ライフサイエンスコーパス: integrin

1 aling and downstream activation of the beta1 integrin.

2 and lysosomal degradation of the alphavbeta6 integrin.

3 bridge between IsdB and host alpha(v)beta(3) integrin.

4 on T(H) cells to induce IL-5 and gut-homing integrin.

5 layilin promoted the activated state of this integrin.

6 romoted the interaction of talin with beta1A-integrin.

7 ocytes exhibited increased S. aureus-binding integrins.

8 RGD)-binding, laminin-binding, and leukocyte integrins.

9 ng capabilities, attributed to their surface integrins.

10 to probe structure-activity relationships in integrins.

11 ated activation of platelet beta1- and beta3-integrins.

12 ts but completely lack classical alphaVbeta3 integrins.

13 the transmembrane domains of alpha and beta integrins.

14 ough binding to alpha5beta1 and alphav-class integrins.

15 nus floor independent of both chemokines and integrins.

16 ivity upstream of the junctional complex and integrins.

17 the functionality of FN-RGE for alphav-class integrins.

18 e (RGD) domains that bind and signal through integrins.

19 tion of the talin head significantly impairs integrin activation and clustering.

20 , kindlin, to the integrin receptors induces integrin activation and clustering.

21 ns are focal adhesion proteins that regulate integrin activation and outside-in signaling.

22 Integrin activation and platelet aggregation in mice who

23 Functionally, leukocyte adhesion and integrin activation are abrogated in the absence of rece

24 ctor of Rap1 GTPases that regulates platelet integrin activation in hemostasis.

25 f the connection between Rap1 and talin-1 in integrin activation is an important remaining gap in our

26 n human T cells, SDF-1alpha-mediated beta(2) integrin activation is driven by a, so far, not-describe

27 beta(2) Integrin activation is pivotal for T cell recruitment an

28 At the phagocytic synapse, SIRPA inhibited integrin activation to limit macrophage spreading across

29 by mechanical force or curvature, can induce integrin activation.

30 interplay between talin and kindlin promotes integrin activation.

31 n with either talin and kindlin-2, the major integrin activators, or filaminA, an integrin activity s

32 influence, at least in part, by coordinating integrin activity in bcCML.

33 e major integrin activators, or filaminA, an integrin activity suppressor.

34 e integrin beta cytoplasmic domain increases integrin activity.

35 ng 100 nm-sized nanoparticles decorated with integrin adhesion motifs, we demonstrate that the uptake

36 Moreover, we show that integrin adhesions spatially segregate GEFs and GAPs to

37 r relative of animals with the most complete integrin adhesome [11, 12].

38 lyses have shown that core components of the integrin adhesome pre-date the emergence of animals [8-1

39 expression was associated with a profibrotic integrin alpha (ITGA) 11-expressing subset of CAFs that

40 Integrin alpha V (ITGAV), a transmembrane glycoprotein r

41 ease in production of IL-5 and expression of integrin alpha(4)beta(7).

42 tin intermediate filaments, (ii) clusters of integrin alpha(5)beta(1), (iii) positive MMP13 staining

43 lpha(v)beta(3) and enhanced selectivity over integrin alpha(5)beta(1).

44 waves and fibrinogen binding to the platelet integrin alpha(IIb)beta(3) (GPIIb/IIIa) through confocal

45 Ibalpha-dependent platelet 'priming' induces integrin alpha(IIb)beta(3) activation that, in turn, med

46 loid aggregation by binding to both GPVI and integrin alpha(IIb)beta(3) Blocking these pathways may t

47 acts with the pro-aggregatory mediators, the integrin alpha(IIb)beta(3) receptor and sulfatides, bloc

48 nism, Dab2 intracellularly downregulates the integrin alpha(IIb)beta(3) receptor, converting it to a

49 Binding of Abeta40 to integrin alpha(IIb)beta(3), fibrinogen, and GPVI collect

50 ing experiments showed that vinculin, talin, integrin alpha(M)beta(2), and other components of podoso

51 e genes (ISGs) and positive correlation with integrin alpha(v) (ITGAV).

52 D peptides display increased affinity toward integrin alpha(v)beta(3) and enhanced selectivity over i

53 BM surgical specimens, which was reversed by integrin alpha(v)beta(5) inhibition.

54 artner ITGB5 and by an antibody specific for integrin alpha(v)beta(5).

55 n levels of both subunits of VLA-4, that is, integrins alpha(4) and beta(1), significantly correlated

56 naling decreased tECM-mediated expression of integrin alpha1, alpha2, and beta1 in hASCs.

57 and AGEs displayed diminished expression of integrin alpha1, PDGF-R1beta and connexin-43.

58 pression were enhanced but COL1 adhesion and integrin alpha2 expression were unchanged upon cholester

59 In contrast, treatment with anti-integrin alpha3 mAb KU44.22B inhibited growth in vitro o

60 ed ITGA3 and ITGB1 expression and subsequent integrin alpha3beta1 signaling, via c-Jun-N-terminal kin

61 The subsequent increase in integrin alpha3beta1 signaling, via JNK, inhibits expres

62 enesis, indicating a protumorigenic role for integrin alpha3beta1.

63 VSMC adhesion force to FN (+33%) and integrin alpha5 expression were enhanced but COL1 adhesi

64 Whereas eCRT strongly induces ECM and integrin alpha5 proteins in K41 wild-type mouse embryo f

65 d encapsulated it into our recently-reported integrin alpha5(ITGA5) active targeting nanoparticles (u

66 Previously, we demonstrated that integrin alpha5beta1 and Fn1 (fibronectin) expressed in

67 Cell-ECM interactions regulated by integrin alpha5beta1 and Fn1 play essential roles at eac

68 to investigate cellular mechanisms by which integrin alpha5beta1 and Fn1 regulate aortic arch artery

69 Here, we identify angiopoietin-2 (Angpt2)-integrin alpha5beta1 signaling as an inducer of fat upta

70 Mechanistically, Angpt2 activated integrin alpha5beta1 signaling in the endothelium and tr

71 conjugated to a cyclic peptide that binds to integrin alpha5beta1, a factor that promotes osteogenesi

72 While integrin alpha6 promotes survival and is a direct transc

73 Here we report that ECM through laminin-integrin alpha6 upregulates ten-eleven translocation enz

74 Moreover, targeting STAT3 disrupts integrin alpha6-FAK signaling and inhibits TET3(+) GSC m

75 Thus, ECM- integrin alpha6-STAT3-TET3 axis regulates hydroxymethyla

76 WISP1 signals through Integrin alpha6beta1-Akt to maintain GSCs by an autocrin

77 nip3 is dependent on adhesion to laminin and integrin alpha6beta1-dependent nuclear translocation of

78 ow that keratinocytes lacking hemidesmosomal integrin alpha6beta4 exhibit increased focal adhesion fo

79 al modulation of the membrane curvature near integrin alphaIIbbeta3 can induce its activation in cell

80 vascular thrombosis by antagonizing platelet integrin alphaIIbbeta3 cannot be achieved without compro

81 Here, we reveal that integrin alphaIIbbeta3, a prototypic adhesion receptor,

82 ssing angle between transmembrane helices of integrin alphaIIbbeta3, which eventually results in para

83 a molecular level, layilin colocalized with integrin alphaLbeta2 (LFA-1) on T cells, and cross-linki

84 hemokines can transduce signals that convert integrin alphaLbeta2 to a high-affinity conformation, wh

85 rtic root aneurysm tissue confirmed elevated integrin alphaV and reduced MRC2 in clinical disease spe

86 of endothelial cells leads to an increase of integrin alphaVbeta3, a molecule observed to be involved

87 nd Cell Reports (Wang et al., 2020) identify integrin alphavbeta5 as an internalization factor that i

88 ASP-Y256 phosphorylation promotes N-WASP and integrin alphaVbeta6 association as well as TGF-beta-med

89 he aptasensor showed specificity to HER2 and integrin alphavbeta6 positive, cell culture-derived, bre

90 Targeting of the integrin alphavbeta6-TGFbeta-SOX4 pathway therefore prov

91 Integrin alphavbeta8 binds with exquisite specificity to

92 ydration impaired interactions between beta3 integrin and Galpha13 (guanine nucleotide-binding protei

93 signaling clusters, direct crosstalk between integrin and growth-factor-signaling, and clarifies how

94 indlin are cytoplasmic proteins that bind to integrin and modulate its affinity for extracellular lig

95 vel subset of vesicles containing both beta1-integrin and Rab13.

96 first time that the protein levels of betaPS integrin and sarcoglycan delta, both core components of

97 rix molecule fibronectin-induced alpha5beta1 integrin and supports a critical role for the RAP1/RAC1

98 ic differentiation in vitro, focusing on the integrin and TGF-beta/SMAD pathways.

99 core components of the dynamic link between integrins and actomyosin.

100 the expression of talin1, a key regulator of integrins and cell adhesions, negatively correlated with

101 The most altered family of proteins were the integrins and focusing on beta3 integrin in detail we fo

102 d the accumulation of endoplasmic reticulum, integrins and Rab11 endosomes in the distal axon, whilst

103 ogether, our findings demonstrate that beta1-integrin- and KV1.3 channel-dependent signaling stimulat

104 n subgroups, leukocyte homing was blocked by integrin antibodies (n = 5).

105 predict the response to the anti-alpha4beta7 integrin antibody vedolizumab are currently lacking.

106 Integrins are a large family of heterodimeric cell surfa

107 These results support a model in which integrins are an upstream component of the mechanosensor

108 beta2 integrins are critical adhesion molecules that regulate

109 By contrast, integrins are dispensable for LN homing, yet still contr

110 Integrins are likely to play an important role in transm

111 Integrins are the major cell surface adhesion receptors

112 We further reveal that beta2 integrins are transcriptional targets of SRF.

113 Our study defines integrins as key controllers of intracellular complement

114 e show that autoinhibitory regulation of the integrin-associated adapter protein talin coordinates ce

115 es contraction by catalysing the assembly of integrin-associated adhesome complexes that activate pat

116 patients, suggesting for the first time that integrin-associated proteins dysfunction may contribute

117 patients, suggesting for the first time that integrin-associated proteins dysfunction may contribute

118 t Basigin is expressed in close proximity to integrin at the glial membrane, and that expression of t

119 ndosome disrupts eventual recycling of beta1 integrins back to the cell surface, resulting in defecti

120 tive talin mutant strengthens and stabilizes integrin-based adhesions in melanocytes, which impinges

121 Integrin-based focal adhesion complexes link the glial m

122 s new matrix assembly mechanism, alpha5beta1 integrin-based focal adhesions slide actively on the und

123 nt but over time are switched to alpha5beta1 integrin-based sliding focal adhesions to assemble fibro

124 on proteins: vinculin (VCL), talin 1 (TLN1), integrin beta 1 (ITGB1), as well as phosphorylated forms

125 We show the HCMV receptor integrin beta 1 dissociates from extracellular matrix pr

126 conserved threonine motif (T788/T789) in the integrin beta cytoplasmic domain increases integrin acti

127 For FGbeta(3) cells, dysregulated integrin beta(3)-KRAS signaling drives tumor progression

128 ecular level, syndecan loss directly impairs integrin beta(7) function, suggesting that syndecan exer

129 l cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicle

130 Tissue-specific ablation of integrin beta1 abolishes the semi-rosette formation, pre

131 esults identify Rab11b-mediated recycling of integrin beta1 as regulating BCBM, and suggest that the

132 hosphatase 1 (SHIP1) was recruited to the gH/integrin beta1 complex, which is critical to aberrant Ak

133 Embryonic deletion of integrin beta1 in the liver disrupts the normal developm

134 rix contact, and found that combined MEK and integrin beta1 inhibition bypassed trametinib resistance

135 we discovered that mechanical stimulation of integrin beta1 leads to the phosphorylation of AKT, an e

136 Furthermore, we found that c-Abl and integrin beta1 regulated the positioning of Abi1 at the

137 Although integrin beta1 was required for SHIP1 recruitment, gB-ac

138 SPRR3 facilitated the association of integrin beta1 with PDGFRbeta and subsequently fibroblas

139 We thus targeted integrin beta1, a mediator of extracellular matrix conta

140 r the coordinated activation of PDGFRbeta by integrin beta1, leading to augmentation of fibroblast pr

141 epidermal growth factor receptor (EGFR) and integrin beta1, respectively, to reshape canonical Akt s

142 raction with the microenvironment, including integrin beta1.

143 Periostin interacted with its receptor, integrin-beta1, to inhibit tubular cell cycle arrest and

144 We show that integrin beta2 and its associated protein vinculin local

145 Finally, using a specific antibody for integrin beta2, we inhibited cell adhesion to a fibronec

146 angiogenesis, suggesting a potential role of integrin beta3 in KSHV pathogenesis and development of K

147 ning collagen peptide that selectively binds integrin beta3 on ovarian tumor cells enhances the phosp

148 roteinase 7, matrix metalloproteinase 3, the integrins beta6 and beta8, and beta-catenin) were signif

149 The presence of a direct integrin binding partner Kindlin-3 is crucial for these

150 How integrin binding under shear stress mechanosignals a fun

151 vessel remodeling, tumor growth, metastasis, integrin binding, and proteolytic regulation.

152 the relation between RGD structure and their integrin-binding capacity.

153 ne, and that expression of the extracellular integrin-binding domain of Basigin is sufficient to resc

154 Although the talin head, the integrin-binding segment in talin, possesses a typical F

155 es associated with Wnt activation, PDGF- and integrin-binding.

156 Additionally, integrin blockade inhibited tECM-driven TGFBR2 expressio

157 Furthermore, the application of GPVI- or integrin-blocking antibodies reduced the formation of pl

158 s was promoted by Vn, and an alpha(v)beta(3) integrin-blocking mAb or cilengitide inhibited adherence

159 force-induced membrane deformation activates integrins by disrupting the association of the transmemb

160 Chemical reactivation of integrin bypassed CD47-mediated inhibition and rescued e

161 hrough S1P antagonist CD69 and expression of integrins CD103/beta7 and CD49a/CD29(beta1).

162 60% to 80% and lowered surface expression of integrin CD11b on monocytes by 20+/-5% (all P<5.0x10(-2)

163 sitive granule release and the expression of integrin CD11b.

164 o as measured by Ca(2+) -flux, shape change, integrin (CD11b) expression, and chemotaxis.

165 Here we identify alphaV-integrin (CD51) as an essential regulator of cardiac PW1

166 r cardiac PW1(+) cells and found that alphaV-integrin (CD51) was expressed in almost all cardiac PW1(

167 e of MoS(2) and NIR stimulation of MoS(2) on integrins, cellular migration, and wound healing.

168 In addition, analysis of beta1 integrin clustering by super-resolution imaging demonstr

169 There are four classes of integrins: collagen-binding, Arg-Gly-Asp (RGD)-binding,

170 CD4+ T cells expressing the gut homing integrin complex alpha4beta7 are associated with HIV-1 a

171 e examine the protein-ligand interactions of integrin complexes and the related structure-based drug

172 beta2 integrins consist of four members, namely, alphaLbeta2,

173 Indeed, beta-cells form integrin-containing adhesions, which provide anchorage t

174 py and DNA damage by beta1/alphaVbeta3/beta5 integrin cross-talk, but efficient radiosensitization ca

175 ear accumulation of the small phosphoprotein integrin cytoplasmic domain-associated protein-1 (ICAP1)

176 omponent of these networks, directly binding integrin cytoplasmic domains and mediating interactions

177 Key proteins in the integrin-cytoskeleton linkage are reduced in haemodialys

178 Key proteins in the integrin-cytoskeleton linkage are reduced in MHD patient

179 ically, through interaction with alphavbeta3 integrin, DEL-1 promoted induction of RUNX1-dependent FO

180 Remarkably, beta1 integrin deletion, specifically in MKs, restores thrombo

181 d spreading, it may be dispensable for beta2 integrin-dependent neutrophil recruitment in vivo.

182 onectin fibrils by indolent cells that drive integrin-dependent pro-survival signals.

183 ich eventually results in parallelization of integrin dimer.

184 However, when combined, anti-beta1/alphaV integrin dual targeting achieved relapse-free radiosensi

185 all compression of the nervous system due to integrin dysregulation, which causes locomotor defects i

186 nce, we targeted beta1 and alphaVbeta3/beta5 integrins, essential extracellular matrix receptors in m

187 EVs, are able to be internalized through integrins expressed in parental cells, in a tissue speci

188 rins has also become clear, because aberrant integrin expression and/or behavior are associated with

189 sed alphavbeta3 and alphavbeta5 cell surface integrin expression as a result of combined CAP-TMZ trea

190 l infiltration in the spinal cord, decreases integrin expression in antigen-specific CD4(+) T cells,

191 These data indicate that beta3-integrin, FAK and cofilin constitute a signaling pathway

192 ire cell-ECM attachment are dependent on the integrin family of adhesion receptors.

193 The integrin family of transmembrane adhesion receptors coor

194 EGFR, EPHA2, GNB1, GNB2, 14-3-3 family, and Integrin family proteins), and 12 proteins (AKR1A1, ALDO

195 in two cell lines with a markedly different integrin fingerprint: ovarian carcinoma A2780 (almost no

196 understanding of the regulatory mechanism of integrin function.

197 The clinical importance of these integrins has also become clear, because aberrant integr

198 crease surface expression of the alphaVbeta3 integrin heterodimer.

199 ins were the integrins and focusing on beta3 integrin in detail we found that S-sulfhydration affecte

200 We show that AP-1B colocalized with beta1 integrin in focal adhesions during cell migration using

201 Here, we review the role of each beta2 integrin in neutrophils and sepsis and consider future d

202 Basigin as a potential negative regulator of integrin in the glia, supporting proper glial and extrac

203 evealed key roles for platelet and leukocyte integrins in adhesion and migration and, thereby, their

204 s been made in the structural elucidation of integrins in recent years.

205 teria with monocytes and cooperate with CD18 integrins in trans to promote internalization of bacteri

206 d the related structure-based drug design of integrin inhibitors.

207 Understanding how integrins interact with signaling by TGF-beta and/or oth

208 hrough non-cell-autonomous regulation of ECM-integrin interactions and soluble molecules.

209 e-arrangement, indicating the possibility of integrin involvement.

210 markers, including increased CCR7 and beta8 integrin (ITGB8) expression.

211 or Fascin, or coreduction of both, decreases integrin levels on the border cell membranes.

212 lyA preferentially binds the alpha(L)beta(2) integrin LFA-1 (CD11a/CD18) of leukocytes and can promis

213 Integrin-ligand interaction mediates the adhesion and mi

214 taneously turn migratory on substrates where integrin ligands are subject to depletion by cellular fo

215 f cell migration elicited by the lability of integrin ligands.

216 W3 encodes a novel membrane-associated alpha integrin-like protein conserved in land plants.

217 ngs revealed a novel and vital role of alpha integrin-like proteins in plant male reproduction.

218 RNA sequencing profiling identified integrin-linked kinase (ILK) as the most upregulated pat

219 Integrin-linked kinase (ILK) is a scaffold protein that

220 AKT, an event which required the presence of integrin-linked kinase (ILK).

221 RAC1 is an integrin-linked, ras-like protein that promotes cell mig

222 also demonstrate that substrate adhesion and integrin localization are enhanced by mammalian fibronec

223 At a molecular level, mural-cell beta3-integrin loss enhances signaling via FAK-p-HGFR-p-Akt-p-

224 transendothelial diapedesis, and depended on integrin lymphocyte-function-associated antigen 1 (LFA-1

225 This integrin mAb induces a substantial survival benefit in h

226 which is specific for the activated beta(2)-integrin Mac-1.

227 results demonstrate that targeting specific integrin make-ups is possible and may open the way to mo

228 iminate between cells that express different integrin make-ups.

229 ation, hence revealing the critical event in integrin mediated FAK activation and signaling at focal

230 Ena/VASP-deficiency also impaired integrin-mediated adhesion accompanied by reduced tracti

231 However, the mechanisms that regulate integrin-mediated adhesion in vivo in melanoblasts are n

232 Precise regulation of integrin-mediated adhesion is important for many develop

233 We thus propose that integrin-mediated adhesion pre-dates the emergence of an

234 We propose integrin-mediated anchorage as an evolutionarily conserv

235 cts, reduction in CAV1 protein abundance, or integrin-mediated cell adhesion in strumpellin-deficient

236 WASHC5 mutations and impairment of CAV1- and integrin-mediated cell adhesion, providing insights into

237 Vinculin plays a fundamental role in integrin-mediated cell adhesion.

238 Our results show that coordinated integrin-mediated cell-ECM attachment is essential for m

239 Given the importance of integrin-mediated cell-matrix adhesion in development of

240 Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for

241 rest-neighbor interaction between individual integrin-mediated mechanosensors.

242 instead can be attributed to alterations in integrin-mediated mechanotransduction and focal adhesion

243 g neurons requiring ECM stimulation of beta3-integrin-mediated phosphorylation of FAK (p-FAK) and cof

244 ing of very late antigen-4 (VLA-4), as a key integrin mediating the adhesion and recruitment of immun

245 ession promotes the formation of dense beta1 integrin membrane clusters.

246 ng, enabling continuous real-time imaging of integrin molecular tensions in live cells.

247 The beta(ps)-integrin Myospheroid, which is necessary for basal cell

248 correlating high percentages of mural-beta3-integrin-negative tumor BVs with increased tumor sizes b

249 The expression of alpha4beta1 integrin on peripheral blood CD4(+) T cells was quantifi

250 erent modes via a magnetic bead bound to the integrins on a cell and quantified cell stiffness, chrom

251 on-toxic, and attributable to the binding to integrins on the surface of epithelial cells.

252 ng the TransComp-R models revealed activated integrin pathway signaling in patients with anti-TNF-res

253 oss of COL6 is associated with reductions in integrin-paxillin-phosphatidylinositol 3-kinase signalin

254 The alphavbeta6 integrin plays a key role in the activation of transform

255 ducing blockade of CXCL12 receptor CXCR4 and integrins rapidly abrogated HSC motility and shape dynam

256 examined the hypothesis that an abnormal ECM-integrin receptor axis contributes to BM megakaryocytosi

257 e applied both types of tPAINT probes to map integrin receptor forces in live human platelets and mou

258 ects, were collected to assess chemokine and integrin receptor levels on monocytes.

259 y, such as disconnections within the antigen/integrin receptor pathway and increased negative regulat

260 hils to delay NETosis; and blocking the beta integrin receptor, alpha(M)beta(2,) abolished fibrinogen

261 eins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clust

262 Integrin receptors regulate normal cellular processes su

263 odeling or by signaling through cell-surface integrin receptors to promote cell adhesion, migration,

264 ity to adhere to the surrounding ECM through integrin receptors, we examined the hypothesis that an a

265 zumab before treatment initiation or dynamic integrin regulation in the early course of treatment see

266 Overexpression of SRF or beta2 integrins rescues HSPC engraftment defects associated wi

267 Cilengitide, an inhibitor of specific integrins, rescues the phenotype of increased post-injur

268 and that alphav-class, but not alpha5beta1, integrins retain FN-RGE binding.

269 beta3 integrin S-sulfhydration was required for endothelial ce

270 racellular matrix, but little is known about integrin's regulators in the glia.

271 e divided into four major groups: cadherins, integrins, selectins, and immunoglobulins.

272 isclosed, extensive network of genes linking integrin signaling and cellular adhesion to the extracel

273 tosis by inhibiting inside-out activation of integrin signaling in the macrophage, with implications

274 sulting lack of glycosylation enhances beta1 integrin signaling leading to dysplastic MKs with severe

275 However, inhibition of integrin signaling through focal adhesion kinase inhibit

276 ion and maturation by disrupting fibronectin-integrin signaling, consistent with recently described d

277 uires functional force sensing machinery via integrin signaling.

278 and the p-FAK and cofilin depended on beta3-integrin signaling.

279 calized, pulsatile and sensitive to adhesion/integrin signaling.

280 in extracellular stiffness and "outside-in" integrin signaling.

281 emonstrate that alpha5beta1 and alphav-class integrins solely recognize the FN-RGD motif and that alp

282 Integrin-specific hydrogels have diverse pleiotropic eff

283 PtdIns4P in mouse and human neutrophils upon integrin stimulation.

284 th epidermis-specific deletion of the alpha3 integrin subunit fail to form skin tumors during two-ste

285 We experimentally showed that the alpha(1) integrin subunit mediated the effectiveness of anti-TNF

286 Our results revealed that the alpha(4) integrin subunit on myeloma cells stimulated vascular ce

287 CM also induced higher expression of several integrin subunits and TGF-beta receptors, and nuclear tr

288 ors in mice, and increased expression of the integrin subunits ITGA3 and ITGB1; expression levels of

289 coprotein of the extracellular matrix; binds integrins, syndecans, collagens, and growth factors; and

290 roliferation, suggesting a role in PDGFRbeta-Integrin synergy.

291 -length talin head in complex with the beta3-integrin tail.

292 diosensitization can be achieved by multiple integrin targeting.

293 tters fluoresce brightly once switched on by integrin tensions and can be switched off by photobleach

294 ls, CFN revealed ultranarrow distribution of integrin tensions at the cell leading edge, and showed t

295 cells induces expression of mechanosensitive integrins that drive fibroblast activation and increase

296 unappreciated contribution of FN-alpha5beta1 integrin to megakaryocytosis in JAK2V617F+ PMF.

297 Pathway analysis is suggestive of integrins transducing the encapsulation effect into intr

298 Here we show that beta1 integrin was dependent on AP-1B and its coadaptor, autos

299 nversely, eCRT induction of alpha5 and beta1 integrins was not mediated by TGF-beta signaling nor inh

300 tribution of non-muscle myosin IIA and beta2-integrin, which facilitate neutrophil arrest and extrava