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1 d that carries a novel antibiotic resistance integron.
2 tant integrons and the Vibrio cholerae super-integron.
3 ng St Spc Gen Kan resistance in the 1,600-bp integron.
4 n or clone, some members carried a different integron.
5 (TCP), and genes within the V. cholerae mega-integron.
6 vated environmental taxa that harbor class 1 integrons.
7  Rhizobacter genus as novel hosts of class 1 integrons.
8 tiple antibiotic-resistance genes on class 1 integrons.
9 of phenotypic resistance in isolates without integrons.
10 segments, such as plasmids, transposons, and integrons.
11 five (40%) of the isolates possessed class 1 integrons.
12  and associated with the presence of class 1 integrons.
13 n PCR method (Int-PCR) for detecting class 1 integrons (1,000, 1,200, and 1,600 bp) in the identifica
14                                  In summary, integrons accelerate resistance evolution by rapidly gen
15 ) and chloramphenicol (Cm), and the 1,600-bp integron added resistance to gentamicin (Gen) and kanamy
16 the presence of both the 1,000- and 1,200-bp integrons added resistance to ampicillin (Amp) and chlor
17 led similar trends to those displayed in the integron amplicon sequencing pipeline described above, c
18 ase chain reaction (PCR)) that links class 1 integrons amplified from single bacterial cells to taxon
19 gdom by pulsed-field gel electrophoresis and integron analysis.
20                                      Rather, integrons and associated resistance genes abound in seve
21 ing and examined for the presence of class 1 integrons and bla(CMY) genes.
22  sequencing were used to identify resistance integrons and extended spectrum beta-lactamase genes.
23 termined, and the isolates were screened for integrons and gyrase A gene mutations.
24 d by mobile genetic elements such as class 1 integrons and insertion sequences.
25 ient elements unrelated to plasmids, phages, integrons and integrative conjugative elements.
26  those of mobile genetic elements (including integrons and plasmids), which serve as carriers in the
27 intermediate between the multidrug-resistant integrons and the Vibrio cholerae super-integron.
28 ethoxazole-trimethoprim constins and class I integrons, and common toxin (ctxAB, rtxA, hap, hlyA, tl,
29  determinants interspersed with transposons, integrons, and other mobile genetic elements is a signif
30 izable between plasmids through transposons, integrons, and recombination events, and contribute to t
31 e, conferring Amp resistance in the 1,200-bp integron; and the aadA and aadB genes, conferring St Spc
32                                 The 1,600-bp integron appears to have the 1,000-bp intergron as its c
33                                              Integrons are extensively targeted as a proxy for anthro
34                                              Integrons are genetic elements consisting of a functiona
35                                      Class 1 integrons are genetic elements that correlate strongly w
36                                              Integrons are mechanisms that facilitate horizontal gene
37                             We conclude that integrons are useful markers for epidemic strains of A.
38                                       Mobile integrons are widespread genetic platforms that allow ba
39 HGT) facilitated by specific transposons and integrons associated with particular microbial hosts.
40                                              Integron-associated gene cassettes encode several aminog
41 ess of this method and suggesting that these integron-associated genes may be excellent targets for s
42 RGs (ermB, qurS, tetM, blaTEM, and sul1) and integron-associated integrase intI1 were detected at hig
43 is protein (AB57_0094), aphA1, bla(TEM), and integron-associated orfX proving the most helpful in dis
44 lfamethoxazole resistance and a 1-kb class I integron bearing aadA for streptomycin resistance.
45 se levels, only cointegrates between the two integron-bearing plasmids were detectable at all growth
46                                              Integron-borne sulI was present in 16.4% of isolates in
47 ts with spontaneous deletions in the class 1 integron (C1I) region, observed in 30% of erm(46)-positi
48                                        These integron cassette arrays have been found in other outbre
49                            DNA sequencing of integrons confirmed the presence of the aminoglycoside a
50   Three of the MDR strains harbored a 750-bp integron containing the dfr7 gene.
51 ion and diversity of integron intI genes and integron-containing bacteria.
52 nt to antibiotics and those carrying class 1 integrons decreased in water samples (p-value <0.001).
53 study's 343 patients included 15 with Verona integron-encoded MBL (VIM)- and 328 with New Delhi MBL (
54 e), SPM-1 (Sao Paulo MBL), and VIM-2 (Verona integron-encoded MBL)) and the identification of suitabl
55                      We identified 14 Verona integron-encoded metallo-B-lactamase (VIM)-producing CRE
56 a pneumoniae carbapenemase (KPC), and Verona integron-encoded metallo-beta-lactamase (VIM) were the m
57 nhibiting the clinically relevant MBL Verona integron-encoded metallo-beta-lactamase (VIM-2).
58 nanomolar beta-lactamase inhibitor of Verona-integron-encoded metallo-beta-lactamase 2, capable of re
59 rsity in the genetic compositions of class 1 integrons, especially among isolates belonging to the sa
60 termine the decay rates for ARGs and class 1 integrons following simulated land application of treate
61                                          One integron from a swine isolate contained the sat-1 gene,
62 e report the genetic organization of a super-integron from Pseudomonas alcaligenes ATCC 55044.
63                                         Some integron GCs, called ORF-less GCs, contain no identifiab
64 sequencing, we successfully assigned class 1 integron gene cassette arrays containing mostly AMR gene
65 hat enables characterization of thousands of integron gene cassette-associated reads, and applied it
66 the evolutionary selection of ddl containing integron gene cassettes is proposed, based on molecular
67  for CPS expression, is characteristic of an integron-gene cassette region, similar to the super inte
68 a(SHV), bla(OXA) and bla(CTX-M)) and class-1 integron genes (int1) in soils from manured (M) versus i
69  profiles and the frequency of quinolone and integron genes were obtained.
70     The presence of any of the three class 1 integron groupings was associated with four-drug resista
71                                        Three integron groupings were detected: 1,000 bp only, 1,600 b
72                          The larger of these integrons had two copies of the first (orfX) of the gene
73           In particular, the distribution of integrons harboring resistance cassettes for TMP-SMX (df
74        This is the first evidence of a super-integron in a non-pathogenic bacterium, one which is wid
75 ts include a multi-resistant complex class 1 integron in Escherichia coli and Klebsiella pneumoniae,
76 resence of the aadAI gene cassette within an integron in these 16 isolates.
77                                     We found integrons in 103 different pathogenic and non-pathogenic
78 yrA mutations and of the presence of class I integrons in a panel of 100 veterinary isolates of Salmo
79  a powerful tool for linking taxa to class 1 integrons in environmental bacterial communities and off
80 acterized the gene cassettes associated with integrons in Methylobacillus flagellatus KT and Dechloro
81  resistance genes and mobile elements called integrons in poultry house litter from commercial poultr
82 nexpectedly, the major reservoir for Class 1 integrons in poultry litter is not their previously iden
83 g a PCR-based screen of ARGs associated with integrons in saliva-derived metagenomic DNA of healthy h
84 e of gyrA mutations and of detecting class-I integrons in Salmonella isolates.
85               Metagenome sequencing revealed integrons in the gut meta-mobilome that were associated
86      In conclusion, the persistent nature of integrons in the infant gut microbiota makes it a potent
87 c-resistant gene cassettes between different integrons in the same cell, facilitating the persistence
88 abilization) on the fate of ARGs and class 1 integrons in wastewater solids-amended soil microcosms.
89                      The discovery of 'super-integrons' in Vibrionaceae suggests a greater impact of
90 on of 1.0 kb, in contrast to the typical two integrons (InC and InD) of 1.0 and 1.2 kb, respectively,
91 sence of other elements such as transposons, integrons, insertion sequence (IS) elements and the 'new
92 obacteriaceae are spread by plasmid-mediated integrons, insertion sequences, and transposons, some of
93 s detected in 75% of isolates, while class 1 integron (int1) was found in 12.5%.
94 ect on the relative abundance of the class 1 integron integrase encoding gene (intI1) was observed.
95 terns of the anthropogenic indicator class I integron Integrase gene (intI1) and several ARGs in 1.2
96 VSP-II, MSHA, HlyA, type IV pilin, PilE, and integron integrase, IntI4) with no notable difference in
97                                              Integron integrases innovated from double-strand- toward
98 nalysis of the distribution and diversity of integron intI genes and integron-containing bacteria.
99 o types: 'bla(TEM-1B) ' and 'classic class 1 integron (IntI1)'.
100                                      Class 1 integrons (intI1) are investigated as a universal AMR in
101 et(W), and tet(X)), the integrase of class 1 integrons (intI1), 16S rRNA genes, 16S rRNA genes of all
102 , and tet(X)], the integrase gene of class 1 integrons (intI1), and 16S rRNA genes were quantified us
103 teria (HF183), the integrase gene of class 1 integrons (intI1), and five ARGs representing a cross-se
104 othesis, we inserted a custom three-cassette integron into Pseudomonas aeruginosa and used experiment
105 is suggests that the present distribution of integrons is due to multiple losses and gene transfer ev
106 some also carries a gene capture system (the integron island) and host 'addiction' genes that are typ
107  active site-specific integration of related integron-like elements (ILEs) found in six environmental
108 istance gene, termed qnr, and found it in an integron-like environment upstream from qacE Delta 1 and
109                                        Super-integrons may contain more than 100 gene cassettes and m
110 itigation efforts toward hotspots of class 1 integron-mediated dissemination of AMR.
111 les and were found to carry only one class I integron of 1.0 kb, in contrast to the typical two integ
112 n-gene cassette region, similar to the super integron of V. cholerae.
113 nes may suggest that the selective impact of integrons on genomes is variable, oscillating between be
114                The diagnostic accuracy of an integron PCR method (Int-PCR) for detecting class 1 inte
115       The gene cassettes present within each integron ranged in size from 0.6 to 2.4 kb, although a 1
116 n, repair of double stranded DNA breaks, and integron recombination.
117  and 27 isolates carried class 1 and class 2 integrons, respectively.
118 esulted in an increase of class 1 resistance integrons (RIs) and the introduction of Pseudomonas spp.
119                     Sequence analyses of the integrons showed that they contained aadA, which confers
120 he multiresistance in DT104 is related to an integron structure designated SGI1, but factors underlyi
121  Multiresistance in DT104 is conferred by an integron structure, designated Salmonella genomic island
122                              Until recently, integrons (systems for acquisition and expression of new
123 conferring St Spc resistance in the 1,000-bp integron; the beta-lactamase gene, conferring Amp resist
124 mids, In823::Kl.pn.I3/In1589-like/In837-like integrons, Tn6296/Tn125/Tn5060 transposons, and insertio
125 ghput qPCR showed that genes associated with integrons, transposons, plasmids, and insertion sequence
126 or epidemic strains of A. baumannii and that integron typing provides valuable information for epidem
127                                    A class 1 integron was found in 25 (93%) of 27 TMP-SMX-resistant C
128                           While a particular integron was usually associated with a strain or clone,
129         Furthermore, the presence of class 1 integrons was detected in 15 CCF isolates, all of which
130 y relevant levels, and an element of Class I integrons, was not detected in any community.
131 Es such as the aadA5-dfrA17-carrying class 1 integron were identified on an assembled scaffold of chi
132 cassettes in the first position of a reverse integron were identified.
133                                         Some integrons were associated with more than one strain.
134                                              Integrons were detected in 16 of the 42 isolates; a frag
135 line resistance and the integrase of Class 1 integrons were enumerated using quantitative PCR from ae
136                                      Class 1 integrons were found in all of the outbreak isolates but
137                                      Class 1 integrons were found to be pervasive across the urban en
138                                   No class 2 integrons were found.
139                                  Two or more integrons were generally present in these isolates.
140                                        Three integrons were identified among the main outbreak strain
141                                Class 1 and 2 integrons were identified in 15 (71.4%) and 3 (14.3%) is
142                                              Integrons were sought in Acinetobacter isolates from hos
143            The cassette arrays of two of the integrons were very similar, both containing gene aacC1,
144                                              Integrons were widely scattered, and their presence was
145 n integrase gene (int1), used as a proxy for integrons (which often carry multiple antimicrobial resi
146      The integrase gene (intI1) from Class 1 integrons, which has been associated with multidrug resi
147 n isolates, representing four serotypes, had integrons with genes conferring resistance to aminoglyco
148                                    The third integron, with a cassette array containing gene aacA4, w
149       Thirty-four isolates contained class I integrons, with 71% of the S. enterica serovar Typhimuri

 
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