ライフサイエンスコーパス: intact

1 s essential for host cell viability, remains intact.

2 ciate with NPR1 at high levels of SA remains intact.

3 lls harboring the non-targeted allele remain intact.

4 rm of cancer immunotherapy, is paradoxically intact.

5 ile leaving other VEGFR2-dependent functions intact.

6 r both facts and autobiographical events was intact.

7 ns, mRNAs and pre-ribosomes can pass the NPC intact.

8 hereas input onto pyramidal neurons remained intact.

9 drag forces on an early thrombus and keep it intact.

10 cenes, while other perceptual nodes remained intact.

11 ving other major counterregulatory responses intact.

12 charge and orbitally ordered network remains intact.

13 while head-direction tuning remains largely intact.

14 CR and plasma IgG specific for Bp were still intact.

15 ion while leaving the maternal-fetal barrier intact.

16 hile the response to passive stretch remains intact.

17 ein reabsorption leaving glomerular function intact.

18 indicated that the CCR4-NOT complex remained intact.

19 as long as the glycine zipper motif remains intact.

20 aceutical was observed, with the fraction of intact (177)Lu-DOTATATE in plasma decreasing rapidly to

21 aller nonenhancing thrombus area compared to intact AAAs (p = 0.001).

22 nd 3D CNN performed similarly in classifying intact ACLs (2D CNN, sensitivity of 93% [188 of 203] and

23 hree-photon (3P) imaging through the head of intact adult zebrafish allows structural and functional

24 to determine the real-time concentrations of intact Ag-Phen and dissociated Ag(+) in the extracellula

25 lly, both the Ecm29 N-terminal domain and an intact AIS structure are required for transport and teth

26 a-cell phenotype as the control mice with an intact Akt1 gene.

27 paper thus demonstrates the importance of an intact alcove in forming and stabilizing the Ni(I)-CO in

28 rast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue.

29 -spread tuberculosis epidemics, whereas TbD1-intact "ancestral" lineages tend to be restricted to spe

30 and soil-water quality characteristics in an intact and a degraded burnt PSF in Brunei Darussalam aff

31 ed overall no significant difference between intact and burnt PSF with a modern signature for both CO

32 Findings were validated using IDA in intact and digested bovine serum albumin solutions using

33 Double homozygous cilia are generally intact and display a normal morphology and distribution.

34 Matching of data for intact and fragment ions against known values for 36 ful

35 ctions, with better performance for LSF than intact and HSF.

36 he comparative bimolecular analysis of fully intact and living zebrafish embryos.

37 o study the dynamics of the complexes inside intact and photosynthetically functional thylakoid membr

38 nt on the protein conformational stabilityof intact and post-translationallycleaved peanut allergen A

39 ne MALS and then identified and confirmed by intact and reduced LC-MS of isolated forms.

40 th ATP-bound HSP70 dimers, which leaves them intact and thereby eliminates an inhibitory effect of TO

41 who were successfully extubated cognitively intact and without focal neurologic deficits.

42 mas (nine IDH wild type, 21 IDH mutant/1p19q intact, and 19 IDH mutant/1p19q codeleted), the classifi

43 The biochemical characterization of an intact animal polyketide biosynthetic enzyme opens the d

44 recording and staining in the optic lobe of intact animals.

45 5) and left ventricular myocardium (n=20) of intact animals.

46 Consequently, direct interrogation of intact antibodies or F(ab')2 and Fab fragments has the p

47 structural epitopes with tightly interacting intact antibodies under native conditions are lacking, w

48 some showed mutual isomerization or remained intact at room temperature.

49 We have postulated that intact autophagic flux is required for higher recoveries

50 detected by dPCR with appropriately diluted intact bacterial cells from pure cultures, culture-spike

51 re more representative of human DIPG with an intact BBB.

52 iments, efficient protein expression from an intact BHLF1 ORF required the EBV posttranscriptional re

53 on of the polymicrobial community across the intact biofilm architecture remains sparse.

54 species and interkingdom communities within intact biofilms formed on teeth of toddlers with caries.

55 eously sequencing and imaging genomes within intact biological samples.

56 in permeabilized cells, it does not work in intact biological systems.

57 -interface often exist behind a functionally intact blood-brain barrier (BBB), and so are shielded fr

58 Most in vitro models are not exposed to intact body physiology, and at the same time, fail to re

59 vity of the separate C2A and C2B domains and intact BON1 to bind to different phospholipids has been

60 mulated with soluble antigens or inactivated intact Bp and the presence or absence of blocking antibo

61 chanisms of the long-range traffic of DAT in intact brain and acute brain slices from the knock-in mo

62 To measure retinal activity in the awake, intact brain, we imaged the synaptic boutons of retinal

63 as an enzymatic model and from solutions of intact BSA and trypsin.

64 oviruses that persist on ART are genetically intact by sequence analysis.

65 -based titrations revealed that Mtf1 with an intact C-tail has no affinity for DNA but deletion of th

66 However, the structure of the intact cap complex, and the molecular basis for its inte

67 amer interfaces are consistent with those in intact capsids and substantially different from the orga

68 In voltage-clamped, intact Casq2-/- cardiomyocytes pretreated with tetrodoto

69 Both intact cells (IC) and intracellular cell-free extracts (

70 In this manner, intact cells and their antigens were separated and indep

71 for investigations of PI distribution within intact cells by exploiting the properties of a bacterial

72 ances its enzymatic activity in vitro and in intact cells.

73 c membranes of various organelles in situ in intact cells.

74 ing of several SHP2 allosteric inhibitors in intact cells.

75 ting the presence of diffusional barriers in intact cells.

76 forces of isolated nuclei and nuclei within intact cells.

77 ith itself (RocA) and CovS, but not CovR, in intact cells.

78 is known about homeostatic mechanisms in the intact central brain in vivo.

79 Despite their intact cGAS sensing pathway, human CD4(+) T cells failed

80 By imaging epithelial cells in intact ChP explants, we observed calcium activity and se

81 age range 18-35 years), to older adults with intact cognition (n = 431; age range 55-90 years) and wi

82 In contrast, subtype 2 showed intact cognitive performance and greater volume, cortica

83 ir binding sites at nucleotide resolution in intact colorectal cancer (CRC) cells.

84 n experiment 3, we replicated the finding of intact context discrimination for at least 15 d in rats

85 as half of the population generally keeps an intact copy of the original genome.

86 Large, intact corals can help build past (century-scale) climat

87 ion rate coefficients in diffusion-dominated intact core microcosms.

88 With intact cortex, theta and gamma oscillations could be rel

89 ) ) rather than the SCN(-) , maintaining the intact cubic structure and facilitating interparticle el

90 oints, which we attribute to the presence of intact cutaneous mechanoreceptors.

91 gen barrier was trimmed and placed under the intact defect-associated papilla with palatal positionin

92 Soils were sampled from intact, degraded and restored alpine grasslands at altit

93 The dimeric complexes on Psi RNA require an intact dimer interface within Gag.

94 ) in one DNA molecule and passage of another intact DNA duplex through the break.

95 reactions to prepare it for interaction with intact DNA.

96 smaller than the corresponding value of the intact double-helix.

97 dicating that the retinal circuitry remained intact during this period.

98 ion of a large intragenic segment within the intact dystrophin gene locus, with the ultimate goal to

99 o visualize the coronary microvasculature in intact embryonic hearts and quantify vessel organization

100 ectron microscopy (cryo-EM) structures of an intact Escherichia coli class-II CAP-dependent transcrip

101 tFAS, as mutants lacking lipoylation have an intact ETC.

102 few strains have been reported to contain an intact ETT2 locus.

103 9 isolates from this collection contained an intact ETT2 together with an associated eip locus which

104 to reconstruct how photoreceptors tilt in an intact eye.

105 Importantly, intact face previews (either incongruent or congruent) r

106 , faster recovery following stimulation, and intact facilitation.

107 of the five CFHR genes in the context of an intact Factor H gene are described in C3 glomerulopathy.

108 receptor kinase (GRK); pretreatment of ovary-intact female mice with the selective GRK2/3 inhibitor,

109 ncreased nicotine IVSA to a larger extent in intact female versus male and OVX females.

110 ast sarcomere-level mechanics in contracting intact fibres from frog skeletal muscle reveal an I-band

111 e perpetuation of electric remodeling in the intact, fibrillating atrium.

112 th in dissociated ommatidia and in vivo from intact flies of both sexes.

113 tDNA has lost most native genes but contains intact foreign homologs acquired from legume host plants

114 ce of maintaining and enhancing structurally intact forests.

115 OCT and QME were performed on the margins of intact, freshly excised specimens from 83 patients under

116 -250-nm-thin regions (called lamella) in the intact frozen cells.

117 genome annotation tools focus on annotating intact genes and do not attempt to distinguish nonfuncti

118 ically viewed as genetic wastelands with few intact genes.

119 esults highlight the importance of assessing intact genital tissue samples to gain insights into HIV

120 ntiated tumors were characterized by largely intact genome integrity, high immune infiltration, and y

121 that the effect of L3740 on L cells required intact GLP-1 receptor and serotonin 5-hydroxytryptamine

122 s and O-glycans of glycoproteins, as well as intact glycolipids in parallel, using the same enriched

123 that this workflow is suitable for TMT-based intact glycopeptide characterization of glycoproteins.

124 t an improved SPS/ETD workflow for TMT-based intact glycopeptide quantification and identification.

125 Further survival analysis reveals that intact glycopeptide signatures of mesenchymal subtype ar

126 for characterizing glycans, glycosites, and intact glycopeptides (IGPs) derived from N-linked glycop

127 For intact glycopeptides, through systematic optimization an

128 ctra were used for the identification of the intact glycopeptides, while the quantitative comparison

129 eates 3 major tumor clusters and 5 groups of intact glycopeptides.

130 Intriguingly, a third strain composed of intact, glycophosphatidylinositol-anchored (GPI-anchored

131 pid synthesis and quantitative evaluation of intact glycoproteins.

132 Cluster analysis of intact glycoproteomic profiles delineates 3 major tumor

133 stry, dual Ca(2+)/voltage optical mapping in intact hearts from alcohol-exposed or aged mice (where J

134 oxic to cultured neurons, exceptionally pure intact high-titer infectious prions are not directly neu

135 A scalable approach for quantifying intact HIV-1 proviruses is critical for basic research a

136 slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental

137 ometry Sequencing (SIMMS(2)) method in which intact HS saccharides are dissociated in an ion mobility

138 nhanced proteasomal degradation and required intact HSP90 chaperone.

139 tion, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and

140 to identify and quantify target proteins in intact human cells.

141 ntrast to the IgE Fc fragment, the IgE Fc in intact IgE is significantly less asymmetrically bent.

142 Our data reveal the first structures of intact IgE suggesting that the IgE Fab is fixed relative

143 ical techniques have been reported to assess intact IgGs subclasses, with recently special interest i

144 Further, an intact immune system and natural co-evolution of tumour

145 meric N-glycans and glycopeptides using both intact IMS and fragment-based IMS glycan sequencing expe

146 gest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval

147 tion, the majority of integrated HIV DNA was intact in both resting and activated T cells.

148 nscriptional response downstream of TLR4 was intact in cells lacking Mm47.

149 tivation of Nlrc4 or Aim2 inflammasomes were intact in cells lacking Mm47.

150 ious retrieval processes, that are generally intact in healthy aging, will be particularly compromise

151 ating exercise heart rate responsiveness are intact in HFpEF.

152 al OXTR ligand binding in the head is mostly intact in Magel2-deficient mice, although it is reduced

153 However, control of lymphoma remained intact in the absence of CD4 T cells.

154 ntica and Alteromonas sp, it remained nearly intact in the Marinobacterium jannaschii and Amphritea j

155 erformed on intact infected red blood cells (intact infected RBC, 77.3% and 79.2%).

156 ficity compared to measurements performed on intact infected red blood cells (intact infected RBC, 77

157 Hence, PV-IN activity remains intact interictally in Scn1a+/- mice, yet exhibits decre

158 d pathophysiology that more closely resemble intact intestine than study under static conditions.

159 y-induced I(Kv1.5) increase also required an intact intracellular N terminus, which contains the bind

160 Islet vascularization is essential for intact islet function and glucose homeostasis.

161 Similar to yeast Pam18, TbPam27 requires an intact J-domain to function.

162 during the day to a similar degree as large, intact kelp forests.

163 Although hepatocyte junctions were intact, KO/KD livers had significant canalicular defects

164 ion of C- but not N-terminal proteoforms nor intact lacritin, from normal human tears promotes loss o

165 late NPCs that are associated with the still-intact lamina.

166 t) over 1959-2015, while the contribution of intact land is reduced by more than half compared with p

167 se muscles can be measured rapidly in whole, intact larval tails by adapting protocols developed for

168 ponsive CD4+ T cells containing defective or intact latent proviruses were found in seven of eight in

169 cord, we found that both lesioned dorsal and intact lateral tracts on the lesion side exhibited promi

170 chine Classification was applied to identify intact liver and tumor tissues.

171 fic chondrocyte lacunar organizations within intact loaded joints and to explore the role of calcifie

172 loss can be highly asymmetric, such that an intact location in one eye has a corresponding point in

173 ino acids in a manner that is dependent upon intact lysosomal function.

174 onfident subclass categorization than CIU on intact mAbs.

175 ntial to rapidly and comprehensively analyze intact mAbs.

176 Chemogenetic inhibition of ChIs in otherwise intact male and female rats caused cued turning deficits

177 , combined with electron cryo-tomography, to intact mammalian cells expressing YFP-rhTRIM5alpha and f

178 d enzyme-derived ubiquitin chains along with intact mass spectrometry, we report that UCH37/UCHL5, a

179 C formation and/or maintenance depends on an intact microtubule network and a viral tegument protein,

180 hpi), and VF coalescence was dependent on an intact microtubule network and actin cytoskeleton.

181 ts with TIM23 and inhibits protein import in intact mitochondria.

182 um suppressed this signal, which required an intact mitochondrial respiratory chain.

183 systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluori

184 the other end of the polymer, which, in the intact molecule, is protected by a connection to the lip

185 three-dimensional maps for the epithelium of intact mouse lenses.

186 new CAP-STRUCTURE-seq method to capture the intact mRNA structurome in Arabidopsis thaliana.

187 Intact mucociliary barrier function and early airway neu

188 lex feedback in regulating force duration in intact muscle.

189 Thus, the persistence of intact N4BP1 in caspase-8-deficient macrophages impairs

190 en the entire alphavbeta8 ectodomain and its intact natural ligand, L-TGF-beta, as well as two differ

191 exposure, mounting an antibody response with intact neutralization capability.

192 a membrane-linked gammadelta TCR recognizing intact non-MHC proteins on the opposing cell surface.

193 e physiological nuclear transport pathway in intact NPCs in cells: that is, inert cargoes ranging fro

194 ell resolution: RAISIN RNA-seq for profiling intact nuclei with ribosome-bound mRNA and MIRACL-seq fo

195 xhibited superior performance in identifying intact O-glycopeptides of the human erythropoietin with

196 are able to discern the dissociated from the intact oligomers and detergent-bound complexes and corre

197 Defective forms accumulated relative to intact ones analogously to what is observed in vivo Mass

198 that while ~40% of the terrestrial planet is intact, only 9.7% of Earth's terrestrial protected netwo

199 the young mammalian eye does not require an intact optic nerve, its fine-tuning is disrupted by ONS.

200 al soil disturbance, including the effect of intact or disturbed arbuscular mycorrhizal networks (CMN

201 a large ratio of partial and pseudogenes to intact OR genes (2:1), suggestive of a dynamic mode of e

202 reading frames, 20 of which are full length, intact OR genes, and found a large ratio of partial and

203 the aggregate determines whether it remains intact or sheds individual platelets or larger fragments

204 Whereas cowpox virus contains intact orthologs of genes present in each orthopoxvirus

205 odes via its cytoplasmic domain and requires intact paranodes.

206 In 133 aMCI and 68 cognitively intact participants the PSS score was higher in the aMCI

207 Subsequent experiments revealed that intact PDGF-B signaling, mediated via Olfml3 binding, is

208 m responses, both in the cell bodies and the intact peripheral endings of nociceptors.

209 c and mineral horizons in palsa underlain by intact permafrost (41.8 +/- 10.8 mg carbon per g soil, 9

210 , can trap organic carbon in soils overlying intact permafrost, and may limit carbon mobilization and

211 he rate observed in littermate controls with intact PHP.

212 As loss of Tex15 causes TE desilencing with intact piRNA production, our results identify TEX15 as a

213 lved stomatal conductance measurements using intact plants, and guard cell patch-clamp experiments we

214 ires mechanical transduction through titin's intact polypeptide chain.

215 roteoforms was performed by fragmentation of intact precursor ions.

216 continuous gigapixel panoramas of the fresh intact prostate circumference, including areas of the pr

217 In addition to imaging the intact prostate, in the first 2 patients the prostate gl

218 oduces rich and informative fragmentation of intact protein ions, but in the case of high mass protei

219 The growing use of intact protein mass analysis, top-down proteomics, and n

220 Intact protein mass spectrometry and protein crystallogr

221 ce liquid chromatography (UPLC) coupled with intact protein mass spectrometry for profiling of mispai

222 enefit from higher resolution approaches for intact proteins and their complexes.

223 Analysis of intact proteins by native mass spectrometry has emerged

224 mpling technique that allows the analysis of intact proteins directly from tissue samples via mass sp

225 umentation have enabled the investigation of intact proteins in situ and in crude samples, offering r

226 try (FAIMS) for mass spectrometry imaging of intact proteins in thin tissue sections have been demons

227 Herein, we use intact proteins to show that the lysine-binding site of

228 cessfully used to separate a mixture of four intact proteins using reversed-phase liquid chromatograp

229 anced capabilities for the analysis of large intact proteins yielding much more detailed and accurate

230 ion, characterization, and quantification of intact proteoforms, including positional isomers of glyc

231 The intact proviral DNA assay (IPDA) is a novel approach to

232 the quantitative viral outgrowth assay, the intact proviral DNA assay, and total HIV gag DNA.

233 e for psi and integrase, and negative by the intact proviral DNA assay, at 27 months.

234 was a reduction in cell-associated DNA load, intact proviral DNA levels, and in inducible SIV reservo

235 Moreover, the integration sites of intact proviral sequences from elite controllers showed

236 eated with long-term antiretroviral therapy, intact proviral sequences from elite controllers were in

237 f oligoclonal to near-monoclonal clusters of intact proviral sequences.

238 that defective proviruses greatly outnumber intact proviruses (by >12.5 fold).

239 c CTL responses, had a smaller proportion of intact proviruses but a distribution of defective provir

240 Rare, intact proviruses can be detected in children who initia

241 We showed that rare, genetically intact proviruses could be detected in children who init

242 No intact proviruses were detected in four children who ini

243 dren treated early failed to detect sequence-intact proviruses.

244 2.2 mg CH(4) m(-2) hr(-1) ) compared to the intact PSF (4.0 +/- 2.0 mg CH(4) m(-2) hr(-1) ) due to p

245 Cholecalciferol also suppressed intact PTH only among patients with severe vitamin D def

246 incubation media as well as in vivo (57-79% intact radiopeptide in blood of BALB/c mice at 1 h p.i.)

247 pression of interrupted units and control of intact rDNA expression.

248 Obtaining structures of intact redox states of metal centers derived from zero d

249 ming to clarify whether visual inputs to the intact retina are necessary for the LPZ responses, here,

250 coarse stereopsis when the distance between intact retinal locations is less than the behavioral and

251 A is lost from metabolically impaired, mtDNA-intact (rho+) cells.

252 ation of some photoreceptor reflectivity and intact RPE after SDD regression should be seen in the la

253 st, Abs against S Typhi interacted with live intact S Enteritidis but did not bind intact S Typhimuri

254 h live intact S Enteritidis but did not bind intact S Typhimurium.

255 urons from the deprived S1BC that project to intact S1BC were hyperexcitable, had stronger responses

256 nd the transcriptomic analysis indicate that intact SA signalling, and not JA signalling, is required

257 ays and transcriptomic analysis we show that intact SA-signalling is required for potato defences aga

258 ermeabilized Casq2-/- cardiomyocytes-lacking intact sarcolemma and devoid of sodium channel contribut

259 the fingertips to address this issue in the intact sensorimotor system.

260 recruitment has been implicated in enhanced intact sensory function.

261 processing and thus enhances performance on intact sensory systems.

262 These 7 intact sequences were from three children who initiated

263 months of age, one of whom had two identical intact sequences, suggestive of a cell clone harboring a

264 aration or MWM platform location, indicating intact short-term memory.

265 icit, with equal density on the lesioned and intact side below the level of the injury in both groups

266 x-wide imaging access and skull thinning for intact skull imaging.

267 Ossicles can be sampled from intact skulls or disarticulated petrous bones without da

268 e; however detection of lipid A derived from intact (smooth) LPS from host-pathogen MSI studies, prov

269 Patients with intact SP threshold at baseline showed improved attentio

270 After sequencing of the remaining intact strands, this allows assignment of Hi-C products

271 Endothelium had intact structure in all cases.

272 However, the actin cytoskeleton remained intact, suggesting that the trafficking defect is not du

273 frequently 70.0%, P=0.06) and neurologically intact survival (rarely 21.9%, occasionally 22.2%, frequ

274 Primary outcome was neurologically intact survival to discharge.

275 ined to develop hand posture percepts in the intact system, but the combination of multiple artificia

276 in the US to 72% in the UK (p < 0.001).Mean intact TAA (iTAA) diameter varied from 59 (US) to 69 mm

277 pathway of ANTP class gene dispersal and an intact three gene ParaHox cluster.

278 s they move through while blood cells remain intact, thus generating differential impedance profiles

279 for assessing the biochemical composition of intact tissue samples.

280 er release and diffusion to be visualized in intact tissue.

281 provide subcellular-level optical access to intact tissues from individual organs and even to some e

282 int barcodes ('zipcodes') onto live cells in intact tissues, in real time and with an on-the-fly sele

283 This establishes intact titin filaments as critical force-transmission ne

284 e then used our previously developed method, intact transition epitope mapping-targeted high-energy r

285 olated from a white eye mutant strain had an intact transposase reading frame and terminal sequences

286 s of PTEN and TP53, while the Gleason 7 PTEN-intact tumor is almost entirely ablated.

287 ruitment and ligase activity but requires an intact ubiquitin-like (UBL) domain.

288 ns below 100 nm, of the mechanical strain in intact untreated joints under physiologically realistic

289 one acetate (MPA) among participants with an intact uterus were carried out at 40 US clinical centers

290 ompared with placebo, among women who had an intact uterus, was significantly associated with a highe

291 ere, we report two cryo-EM structures of the intact V-ATPase from bovine brain with all the subunits

292 Relatively intact value processing was also confirmed using DDM mix

293 lcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but

294 lly, but characterization of Env embedded in intact virus membranes has been limited to low resolutio

295 he complete structure of assembled M1 within intact virus particles, as well as the structure of M1 o

296 est results and reproduction and shedding of intact virus.

297 Here, we show that a virus without an intact vpr gene is more highly restricted by REAF and, u

298 odel that interhemispheric takeover supports intact whisker processing.SIGNIFICANCE STATEMENT Amputat

299 fter) with combined aesthetic features (e.g. intact wood patterns), excellent optical properties (an

300 0 s recordings of beating atria in 381 live, intact zebrafish embryos at 2 and 5 days post-fertilizat