ライフサイエンスコーパス: integrin alpha3beta1

1 e transmembrane 4 superfamily (TM4SF) and an integrin (alpha3beta1).

2 enesis, indicating a protumorigenic role for integrin alpha3beta1.

3 also form normally in mice deficient in the integrin alpha3beta1.

4 ion of COX-2 by alpha3(IV)NC1 is mediated by integrin alpha3beta1.

5 , including the scavenger receptor MARCO and integrin alpha3beta1.

6 Integrin alpha3beta1, a major receptor for epidermal adh

7 Integrin alpha3beta1, a major receptor in the epidermis

8 We previously showed that integrin alpha3beta1 activates the Rho family GTPase Rac

9 Interestingly, in cells lacking integrin alpha3beta1, adhesion to the alpha3NC1 domain w

10 ptive neurons express fibronectin receptors, integrin alpha3beta1, alpha4beta1, and alpha5beta1, at h

11 cally associated with Kaposi's sarcoma, uses integrins (alpha3beta1, alphaVbeta3, and alphaVbeta5) an

12 surface receptors, such as heparan sulfate, integrins (alpha3beta1, alphaVbeta3, and alphaVbeta5), a

13 (HMVEC-d) cell surface heparan sulfate (HS), integrins alpha3beta1, alphaVbeta3, and alphaVbeta5, and

14 ed by persistent, disorganized expression of integrin alpha3beta1 and enhanced production of urinary-

15 The interaction between integrin alpha3beta1 and laminin-5 is essential for esta

16 in CD151 forms a stoichiometric complex with integrin alpha3beta1 and regulates its endocytosis.

17 Finally, in vitro studies showed that integrin alpha3beta1 and the Lutheran glycoprotein media

18 with other TM4SF members (CD9 and CD81) and integrins (alpha3beta1 and alpha6beta1).

19 EphA2 was also associated with KSHV and integrins (alpha3beta1 and alphaVbeta3) in LRs early dur

20 igation of the laminin- and collagen-binding integrins alpha3beta1 and alpha2beta1 did not cause thes

21 direct interaction with the laminin-binding integrins alpha3beta1 and alpha6beta1.

22 M on laminin alpha5 may overlap with that of integrins alpha3beta1 and alpha6beta1.

23 Integrins alpha3beta1 and alpha6beta4 are abundant recep

24 Furthermore, laminin-5, a common ligand for integrins alpha3beta1 and alpha6beta4, was detected in t

25 with both of the major laminin-5 receptors, integrins alpha3beta1 and alpha6beta4.

26 Mutation within the synergy site decreased integrin alpha3beta1 binding 17-fold, and the four-Gly i

27 in binding domain led us to hypothesize that integrin alpha3beta1 binding may also be modulated by th

28 pacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn.

29 Then, integrin alpha3beta1-binding octapeptide cNGQGEQc was mo

30 ing RNA also blocked uPA induction following integrin alpha3beta1 clustering.

31 Mice were immunized with integrin alpha3beta1-containing complexes isolated from

32 Integrin alpha3beta1 coprecipitated and colocalized with

33 the integrin beta1 subunit and regulator of integrin alpha3beta1-dependent Akt activation.

34 tion plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required f

35 better substrate than LM-511 for stimulating integrin alpha3beta1-dependent collecting duct cell func

36 mental program; however, the LM types and LM/integrin alpha3beta1-dependent signaling pathways are po

37 llel changes in the expression of laminin 5, integrin alpha3beta1, E-cadherin, and the gap junctional

38 Compared with other integrins, alpha3beta1 exhibited a considerably higher l

39 Integrin alpha3beta1 had the highest affinity for FnIII9

40 The laminin-binding integrin alpha3beta1 has previously been shown to regula

41 In these cells, soluble alpha3NC1 bound integrin alpha3beta1; however, unlike alphavbeta3, alpha

42 Our findings indicate a role for integrin alpha3beta1 in BM stability through fibulin-2 i

43 Our findings support a role for keratinocyte integrin alpha3beta1 in controlling the secretion of IL-

44 xplored the role of the prominent epithelial integrin alpha3beta1 in experimental fibrosis by generat

45 alpha1, alpha5, beta1,gamma1; and epithelial integrin alpha3beta1 in human diabetic retinopathy (DR)

46 ion, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting tha

47 Thus integrin alpha3beta1, in conjunction with integrin alpha

48 Second, integrin alpha3beta1 independently activates two recepto

49 ng that the main podocyte adhesion receptor, integrin alpha3beta1, interacts with the tetraspanin CD1

50 Integrin alpha3beta1 is a cell adhesion receptor for lam

51 Integrin alpha3beta1 is a major receptor for laminin.

52 These findings indicate that integrin alpha3beta1 is a receptor for the alpha3NC1 dom

53 The laminin (LM)-binding integrin alpha3beta1 is crucial for this developmental p

54 The laminin-binding integrin alpha3beta1 is expressed at high levels in lung

55 Integrin alpha3beta1 is highly expressed in breast cance

56 The laminin-binding integrin alpha3beta1 is highly expressed in epidermal ke

57 n, we next investigated the possibility that integrin alpha3beta1 is involved in mediating the prolif

58 ied onto ELV platform for tumor targeting as integrin alpha3beta1 is overexpressed on NSCLC cells.

59 First, integrin alpha3beta1 is required for autophagy-induced c

60 The integrin alpha3beta1 is the major mediator of breast car

61 The integrin alpha3beta1 is thought to mediate interactions

62 nase activity, induced apoptosis by reducing integrin alpha3beta1 levels, activating anoikis, and blo

63 Altogether, our data indicate that integrin alpha3beta1 may be a therapeutic target on the

64 We demonstrate that integrin alpha3beta1-mediated cell adhesion to LM-332 mo

65 nd pulmonary fibrogenesis require epithelial integrin alpha3beta1-mediated cross-talk between TGFbeta

66 The integrin alpha3beta1 mediates cellular adhesion to the m

67 The results indicate that overexpression of integrin alpha3beta1 plays a central role in the promoti

68 further suggest a mechanistic model in which integrin alpha3beta1-promoted calcium influx stimulates

69 Previously, we established that keratinocyte integrin alpha3beta1 promotes wound angiogenesis through

70 oncogenic Ras mutation in the acquisition of integrin alpha3beta1-regulated phenotypes that promote S

71 Integrin alpha3beta1 regulates adhesive interactions of

72 ed ITGA3 and ITGB1 expression and subsequent integrin alpha3beta1 signaling, via c-Jun-N-terminal kin

73 The subsequent increase in integrin alpha3beta1 signaling, via JNK, inhibits expres

74 correlated with an altered expression of the integrin alpha3beta1, suggesting that it plays an import

75 gesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative lig

76 n resonance to determine binding kinetics of integrin alpha3beta1 to the Fn fragments.

77 echanistically, we found that GATA3-mediated integrin alpha3beta1 upregulation on RORgammat(fm+) cILC

78 Several novel molecules, including integrin alpha3beta1, VE-cadherin, ICAM-2, junctional ad

79 val of laminin-adherent cells by maintaining integrin alpha3beta1 via a kinase-independent mechanism.

80 In this study, we report that integrin alpha3beta1 (VLA-3; CD49c/CD29) is dramatically

81 Adhesion of epithelial cells to laminin via integrin alpha3beta1 was previously shown to activate at

82 Integrin alpha3beta1 was required for full FAK auto-phos

83 major cellular receptors for laminin-332 are integrin alpha3beta1, which mediates rapid tumor cell mi

84 nese hamster ovary cells, the interaction of integrin alpha3beta1 with laminin 5 was sufficient to pr