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1 nal approaches to MicroED sample preparation insurmountable.
2 als, showing that the comparative gap is not insurmountable.
3  achieve elimination is substantial, but not insurmountable.
4 ver, there are challenges that have remained insurmountable.
5 nch-to-bedside translation, but they are not insurmountable.
6 we speculate that CA's toxicity might not be insurmountable.
7 ies, but the 1 GeV barrier has so far proven insurmountable.
8 ralizing antibodies (NAbs) have often seemed insurmountable.
9 ical barriers to xenotransplantation are not insurmountable.
10 h TMX-1 suggests that these problems are not insurmountable.
11 and selectivity of this protein is rooted in insurmountable activation barriers to the binding of lig
12 anism and structural components required for insurmountable activity of a GnRHR antagonist.
13 us, although it can seem that pathogens gain insurmountable advantages by mimicking cellular componen
14                   The need is great, but not insurmountable and innovative and faster development pat
15   The inhibitory effects of candesartan were insurmountable, and a vasodepressor or vasodilator respo
16               ACT-777991 is a highly potent, insurmountable, and selective CXCR3 antagonist that show
17 icyclic lactone intermediate was found to be insurmountable, and the later strategy comprising OsO(4)
18                           Drugs that exhibit insurmountable antagonism are proposed to provide improv
19                               Therefore, the insurmountable antagonism observed in the functional ass
20                 Quantitative analyses of the insurmountable antagonism of CCR5 internalization by the
21 he amino terminus of hGnRHR also ablates the insurmountable antagonism of TAK-013.
22           A mechanistic understanding of the insurmountable antagonism of the angiotensin II type 1 (
23 ide had the opposite effect on cAMP, causing insurmountable antagonism of the concentration-effect cu
24 as an unusual structure and displays potent, insurmountable antagonism of the Y(1) receptor.
25 f action of 5 from insurmountable to partial insurmountable antagonism while it had no effect on that
26 ation- and time-dependent manner, suggesting insurmountable antagonism.
27 or of 5 and converted 6's surmountable to an insurmountable antagonism.
28  and in addition may offer new insights into insurmountable antagonism.
29  as a tool to elucidate the mechanism of its insurmountable antagonism.
30 he acid-base group contacts are critical for insurmountable antagonism.
31                        TAK-013 behaves as an insurmountable antagonist at the human receptor (hGnRHR)
32 ain barrier and acts as slowly diffusing and insurmountable antagonist for G(q) protein activation an
33 pound 45 (IDOR-1117-2520) is a selective and insurmountable antagonist of CCR6.
34  that GIV3727 likely acts as an orthosteric, insurmountable antagonist of hTAS2R31.
35  In functional studies, QAW039 behaved as an insurmountable antagonist of PGD2-stimulated [(35)S]-GTP
36 -1004-1239 demonstrated that it is a potent, insurmountable antagonist.
37  (mGnRHR-P203S/V300L) converts TAK-013 to an insurmountable antagonist.
38 th Gln(257) in transmembrane 6 distinguishes insurmountable antagonists and that abolishing these int
39 ere, we identify carvones as noncompetitive, insurmountable antagonists of AhR and characterize the s
40 rtan and EXP3174 are competitive, reversible insurmountable antagonists of the AT(1) receptor.
41           We propose that leaning ability of insurmountable antagonists on Gln(257) in the wild-type
42                     We have administered the insurmountable AT(1) antagonist Candesartan, s.c. via os
43 locker that can induce both surmountable and insurmountable AT1 receptor blockade and provide support
44 bres offers a potential way to overcome this insurmountable attenuation limit set by the glass's scat
45  characteristics of senescence but is not an insurmountable barrier to further growth.
46     Alloimmunization can present a virtually insurmountable barrier to kidney transplantation.
47 y T cells in the recipient poses a sometimes insurmountable barrier to long-term graft survival and t
48 cid backbone structure may not have posed an insurmountable barrier to the emergence of functionality
49 tionally silent proviruses poses a currently insurmountable barrier to the eradication of the human i
50   Thus, the nucleosome is not necessarily an insurmountable barrier to transcript elongation by pol I
51 g regions of a protein does not introduce an insurmountable barrier to transmembrane movement.
52 enic variation(3)-that present an apparently insurmountable barrier to vaccination.
53  type 1 (HIV-1) proviruses currently pose an insurmountable barrier to viral eradication in infected
54 ntly infected with HIV represent a currently insurmountable barrier to viral eradication in infected
55 force in the USA, this challenge presents an insurmountable barrier.
56 y capacity of most cancer populations remain insurmountable barriers to cure.
57  has raised concerns about whether there are insurmountable barriers to entry in such markets.
58 titive or noncompetitive and surmountable or insurmountable based on functional antagonism.
59 sely, the mutation hNK(3)-Y315F enhanced the insurmountable behavior of 5 and converted 6's surmounta
60 rawbacks, for example, high non-specificity, insurmountable binding, or short half-life.
61 t in an insurmountable manner, indicating an insurmountable blockade of AT1 receptors.
62  T-type calcium channel blockers produced an insurmountable blockade of CatSper, whereas the three st
63 human P2X4 in the presence of BX430 shows an insurmountable blockade, indicating a noncompetitive all
64  carcinoma, there is hope that the seemingly insurmountable burden of this disease will come under be
65 ereas at hNK(3), they differ in that 5 is an insurmountable but 6 a surmountable antagonist.
66 Regulatory and reimbursement hurdles are not insurmountable but pose substantial challenges to commer
67                       These barriers are not insurmountable but will require a concerted effort to ov
68 caused the appearance of inhibition that was insurmountable by 5-HT.
69 of possible interventions, both of which are insurmountable by experiments.
70 erene monomalonate adducts are unaltered and insurmountable by increased concentrations of arginine,
71                      None of these causes is insurmountable; by designing strategies that systematica
72 ative care is a major and persistent but not insurmountable challenge for health systems worldwide.
73 a naive fly genome to overcome the initially insurmountable challenge imposed by a newly encountered
74 e of human cells has often been viewed as an insurmountable challenge.
75 0 mg has, for many years, been considered an insurmountable challenge.
76 ponses to HIV through vaccination remains an insurmountable challenge.
77              Increasing population has posed insurmountable challenges to agriculture in the provisio
78 s disease 2019 (COVID-19) pandemic is posing insurmountable challenges to healthcare systems globally
79 g combinations could overcome this currently insurmountable clinical challenge.
80                                   This poses insurmountable computational challenges.
81  in the natural world, infants would face an insurmountable computational problem.
82  CNT predicts that the nucleation barrier is insurmountable, consistent with the absence of ice forma
83      Thus, antagonism can be surmountable or insurmountable depending on the signaling pathways measu
84                                Major, almost insurmountable, deterrents exist to the use of the small
85         Here, we report that this previously insurmountable electronic repulsion may be overcome thro
86 ng allowed species to overcome the seemingly insurmountable energetic constraint on growing large bra
87 brane hydrocarbon core and water presents an insurmountable energetic penalty to burial of electric c
88 dth will introduce significant (and probably insurmountable) error variation into radiographic outcom
89 ntagonist-induced ligand-receptor behaviors, insurmountable for CCR6 and surmountable for CXCR2.
90        The obstacles are substantial but not insurmountable for resourceful collaborative teams that
91 oses an additional challenge that can become insurmountable for some approaches.
92     These challenges, however, are in no way insurmountable for users with knowledge of the general C
93 baboon-to-human transplants may represent an insurmountable hurdle in the race to save lives.
94                                          The insurmountable hurdle of targeting oncogene KRAS, the mo
95 data are being reported, and many previously insurmountable hurdles have been overcome by developing
96 s more O2 than it can supply CO2, leading to insurmountable imbalances in both carbon and oxygen.
97 motivational properties and are perceived as insurmountable impediments.
98                 Based on our results showing insurmountable inhibition of ADP-induced Ca(2+) release
99 have demonstrated that analogues 1 and 2 are insurmountable inhibitors of MTII agonist activity at th
100 elusive target for chemical synthesis due to insurmountable issues of reactivity and selectivity asso
101 in in females is not sufficient to induce an insurmountable level of dosage compensation, suggesting
102    Overall, this work highlights a currently insurmountable limitation of immunotherapy and reveals a
103                                 Although not insurmountable, logistic challenges of 24-h urine collec
104 e-response curve to AngII to the right in an insurmountable manner, indicating an insurmountable bloc
105       Moreover, these compounds displayed an insurmountable mechanism of inhibition in both receptors
106 ect competitive antagonism and an apparently insurmountable mechanism that only occurs after preincub
107                    Both compounds exhibit an insurmountable mode of antagonism at hNK(1), whereas at
108 e that tolerance to tumor antigens is not an insurmountable obstacle and points to modulation of APC
109    The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate
110 rties of the skin pose a significant but not insurmountable obstacle for development of new effective
111 ared QCLs has so far constituted a seemingly insurmountable obstacle for the formation of ultrashort
112 uctures, and the design challenge remains an insurmountable obstacle for the large number of proteins
113  at small scales and has so far presented an insurmountable obstacle for untethered flight in insect-
114 me and biocompatibility, represents a nearly insurmountable obstacle to ML-aided design of biomateria
115 y inevitable protein corona appears to be an insurmountable obstacle to wider application of function
116 ing are helping to overcome these previously insurmountable obstacles and improve the future of pepti
117 ggesting that opposing polymerases represent insurmountable obstacles for each other.
118 loping brain-targeted drug delivery systems, insurmountable obstacles remain.
119  Position effects also represent potentially insurmountable obstacles to the rigorous functional comp
120 omplex challenge for researchers, but not an insurmountable one.
121             What we previously thought of as insurmountable physical and chemical barriers to life, w
122 d, nevertheless, be expected to guarantee an insurmountable physical block to polyspermy.
123      However, these laryngeal structures set insurmountable physiological limits to the frequency ran
124   Although myocardial damage/loss remains an insurmountable problem for adult mammals, the same is no
125 treatment failure response has emerged as an insurmountable problem.
126 ecules, it has to face an additional, so far insurmountable problem: Autoionization is slow, and nucl
127 lex polymers has created daunting, sometimes insurmountable problems for their chemical analysis.
128 o a dead-end as the trans intermediates have insurmountable rotation barriers that prohibit formation
129  inspired sensors to overcoming a previously-insurmountable size constraint in engineered sound-local
130 n monoclonal antibodies (MAbs) and perceived insurmountable technical, financial, and logistical hurd
131 ference approaches." The formidable, but not insurmountable, tensions call for causal reasoning and e
132 stacles, such as a lack of data, rather than insurmountable theoretical difficulties.
133 hly desirable, but the task has proven to be insurmountable to date.
134 F264Y converted the mode of action of 5 from insurmountable to partial insurmountable antagonism whil
135 hat abolishing these interactions transforms insurmountable to surmountable antagonism.
136 structure of TTR, creating a barrier that is insurmountable under physiological conditions.
137 se coffee pods accompanying each use creates insurmountable waste in landfills.
138 , but that of Na is significantly larger and insurmountable, which accounts for the orientation-depen
139           Inhibition of NR1A/2B receptors is insurmountable with respect to glutamate and glycine and

 
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