ライフサイエンスコーパス: inotropic

1 Given that IL-1beta has a negative inotropic action on the heart, and that both its natural

2 olinergic (NANC) peptide with vasodilatative/inotropic action that may benefit the failing heart.

3 es to enhanced myocyte calcium transient and inotropic action.

4 ucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-te

5 meningococci in vitro abolished the negative inotropic activity.

6 normalities and repletion doses, duration of inotropic administration, and mortality.

7 lation period, absence of any vasopressor or inotropic agent (dopamine, epinephrine) use, higher lowe

8 serve as an alternative to dobutamine as an inotropic agent for management of postresuscitation myoc

9 Levosimendan is an inotropic agent that has been shown in small studies to

10 Omecamtiv mecarbil (OM) is a novel inotropic agent that prolongs systolic ejection time and

11 ough digoxin has been used for decades as an inotropic agent to treat heart failure, it does not impr

12 TE shortening corresponded to a reduction in inotropic agent use and improvement in cardiac function.

13 Overall, an inotropic agent was administered in 7691 of 126 564 (6.1

14 Before implantation, 100% were on > or =1 inotropic agent, and 77% had an intra-aortic balloon pum

15 n, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001), and to h

16 ated from the maximum dose of the individual inotropic agents administered in the first 3 days after

17 cur without hypertrophic cardiomyopathy when inotropic agents are used for hypotension.

18 The negative inotropic agents BDM (5 mm) or blebbistatin (10 microM)

19 Use of intravenous inotropic agents during hospitalization for heart failur

20 The positive inotropic agents EMD 57033 or CGP 48506 (1 microM) incre

21 Traditional inotropic agents exert their effect by modulating calciu

22 cement of an RV assist device, or the use of inotropic agents for >14 days.

23 m for the development of Ca2+ sensitizers as inotropic agents for heart failure has been tempered by

24 We found marked differences in the use of inotropic agents for heart failure patients among a dive

25 uidelines recommend targeted use of positive inotropic agents in highly selected patients, but data a

26 ne hospital variation in the use of positive inotropic agents in patients with heart failure.

27 a series of oxadiazolothiazinones, selective inotropic agents on isolated cardiac tissues, devoid of

28 The inotropic agents or an equivalent volume of placebo dilu

29 There is a pressing need for new inotropic agents that avoid these harmful effects.

30 e of pulmonary vasodilators, optimization of inotropic agents to support cardiac function, maintenanc

31 ar tachycardia, profound shock refractory to inotropic agents, and metabolic acidosis developed in th

32 lay robust contractile responses to positive inotropic agents, such as myofilament calcium sensitizer

33 is generally modified by the use of positive inotropic agents, volume resuscitation, and pacing.

34 nd the clinical utility of some of the older inotropic agents, which are still commonly used, and pro

35 nearly 80% of patients receiving intravenous inotropic agents.

36 a lead compound for a new class of positive inotropic agents.

37 uration was 20.8+/-20.6 months, 95% required inotropic and 20% temporary mechanical support, left ven

38 both eNOS coupled activity and the negative inotropic and [Ca(2+)](i) transient response to beta(3)-

39 lytic substrate for ACE2 and functions as an inotropic and cardioprotective peptide.

40 plications of this approach, we examined the inotropic and chronotropic responses of cardiomyocyte co

41 We evaluate both inotropic and chronotropic responses of the heart of zeb

42 T) at the leaflet approximation point during inotropic and chronotropic stimulation.

43 ular decompensation related through negative inotropic and hypotensive effects.

44 uded UNOS status 1A, mechanical ventilation, inotropic and intra-aortic balloon pump support, pulmona

45 tment augmented heart rate, exhibited potent inotropic and lusitropic actions on the left ventricle,

46 Stimulation with the inotropic and lusitropic agent isoproterenol eliminated

47 te expression of R9C-PLB exerts a positively inotropic and lusitropic effect in cardiomyocytes.

48 ndent binding to troponin C, exerts positive inotropic and lusitropic effects in failing human myocar

49 sensitization with levosimendan exerts mild inotropic and lusitropic effects in humans with left ven

50 pe 1A receptor (AT(1A)R) results in positive inotropic and lusitropic effects in isolated adult mouse

51 Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part

52 classical PKC isoforms relieved the negative inotropic and lusitropic effects of ET-1 after CA.

53 tidine-modified troponin I maintains cardiac inotropic and lusitropic performance and markedly improv

54 Istaroxime is a novel intravenous agent with inotropic and lusitropic properties related to inhibitio

55 w that miR-22-deficient mice are impaired in inotropic and lusitropic response to acute stress by dob

56 lerates muscle relaxation, and amplifies the inotropic and lusitropic response to increased stimulati

57 cient knockout (KO) mice, exhibited positive inotropic and lusitropic responses to both ANG and SII.

58 r-cAMP treatment, diabetic mice had impaired inotropic and lusitropic responses, thus demonstrating p

59 renol (ISO), a beta-AR agonist, led to small inotropic and lusitropic responses.

60 ercise training in hypertension improves the inotropic and lusitropic responsiveness to beta-adrenerg

61 t, cardiac GRK2 is a major factor regulating inotropic and lusitropic tachyphylaxis to beta-adrenergi

62 ist isoproterenol, with impairment of normal inotropic and lusitropic tachyphylaxis, and exhibited ac

63 and 9.0 (6.0-11.0); durations of vasoactive-inotropic and mechanical ventilation support were 3.0 da

64 osimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes

65 Future studies should prespecify analyses of inotropic and other therapies to determine how disease s

66 Lipid emulsion exerts rapid, positive inotropic and positive lusitropic effects in both intact

67 inase A (PKA) pathway, resulting in positive inotropic and relaxant effects in the heart.

68 ibitors, by raising cAMP content, have acute inotropic and vasodilatory effects in treating congestiv

69 Epinephrine is frequently used as an inotropic and vasopressor agent in critically ill patien

70 Inotropic and vasopressor drugs are routinely used in cr

71 hemodynamic derangement despite intravenous inotropic and/or vasodilator therapy, CAFA improved hemo

72 derangement despite intravenous diuretic and inotropic and/or vasodilator treatment.

73 Aging is accompanied by a blunted inotropic but preserved chronotropic response to steady-

74 Apelin-13 is a powerful inotropic candidate that could be considered as an alter

75 e shown that local epicardial application of inotropic compounds drives myocardial contractility with

76 clear how long-term application of negative inotropic compounds improves cardiac performance, slows

77 Local epicardial inotropic delivery illustrates then a paradigm of how ta

78 . 34 years, P < .01) and had higher rates of inotropic dependence (48% vs. 42%, P < .01).

79 essive decline) in 291, INTERMACS profile 3 (inotropic dependence) in 176, and INTERMACS profile 4 (r

80 stay, length of hospital stay, peak glucose, inotropic dose, graft dysfunction, and survival after HT

81 is the currently recommended beta-adrenergic inotropic drug for supporting sepsis-induced myocardial

82 and that required a vasopressor or positive inotropic drug or mechanical or surgical intervention (H

83 nt improvement in myocardial pathology after inotropic drug withdrawal.

84 with omecamtiv mecarbil, a positive cardiac inotropic drug, rescued the contractile deficit in AAA c

85 Inotropic drugs are commonly used perioperatively to sup

86 Inotropic drugs are frequently administered in hypotherm

87 uide administration of intravenous fluid and inotropic drugs as part of a hemodynamic therapy algorit

88 study tested the hypothesis that the use of inotropic drugs is associated with postoperative AF.

89 OF mutants and will guide the development of inotropic drugs that target TnC.

90 e for physicians on the development of newer inotropic drugs.

91 h for simultaneously predicting drug-induced inotropic effect (sarcomere shortening) and generating m

92 Ca2(+) current amplitude, and abolished the inotropic effect following acute beta-AR stimulation, wi

93 Albumin exerts a positive cardiac inotropic effect in rats with cirrhosis and ascites coun

94 The literature supporting its inotropic effect is sparse.

95 les eNOS activity and abolishes the negative inotropic effect of beta(3)-AR stimulation in nNOS(-/-)

96 TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the v

97 ogous PKD expression suppressed the positive inotropic effect of ET1 seen in control cells, without a

98 treatment significantly reduced the positive inotropic effect of isoproterenol in NTG myocytes but no

99 rate of SERCA2a activity, accounting for an inotropic effect of metformin.

100 ow that lack of IP3R2 abolishes the positive inotropic effect of neurohumoral stimulation with ET-1 a

101 nstitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor

102 ic receptor (beta(3)-AR) produces a negative inotropic effect that is dependent on eNOS.

103 compound 5 exhibited a significant in vitro inotropic effect up to 283% of the baseline value and in

104 lated cardiomyocytes demonstrated a positive inotropic effect via increasing calcium transient amplit

105 hich, in turn, negates cAMP-induced positive inotropic effect via inhibiting sarcolemmal Ca2+ influx

106 SSA78 infusion in mice results in a positive inotropic effect with enhanced contractile function yet

107 ith congestive heart failure have a negative inotropic effect, resulting in reduced cardiac contracti

108 BID; chosen to reduce dronedarone's negative inotropic effect-see text below) over 12 weeks in 134 pa

109 ich contributes to the NOS1-induced positive inotropic effect.

110 g/mL, P=0.008), consistent with its expected inotropic effect.

111 rial Ca(2+) signalling and exerts a positive inotropic effect.

112 sulted in: 1) positive left ventricular (LV) inotropic effects (adjusted peak left ventricular pressu

113 DE3B, is the subfamily responsible for these inotropic effects and that murine PDE3A1 associates with

114 s the first to show that apelin has positive inotropic effects in vivo in both normal rat hearts and

115 , indicating that conoCAP-a cardiac negative inotropic effects might be mediated via impairment of in

116 ctivity probably contributes to the positive inotropic effects observed at EGCG concentrations >1 muM

117 Na(+)-free solution (replaced by Li(+)) the inotropic effects of DIG and ACS were completely prevent

118 We conclude that the acute inotropic effects of DIG, ACS and OUA (and the effects o

119 Accordingly, the inotropic effects of Hsp20 were abrogated in cardiomyocy

120 been associated with NO-associated negative inotropic effects of IL-6 during acute exposure; however

121 rts from Tpcn2(-/-) mice also showed reduced inotropic effects of isoproterenol and a reduced tendenc

122 ure, enhanced CaTs during ECC exert positive inotropic effects on atrial contractility which facilita

123 beta-Adrenergic signalling induces positive inotropic effects on the heart that associate with pro-a

124 reduce arterial pressure and exert positive inotropic effects on the heart.

125 e stimulating cardioprotective signaling and inotropic effects through the beta2AR and serves as a mo

126 ptor (beta-AR) stimulation leads to positive inotropic effects, it can also induce arrhythmogenic Ca2

127 hanistic insights into Akt-mediated positive inotropic effects, transcriptional profiles in the heart

128 id emulsion infusion exerts direct, positive inotropic effects.

129 lammatory mediators with negative myocardial inotropic effects.

130 recently been identified as a Ca2+-dependent inotropic factor in the heart, this study sought to expl

131 into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysi

132 dopamine, tapering or discontinuation of the inotropic infusion resulted in a significant diminution

133 spite severe compromise, patients undergoing inotropic infusions at randomization derived major LVAD

134 t hoc basis, outcomes in patients undergoing inotropic infusions at randomization.

135 Nineteen patients (70%) were receiving inotropic infusions at the time of organ availability.

136 Patients not undergoing inotropic infusions had higher survival rates both with

137 For 38 patients not undergoing inotropic infusions, 6-month survival was 61% for those

138 culae from vehicle-treated mutants displayed inotropic insufficiency, increased diastolic tension, an

139 (HNO) donor, Angeli's salt, exerts positive inotropic, lusitropic, and vasodilator effects in vivo t

140 lar function, combining concomitant positive inotropic, lusitropic, and vasodilator properties.

141 This has an acute inotropic/lusitropic effect but yields negative conseque

142 Patients requiring intravenous inotropic/mechanical support or listed status 1A/1B for

143 R, 1.61; 95% CI, 1.26-2.05), and vasopressor/inotropic medications (p = .035; OR, 1.22; 95% CI, 1.01-

144 Although LTCC inhibition is negative inotropic, NCX inhibition has the opposite effect.

145 or antagonist, esmalol, had no effect on the inotropic or lusitropic effects of UcnII in vivo, indica

146 higher in patients who require perioperative inotropic or mechanical cardiovascular support, compared

147 so higher in those who require postoperative inotropic or mechanical cardiovascular support, compared

148 all patients with FM will need some form of inotropic or mechanical circulatory support to maintain

149 ation, or hemodynamic decompensation needing inotropic or mechanical support were similar between yea

150 lic blood pressure <90 mm Hg or the need for inotropic or vasoactive medication and the requirement f

151 ion for HF, or administration of intravenous inotropic or vasodilator drugs for 4 hours or more witho

152 d ACR 2 were higher in patients who required inotropic or vasopressor support and correlated with dur

153 llitus (OR, 1.39; P=0.005), and preoperative inotropic (OR, 2.61; P=0.001) and extracorporeal membran

154 Inotropic (peak +dP/dt) and lusitropic (Tau) responses w

155 An inotropic peptide (BjIP) isolated from the full venom by

156 port the cardiac effects of a novel positive inotropic peptide isolated from the toxin of the Black J

157 icate a calciotropic role in addition to the inotropic property of beta1-AR.

158 unlike classical neurotransmitters, have no inotropic receptors.

159 ar dysfunction or hypertrophy, and high-dose inotropic requirement.

160 was associated with reductions in vasoactive inotropic requirements and in the incidence of the compo

161 creases circulating CAs and improves cardiac inotropic reserve and function.

162 can impair beta-adrenergic receptor-mediated inotropic reserve and its inhibition, or molecular reduc

163 r inducible NOS) contributes to this loss of inotropic reserve in human HF.

164 drenergic and dopaminergic receptors impairs inotropic reserve in PAH-RVH.

165 of low-dose dobutamine and quantification of inotropic reserve in segments with 1%-50% infarct transm

166 Inotropic reserve was assessed in RV- and left ventricul

167 A loss of inotropic reserve, uncovered during beta-adrenergic stim

168 did not affect baseline cardiac function or inotropic reserve, we focused on the involvement of skel

169 protein-coupled receptor activation provides inotropic reserve, which is hampered by electric instabi

170 f beta-adrenergic receptor signaling impairs inotropic reserve.

171 ing that both cell types maintained a strong inotropic reserve.

172 h, reduced beta1AR expression, and decreased inotropic reserve.

173 ocyte deletion of insulin receptors (CIRKO), inotropic reserves were reduced, and mitochondria manife

174 muscle displays an increased beta-adrenergic inotropic response both in vitro and in vivo.

175 pholamban, beta-adrenergic receptor, and the inotropic response fully recovered.

176 tudy, the molecular mechanism underlying the inotropic response in skeletal muscle is not well unders

177 lly loaded ssTnI hearts whereas the positive inotropic response of isovolumic hearts or unloaded isol

178 that cTnI has a pivotal role in the positive inotropic response of the murine heart to beta-adrenergi

179 ity but does not inhibit the native positive inotropic response of the right ventricle to increased a

180 ecreased ERO1 activity blunted cardiomyocyte inotropic response to adrenergic stimulation and sensiti

181 atients with diabetes show a blunted cardiac inotropic response to beta-adrenergic stimulation despit

182 ession in hESC/iPSC-vCMs restores a positive inotropic response to beta-adrenergic stimulation.

183 from normal and failing hearts displayed no inotropic response to CGRP, further supporting indirect

184 WT mice maintained a positive inotropic response to dobutamine 8 weeks after MI.

185 Basal LV hemodynamics and the inotropic response to dobutamine infusion (4 and 16 ng.g

186 d-recruitable stroke work) but an attenuated inotropic response to dobutamine infusion (P<0.01 versus

187 ostatin significantly decreased the positive inotropic response to endothelin-1 (ET-1).

188 However, the positive inotropic response to isoprenaline was also blunted in s

189 S1P inhibits the positive inotropic response to isoproterenol and this response is

190 re are two mechanisms that underlie the slow inotropic response to stretch: activation of NHE; and of

191 se to external stretch, and a dose-dependent inotropic response to the beta-adrenergic agonist isopro

192 The inotropic response was markedly blunted by heart failure

193 beta-Adrenergic receptor and inotropic response were decreased in failing hearts.

194 hearts, TG-LVH hearts showed no increase in inotropic response when compared with WT-LVH hearts.

195 ssion in the normal heart allows an enhanced inotropic response with no compromise in energy supply a

196 g rise in LA pressure, greatly attenuated LV inotropic response, and markedly reduced survival.

197 cited a positive chronotropic but negligible inotropic response, suggesting sarcoplasmic reticulum im

198 lux into ventricular myocytes and a positive inotropic response.

199 lux into ventricular myocytes and a positive inotropic response.

200 c stimulation may synergistically facilitate inotropic responses and contribute to a CaMKII-Ca(2+)-Ca

201 The mechanisms underlying both the inotropic responses and hyperglycemia's effects on them

202 handling changes underlying chronotropic and inotropic responses have been studied in detail in isola

203 effect on diastolic function and blunted the inotropic responses of cardiac muscle to beta-adrenergic

204 However, no differences of maximal inotropic responses of myocardial fibers from Tg-CTGF mi

205 vascular tone and depressed beta-adrenergic inotropic responses that were associated with impaired b

206 However, attenuation of the chronotropic and inotropic responses to a beta-AR agonist may depend upon

207 Hyperglycemia diminishes positive inotropic responses to agonists that activate phospholip

208 Mammalian hearts exhibit positive inotropic responses to beta-adrenergic stimulation as a

209 (3) a positive force-frequency response; (4) inotropic responses to beta-adrenergic stimulation media

210 rly displayed positive chronotropic but null inotropic responses to beta-adrenergic stimulation.

211 ne metabolites to hyperglycemia's effects on inotropic responses was examined in isolated perfused ra

212 and abolished for forskolin, whereas maximum inotropic responses were markedly blunted only for serot

213 that isoform-selective inhibition may allow inotropic responses without an increase in mortality.

214 oproterenol displayed attenuation of maximal inotropic responses.

215 t requires APD shortening to produce optimal inotropic responses.

216 Reduced inotropic responsiveness is characteristic of heart fail

217 (P<0.001) common atrial pressure (P=0.042), inotropic score (P<0.001), and need for greater volume r

218 quiring a support equivalent to a Vasoactive Inotropic Score greater than 50 to reach a mean arterial

219 t (1.01-1.02), p < 0.001; highest vasoactive-inotropic score, 1.02/per point (1.00-1.04), p = 0.003;

220 s of stay, maximum and cumulative vasoactive-inotropic scores, duration of mechanical ventilation, ne

221 in cardiac index, arrhythmias, peak lactate, inotropic scores, urine output, duration of mechanical v

222 ecific GRK2 knockout mice exhibited enhanced inotropic sensitivity to the beta-adrenergic receptor ag

223 Isolated increase in heart rate or inotropic state did not alter peak stitch tension wherea

224 rial pacing at 130 minutes(-1) (n=5) whereas inotropic state was increased with i.v.

225 T mice could limit the isoproterenol-induced inotropic state.

226 1%; this was true also over a wide range of inotropic states induced by varied [Ca(2+)](o).

227 raction coupling, and the effect of positive inotropic stimulation on the spatial profile of the Ca(2

228 o quantify the influence of chronotropic and inotropic stimulation on torsion, nine healthy volunteer

229 However, when acutely stressed by inotropic stimulation or ischemia/reperfusion, GAMT-/- m

230 However, during inotropic stimulation with dobutamine, preload-recruitab

231 and relaxation in normal mouse hearts during inotropic stimulation with isoproterenol.

232 During inotropic stimulation, DKO/mCryAB(Tg) showed blunted sys

233 spectroscopy experiments showed that during inotropic stimulation, isolated WT hearts utilized PCr,

234 stressed with either ischemia/reperfusion or inotropic stimulation.

235 ute to enhanced contractility in response to inotropic stimuli.

236 reduce the responsiveness of mouse hearts to inotropic stimuli.

237 rdiac energetics are further deranged during inotropic stress, in association with continued diastoli

238 For similar levels of inotropic stress, there were smaller increases in peak f

239 apsibility of the superior vena cava>/=36%), inotropic support (left ventricular fractional area chan

240 ratio, 1.08; 95% CI, 1.01-1.17) and need for inotropic support (odds ratio, 6.53; 95% CI, 1.86-23.08)

241 s with decompensated CHF requiring transient inotropic support and 6 age-matched, healthy controls we

242 without EM, except for a higher frequency of inotropic support and assist devices in EM patients.

243 ence of myocardial dysfunction) and required inotropic support and fluid resuscitation (including 23/

244 ioplegic technologies, some patients require inotropic support and/or mechanical assist devices posto

245 gender transplant year, renal function, and inotropic support at transplant to form a cardiomyopathy

246 und in the prescription of fluid loading and inotropic support derived from early transesophageal ech

247 right-sided circulatory support, continuous inotropic support for >/=14 days, or nitric oxide ventil

248 Acute inotropic support in RVH is best accomplished by dobutam

249 ed management guidelines for vasopressor and inotropic support in septic shock that would be of pract

250 It is hypothesized to be related to inotropic support or metabolic derangements from chronic

251 long-term clinical outcomes irrespective of inotropic support or renal dysfunction and remains an ex

252 SNP was not associated with higher rates of inotropic support or worsening renal function during hos

253 hemodynamic monitoring, management of proper inotropic support to maintain left ventricular and right

254 tween the two approaches for the decision of inotropic support was weak (kappa: 0.23 [-0.04;0.50]).

255 al class IV symptoms who failed weaning from inotropic support were offered a Novacor LVAD.

256 pronounced hemodynamic compromise requiring inotropic support whereas those in Group III remained he

257 fraction was <30% in one-third; 80% required inotropic support with 28% treated with extracorporeal m

258 ne sodium-potassium pump inhibitors, provide inotropic support without arrhythmogenic increases in cy

259 iogenic shock requiring fluid resuscitation, inotropic support, and in the most severe cases, mechani

260 uid resuscitation > 5 L/24 hr, vasoactive or inotropic support, and renal replacement therapy); 2) 20

261 ive care unit stay, length of hospital stay, inotropic support, and survival.

262 al fibrillation, the need for post-operative inotropic support, and the length of hospital stay.

263 Adequate fluid resuscitation, appropriate inotropic support, attention to rewarming, and ventilato

264 Thus, INaL offers inotropic support, but negatively interferes with cellul

265 treatment of cardiogenic shock refractory to inotropic support, thereby minimizing the detrimental ef

266 diac function by echocardiography on minimal inotropic support.

267 occal septic shock who are not responsive to inotropic support.

268 of low cardiac output state and the need for inotropic support.

269 e intensive care unit with antimicrobial and inotropic support.

270 ), driven by a higher incidence of prolonged inotropic support.

271 r right ventricular dysfunction, and lack of inotropic support.

272 ion therapy but not dependent on intravenous inotropic support.

273 he potential for Orai1 channel inhibitors as inotropic therapies for maintaining contractility reserv

274 there is a need to develop and explore novel inotropic therapies that can act via calcium-independent

275 Current inotropic therapies used to increase cardiac contractili

276 the efficacy of fluid resuscitation (1C) and inotropic therapy (2C), presence of RV dysfunction (2C)

277 icacy and hemodynamic changes of patients on inotropic therapy (milrinone, levosimendan, and istaroxi

278 management of these patients with empirical inotropic therapy (with or without a vasodilator), morta

279 ts randomized, 91 were receiving intravenous inotropic therapy at randomization to LVAD or optimal me

280 Median days out of hospital for patients on inotropic therapy at randomization were 255 with LVAD an

281 A minority of patients can discontinue inotropic therapy because of clinical improvement.

282 Outpatient intravenous inotropic therapy can be safely used as a bridge to tran

283 Intravenous inotropic therapy can be used to support children awaiti

284 analyses suggest that the use of intravenous inotropic therapy for patients hospitalized with heart f

285 gan Sharing status 1A patients discharged on inotropic therapy from 1999 until 2012.

286 Inotropic therapy has been predominantly used in the man

287 ly lower in-hospital mortality than positive inotropic therapy in patients hospitalized with ADHF.

288 s explain observed differences in the use of inotropic therapy is not known.

289 Intravenous inotropic therapy was initiated for cardiac symptoms not

290 al pressure > or = 65 mm Hg (1C); dobutamine inotropic therapy when cardiac output remains low despit

291 l realize the potential clinical benefits of inotropic therapy without the risk remains a subject of

292 EM may be related to intravenous inotropic therapy, and this is the first study to docume

293 infusion in a rat model of local epicardial inotropic therapy.

294 t failure and high prevalence of intravenous inotropic therapy.

295 transplant or receiving chronic intravenous inotropic therapy.

296 sm-related adverse effects restrict existing inotropic treatments.

297 uirement for, or withdrawal of, conventional inotropic vasoconstrictor agents (i.e., dopamine and nor

298 ntinuous IV administration of epinephrine as inotropic/vasopressor agent is not associated with a wor

299 low despite fluid resuscitation and combined inotropic/vasopressor therapy (1C); stress-dose steroid

300 r (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid