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1 cific CD4(+) T cells robustly expressing the integrin alpha4beta1.
2 EGF-A, induce lymphatic vessel expression of integrin alpha4beta1.
3 lation of the T-cell antigen receptor or the integrin alpha4beta1.
4 in that serves as a ligand for the leukocyte integrin, alpha4beta1.
5 amily, as validated with a distantly related integrin, alpha4beta1.
6 macological inhibition of MLCK210 suppresses integrin alpha4beta1 activation, as well as tumor inflam
8 ese hamster ovary cells that express defined integrins (alpha4beta1, alpha5beta1, or both), and cell
11 t soluble uPAR (suPAR) specifically binds to integrins alpha4beta1, alpha6beta1, alpha9beta1, and alp
12 st small molecule agonist identified for the integrin alpha4beta1 (also known as very late antigen-4
13 We show here that the fibronectin-binding integrin alpha4beta1 and its ligand fibronectin are nove
18 adhesion mediated by the interaction between integrin alpha4beta1 and VCAM-1 is important in normal p
21 CC chemokine receptor 9, and binding of the integrins alpha4beta1 and alphaLbeta2 to their respectiv
23 t VEGFR1+ cells express VLA-4 (also known as integrin alpha4beta1), and that tumour-specific growth f
24 ed T cell activation, enhanced expression of integrin alpha4beta1, and infiltration of activated T ce
25 al conformational equilibrium set points for integrin alpha4beta1 are cell type specific and differ f
27 igand for very late Ag-4 (VLA-4; also called integrin alpha4beta1) binding cells in granulomas, and c
32 mature naive T cells was sufficient to drive integrin alpha4beta1 expression and CNS migration, where
33 nduced lymphangiogenesis, as genetic loss of integrin alpha4beta1 expression in Tie2Cre+ alpha4(loxp/
35 We demonstrate that ectopic expression of integrin alpha4beta1 in animal cap cells results in atta
36 es indicate the usefulness of antagonists of integrin alpha4beta1 in suppressing macrophage colonizat
37 e sequence recognized by the closely related integrin alpha4beta1, in the inducible endothelial ligan
39 accurately predict poor disease outcome, and integrin alpha4beta1 is a biomarker of lymphatic endothe
44 e encoding the alpha4 subunit of alpha4beta1 integrin (alpha4beta1) is essential for this migratory p
46 metastatic disease, these results show that integrin alpha4beta1-mediated tumor lymphangiogenesis pr
48 alpha9beta1, like the structurally related integrin alpha4beta1, mediates accelerated cell migratio
49 odes promotes tumor metastasis by activating integrin alpha4beta1 on lymph node lymphatic endothelium
50 ecific peptidomimetic ligand (LLP2A) against integrin alpha4beta1 on the MSC surface to a bisphosphon
51 ients, these results indicate that targeting integrin alpha4beta1 or VCAM to inhibit the interactions
53 interactions in shear flow of cells bearing integrins alpha4beta1 or alpha4beta7 with VCAM-1 and MAd
56 l phenotype and exhibited elevated levels of integrin alpha4beta1, potentially making these cells les
60 gration, whereas pharmacologic inhibition of integrin alpha4beta1 reduced the abnormal T cell presenc
63 mical cross-linking to identify sequences in integrin alpha4beta1 that are involved in its interactio
64 vation, leading to conformational changes in integrin alpha4beta1 that promote myeloid cell extravasa
66 n and paxillin with the cytoplasmic tails of integrin-alpha4beta1, thereby stimulating myeloid cell a
68 eta (IL-1beta) collaborate with myeloid cell integrin-alpha4beta1 to promote tumor inflammation and g
69 o cell types and was partly dependent on the integrin alpha4beta1 (very late activation 4[VLA-4]) and
70 with monoclonal antibodies (MoAbs) enhanced integrin alpha4beta1 (very late antigen [VLA]-4) and alp
71 m and precursor cells (NPCs) expresses VLA4 (integrin alpha4beta1, very late antigen-4) that facilita
75 ously shown the constitutive activity of the integrin, alpha4beta1 (VLA4), on a unique subpopulation
76 addition of 12G10 mAb to cells adhering via integrin alpha4beta1 was found to trigger disruption of