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1 ion errors (i.e. ribonucleotide and mismatch insertions).
2 at is identical to flanking DNA ("templated" insertions).
3 interaction with Get3/TRC40 important for TA insertion.
4 e insertion before proceeding to spacer-side insertion.
5 rotein is tolerant to amino acid deletion or insertion.
6 limited reversible capacity during Na(+) de/insertion.
7 tiple voltage plateaus upon Na(+) extraction/insertion.
8 hanistic framework to understand TA membrane insertion.
9 ating needle-cannula motions for incremental insertion.
10 of a long-chain AC, plausibly caused by its insertion.
11 te, whereas G3 exhibits no sequence-specific insertion.
12 timulation unless accompanied by optic fiber insertion.
13 ly experience these heat-induced de novo Tc1 insertions.
14 lls contained large numbers of likely clonal insertions.
15 apart from classical muscle-to-bone type of insertions.
18 We characterized fixed and polymorphic LAVA insertions across multiple gibbons and found 96 LAVA ele
19 sequencing was used to uncover a frame-shift insertion affecting the alpha-L-iduronidase (IDUA) gene
20 aracterized Arabidopsis Skp1-Like1 (ASK1) Ds insertion allele, ask1, in different Arabidopsis accessi
24 hes allowed us to map the details of uridine insertion and deletion editing events upon the kDNA tran
25 re-order traversal, inferring on which edges insertion and deletion events occurred using those inter
26 -in rates, systematically reduces off-target insertion and deletion events, maintains or increases si
28 ng system that uses guide RNAs to direct the insertion and deletion of uridines in mitochondrial mRNA
29 ing rates, and effectively reduces on-target insertion and deletion rates in knock-in applications.
30 comprehensively analyzed enhancer-associated insertion and deletion variants for both human and murin
33 rochemical reaction during repetitive Zn(2+) insertion and extraction, as demonstrated by in situ syn
35 ave limited understanding of how EMC enables insertion and integrity of diverse clients, from tail-an
36 treat a variety of illness and involves the insertion and manipulation of needles into specific poin
37 diimine Pd(II) complex combines coordination insertion and radical polymerization to form polyolefin-
39 the movement speed, the force impulse after insertion and the endpoint stiffness magnitude decreased
40 ly mediated by an increase in the N terminus insertion and, as shown by X-ray crystallography, partly
42 ing single-nucleotide variants (SNVs), small insertions and deletions (indels), copy-number variation
45 ture of single-nucleotide variants and small insertions and deletions in exomes has been understudied
46 plant prime editors enable point mutations, insertions and deletions in rice and wheat protoplasts.
48 ize accuracy, and genotype for 1235 putative insertions and deletions sampled from different size bin
49 methods have been applied to generate random insertions and deletions, large deletions, targeted inse
52 e-mediated ring-opening, metal-catalyzed C-C insertions and eliminations, oxidative fragmentation usi
54 attributes: sequence, position, deletion and insertion, and can be applied to nucleotide and protein
56 ffected Schipperkes were homozygous for this insertion, and the sequenced healthy dogs were either he
57 (SVs), including thousands of new transposon insertions, and of highly polymorphic and medically impo
58 e nucleotide variants (SNVs), mobile element insertions, and structural changes in the DNA, is a comm
60 ate Mn hydride more stable; subsequent CO(2) insertion appears to be faster than heterolytic H(2) pro
63 21 +/- 3 angstrom(2) was obtained for the AC insertion area, which is roughly the same as the cross-s
66 de/membrane interfaces in fuel cells and ion insertion at electrode/electrolyte interfaces in solid-s
68 er-repeat junction and performed leader-side insertion before proceeding to spacer-side insertion.
70 remaining six C8A alleles contained a 10 nt insertion between nt 992 and 993 corresponding to the ju
71 erminal rDNA sequences; acquisition of MoTeR insertions by 'plain' telomeres; insertion of the MAGGY
72 on of length and sequence diversity of novel insertions by insertional-scanning mutagenesis (InScaM).
73 We also assess the cooperativity of domain insertion, by expressing the individual transporter doma
75 ion of homozygous mutant cell lines using an insertion cassette which autocatalytically generates ins
76 obligatory carrier parents identified a 1 bp insertion (CFA20:g.33,717,704_33,717,705insT (CanFam3.1)
77 s of cyclobutanones based on the C(sp(3) )-H insertion chemistry of oxidatively generated gold carben
79 el in which Cpn60 captures and then releases insertion-competent Plsp1, whereas cpSecA1 recognizes fr
80 sequences revealed 63% (57/90) of these L1Hs insertions could be genotyped in 1000 Genomes Project se
81 adiation, can be applied in transannulation, insertion, cyclopropanation, and many other transformati
82 st genomes using multiple de novo transposon insertion datasets in both plants and animals and compar
84 tion of mRNAs that require extensive uridine insertion/deletion (U-indel) editing for their maturatio
85 impact on specific mutational classes (e.g., insertion/deletion [indel] vs. single nucleotide variant
88 contained 82 intraspecific substitution and insertion/deletion mutations, and provided evidence for
89 e also found that RNF8 suppresses EJ without insertion/deletion mutations, which is a hallmark of C-N
92 Reliable identification of expressed somatic insertions/deletions (indels) is an unmet need due to ar
95 United States with intrauterine device (IUD) insertions during 2011-2018, there was no increased risk
97 the tube; anterior chamber (AC) flare; tube insertion entry site position relative to Schwalbe's lin
98 nct structure is common to a large subset of insertion events in both mouse and human cells and is co
102 he open reading frame is disrupted by a 1-bp insertion, expresses very small amounts of EBNA3A using
103 l, the benzylic site is activated via Ni C-H insertion, followed by beta elimination of the phenoxide
105 a built-in mechanism controlling Gc membrane insertion for fusion, pave the way for immunogen design
107 second reactor at 200 degrees C) enabling CO insertion for the production of C3 oxygenates (propanal
108 ulations, iStent (Glaukos; San Clemente, CA) insertions, goniotomies, and canaloplasties performed by
111 enerated libraries are enriched for in-frame insertions, have drastically reduced sequence bias as we
112 ormMu (W22) library, we identified conserved insertion hotspots between different genetic backgrounds
113 onary resuscitation was ongoing during REBOA insertion in 17 patients (26.6%) and 10 patients (58.8%)
114 Panel (DGRP) contain at least one P-element insertion in a piRNA cluster, indicating that repressor
115 ysis of the FSTs showed a uniform pattern of insertion in all the chromosomes (1-5) without any prefe
117 bollworm cadherin gene (PgCad1) has a 234-bp insertion in exon 12 encoding a mutant PgCad1 protein th
118 A substitution in FTSJ3 and a splice donor insertion in GH1 are strongly associated with MCM and re
120 plasmic retention domain of HDAC6, stop/gain insertion in MORF4L1, and deletion mutations within SWI/
121 the mosquito proboscis were adopted for MPI insertion in prostate biopsy: (1) the harpoon-shape notc
122 cently discovered 40-amino acid mutation and insertion in the ACLP discoidin domain regulates collage
123 ngle and double deletion or a single alanine insertion in the large (L) polymerase protein that are g
124 nstrate a mouse model carrying a HaloTag-TEV insertion in the protein titin, the main determinant of
125 g of a PRA case, we have identified a LINE-1 insertion in the retinal candidate gene IMPG2 that is as
131 ne pancreatic tumor, there were many more L1 insertions in aneuploid than in euploid tumor cells.
133 a linear peptidomimetic with three triazole insertions in its backbone and maintained biological act
135 cop- background and isolated strains with Tn insertions in the mntABC operon that permitted growth in
136 ge from a unique muscle anlage and establish insertions in the sclera, which sets these muscles apart
137 zak-controlled regulation is correlated with insertions in translational initiation factors in fideli
138 h, and found a variable number of somatic L1 insertions in tumors of the same type from patient to pa
139 rone-mediated trafficking of the cluster and insertion into [2Fe-2S] target apoproteins; and catalyti
141 signated K1 and K2) concomitant with carbide insertion into an [Fe(8)S(9)C] cofactor core (designated
143 oton-motive force which could impair protein insertion into and translocation across the inner membra
144 d its efficient function in co-translational insertion into and translocation across the inner membra
147 est that, despite fast double bond migratory insertion into Ir-H, the reaction proceeds through a mod
149 antioselective, intermolecular diarylcarbene insertion into Si-H bonds for the synthesis of silicon-s
150 r mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron
154 hat mediates posttranslational targeting and insertion into the endoplasmic reticulum (ER) via the Gu
156 P-C bond formation may occur via substrate insertion into the M-H bond, followed by P-C reductive e
157 followed by P-C reductive elimination, or by insertion into the M-P bond and C-H reductive eliminatio
158 notecan-loaded Drug Eluting Seeds (iDES) for insertion into the margin of the GBM resection cavity to
159 Patients with invasive BC who underwent clip insertion into the most suspicious axillary lymph node (
161 The provector platform consists of a peptide insertion into the virus capsid which disrupts the virus
162 ssor alleles are produced by transpositional insertions into piRNA clusters, genomic regions encoding
163 the median dose area product (DAP) for CVAD insertion is 0.7Gy.cm(2) and 0.3Gy.cm(2) for procedures
166 d evolution, we analyzed the stepwise oxygen-insertion mechanism of tryptophan 2,3-dioxygenases, and
167 bidopsis (Arabidopsis thaliana) transfer DNA insertion mutant of LAC2 displayed a short primary root
168 Using forward genetic approaches in a Tnt1 insertion mutant population of the model legume Medicago
169 rary of over 13,000 K. pneumoniae transposon insertion mutants in the lungs of wild-type (WT) and neu
171 f allylbenzene, is unlikely as the migratory insertion needs to overcome a prohibitively high energy
173 neage diversification, we estimated that the insertion occurred millions of years ago, and we propose
175 could more accurately predict the subsequent insertion of a chest tube with an area under the curve (
179 min A biofortified rice event GR2E confirmed insertion of a single copy of the transfer-DNA in the ge
181 heptad repeat approach), we examine how the insertion of a three residue discontinuity, known as a s
182 ace electrostatics of the outer leaflet, the insertion of ACs, in particular their long-chain counter
183 ion of pyridine-AlMe(3) before the migratory insertion of allylbenzene, is unlikely as the migratory
184 IP1-AMPAR association and, subsequently, the insertion of AMPARs into the postsynaptic membrane.
185 enhancing the rate- and enantio-determining insertion of an arylpalladium species into a chiral norb
186 ic proofreading of activator-DNA recognition-insertion of an energy-dissipating delay step into the a
189 lar structure of the retina and requires the insertion of an exogenous dye with potential adverse sid
190 review focuses on enzymes which catalyse the insertion of an oxygen atom into the substrate and, in s
191 targets, we created vectors that facilitate insertion of any gene target sequence in tandem with the
192 In Gram-negative bacteria, the folding and insertion of beta-barrel outer membrane proteins (OMPs)
195 h regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homo
196 iation of the fluorophores, followed by slow insertion of hydrophobic moieties into the lipid bilayer
197 These results demonstrate targeted gene insertion of marker-free DNA in rice using CRISPR-Cas9 g
199 aphite intercalation compounds; instead, the insertion of Mg-Cl superhalides makes the graphite parti
202 anism in which membrane fluidity governs the insertion of PlsX and thus regulates the biosynthesis of
203 pses glutamatergic currents by promoting the insertion of postsynaptic AMPARs that contain fast desen
205 Cas-mediated adaptive immunity relies on the insertion of short DNA sequences from parasite genomes i
208 e linker region to unwrap, which facilitates insertion of the catalytic core between the histone octa
209 Irradiation of TripP=C=C(H)tBu led by the insertion of the central C atom of the P=C=C group into
210 cobaltacycle by C-H activation and migratory insertion of the diene is followed by beta-hydride elimi
211 arr1 to phosphorylated receptor residues and insertion of the finger loop of betaarr1 into the M2R se
212 ic eyes is uncomplicated and facilitates the insertion of the flexible tube into the posterior chambe
214 on of MoTeR insertions by 'plain' telomeres; insertion of the MAGGY retrotransposons into MoTeR array
217 of a new hydrophobic pocket generated by the insertion of the six amino acid substitutions, into whic
218 loped a transgenic model using site-directed insertion of the variable domain of a pathogenic human L
219 essential for the posttranslational membrane insertion of YohP by either the SecYEG translocon or by
220 e evident in characteristic genomic scars as insertions of 3 to 30 bp of sequence that is identical t
221 including single-nucleotide variants, small insertion or deletion (indel) variants and structural va
222 tential'-hundreds of ancient haplotypes bear insertion or deletion polymorphisms, many of which are a
223 ange of HDR applications such as the precise insertion or replacement of DNA fragments that contain t
224 ons and deletions, large deletions, targeted insertions or replacements of short sequences, and preci
225 s were collected 3 or 15 days after ligature insertion (or no ligature insertion for controls) and tr
227 ics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues a
228 embryogenesis, generating an average of 6.37 insertions per line in a population of 19 independent R1
230 tals and stamen filaments beneath the anther insertion point; by contrast, neither pollen size nor ma
233 ned as all of the entry site behind SL (tube insertion position 1), less than 50% of entry site anter
234 than 50% of entry site anterior to SL (tube insertion position 2), more than 50% but less than 100%
235 than 100% of entry site anterior to SL (tube insertion position 3 [TIP3]), and all of the entry site
236 d all of the entry site in front of SL (tube insertion position 4 [TIP4]); anterior segment (AS) OCT
237 esidues exposed to the solvent upon membrane insertion, predicting a possible topology of the membran
239 osase ShCAST system could lead to additional insertion products beyond simple integration of the dono
242 modified TiO(2) structure, which affects the insertion properties of the neighbouring host sites.
244 Our European sequence-indexed library of Mu insertions provides an important resource for functional
246 mistry; although applications in C-H and X-H insertion reactions are few in number, they demonstrate
248 The first example of enantioselective S-H insertion reactions of sulfoxonium ylides is reported.
249 ears) cis-acting 2.25-kb LTR retrotransposon insertion reducing expression of the NDP gene with conse
252 gnated FeMo-cofactor, whose biosynthesis and insertion requires the action of over a dozen maturation
254 African Americans, a 5' untranslated region insertion (rs568223361) was associated with lower alpha-
258 ntify thousands of MGEs, including candidate insertion sequences, conjugative transposons, and propha
261 since the introduction of modern transposon-insertion sequencing (TIS) methods, which combine genome
262 e-gene deletion strains and a new transposon insertion sequencing (Tn-Seq) dataset that we generated.
266 tion assays, finding that for G1 and G2, the insertion site is recognized through defined mechanisms,
268 ansposon mutagenesis and transposon-directed insertion-site sequencing to determine the set of genes
269 new version of "TraDIS" (transposon directed insertion-site sequencing) that we term "TraDIS-Xpress"
270 x that identifies integrative MGEs and their insertion sites by using short-read sequencing data.
271 examination of 137,410 somatic and germinal insertion sites revealed that 50% of the tagged genes ha
272 ssign labels describing SV type (deletion or insertion), size accuracy, and genotype for 1235 putativ
273 ntify 127,727 recurrent non-reference unique insertions spanning 18,048,877 bp, some of which disrupt
277 th scaffolds, and we identify hundreds of TE insertions that were missed by Illumina-based methods, i
278 ently punctured the skin and after a limited insertion time (150 s) a significant proportion of the t
279 al battery electrolyte, and uses lithium-ion insertion to produce shape changes at low voltages.
281 owever, contributions of lineage-specific TE insertions to recent regulatory adaptations remain poorl
282 tate (TS) for the regiocontrolling migratory insertion, triggered by the Rh-hydride addition to the a
283 on of aliphatic amide, followed by maleimide insertion, triggers a relayed, second C(sp(3))-H activat
284 infections and colonization according to the insertion type (femoral vs nonfemoral) included in the f
285 52-bp deletion (type I mutation) and a 5-bp insertion (type II mutation) are the most frequent genet
287 volves graphene-oxide/I(2)-catalyzed nitrene insertion using PhINTs as a nitrene (NT) source in water
288 tion process that followed the arylpalladium insertion was controlled by a fine-tuning of the reactio
291 e absence of CL in protein translocation and insertion, we analyzed translocon activity, SecYEG stabi
292 3, 4, and 5 years after anterior chamber BGI insertion, we evaluated the central corneal ECD (CCECD)
293 g of membrane-associated peptide folding and insertion, we have studied the kinetics of three single
294 ethod of single-cell analysis for somatic L1 insertions, we studied adenocarcinomas of colon, pancrea
295 different reaction pathways for oxygen atom insertion were explored-each encompassing a unique eleme
296 beta (pol beta) and characterized r8-oxo-GTP insertion with DNA substrates containing either a templa
297 group (n = 164) underwent bedside chest tube insertion with local anesthesia followed by administrati
299 can be understood by assuming a nitrene C-H insertion within a hydrogen-bonded silver complex in whi
300 ant positions, and a triplet ATT codon (Ile) insertion within ATP synthase subunit 8, were unique wit