ライフサイエンスコーパス: integrative

1 GWAS Central resource provides a toolkit for integrative access and visualization of a uniquely exten

2 explosion of high-throughput data, effective integrative analyses are needed to decipher the knowledg

3 The development of multi-omics integrative analyses have enabled new ways to dissect th

4 Our integrative analyses identified altered GMB with related

5 Integrative analyses of DNA methylation profiles showed

6 We conducted integrative analyses of genetic variants associated with

7 Integrative analyses of metabolomics and transcriptomics

8 Integrative analyses of mRNAs, miRNAs, lncRNAs, chromati

9 Studies of complex disorders benefit from integrative analyses of multiple omics data.

10 In this study, integrative analyses of published lymphoblastoid cell li

11 ecture of psychiatric disorders and enabling integrative analyses of regulatory noncoding variants in

12 Integrative analyses of RNA splicing and chromatin occup

13 Together, these integrative analyses reveal epigenetic memory underlying

14 Integrative analyses reveal that pulmonary function inst

15 Integrative analyses revealed that the HOXA5-9 transcrip

16 Integrative analyses revealed the E+ microbiota correlat

17 n Nucleolar 3 (GNL3) as a BD risk gene, with integrative analyses revealing GNL3's roles in cell prol

18 m the latest BD GWAS findings, and performed integrative analyses, including brain expression quantit

19 novel meta-analysis framework, Network-Based Integrative Analysis (NBIA), that transforms the challen

20 Integrative analysis across clinical and molecular featu

21 data provides an approach simultaneously for integrative analysis and biomarker discovery.

22 Through integrative analysis and functional validation, we revea

23 a critical need to address selection bias in integrative analysis and to use caution in interpreting

24 Systematic integrative analysis can help meet this need, and the VI

25 Our findings suggest that integrative analysis can lead to substantial relative bi

26 An integrative analysis combining cytology with genomic and

27 pen-source toolbox that facilitates a robust integrative analysis for population structure and genomi

28 Through integrative analysis of 11,596 epigenomic profiles and m

29 n the context of these factors using a novel integrative analysis of absolute copy-number analysis an

30 e we developed CHOmics, a web-based tool for integrative analysis of CHO cell line omics data that pr

31 Integrative analysis of chromatin accessibility and gene

32 Our integrative analysis of coordinated epigenetic modificat

33 roach for identification, visualization, and integrative analysis of focal and large-scale CNV events

34 XAB2 showing the strongest association using integrative analysis of genome-wide association studies

35 Integrative analysis of genomic data that includes stati

36 plex traits, we propose a method, Primo, for integrative analysis of GWAS summary statistics with mul

37 ent of an experimental system that allows an integrative analysis of how Gag's multiple functionaliti

38 , Statistical Utility for RBP Functions, for integrative analysis of large collections of CLIP-seq an

39 This study utilized integrative analysis of Mendelian randomization and colo

40 e of healing human gingiva and to provide an integrative analysis of miRNA/mRNA expression during hum

41 We further discuss the integrative analysis of molQTLs through a multi-omics pe

42 This integrative analysis of morphometric and transcriptomic

43 ile of experimental human oral wounds and an integrative analysis of mRNA/miRNA expression.

44 Recently it has been used for integrative analysis of multiple high-dimensional -omics

45 ata of human T cell precursors along with an integrative analysis of other hematopoietic populations.

46 In addition, integrative analysis of our single-cell RNA sequencing d

47 s may be critical for ATAA by performing the integrative analysis of our single-cell RNA sequencing d

48 Here, we carry out integrative analysis of RNA editing profiles between epi

49 However, effective approaches for the integrative analysis of such data are lacking.

50 o miRDB for prediction of miRNA functions by integrative analysis of target prediction and Gene Ontol

51 ant for regeneration are constructed through integrative analysis of the epigenome map, and a knockou

52 However, all hypotheses lacked any integrative analysis of the site formation processes.

53 Integrative analysis of the ZMAT3 RNA-binding landscape

54 riptomics, proteomics, and metabolomics, and integrative analysis of these data, enable new, systems-

55 An integrative analysis of these variants provided a more f

56 Application to the integrative analysis of transcriptomics data and proteom

57 pecies are identified through a multi-study, integrative analysis on 4347 human stool metagenomes fro

58 that increases diabetes risk, by performing integrative analysis on publicly available, high-through

59 tudy, an automated microbiome and metabolome integrative analysis pipeline (M2IA) has been developed

60 Our integrative analysis shows that positively selected site

61 Our integrative analysis supports a biological link for Cd a

62 Our integrative analysis that combines proteomics and regula

63 Integrative analysis uncovered plausible mechanisms for

64 Integrative analysis with mRNA profiles uncovered PAK6 a

65 Integrative analysis yielded four key results.

66 Through integrative analysis, this work shows the utility of MOC

67 t of methods for comparative epigenomics and integrative analysis, which we expect to be broadly appl

68 mprehensive data set is subjected to unique, integrative analytical strategies that accommodate molec

69 le, quantitative omics methods as well as in integrative analytical strategies, systems biology appro

70 pment for juvenile songbirds under Arnold's (Integrative and Comparative Biology, 23, 1983, 347) clas

71 e mobilome, including the disease-associated integrative and conjugative element (ICE), tfs4.

72 Conjugative transfer of the integrative and conjugative element ICEclc in Pseudomona

73 By using IDEAS as our integrative and discriminative epigenome annotation syst

74 ensive and wide-spread parallel evolution of integrative and effector systems across Metazoa.

75 st few years, we have developed Epiviz as an integrative and interactive genomic data analysis tool t

76 Here, we develop an integrative and scalable computational method, iDEA, to

77 We designed an integrative and translational study to experimentally ex

78 Integrative annotation using two-sample Mendelian random

79 utational tool: Competing Endogenous RNA for INtegrative Annotations (Cerina), to predict biological

80 Here we illustrate the use of such an integrative approach and report the occurrence of North

81 single-cell transcriptomic datasets, and our integrative approach at single-cell resolution may be ad

82 We propose an integrative approach based on the concept of the 'nidobi

83 We believe this integrative approach can solve the sample rarity issue i

84 Here, we apply an integrative approach combining atomic force microscopy,

85 n be prioritized to enable a community-wide, integrative approach for functional epigenomic studies.

86 Here, we used an integrative approach including genomics, network reconst

87 Our integrative approach may be useful to improve the power

88 Here we used an integrative approach of experimentation and mathematical

89 This integrative approach opens new avenues to study adaptati

90 Our integrative approach streamlines GWAS follow-up studies

91 Using an integrative approach that combines crystallographic stru

92 biogenesis and degradation, incorporating an integrative approach that is critical not only for a mec

93 Our integrative approach thus links glutamine addiction to g

94 This study utilized an integrative approach to determine the miRNA interactome

95 erent experimental campaigns, enabling a new integrative approach to improving target specificity.

96 We used the integrative approach to map the relative abundance of th

97 We propose an integrative approach to the study of threat-related proc

98 hasizing the importance of a comparative and integrative approach to understanding avian sensory syst

99 Our integrative approach was predictive of IA (area under th

100 Here, we adopt an integrative approach, leveraging techniques from histori

101 etween human and macaque using a two-pronged integrative approach, such as single-cell strand sequenc

102 Using this integrative approach, we have ablated cells in zebrafish

103 Here, using an integrative approach, we provide the structural characte

104 rocesses demonstrating the usefulness of the integrative approach.

105 Emphasising the importance of integrative approaches and theoretical simulations to ob

106 servation and highlighting the importance of integrative approaches to pesticide use monitoring.

107 rons in the brainstem that connect a sensory integrative area with distinct features of motor behavio

108 geographic factors, emphasizing the value of integrative assessments of climatic adaptive traits for

109 isual intelligence with the case study of an integrative benchmarking platform called Brain-Score.

110 a, we believe that now is the time to create integrative benchmarking platforms that incentivize ambi

111 Here we present an integrative bioinformatic and high throughput drug scree

112 Using an integrative biophysical approach that includes nuclear m

113 Sex and hormonal influences on integrative blood flow regulation have further implicati

114 ing 3D imaging approaches, we established an integrative blueprint for the EOM functional unit.

115 , void of emotional meaning, are assessed by integrative brain structures steps removed from raw sens

116 fied as a potential prometastatic gene in an integrative breast cancer datasets.

117 id consequences on gene activity in a higher integrative center of the brain, triggering epigenetic m

118 anarthropoda support the view that ancestral integrative circuits crucial to action selection and mem

119 ts by using single-cell RNA-seq to decompose integrative cis-element (IDEAS) models that were derived

120 of the genome, we propose CScape-somatic, an integrative classifier for predictively discriminating b

121 breast cancer subtype, which we also call an integrative cluster (IC)(2).

122 benchmark COCA, and present Kernel Learning Integrative Clustering (KLIC) as an alternative strategy

123 nterface for 10 state-of-the-art multi-omics integrative clustering algorithms, and incorporates the

124 ubtyping-have demonstrated the importance of integrative clustering techniques for combining informat

125 del is used to study the distribution of the integrative coefficient.

126 Through integrative comparative analysis, we define a consensus

127 An integrative comparative transcriptomic approach on six s

128 We applied a phylogenomics-based integrative, comparative approach to test hypotheses abo

129 in vivo stability of genomic islands (GIs), integrative conjugative elements (ICEs), and prophages.

130 ion of a multimodal biological network in an integrative context.

131 Integrative cross-population analysis and cross-omics ma

132 atures at Kilauea Volcano, Hawai'i, using an integrative crystallographic and chemical approach place

133 M2IA streamlines the integrative data analysis between metabolome and microbi

134 Based on our integrative data approach and confirmatory experiments,

135 ng cofactor, which will serve as a valuable, integrative data source to foster metalloenzyme related

136 ecades resulting in increasing importance of integrative data-driven approaches.

137 way disease (P = 0.007).Conclusions: In this integrative deep sequencing study of SERPINA1 with alpha

138 The integrative disease-modelling strategy may reveal new in

139 eration are identified and validated through integrative epigenome analysis.

140 show the framework's utility by providing an integrative explanation of infant vocal production learn

141 Here, we developed an integrative framework and synthesized data from 256 stud

142 Our study provides an integrative framework for the cognitive processes that d

143 Therefore, we developed an integrative framework to improve the candidate gene pred

144 ll as to phase polyploid genomes in a single integrative framework, substantially grows as the amount

145 , these results point towards a discrete but integrative function of pDCs in the human immune respons

146 Trait mapping and integrative functional genomic analysis in GeneWeaver ha

147 ibition is to support contrast enhancing and integrative functions by co-opting the capacities of the

148 dings set a benchmark for current and future integrative genetic association analysis applications.

149 Integrative genetic elements (IGEs) are mobile multigene

150 These findings demonstrate that integrative genomic analysis of dietary information may

151 Integrative genomic and transcriptomic analysis of diffu

152 Our results highlight how integrative genomic approaches can reveal the phenotypic

153 er types, we constructed MutEx, a pan-cancer integrative genomic database.

154 Combining integrative genomics and systems biology approaches has

155 Our integrative genomics approach suggests that ERCC6 may be

156 ese limitations, we used a hypothesis-driven integrative genomics approach to test the association of

157 Over the past decade, large-scale integrative genomics efforts have enhanced our understan

158 We used integrative, high resolution multi-omics methods to deli

159 nts on isolated SMC-derived cells, conducted integrative human genomics, and used pharmacological stu

160 longitudinal data from the IBD cohort of the integrative human microbiome (iHMP-IBD) project.

161 the integrative memory model would be more "integrative" if the temporal dynamics of the interaction

162 the design, assembly, and performance of the integrative imaging system, and discuss potential applic

163 Using this integrative imaging system, we performed a demonstrative

164 In this work, we developed an integrative in-cell structural approach using the genome

165 This integrative index of self-enactable techniques can assis

166 ental biology questions should be central to integrative, interdisciplinary research on causal ecolog

167 : lasso, group lasso, sparse-group lasso and Integrative LASSO with Penalty Factors (IPF-lasso).

168 is to offer freely accessible resources for integrative longitudinal analysis for metabolomics scien

169 identified across disparate sources using an integrative machine learning algorithm and optimization-

170 onotype in school-age children using a novel integrative measurement (TAP) derived from non-invasive

171 Together, our results provide an integrative mechanistic account that encompasses measure

172 The integrative memory model combines five core memory syste

173 The integrative memory model contains multiple subsystems.

174 The integrative memory model formalizes a new conceptualizat

175 tor, could enhance the implementation of the integrative memory model in research and the clinic.

176 Although the integrative memory model proposed by Bastin et al. is in

177 In the integrative memory model proposed by Bastin et al., fami

178 se with the proposed neural substrate of the integrative memory model supporting the core and attribu

179 By considering the integrative memory model through the lens of semantic de

180 cale architecture of declarative memory, the integrative memory model would be more "integrative" if

181 According to Bastin et al.'s integrative memory model, familiarity may be attributed

182 et al. fail to include the amygdala in their integrative memory model.

183 level of the attributional system in the new integrative memory model.

184 gent evidence to help refine Bastin et al.'s integrative memory model.

185 Using an integrative meta-analysis approach, we validated the lin

186 In this study, we used integrative metabolomic and transcriptomic approaches to

187 In conclusion, an integrative metabolomic biomarker panel in mid-trimester

188 veloped a negative binomial regression-based Integrative Method for mutation Burden analysiS (NIMBus)

189 ActivePathways is an integrative method that discovers significantly enriched

190 mporal scope of inference and recommend this integrative methodology as a powerful tool for future tr

191 iew learning is more effective than previous integrative methods for learning data's heterogeneity an

192 ystallography, cryo-electron microscopy, and integrative methods.

193 be inferred in a specific cell type based on integrative methods.

194 studies were then incorporated; we performed integrative methylation and RNA-sequencing analyses to i

195 We performed integrative methylomic, genomic, and transcriptomic anal

196 der, a bioinformatic toolbox that identifies integrative MGEs and their insertion sites by using shor

197 Here we propose an integrative microbiome neuro-immuno-affective framework

198 Our aim was both synthetic - building an integrative model adequate to account for key features o

199 Collectively, these results with an integrative model are consistent with a Zip14 function i

200 nts (e.g., ketamine) as a means to test this integrative model by attempting to simultaneously revers

201 Bastin and colleagues present an integrative model of how recollection- and familiarity-b

202 The current review presents a novel integrative model of neuroplasticity as a multi-domain n

203 ur extensive simulation study shows that the integrative model provides a better fit to the data than

204 We propose an integrative model to estimate latent unknown clusters (L

205 To do so, we developed a Network-based Integrative model to Prioritize Potential immune respond

206 Our results underscore the importance of integrative modeling and validation in generating and dr

207 We used integrative modeling and validation to apply conformatio

208 perimental data as restraints, we adopted an integrative modeling approach to create a sparse ensembl

209 This integrative modeling is challenging in several ways: the

210 Structural proteomics and integrative modeling revealed multiple distinct and nono

211 etry, cellular cryo-electron tomography, and integrative modeling to determine an in-cell architectur

212 Using integrative modeling, we determine the architecture of L

213 , microbiota and metabolites, as assessed by integrative modelling.

214 Here, using a process based, integrative, modelling approach to upscale from existing

215 disease-relevant exposures, we developed an integrative mouse model to study gastric premalignancy.

216 plays in SCCOHT tumorigenesis, we performed integrative multi-omic analyses in SCCOHT cell lines +/-

217 ed in AD mutant SORL1 and TREM2 hMGLs, while integrative multi-omic analysis of combined epigenetic a

218 A change to the status quo calls for integrative multi-omics and inter-omics analyses with ap

219 KD are uniquely poised to benefit from these integrative, multi-omics approaches since the kidney bio

220 GAM, ITGAX, and POMC In summary, applying an integrative multiomics approach, our study provides evid

221 he superior targeting efficiency and the non-integrative nature of our approach underscore broader ap

222 This integrative network analysis approach revealed that gene

223 egions from leukemia patients, we present an integrative network analysis of differentially methylate

224 Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics profiling of

225 Integrative network analysis using graph diffusion and m

226 In summary, this study presents an integrative network medicine platform for predicting dis

227 However, the discovery of another prominent integrative neuropil in the stomatopod lateral protocere

228 ew findings, we propose that ZI serves as an integrative node for global modulation of behaviors and

229 xperimental relationships (LIGER), that uses integrative nonnegative matrix factorization to address

230 We aimed to model an integrative (nutri) prototype based on genetic, phenotyp

231 Using an integrative omics, biochemical and imaging approach, we

232 These data reveal an integrative organ adaptation that involves circulating S

233 subcutaneous adipose tissues and suggests an integrative pathway, with a discriminative flux between

234 Through machine learning based integrative pharmacogenomic analysis, the microRNA bioma

235 Taken together, this integrative phenotyping approach of platelet-fibrin thro

236 react to stimuli and can be measured by the integrative physiological parameter of resting heart-rat

237 f critical zone (CZ) science has provided an integrative platform for investigating plant ecophysiolo

238 ay provide an essential focal point for this integrative process.

239 ns, and structural linkages together support integrative processing across brain systems in order for

240 gated conductance that profoundly alters the integrative properties and visual responses of cortical

241 alters synaptically evoked spike firing and integrative properties of these neurons.

242 s from up to 55 SCs per mouse, we found that integrative properties vary between mice and, in contras

243 from the Lundbeck Foundation Initiative for Integrative Psychiatric Research for replication (N=37,0

244 erstanding of supply size abundance and more integrative quantification of supply energy and environm

245 ese results should be used to inform ongoing integrative, regenerative medicine approaches to HSCR.

246 pling rates and its ability to operate in an integrative regime were investigated for 12 pesticides a

247 ant effect on POCIS ability to operate in an integrative regime.

248 In the context that multiple integrative regulatory and often redundant pathways have

249 We performed a non-integrative reprogramming of dermal fibroblasts obtained

250 Finally, we incorporate discussion of integrative research methods capable of building additio

251 Beyond the intrinsic knowledge gain such integrative research will increasingly provide the conte

252 To identify new avenues for integrative research, we synthesise current literature o

253 This integrative review aimed to understand how family rounds

254 rent thinking on range limits and perform an integrative review to evaluate support for iRLT and trop

255 comes guidelines with the introduction of an integrative risk-based approach.

256 Integrative RNA sequencing and m(6)A mapping analysis re

257 heterogeneous brain structure which plays an integrative role in guiding behavior.

258 Thus, it is well poised to play a broad and integrative role in visual perception and recognition-th

259 Polar organic chemical integrative sampler (POCIS) is a passive sampling device

260 interaction between two monomers induces an integrative self-sorting of rosettes.

261 fic recombinase Integrase (Int) can catalyze integrative site-specific recombination and recombinase-

262 ants of Int were constructed and examined by integrative site-specific recombination and RMCE assays

263 We propose a data integrative solution (called DisoFun) to Differentiate i

264 ubjects and prioritized genes by applying an integrative strategy based on criteria including recurre

265 Here, we report an integrative strategy based on mass spectrometry for the

266 Here, we report the use of an integrative strategy including enzymatic assays, mutant

267 Taken together, this integrative structural approach provides important bioph

268 Recent integrative structural approaches have provided insights

269 Here, we use integrative structural biology combined with yeast genet

270 culation protocol that exploits the power of integrative structural biology to characterize conformat

271 future directions and impacts of cryoET for integrative structural cell biology analyses of viruses.

272 SCAP to cross-linking mass spectrometry, an integrative structural model of the complex of interest

273 and cross-linking mass spectrometry to build integrative structural models of protein complexes.

274 Our integrative structure analysis workflow can be generaliz

275 Here, we describe an integrative structure determination approach that relies

276 roach provides an efficient means to augment integrative structure determination with in vivo observa

277 rapid escape response bypassing the central integrative structure known as the aboral sensory organ.

278 We applied this approach with integrative structure modeling to determine the interact

279 rovide insights regarding the effects of the integrative structure of critical care organizations on

280 uncertainty and maximize the accuracy of an integrative structure, (ii) an efficient approach for FR

281 how a tractable model species combined with integrative studies can reveal how animals cope with res

282 pe of nanodiscs, and pave the way for future integrative studies of larger complex systems such as me

283 Integrative studies reveal an exceptionally high affinit

284 Here we performed an integrative study linking single-cell molecular and elec

285 past 32 years, we have conducted a long-term integrative study of individually marked North American

286 We present an integrative study of p27 and its binding to Cdk2/Cyclin

287 We propose that an integrative study of several unicellular taxa closely re

288 modelling of multi-cellular systems using an integrative systems biology approach, better understandi

289 Our results support the usefulness of integrative, systems biology approach to gain insights i

290 e a vision for future research that includes integrative theory and cross-system empirical studies.

291 -mesenchymal transition (EMT), we develop an integrative tool that combines unsupervised learning of

292 ecular formula assignment is growing, but an integrative tool where all crucial steps are reproducibl

293 We designed NormiRazor - an integrative tool which implements those methods in a par

294 In addition, most integrative tools completely ignore the topological orde

295 Integrative transcriptome analyses were used to investig

296 Integrative transcriptome analysis and ATAC-seq revealed

297 Employing integrative transcriptomic analysis and machine-learning

298 In this integrative transcriptomic and quantitative protein anal

299 We applied integrative transcriptomics on six varieties exhibiting

300 essed independently, and provide support for integrative views of MFC function.SIGNIFICANCE STATEMENT