ライフサイエンスコーパス: insula

1 eral (dl)PFC], and a salience network (e.g., insula).

2 s a cortico-striatal circuit (striatum, ACC, insula).

3 rior cingulate cortex, ventral striatum, and insula.

4 associated neural circuitry centered on the insula.

5 ere nonsignificant with the exception of the insula.

6 late, supplementary motor area, and anterior insula.

7 ily to the frontal operculum rather than the insula.

8 ith activity in the vHPC, mPFC, amygdala and insula.

9 the left inferior frontal gyrus and superior insula.

10 vidence of the human gustatory cortex in the insula.

11 t modulate pain processing, the striatum and insula.

12 l gyrus and happy < baseline in the anterior insula.

13 , the intraparietal sulcus, and the anterior insula.

14 mical and histological features of the human insula.

15 ex (OFC), and another was found in posterior insula.

16 or social behavior, such as the amygdala and insula.

17 C between the DLPFC and the left putamen and insula.

18 e in thalamus, caudate nucleus, and anterior insula.

19 reased GBCr in the lateral PFC, caudate, and insula.

20 ula, as well as bilateral regions of the mid-insula.

21 precuneus, superior temporal gyrus (STG) and insula.

22 rmalities of the frontal lobe, amygdala, and insula.

23 obtained by direct stimulation of mid-dorsal insula.

24 ion in bilateral anterior cingulate and left insula.

25 values were lower in the striatum, OFC, and insula.

26 the anterior prefrontal cortex and anterior insula.

27 activation in posterior OFC extending to the insula.

28 cingulate cortex, orbitofrontal cortex, and insula.

29 developing opercular cortex compared to the insula.

30 decreased the impact of the amygdala on the insula.

31 l prefrontal cortex (vmPFC) and the anterior insula.

32 ucleus accumbens, and anterior and posterior insula, 2) to unexpected reward receipt in the anterior

33 lateral pallium-originated areas (e.g., the insula) [5, 6].

34 ocessing, with a critical role for the right insula 5HT(2A) in the regulation of affective responses

35 We identified the insular cortex (insula), a region involved in regulating interoception,

36 Within the dorsal anterior insula, a brain region implicated in salience processing

37 connectivity between the piriform cortex and insula, a region involved in integrating feeding-related

38 The dorsal posterior insula, a region involved in pain processing, emerged as

39 ssively marked down by disincentive anterior insula activity if the sequence of experienced outcomes

40 Anterior insula activity mediated the relationship between PNA an

41 Furthermore, a shift in insula activity occurred during the recovery period, aft

42 PNA, via insula activity, may relate to arousal in ways that coul

43 was related to increased bilateral anterior insula activity.

44 ior cingulate cortex (dACC) and the anterior insula (AI) constitute the salience network and form as

45 The hub role of the right anterior insula (AI) has been emphasized in cognitive neuroscienc

46 Results showed a network of dACC, anterior insula (AI), and intraparietal sulcus (IPS) to be more a

47 nterior cingulate cortex (dACC) and anterior insula (AI), have been shown to be equally sensitive to

48 equire neuronal activity within the anterior insula (aIC) and the basolateral amygdala (BLA).

49 s well as decreased activity in the anterior insula [AIns]).

50 s also exhibited significantly decreased mid-insula, amygdala, and orbitofrontal activity while atten

51 included decreases in orbitofrontal cortex, insula, amygdala, and temporal cortex.

52 The ventromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray

53 The rCMRglu in the right anterior insula and adjacent prefrontal and striatal areas was lo

54 Lastly, greater pre-treatment insula and amygdala activity during emotion perception p

55 SSRI and CBT treatments similarly attenuated insula and amygdala activity during emotion perception,

56 n, and greater treatment-related decrease in insula and amygdala activity was correlated with greater

57 Activations in the right anterior insula and amygdala were markedly reduced when participa

58 e network regions, specifically the anterior insula and anterior and posterior cingulate.

59 h consists of primarily the ventral anterior insula and anterior cingulate cortex, based on functiona

60 and following an empathy prompt in anterior insula and anterior/middle cingulate cortex, respectivel

61 re identified (behavioural variant, anterior insula and caudate; semantic variant, anterior temporal

62 e ability were associated with higher GWC in insula and cingulate cortices and with lower GWC in pre-

63 ymptom severity, increased activation in the insula and DLPFC, and decreased DLPFC Glx.

64 al representations of overall uncertainty in insula and dorsal anterior cingulate cortex.

65 ent x opponent interaction in right anterior insula and dorsal caudate.

66 stimuli correlated with left dorsal anterior insula and frontal pole atrophy.

67 significantly increased in temporal regions, insula and fusiform gyrus, consistent with those areas k

68 at 5HT(2A) BP in the adjacent right anterior insula and insula proisocortex was negatively correlated

69 on of prediction error responses in anterior insula and insula-vmPFC connectivity during self-esteem

70 ater decreases in activation in the anterior insula and lateral orbitofrontal cortex in response to a

71 ess of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygda

72 ith eigenvector centrality negatively in the insula and midcingulate cortex, and positively in the in

73 iant patients had pronounced atrophy in left insula and middle frontal gyrus, combined with more rapi

74 ere also positively connected with bilateral insula and negatively connected with the hypothalamus.

75 e of eye movements and suggest that distinct insula and OFC activation dynamics may be important for

76 stinct patterns of activity, one in anterior insula and one in the dorsal raphe nucleus, that track g

77 and secondary taste cortices, located in the insula and orbitofrontal cortex (OFC), respectively.

78 lume in limbic regions such as the amygdala, insula and orbitofrontal cortex, and functional abnormal

79 These were found in the insula and overlying operculum, with regions in the ante

80 t to the stomach originated from the rostral insula and portions of medial prefrontal cortex, regions

81 r activity in the posterior cingulate gyrus, insula and precuneus in the bed rest group in both ERP t

82 correlated with atrophy in right ventral mid-insula and right amygdala.

83 he anterior cingulate and bilateral anterior insula and right inferior frontal cortex.

84 on-related neural activity in right anterior insula and right putamen in smokers and decreased dorsal

85 region spanning the right anterior/posterior insula and right temporal pole (r = +0.661, p = 0.000).

86 during stimulation in the mid- and posterior insula and secondary somatosensory cortex (S2).

87 areas important for interoception, including insula and sensorimotor cortical regions.

88 ous and task-evoked activations in the human insula and support a clear link between these activation

89 tex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10

90 l, regardless of the substance, included the insula and the medial orbitofrontal cortex.

91 tate functional connectivity between the mid-insula and the ventral striatum and ventral pallidum.

92 Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central 'nodes' or h

93 frontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior

94 e left anterior insula to the right anterior insula and TPJ; increased SFC from the left centromedial

95 summarize the physiological functions of the insula and underscore its pathological roles in psychiat

96 of the frontal, temporal and parietal lobes, insula and whole brain.

97 ial prefrontal cortex, cingulate cortex, and insula) and lower activation in self-reference regions (

98 s, i.e., sensitivity to unfairness (anterior insula) and negative affectivity (amygdala).

99 entral precentral and postcentral gyrus, and insula), and concrete words (pars orbitalis and pars tri

100 and thalamus), salience detection (anterior insula), and learning and memory (caudate and parahippoc

101 reward receipt in the anterior and posterior insula, and 3) to unexpected reward omission in the caud

102 her brain pain processing regions (thalamus, insula, and amygdala) accounted for 40.0% and 13.1% of t

103 regions, including the orbitofrontal cortex, insula, and amygdala, were persistent and thus may play

104 in the postcentral gyrus, prefrontal cortex, insula, and anterior cingulate cortex, and increases in

105 lection for the head of the caudate nucleus, insula, and cortical spread to the limbic system, wherea

106 l anterior cingulate cortex (dACC), anterior insula, and intraparietal sulcus, independent of task sp

107 ral and orbital frontal cortex, the anterior insula, and mesiotemporal structures.

108 l (BP(ND)) values in the striatum, amygdala, insula, and orbitofrontal cortex (OFC).

109 n the hippocampus/parahippocampus, striatum, insula, and orbitofrontal cortex.

110 the superior temporal sulcus, the posterior insula, and orbitofrontal cortex.

111 rk, left dorsolateral prefrontal cortex, and insula, and reduced connectivity between the hippocampus

112 -IR in the nucleus accumbens, right and left insula, and right cingulate gyrus (P < 0.005, corrected

113 matosensory representation in the mid-dorsal insula, and suggest that this part of the insula may be

114 temporal cortex, central operculum/posterior insula, and supplementary motor area.

115 salience network (dorsal anterior cingulate, insula, and thalamus) showed early learning task-related

116 tor cortex was functionally connected to the insula, and the threshold for detection of an additional

117 in the anterior cingulate cortex (ACC), left insula, and visual cortex using 7T proton magnetic reson

118 e, putamen, nucleus accumbens) and cortical (insula, anterior cingulate cortex [ACC]) regions even in

119 self-touch, we instead found deactivation in insula, anterior cingulate cortex, superior temporal gyr

120 y spontaneous empathic responses in anterior insula, anterior/mid-cingulate cortex and supplementary

121 e key brain regions such as the amygdala and insula appear to be primarily involved in the prediction

122 in frontal and temporal lobes, amygdala, and insula are less consistent.

123 coded taste quality within the bilateral mid-insula as well as the striatum, orbitofrontal cortex, an

124 anterior and posterior sectors of the right insula, as well as bilateral regions of the mid-insula.

125 t the driving role of the mid- and posterior insula, as well as S2, in modulating PLP.

126 abnormalities in left thalamus and bilateral insula associated with risk for SCZ, in left supramargin

127 y individual differences in predispositional insula-based striatal-frontal circuits, highlighting the

128 ectively, this study supports a role for the insula-BNST neural circuit in negative affective disturb

129 (2020) demonstrate that the insula bridges different timescales of interoception by

130 t in posterior orbitofrontal cortex/anterior insula but were also found in three other frontal cortic

131 taste cortex within the bilateral dorsal mid-insula, but no brain region exhibited a consistent prefe

132 rimary taste cortex within the bilateral mid-insula, but no brain region exhibited any consistent tas

133 tivation in posterior OFC extending to right insula, caudate region and frontal medial OFC respective

134 tion in a network of cortical (motor cortex, insula, cingulate, amygdala) and sub-cortical (putamen,

135 es, hippocampus, para hippocampus, amygdala, insula, cingulate, caudate, thalamus, and cerebellum) in

136 antly stronger inter-subject correlations in insula, cingulate, medial and lateral prefrontal, superi

137 g more often in some brain regions (e.g. the insula) compared to others (e.g. the occipital lobe).

138 esses associated with dysfunctional amygdala-insula connectivity that are not targeted by CBT alone.

139 ffective for patients with abnormal amygdala-insula connectivity.

140 : food-selective representations in the left insula continue to be recruited when prototypical taste

141 d increased activation in the left and right insula (coordinates, 44, 14, -14 and -38, 20, -8; k=2,10

142 of connections from the dACC to the anterior insula correlated negatively with severity of social wit

143 centromedial amygdala to the right anterior insula correlated with clinical improvement.

144 h of the frontal and temporal lobes over the insula, corresponding to domains of highly expressed tra

145 ish in male mice, a wiring chart between the insula cortex (IC), a major sensory input region of the

146 ues to investigate how a sensory region, the insula cortex (IC), connects with the motor, physiologic

147 neurons in behaving rats from the posterior insula cortex (pIC), a subdivision considered as a prima

148 late connections originating in the anterior insula cortex and targeting salience-related and attenti

149 lume and functional connectivity between the insula cortex and the corticolimbic circuitry.

150 me decoded functional MRI responses from the insula cortex as input into a closed-loop control system

151 to males throughout maturation except in the insula cortex at P25.

152 in the subgenual anterior cingulate cortex, insula cortex, and left amygdala, brain regions involved

153 In the insula cortex, D1:D2 ratio initially increased in males

154 e prelimbic cortex, infralimbic cortex (IL), insula cortex, dorsal striatum, and ventral striatum of

155 decision-making regions of the striatum and insula cortex.

156 ical abuse also correlated with amygdala and insula coupling to motor cortices.

157 as young as the age of six activate the left insula, cuneus, inferior parietal lobule and prefrontal

158 igh-ED cues compared with low-ED cues in the insula, declive, and precentral gyrus were negatively re

159 The right insula demonstrated an increasing response to emotional

160 lum, with regions in the anterior and middle insula discriminating all tastes and representing their

161 The amygdala and insula displayed widespread patterns of primarily subreg

162 ese findings support the conclusion that the insula does not serve pre-articulatory preparatory roles

163 network (SN) anchored in the right anterior insula, dorsal anterior cingulate cortex (rdACC), and ve

164 ven that the multimodal integration network (insula, dorsal cingulate, temporoparietal junction (TPJ)

165 rontoinsular-default network state involving insula, dorsolateral and medial prefrontal cortex, and p

166 creased over time, whereas activation in the insula, dorsomedial PFC and DLPFC increased over time.

167 ivity in the right caudate and left anterior insula during anticipation of erotic relative to monetar

168 d by reduced activation of the mid/posterior insula during attention to heartbeat sensations.

169 increase in functional connectivity with the insula during imagined thirst relative to imagined drink

170 bilateral anterior cingulate, and bilateral insula during the emotion face-processing task consisten

171 e predictive coding model, whereas posterior insula encoded stimulus intensity.

172 sular propagation in 12 patients with "pure" insula epilepsy (n = 9) or insular and only deepest oper

173 With adequate sampling, "pure" insula epilepsy can be identified and focal curative res

174 Insula epilepsy is rare and can be evaluated effectively

175 (e.g., the orbitofrontal cortex and anterior insula), expressed as response inhibition deficits that

176 line were distinguished by a decrease in NAc-insula FC (p < 0.001) and to venlafaxine-XR by an increa

177 , early recovery, and no aura from posterior insula features of early dystonia, early tonic motor fea

178 dings about the crucial role of the anterior insula for ipsilateral affective touch perception open n

179 temporal gyri, as well as the left and right insula, for those with MDD relative to HC.

180 ues in the amygdala, white matter, cingulum, insula, frontal cortex, putamen, temporal and parietal c

181 in 5 out of 10 regions-of-interest including insula, frontal lobe and putamen in AD compared with con

182 mentary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal

183 lamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and media

184 RI offers a powerful approach for evaluating insula function, and could be a useful probe for examini

185 ulation was associated with reduced amygdala-insula functional connectivity.

186 Seizure onset and first ictal change within insula functional subdivision correlated with aura and r

187 to identifying seizure onset and relates to insula functional subdivision.

188 in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygd

189 These data suggest that smaller DLPFC and insula GMV plausibly represent genetically conferred pre

190 DLPFC and insula GMV represent promising biomarkers for alcohol-co

191 (i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use a

192 cytoarchitectonic organization of the human insula has been investigated over the last century using

193 and lateral prefrontal/cingulate cortex and insula in maintaining anxiety responding.

194 ampus and the left putamen, hippocampus, and insula in response to neutral stimuli.

195 tudy suggests distinct roles of the anterior insula in response to trauma between the PTSD and Resili

196 Here, we show that the anterior insula in the human brain marks down the overall value o

197 etween the dorsal/ventral medial nucleus and insula in the less frequent connectivity state, and temp

198 studies regarding the role of the posterior insula in the perception of affective touch.

199 a key node of the salience network (anterior insula) increased linearly across the lifespan across da

200 reased connectivity between the amygdala and insula; increased connectivity of both regions with the

201 tom mapping confirmed that striatum but also insula, internal capsule, and external capsule were asso

202 ging data of rats (n = 32) to parcellate rat insula into functional subdivisions and to identify a po

203 operties of taste.SIGNIFICANCE STATEMENT The insula is the primary cortical substrate involved in tas

204 In the mammalian brain, the insula is the primary cortical substrate involved in the

205 connectivity and GMV reductions converged in insula, lateral postcentral cortex, striatum, and thalam

206 stantial dysconnectivity in schizophrenia in insula, lateral postcentral cortex, striatum, and thalam

207 and cortical regions including the striatum, insula, lateral prefrontal cortex and anterior cingulate

208 mine users showed decreased GMV in the right insula, left inferior parietal lobule, left dorsolateral

209 revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilat

210 as assessed by subregion in the amygdala and insula, limbic structures key to the disorder pathophysi

211 frontal gyrus (IFG) and clusters in the left insula (LINS), lentiform nucleus (LENT), and midcingulat

212 timulation of a relatively delimited zone of insula, located in its mid-dorsal part (posterior short

213 rgest principal component separated anterior insula manifestations, including early hypermotor signs,

214 al insula, and suggest that this part of the insula may be an integrated oral sensory region that pla

215 ble strategies through which the role of the insula may be further understood for both basic and clin

216 The dorsal anterior cingulate cortex and insula may play important roles in switching between the

217 uneus, and negatively with metabolism in the insula, medial frontal gyrus, hippocampus in the left he

218 connectivity involving the caudate nucleus, insula, medial prefrontal cortex and other domain-specif

219 ta from 413 participants revealed that human insula microstructure differs significantly across subdi

220 cant activations in brain regions, including insula, middle occipital, anterior cingulate and fusifor

221 to the right inferior frontal gyrus/anterior insula node of the salience network, which was targeted

222 pression specifically in the right posterior insula of individuals homozygous for the anxiety-related

223 ior cingulate cortex [dACC] and the anterior insula) of 20 patients with first-episode psychosis and

224 ural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the de

225 here with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the ins

226 reward, and emotional processing (thalamus, insula, orbitofrontal cortex, hippocampus, and anterior

227 etal (P = 0.039), occipital (P = 0.024), and insula (P < 0.001) cortices; and in the subcortical regi

228 x 10(-17)); they most often connected to the insula (P < 6 x 10(-17)).

229 ntal cortex (p = .342, Cohen's d = 0.38) and insula (p = .466, Cohen's d = 0.29).

230 (p=0.022) and posterior cingulate (p=0.036), insula (p=0.0051), frontal (p=0.0016), parietal (p=0.019

231 creases in amygdala-frontal connectivity and insula-parietal connectivity were associated with larger

232 Adults demonstrate frontal-insula-parietal-anterior cingulate cortex activation dur

233 d enhanced connectivity to the left anterior insula, periaqueductal grey and hypothalamus among other

234 ed that high-frequency gamma activity in the insula positively correlates with physiological arousal

235 nterior midcingulate cortex (aMCC), anterior insula, precentral gyrus, inferior frontal gyrus, middle

236 lated attenuation of taste activation in the insula predicted increased subsequent ad libitum food in

237 fective connectivity with the right anterior insula predicts children's inhibitory control.

238 ective connectivity between the amygdala and insula predicts people's ability to recognize the absenc

239 nalysis identified clusters in the bilateral insula, prefrontal, and cingulate cortex associated with

240 BP in the adjacent right anterior insula and insula proisocortex was negatively correlated with trait

241 selectively recruit dBNST neurons receiving insula projections.

242 mates, in contrast, recruited right anterior insula (rAI).

243 ortex), and salience network (right anterior insula [rAI]).

244 organization in the insula, whereby distinct insula regions are selectively responsive to one of the

245 Thalamus, somatomotor, and posterior insula regions play a critical role in dysconnectivity s

246 identity of distinct tastes within those mid-insula regions, as well as brain regions involved in aff

247 ventromedial prefrontal cortex, and anterior insula, regions previously implicated in aversive and so

248 on of olfactogustatory representation in the insula remains controversial.

249 connectivity in the dACC and in the anterior insula, respectively.

250 , a primary taste cortex region in the right insula responded more to the sweeter drink (P < 0.001, u

251 in resistance correlated positively with the insula response to food cues.

252 The change in parahippocampal/amygdala and insula responses during the perception of emotional face

253 in conductance, pupil dilation, and anterior insula responses to cued pain stimuli strictly followed

254 re positively correlated with right anterior insula responses.

255 rior frontal gyrus, left thalamus, bilateral insula, right cerebellum, and right superior frontal gyr

256 mporal gyrus; increased grey matter in right insula, right putamen, left temporal pole, and bilateral

257 Furthermore, these decreases in right insula/salience network connectivity correlated with bas

258 und an anterior, intermediate, and posterior insula seizure onset group.

259 at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC.

260 Furthermore, the posterior insula showed greater activation to primary rewards, ind

261 Insula showed the expected aversive conditioning effect,

262 p between dosage and activation in bilateral insula, somatosensory and premotor regions, cingulate co

263 0.77 for cingulate cortex, globus pallidus, insula, striatum, and frontal cortex, respectively, cons

264 mimic eCB signaling, we demonstrate that the insula strongly influences the CDFA behavioral phenotype

265 renchymal hemorrhage not extending to cortex/insula, subarachnoid, or subdural spaces.

266 ns (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and

267 to age-advanced connectivity across several insula subregions, but to age-delayed connectivity with

268 ve to CW, showed increased activation in mid-insula, superior frontal gyrus, putamen, dorsal anterior

269 veral areas, including somatosensory cortex, insula, superior temporal gyrus, supramarginal gyrus, st

270 ior temporal sulcus, angry < baseline in the insula, superior temporal sulcus and superior temporal g

271 in processing network, particularly anterior insula, supporting the view that pain empathy partly rel

272 ered social reward prediction signals in the insula, temporal lobe, and prefrontal cortex, while DA d

273 us, combined with more rapid atrophy of left insula than other non-amnestic patients.

274 eft anterior ventrolateral prefrontal cortex/insula, the dorsal midbrain, and the left ventromedial p

275 ft prefrontal cortex as well as the anterior insula, the right ventrolateral prefrontal cortex, the r

276 e effort value computations, instantiated by insula, thereby increasing an individual's subjective va

277 With adequate sampling of the insula, this study shows this is possible.

278 nnectivity with the orbitofrontal cortex and insula to implicit happiness, but a negative connectivit

279 ulated right inferior frontal gyrus/anterior insula to the rest of the salience network was associate

280 ted with enhanced SFC from the left anterior insula to the right anterior insula and TPJ; increased S

281 in several brain regions, ranging from 11% (insula) to 14% (striatum).

282 Hunger had a similar opposite effect on insula-to-ventral caudal putamen functional connectivity

283 l dissociation of pain processing within the insula together with previously observed alterations in

284 rom motor regions to the bilateral posterior insula, TPJ, middle cingulate cortex and putamen.

285 To this end, we assessed amygdala and insula treatment-related connectivity changes and their

286 eating symptoms demonstrates adaptations in insula-ventral striatal circuitry and metabolic regulato

287 : an ACC glutathione-glutamate component; an insula-visual glutathione-glutamate component; and a glu

288 ction error responses in anterior insula and insula-vmPFC connectivity during self-esteem updates.

289 onsistent with our hypothesis, the right mid-insula was maximally responsive during the peak period o

290 y in posterior orbitofrontal cortex/anterior insula was measured at rest, and its pattern of coupling

291 e their brain activity, pain encoding in the insula was paradoxically degraded.

292 The posterior insula was robustly active bilaterally, but after the on

293 pplementary motor area, cingulate cortex and insula were commonly activated both in the aesthetic jud

294 perfusion in the left frontal operculum and insula, whereas fear symptoms were associated with less

295 dentified a "gustotopic" organization in the insula, whereby distinct insula regions are selectively

296 ast, chemogenetic inhibition of the anterior insula, which receives collateral projections from NAcC-

297 igher in the left inferior frontal gyrus and insula, while GMV was significantly lower in the bilater

298 buse specifically associated in the anterior insula with a downregulation of the kappa opioid recepto

299 date nucleus, the lentiform nucleus, and the insula (with areas under the receiver operating characte

300 rtex, amygdala, occipitotemporal cortex, and insula (Z > 2.3; p < 0.05; whole-brain corrected).