ライフサイエンスコーパス: inositol monophosphatase

1 with that proposed previously for the human inositol monophosphatase.

2 beta-bulge that is conserved in related myo-inositol monophosphatases.

3 ial target of lithium action, in addition to inositol monophosphatases.

4 A homozygous mutation in the inositol monophosphatase 1 (IMPA1) gene was recently ide

5 bundant transcript in axons was mRNA for myo-inositol monophosphatase-1 (Impa1), a key enzyme that re

6 Noteworthy enzymes such as sucrose synthase, inositol monophosphatase 3, and galactokinase were found

7 of human inositol monophosphatase, exhibits inositol monophosphatase activity but with substrate spe

8 The purified protein has inositol monophosphatase activity that is inhibited by t

9 In the inm1Delta:URA3 null mutant, inositol monophosphatase activity was reduced but not el

10 likely related to its known ability to block inositol monophosphatase activity.

11 ich reduces InsP3 levels by interfering with inositol monophosphatase, also failed to alter I(CRAC).

12 id sequence significantly similar to that of inositol monophosphatase, an enzyme that is not involved

13 oM and 302 microM for the wild-type, [Gln217]inositol monophosphatase and [Phe219]inositol monophosph

14 .8 mM and 29.1 mM for the wild-type, [Gln217]inositol monophosphatase and [Phe219]inositol monophosph

15 is suppressed by an inhibitor of the enzyme inositol monophosphatase and hence of the phosphatidylin

16 report that the antioxidant ebselen inhibits inositol monophosphatase and induces lithium-like effect

17 es of lithium were mediated by inhibition of inositol monophosphatase and led to free inositol deplet

18 thium also inhibits other targets, including inositol monophosphatase and structurally related phosph

19 residues are required for activation of myo-inositol monophosphatase, and enzyme activation is enhan

20 Lithium inhibits inositol monophosphatase at therapeutically effective co

21 other Li(+)-sensitive phosphatases, such as inositol monophosphatase, but molecular modelling of I(1

22 e (ORF) YHR046c (termed INM1), which encodes inositol monophosphatase, characterized the protein Inm1

23 Inositol monophosphatase (EC 3.1.3.25) in hyperthermophi

24 [Gln217]inositol monophosphatase and [Phe219]inositol monophosphatase enzymes respectively.

25 [Gln217]inositol monophosphatase and [Phe219]inositol monophosphatase enzymes, respectively, each sho

26 is substantially homologous to that of human inositol monophosphatase, exhibits inositol monophosphat

27 Candidates include inositol monophosphatases, glycogen synthase kinase-3 (G

28 Myo-inositol (inositol) monophosphatase (IMP), an enzyme which catalyz

29 ed the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its r

30 We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-l

31 ces mTOR-independent autophagy by inhibiting inositol monophosphatase (IMPase) and reducing inositol

32 Inositol monophosphatase (IMPase) catalyzes the hydrolys

33 ntial biomolecule that is synthesized by myo-inositol monophosphatase (IMPase) from inositol monophos

34 Lithium sensitive myo-inositol monophosphatase (IMPase) is a pivotal enzyme wh

35 a coli product of the suhB gene, SuhB, is an inositol monophosphatase (IMPase) that is best known as

36 During the course of our analysis of myo-inositol monophosphatase (IMPase), a key enzyme of brain

37 In this context, we examined host inositol monophosphatase (IMPase), reduced levels of whi

38 first step in inositol biosynthesis, nor the inositol monophosphatase (IMPase), which generates myo-i

39 s is that lithium acts through inhibition of inositol monophosphatase (IMPase).

40 Li inhibits inositol-monophosphatase (IMPase)-1.

41 previously in prokaryotes and resembles myo-inositol monophosphatases (IMPases).

42 ion of inositol metabolism, we characterized inositol monophosphatase in this yeast.

43 tial for the catalytic activity of mammalian inositol monophosphatase, increase the ellipticity in th

44 mimetic with the potential both to validate inositol monophosphatase inhibition as a treatment for b

45 Inositol monophosphatase is a key enzyme in the de novo

46 Inositol monophosphatase is a possible target but no bio

47 oader than those of bacterial and eukaryotic inositol monophosphatases (it can also act as a fructose

48 y converted to the final product, DIP, by an inositol monophosphatase-like phosphatase.

49 Inositol monophosphatase plays a vital role in the de no

50 s are pretreated with Li(+), an inhibitor of inositol monophosphatases that prevents PIP2 resynthesis

51 d enzymes, inositol-1-phosphate synthase and inositol monophosphatase, were identified.