor (ITPR1) and genes involved in inositol 1,4,5-trisphosphate receptor degradation (ERLIN

66 onapoptotic necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor-dependent calcium

67 have examined the distribution of the type 1 inositol 1,4,5-trisphosphate receptor during development

68 2+) signals interact with both ryanodine and inositol 1,4,5-trisphosphate receptors during agonist st

69 iquitin E3 ligase gene RNF170, which targets inositol 1,4,5-trisphosphate receptors for degradation,

70 (2+) binding protein that interacts with the inositol 1,4,5-trisphosphate receptor from a human brain

71 Adenophostin A, a potent activator of the inositol 1, 4,5-trisphosphate receptor, has been reporte

72 to a loss of function in the localization of inositol 1,4,5-trisphosphate receptors in ankyrin-B muta

73 Inositol 1,4,5-trisphosphate receptors in Caenorhabditis

74 many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation

75 transients (CaTs) are due to upregulation of inositol-1,4,5-trisphosphate receptor induced Ca(2+) rel

76 phospholipase C inhibitor U73122 and by the inositol 1,4,5-trisphosphate receptor inhibitor Xestospo

77 Xestospongin C (an inositol 1,4,5-trisphosphate receptor inhibitor) had no

78 crom concentrations of the membrane-permeant inositol 1,4,5-trisphosphate receptor inhibitor, 2-amino

79 However, xestospongin C, a specific inositol 1,4,5-trisphosphate receptor inhibitor, did not

80 tin A (AdA) is a potent agonist of the d-myo-inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P3R).

81 The inositol (1,4,5)-trisphosphate receptor (InsP(3)R) is an

82 Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP(3)R) is t

83 ATP enhances Ca(2+) release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R).

84 Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by

85 +)) by generating InsP(3) and activating the inositol 1,4, 5-trisphosphate receptor (InsP(3)R).

86 ut not wild-type Atx2 specifically binds the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and inc

87 ng proteins (CaBPs) was shown to bind to the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+)

88 (i)) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+)-

89 The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is a te

90 The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is a te

91 The molecular mechanisms required for inositol 1,4,5-trisphosphate receptor (InsP(3)R) targeti

92 of SOCs and TRP channels is mediated by the inositol 1,4,5-trisphosphate receptor (InsP(3)R) was exa

93 The inositol 1,4,5-trisphosphate receptor (InsP(3)R), an int

94 protein that modulates Ca(2+) release by the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

95 o binds to and amplifies the activity of the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

96 The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a u

97 th the cytosolic C-terminal region of type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

98 ) specifically binds to and activates type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

99 exp) specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

100 -mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in car

101 The type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) was id

102 Phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) by PKA

103 Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) can be

104 Regulation of Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) has im

105 n kinase A (PKA)-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) in mou

106 Inositol 1,4,5-trisphosphate receptors (InsP(3)R) play a

107 calcium ([Ca(2+)](c)) through activation of inositol 1,4,5-trisphosphate receptors (InsP(3)R).

108 hannels interact directly with intracellular inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) and t

109 Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) repre

110 ositive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs).

111 through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP(3)Rs), whic

112 Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP3R) and thus

113 PS1 (M146L)and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+ rele

114 2+ release from intracellular stores through inositol 1,4,5-trisphosphate receptor (InsP3R) channels

115 The inositol 1,4,5-trisphosphate receptor (InsP3R) family of

116 tracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been

117 Both CGA and CGB associate with inositol 1,4,5-trisphosphate receptor (InsP3R) in a pH-d

118 We examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R) in mediat

119 The inositol 1,4,5-trisphosphate receptor (InsP3R) is an int

120 The inositol 1,4,5-trisphosphate receptor (InsP3R) is an int

121 ves are polarized in hepatocytes because the inositol 1,4,5-trisphosphate receptor (InsP3R) is concen

122 Wu et al. convincingly demonstrate that the inositol 1,4,5-trisphosphate receptor (InsP3R) is involv

123 The inositol 1,4,5-trisphosphate receptor (InsP3R) is the ma

124 ion of Ca(2+) waves, we examined the role of inositol 1,4,5-trisphosphate receptor (InsP3R) isoforms

125 xpression and function of the two rat type-1 inositol 1,4,5-trisphosphate receptor (InsP3R) ligand bi

126 The inositol 1,4,5-trisphosphate receptor (InsP3R) plays a k

127 , neuronal calcium sensor 1 (NCS-1), and the inositol 1,4,5-trisphosphate receptor (InsP3R) to preven

128 er intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor (InsP3R), is neces

129 Here we examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R)/Ca(2+) re

130 Inositol 1,4,5-trisphosphate receptors (InsP3R) are the

131 e- and splice variant-specific modulation of inositol 1,4,5-trisphosphate receptors (InsP3R) by inter

132 functional properties of the three mammalian inositol 1,4,5-trisphosphate receptors (InsP3R) isoforms

133 Inositol 1,4,5-trisphosphate receptors (InsP3R) play a k

134 discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and in

135 The type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) plays

136 he three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) has been

137 known to increase the activity of the type-1 inositol 1,4,5-trisphosphate receptor (InsP3R1).

138 Type 1 inositol (1,4,5)-trisphosphate receptors (InsP3R1s) play

139 alicular membrane is mediated by the type II inositol 1,4,5-trisphosphate receptor (InsP3R2), so we i

140 mutation in ITPR2, which encodes the type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2), that wa

141 Antibodies against type 2 inositol 1,4,5-trisphosphate receptors (InsP3R2) and cal

142 The type III isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R3) is apica

143 Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are end

144 lved in cardiac hypertrophic signaling, that inositol 1,4,5-trisphosphate receptors (InsP3Rs) in vent

145 nt isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using i

146 ctivation of certain cell surface receptors, inositol 1,4,5-trisphosphate receptors (InsP3Rs), which

147 family, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs).

148 regulates several Ca(2+) channels, including inositol 1,4,5-trisphosphate receptors (InsP3Rs).

149 Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubi

150 we reported selective augmentation of type 3 inositol (1,4,5) trisphosphate receptors (IP(3)R3) in ly

151 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and rya

152 s) can be elicited from discrete clusters of inositol 1,4,5 trisphosphate receptors (IP(3)Rs) at low

153 lobal Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activatio

154 ked by ryanodine (100 microM) but not by the inositol 1,4,5-trisphosphate receptor (IP(3)R) blocker,

155 poptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2)(+)

156 in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel f

157 t gating dynamics of a single, nonconducting inositol 1,4,5-trisphosphate receptor (IP(3)R) channel,

158 Inositol 1,4,5-trisphosphate receptor (IP(3)R) channels,

159 The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a calc

160 the regulatory domain of the neuronal type-I inositol 1,4,5-trisphosphate receptor (IP(3)R) isoform (

161 tly transfected with type I and type III myo-inositol 1,4,5-trisphosphate receptor (IP(3)R) isoforms

162 examethasone induces a striking elevation of inositol 1,4,5-trisphosphate receptor (IP(3)R) levels in

163 euronal Ca(2+) signaling by enhancing type-1 inositol 1,4,5-trisphosphate receptor (IP(3)R) steady-st

164 we demonstrated that PC2 interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) to modula

165 nce tags (ESTs) demonstrated that the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R) was signi

166 tration-dependently and reversibly inhibited inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated

167 st three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R).

168 ) Ca2+ depletion and prolonged activation of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca2+ rele

169 The inositol 1,4,5-trisphosphate receptor (IP(3)R-1), which

170 ng a proteomics approach, we identify type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R1) as a spe

171 During oocyte maturation, the inositol 1,4,5-trisphosphate receptor (IP(3)R1), the cha

172 In cardiac myocytes the type-2 inositol 1,4,5-trisphosphate receptor (IP(3)R2) is the p

173 Inositol 1,4,5-trisphosphate receptors (IP(3)R) and ryan

174 Others, including the almost ubiquitous inositol 1,4,5-trisphosphate receptors (IP(3)R) and thei

175 The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspa

176 llular functions, including Ca(2+) efflux at inositol 1,4,5-trisphosphate receptors (IP(3)R) on the e

177 stimulates formation of cAMP and sensitizes inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3)

178 in A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thou

179 novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP(3)R).

180 upling of sarcoplasmic reticulum (SR) type 1 inositol 1,4,5-trisphosphate receptors (IP(3)R1) to plas

181 IP of Sec8 coimmunoprecipitates Sec6, type 3 inositol 1,4,5-trisphosphate receptors (IP(3)R3), and th

182 es of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and rya

183 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a f

184 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are ubi

185 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) form te

186 A number of studies have demonstrated that inositol 1,4,5-trisphosphate receptors (IP(3)Rs) interac

187 roximity of the C- and N-terminal domains of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) may be

188 Calcium (Ca(2+)) release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs) regulat

189 knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) stimula

190 gh the intracellular Ca(2+) release channel (inositol 1,4,5-trisphosphate receptors (IP(3)Rs)) that i

191 pled receptors stimulates Ca(2+) release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs), engagi

192 etabotropic glutamate receptors (mGluRs) and inositol 1,4,5-trisphosphate receptors (IP(3)Rs), suppor

193 ted by intracellular calcium release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs).

194 IP(3) (inositol 1,4,5-trisphosphate) receptors (IP(3)Rs) regula

195 Inositol-1,4,5-trisphosphate receptors (IP(3)Rs) and rya

196 d the detailed intracellular distribution of inositol-1,4,5-trisphosphate receptors (IP(3)Rs), and ry

197 s (RyRs), dihydropyridine receptors (DHPRs), inositol-1,4,5-trisphosphate receptors (IP(3)Rs), canoni

198 ) release through the ryanodine receptors or inositol 1,4,5-trisphosphate receptors (IP3 R) and upon

199 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a fa

200 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calc

201 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expr

202 Inositol-1,4,5-trisphosphate receptors (IP3 Rs) modulate

203 Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated

204 e of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanod

205 The inositol 1,4,5 trisphosphate receptor (IP3R) is an intra

206 is and the degradation of the Ca(2+) channel inositol 1,4,5-trisphosphate receptor (IP3R) affects pro

207 e increased amounts of messenger RNA for the inositol 1,4,5-trisphosphate receptor (IP3R) and increas

208 Inositol 1,4,5-trisphosphate receptor (IP3R) antagonists

209 Furthermore, inositol 1,4,5-trisphosphate receptor (IP3R) but not rya

210 t by evaluating the regulation of the type I inositol 1,4,5-trisphosphate receptor (IP3R) by TGF-beta

211 sm involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channe

212 A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, wh

213 Ca2+ liberation through inositol 1,4,5-trisphosphate receptor (IP3R) channels ge

214 PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels.

215 myo-Inositol 1,4,5-trisphosphate receptor (IP3R) degradation

216 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

217 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

218 r ryanodine (400 microM), the antagonists of inositol 1,4,5-trisphosphate receptor (IP3R) or ryanodin

219 The inositol 1,4,5-trisphosphate receptor (IP3R) plays an es

220 cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein.

221 ime and this is accompanied by a decrease in inositol 1,4,5-trisphosphate receptor (IP3R) responsiven

222 om apical Ca(2+) pools that are gated by the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and

223 beled cells provided the first evidence that inositol 1,4,5-trisphosphate receptor (IP3R) was phospho

224 of intracellular Ca2+ channels, such as the inositol 1,4,5-trisphosphate receptor (IP3R), have gener

225 strated to physiologically interact with the inositol 1,4,5-trisphosphate receptor (IP3R), the ryanod

226 The resistance of inositol 1,4,5-trisphosphate receptor (IP3R)-deficient c

227 o phospholipase C (PLC) isoforms, and (3) an inositol 1,4,5-trisphosphate receptor (IP3R).

228 not TRPC4, interacts with PLCgamma1 and the inositol 1,4,5-trisphosphate receptor (IP3R).

229 multiple intracellular targets including the inositol 1,4,5-trisphosphate receptor (IP3R).

230 Most inositol 1,4,5-trisphosphate receptors (IP3R) are expres

231 Inositol 1,4,5-trisphosphate receptors (IP3R) are mediat

232 intracellular calcium concentration through inositol 1,4,5-trisphosphate receptors (IP3R) on endopla

233 d or refilled from one small site via either inositol 1,4,5-trisphosphate receptors (IP3R) or ryanodi

234 The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precise

235 m the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP3R), accountin

236 In DT40 B cells devoid of inositol 1,4,5-trisphosphate receptors (IP3R), the lack

237 hese channels: ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R).

238 Recent studies have suggested that inositol-1,4,5-trisphosphate-receptor (IP3R)-mediated Ca

239 The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) calcium re

240 a presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, w

241 ype 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-trisphosphate receptors (IP3R2s).

242 inds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulatin

243 Inositol (1,4,5)-trisphosphate receptors (IP3Rs) contrib

244 lting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate receptors (IP3Rs).

245 ms, like the endoplasmic reticulum-localized inositol 1,4,5-trisphosphate receptors (IP3Rs) and the v

246 supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close

247 Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the ad

248 Ca2+ liberation through inositol 1,4,5-trisphosphate receptors (IP3Rs) plays a u

249 Inositol 1,4,5-trisphosphate receptors (IP3Rs) release c

250 hat Bok binds strongly and constitutively to inositol 1,4,5-trisphosphate receptors (IP3Rs), proteins

251 cell lines that Bok interacts strongly with inositol 1,4,5-trisphosphate receptors (IP3Rs), suggesti

252 otic cell death require calcium release from inositol 1,4,5-trisphosphate receptors (IP3Rs).

253 All three cell types express the three known inositol 1,4,5-trisphosphate receptors (IP3Rs).

254 n-regulation of both type I and type III myo-inositol 1,4,5-trisphosphate receptors (IP3Rs).

255 Such release occurs through a cluster of inositol 1,4,5-trisphosphate receptors (IP3Rs).

256 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shan

257 e also show, for the first time, that type 1 inositol 1,4,5-trisphosphate receptor is expressed in th

258 athway in which the expression of the type-1 inositol 1,4,5-trisphosphate receptor is regulated by th

259 Inositol 1,4,5-trisphosphate receptor isoforms are a fam

260 These data suggest separate roles for inositol 1,4,5-trisphosphate receptor isoforms in develo

261 g gate structure is conserved in all RyR and inositol 1,4,5-trisphosphate receptor isoforms.

262 n genes encoding the neuronal isoform of the inositol 1,4,5-trisphosphate receptor (ITPR1) and genes

263 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

264 The type 3 isoform of the inositol 1,4,5-trisphosphate receptor (ITPR3) is the mos

265 The type 3 inositol 1,4,5-trisphosphate receptor (ITPR3) is the pri

266 mutation in itr-1, which encodes the single inositol 1,4,5-trisphosphate receptor (ITR) in C. elegan

267 Moreover, direct PC2 binding to inositol 1,4,5-trisphosphate receptor, KIF3A, and TRPC1

268 of ankyrin-B are still capable of restoring inositol 1,4,5-trisphosphate receptor localization and n

269 l melastatin subfamily 4 channels via type 2 inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) re

270 Additionally, inositol 1,4,5-trisphosphate receptor-mediated release o

271 An increase in type-1 inositol 1,4,5-trisphosphate receptor mRNA and protein s

272 reticulum membrane (ryanodine receptors and inositol 1,4,5-trisphosphate receptors) of isolated card

273 vation of cytosolic Ca(2+) by binding to the inositol 1,4,5-trisphosphate receptor on the endoplasmic

274 on of Mcl-1 did not affect expression of the inositol 1,4,5-trisphosphate receptor or the size of end

275 ta) stimulates phosphorylation of the type I inositol 1,4, 5-trisphosphate receptor, possibly via pro

276 monitor conformational changes of the type I inositol 1,4,5-trisphosphate receptor protein in membran

277 nd blockade of either ryanodine receptors or inositol 1,4,5-trisphosphate receptors reduced [Ca(2+)](

278 hrough L-type Ca2+ channels and release from inositol 1,4,5-trisphosphate receptor-sensitive intracel

279 athways (Ca(2+)/calmodulin-dependent kinase, inositol 1,4,5-trisphosphate receptor, SERCA).

280 uences in p53, CD44, neurofascin/L1, and the inositol 1,4,5-trisphosphate receptor suggests that the

281 ught to signal through the phospholipase and inositol (1,4,5)-trisphosphate receptor system, or throu

282 rypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(

283 sed from these organelles through a channel, inositol 1,4,5-trisphosphate receptor (TbIP(3)R), which

284 astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2

285 The inositol 1,4,5 trisphosphate receptor type 1 (IP3R1) in

286 The potentiation is absent in conditional inositol 1,4,5 trisphosphate receptor type 2 KO mice, wh

287 t processes: the intracellular Ca receptors, inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) and

288 ubiquitinated endoplasmic reticulum protein inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), wh

289 563del] and c.7659T>G [p.Phe2553Leu]) in the inositol 1,4,5-trisphosphate receptor type 1 gene (ITPR1

290 Furthermore, we show that induction of the inositol 1,4,5-trisphosphate receptor type 1 is controll

291 TPase and ryanodine receptor type 2, but not inositol 1,4,5-trisphosphate receptor type 2, were requi

292 mma13, phospholipase C-beta2 (PLC-beta2) and inositol 1,4,5-trisphosphate receptor type III (IP3R3).

293 n immunoprecipitation assay, we found ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) as a dire

294 A variant (rs718314) in the inositol 1,4,5-trisphosphate receptor, type 2 gene (ITPR

295 espective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), a

296 neurons, cGKII-dependent phosphorylation of inositol 1,4,5-trisphosphate receptors was decreased, re

297 tin A, two metabolically stable agonists for inositol 1,4,5-trisphosphate receptors, was investigated

298 ty filter, and S6 transmembrane helix of the inositol 1,4,5-trisphosphate receptor were mutated in or

299 activity were also blunted by inhibition of inositol 1,4,5-trisphosphate receptors with 2-aminoethox

300 y approximately 30% by the inhibition of the inositol 1,4,5-trisphosphate receptors with caffeine or