ライフサイエンスコーパス: intellectual

1 fundamental cognitive functions determining intellectual abilities, such as the broadly defined exec

2 e process involved in another determinant of intellectual abilities, the working memory, measured by

3 ctions, contributes substantially to general intellectual ability, especially fluid intelligence.

4 tially accounts for life-span transitions in intellectual ability, memory, and susceptibility to beha

5 ional complexity and engagement in cognitive-intellectual activities, are frequently considered indic

6 ildren with CHD frequently display long-term intellectual and behavioral disability.

7 Progress in addressing the origins of intellectual and developmental disabilities accelerated

8 National Institutes of Health and associated Intellectual and Developmental Disabilities Research Cen

9 ea cycle disorders (UCDs) often present with intellectual and developmental disabilities.

10 a phenotype that is mainly characterized by intellectual and developmental disability.

11 of autism and are associated with prominent intellectual and language deficits.

12 rboxylate transporter 8 (MCT8) causes severe intellectual and motor disability and high serum tri-iod

13 SHANK3 are commonly associated with autism, intellectual, and language deficits.

14 s have a crucial impact on the course of the intellectual battle between the two historically competi

15 miologic studies of the Flynn effect is that intellectual capacity gains due to education plateau in

16 nd without help, or if they had insufficient intellectual capacity to understand questions and follow

17 are busy with the day-to-day management and intellectual challenges of a research lab.

18 tron transfer (EET) stimulates a plethora of intellectual concepts leading to potential applications

19 have recently been identified as a cause of intellectual deficit in humans.

20 individuals have global developmental and/or intellectual delay, all had seizures, two had polymicrog

21 Iodine is an essential micronutrient for intellectual development in children.

22 senting heterozygous dominant de novo autism-intellectual disabilities (ID) causing mutations is acti

23 Disqualifying patients with intellectual disabilities (ID) from transplantation has

24 autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are therefore cla

25 es of neurodevelopmental disorders including intellectual disabilities and epilepsies.

26 es including Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome.

27 certained autism spectrum disorder (ASD) and intellectual disabilities from records of additional sup

28 (Spain) and through services for people with intellectual disabilities in Cambridge (UK).

29 d and a plausible overlapping of obesity and intellectual disabilities in several cases.

30 X syndrome (FXS), a common form of inherited intellectual disabilities with a high risk for ASDs.

31 orders, including autism spectrum disorders, intellectual disabilities, and schizophrenia, are linked

32 Those affected may have intellectual disabilities, dysmorphic facial features, a

33 mosome-linked disease associated with severe intellectual disabilities.

34 genes, including some involved in autism and intellectual disabilities.

35 FMRP leads to sensory dysfunction and severe intellectual disabilities.

36 ght also underlie developmental delay and/or intellectual disability (DD and/or ID) disease phenotype

37 thylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorde

38 with neurodevelopmental diseases, including intellectual disability (ID) and autism spectrum disorde

39 pe subunits have recently been implicated in intellectual disability (ID) and developmental delay (DD

40 y identified in nine individuals with severe intellectual disability (ID) and disruptive behavior.

41 merged as a collectively common etiology for intellectual disability (ID) and growth disruption.

42 RIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abno

43 icase DDX3X account for 1%-3% of unexplained intellectual disability (ID) cases in females and are as

44 e contribution of de novo variants in severe intellectual disability (ID) has been extensively studie

45 the most common cause of autosomal recessive intellectual disability (ID) in Arabia.

46 Intellectual disability (ID) is a genetically and clinic

47 Intellectual disability (ID) is a heterogeneous clinical

48 efficacy for ADHD in children with comorbid intellectual disability (ID) or borderline intellectual

49 ree affected parents with varying degrees of intellectual disability (ID) or developmental delay (DD)

50 families with multigenerational nonsyndromic intellectual disability (ID) segregating with a recurren

51 r rates of global developmental delay (GDD), intellectual disability (ID), and motor delay in individ

52 ociated with autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SZ).

53 ficantly different in their association with intellectual disability (ID), consistent with the existe

54 Intellectual disability (ID), defined as IQ<70, occurs i

55 -q13.3 locus with a common facial phenotype, intellectual disability (ID), distinctive behavioral fea

56 e facial features with gingival enlargement, intellectual disability (ID), hypertrichosis, and hypopl

57 neurodevelopmental disorder characterized by intellectual disability (ID), motor and speech delay, au

58 Intellectual disability (ID), which presents itself duri

59 including autism spectrum disorder (ASD) and intellectual disability (ID).

60 Intellectual disability (intellectual quotient < 70, cSD

61 congenital cataracts, central hypotonia and intellectual disability (Lowe syndrome).

62 ating protein whose mutations cause X-linked intellectual disability (XLID) in humans.

63 c circuitry in Ophn1 mouse model of X-linked intellectual disability (XLID).

64 iduals, with male-to-female ratios of 2:1 in intellectual disability and 4:1 in autism spectrum disor

65 al phenotypic overlap, including features of intellectual disability and abnormal growth, underscorin

66 USP9X mutations in patients with intellectual disability and autism ablate its catalytic

67 ral brain disorders, including the inherited intellectual disability and autism spectrum disorder, fr

68 iquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder.

69 aptic disorder, and a disease model for both intellectual disability and autism spectrum disorder.

70 in individuals with Pitt-Hopkins syndrome-an intellectual disability and autism spectrum disorder.

71 the fourth mutation, A1622D, causing severe intellectual disability and autism without epilepsy, we

72 ontrast, the R1620L mutation associated with intellectual disability and autism-but not epilepsy-redu

73 hared and specific biological information of intellectual disability and CHD by conducting systems bi

74 Here, we report 19 subjects with intellectual disability and developmental delay carrying

75 ts in RALA were also described as a cause of intellectual disability and developmental delay, indicat

76 ntribute to this proposed monogenic cause of intellectual disability and epilepsy remain unresolved.

77 four children from independent families with intellectual disability and epilepsy, revealing bi-allel

78 lution, in a patient diagnosed with profound intellectual disability and epilepsy.

79 neurodevelopmental disorder characterized by intellectual disability and epilepsy.

80 were recently reported to be associated with intellectual disability and epilepsy; the functional eff

81 enriched for syndromic causes of autism and intellectual disability and for genes that in later deve

82 on of trisomy 21, we have learned much about intellectual disability and genetic risk factors for con

83 individuals had developmental delays and/or intellectual disability and impairments in speech and la

84 yndrome is the most common form of inherited intellectual disability and is caused by a deficiency of

85 neurodevelopmental disorder characterized by intellectual disability and lack of speech.

86 alencephaly, a subgroup with higher rates of intellectual disability and larger cerebral volumes, may

87 yseal dysplasia, sensorineural hearing loss, intellectual disability and Leber congenital amaurosis (

88 is case-control study, we used data from the Intellectual Disability and Mental Health: Assessing the

89 t variants in KDM4B are associated with GDD/ intellectual disability and neuroanatomical defects.

90 elative short stature and variable degree of intellectual disability and neurological features as the

91 rological phenotype, with high prevalence of intellectual disability and optic nerve atrophy/hypoplas

92 icated in Xia-Gibbs syndrome, which involves intellectual disability and other features.

93 lepsy, cerebral palsy, feeding difficulties, intellectual disability and other neurological and behav

94 d NETO genes in individuals with Scz, ASD or intellectual disability and population controls; perform

95 ofound hypotonia and muscle weakness, severe intellectual disability and progressive cerebellar atrop

96 neurodevelopmental disorders with epilepsy, intellectual disability and schizophrenia (SCZ).

97 culminating in a recognizable syndrome with intellectual disability and signature brain and congenit

98 potonia, feeding difficulties, hypogonadism, intellectual disability and sleep apnea.

99 est that SHANK3 deficiency may predispose to intellectual disability and socio-communicative impairme

100 gical manifestations were present, including intellectual disability and spasticity.

101 e (FXS) is the most common form of inherited intellectual disability and the leading monogenetic caus

102 yndrome (FXS) is the leading known inherited intellectual disability and the most common genetic caus

103 cause of a neurodevelopmental disorder with intellectual disability and variable brain anomalies.

104 ilies with the common phenotypic features of intellectual disability and/or global developmental dela

105 eafness, onychodystrophy, osteodystrophy and intellectual disability are associated with a spectrum o

106 Brain abnormalities and intellectual disability are commonly observed in individ

107 genetic variations found in individuals with intellectual disability are the causes for the phenotype

108 are associated with X-linked NDDs comprising intellectual disability as a core feature.

109 rphisms, short stature, developmental delay, intellectual disability as well as cardiac hypertrophy.

110 e, Dravet syndrome and infantile spasms with intellectual disability as well as relatively mild epile

111 icantly enriched in patients with autism and intellectual disability compared to healthy controls and

112 ther genes carrying rare mutations linked to intellectual disability contribute to ADHD risk through

113 that are associated with human cancer or the intellectual disability disorder Sifrim-Hitz-Weiss syndr

114 ctor eIF2, cause MEHMO syndrome, an X-linked intellectual disability disorder.

115 SWI/SNF-related intellectual disability disorders (SSRIDDs) are rare neu

116 SRPK family genes are also mutated in intellectual disability disorders, and patient-derived S

117 al synaptic plasticity may contribute to the intellectual disability frequently seen in BBSOAS.

118 The intellectual disability gene set was significantly assoc

119 in a diagnostic gene panel of 396 autosomal intellectual disability genes were tested for associatio

120 tified 28 rare or novel CNVs associated with intellectual disability in 22 additional obese subjects

121 to the OGT catalytic domain lead to X-linked intellectual disability in boys, but it is not clear if

122 elp uncover novel mechanisms contributing to intellectual disability in Down syndrome.

123 Clinical trials to ameliorate intellectual disability in DS signal a new era in which

124 in the SYNGAP1 gene have been shown to cause intellectual disability in humans and have been linked t

125 Mutations in Camk2a or Camk2b cause intellectual disability in humans, and severe plasticity

126 syndrome, the most common form of inherited intellectual disability in humans.

127 osition 50 to alanine (p.D50A), resulting in intellectual disability in male patients.

128 phenotype of thrombocytopenia accompanied by intellectual disability in patients with a de novo heter

129 d significant speech delay (50% non-verbal); intellectual disability in the moderate to severe range;

130 e role of genetic variation in both genes in intellectual disability may be through different mechani

131 UR2-containing K(ATP) channels ABCC9-related Intellectual disability Myopathy Syndrome (AIMS).

132 had motor and language developmental delay, intellectual disability often associated with early-onse

133 th autism spectrum disorder (autism) without intellectual disability often have normal structural lan

134 n patients with autism spectrum disorder and intellectual disability or developmental disorders to sh

135 All had developmental delay or intellectual disability ranging from mild to severe.

136 Weaver syndrome (WS), an overgrowth/intellectual disability syndrome (OGID), is caused by pa

137 se Nicolaides-Baraitser syndrome (NCBRS), an intellectual disability syndrome associated with delayed

138 nyder-Robinson syndrome (SRS) is an X-linked intellectual disability syndrome caused by a loss-of-fun

139 al E3 ubiquitin ligase that is mutated in an intellectual disability syndrome.

140 ions) in 4,789 (0.6%) children, with ASD and intellectual disability the most common combination.

141 ted with diseases ranging from developmental intellectual disability to cancer.

142 disability (present in 84%) ranged from mild intellectual disability to severe global disability; mov

143 equencing on 1696 patients with epilepsy and intellectual disability using a gene panel with 480 epil

144 rt of children with autism spectrum disorder/intellectual disability versus healthy controls revealed

145 d clinically recognizable syndromic forms of intellectual disability with contrasting craniofacial dy

146 characterized by global developmental delay, intellectual disability with language deficit, autistic

147 features, especially midface hypoplasia, and intellectual disability with severe expressive language

148 causing intermediate or severe epilepsy, or intellectual disability without epilepsy, respectively)

149 autism spectrum disorder (ASD), seizures and intellectual disability(2,4,5).

150 fication factors (site, age at baseline, and intellectual disability), with an additional prespecifie

151 ith de novo heterozygous mutations displayed intellectual disability, ambulation deficits, severe lan

152 disorder (CDD) is characterized by epilepsy, intellectual disability, and autistic features, and CDKL

153 otonia (which had been present since birth), intellectual disability, and autistic features.

154 a few individuals with developmental delay, intellectual disability, and brain malformations have mi

155 of CHARGE syndrome, developmental delay and intellectual disability, and cerebellar hypoplasia.

156 sorders, including autism spectrum disorder, intellectual disability, and epilepsy.

157 our unrelated individuals with microcephaly, intellectual disability, and epilepsy.

158 Na(v)1.6 mutations cause epilepsy, intellectual disability, and movement disorders.

159 ral sclerosis, Huntington disease, dementia, intellectual disability, and other brain diseases from 1

160 associated with cancer-related pathologies, intellectual disability, and schizophrenia are increasin

161 e disease marked by autistic-like behaviors, intellectual disability, and seizures.

162 al phalanges with small finger and toenails, intellectual disability, and seizures; this condition ov

163 ons, seizures, global developmental delay or intellectual disability, and severe sleep disturbance.

164 ADHD often co-occurs with intellectual disability, and shared overlapping genetics

165 e epilepsy, autism spectrum disorder, and/or intellectual disability, as well as other systemic manif

166 ntal symptoms including developmental delay, intellectual disability, ataxia, axial hypotonia, cerebr

167 such as developmental delay, mild-to-severe intellectual disability, ataxia, epilepsy, and behaviora

168 le to neurodevelopmental disorders including intellectual disability, autism spectrum disorder, and a

169 phenotypes that include developmental delay, intellectual disability, autism spectrum disorder, and b

170 The most common features in our cohort were intellectual disability, autism spectrum disorder, seizu

171 nked to neurodevelopmental disorders such as intellectual disability, autism, and schizophrenia.

172 ts (CNVs) have been robustly associated with intellectual disability, autism, and schizophrenia.

173 with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipo

174 clinical features, including mild to severe intellectual disability, autism, severe speech and motor

175 n inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epi

176 autistic behavior, language impairment, and intellectual disability, but feeding difficulties and ga

177 isk factors for autism spectrum disorder and intellectual disability, but it has not been reported if

178 , and wide mouth, developmental delay and/or intellectual disability, corpus callosum agenesis or hyp

179 m of clinical features including ichthyosis, intellectual disability, decreased fertility, and short

180 VTs or indices, in clinical populations with intellectual disability, degenerative brain disease, bra

181 ected individuals include variable levels of intellectual disability, delayed speech and motor milest

182 ion variants in DYRK1A exhibit microcephaly, intellectual disability, developmental delay and/or cong

183 ts are the cause of a recessive disease with intellectual disability, developmental delay, and short

184 er characterized with a spectrum of central (intellectual disability, developmental delay, motor impa

185 guineous families with probands that exhibit intellectual disability, developmental delay, short stat

186 fox1, an RNA binding protein associated with intellectual disability, epilepsy and autism, increases

187 lapping, syndromic forms of NDDs with severe intellectual disability, epilepsy and microcephaly.

188 eurodevelopmental disorders that manifest as intellectual disability, epilepsy, autism, or schizophre

189 In seven individuals with intellectual disability, epilepsy, ptosis, hypothyroidis

190 IFA (cleft lip, cataract, tooth abnormality, intellectual disability, facial dysmorphism, attention-d

191 individuals with developmental delay and/or intellectual disability, facial dysmorphisms, and congen

192 erozygous mutations have been shown to cause intellectual disability, growth deficiency, and dysmorph

193 phenotype consisting of developmental delay, intellectual disability, growth retardation, microcephal

194 ation of 15q11.2-13.1) cases associated with intellectual disability, highlight RNA-editing dysregula

195 ndrome (FXS) is characteristically displayed intellectual disability, hyperactivity, anxiety, and abn

196 lobal motor development delay, speech delay, intellectual disability, hypotonia and a history of seiz

197 ls include global developmental delay and/or intellectual disability, hypotonia, cerebellar ataxia, c

198 ndividuals present with developmental delay, intellectual disability, hypotonia, feeding difficulties

199 and Rett syndrome (RTT) are associated with intellectual disability, infantile spasms and seizures.

200 In a patient with HME, severe intellectual disability, intractable seizures and hypoch

201 Syndrome (FXS), a common inheritable form of intellectual disability, is known to alter neocortical c

202 ile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic caus

203 neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abn

204 s in PAK1 in four unrelated individuals with intellectual disability, macrocephaly and seizures.

205 variants in PAK1 lead to moderate-to-severe intellectual disability, macrocephaly caused by the pres

206 symptoms included neurodevelopmental delay, intellectual disability, macrocephaly, and psychiatric d

207 ly recognizable by the combined phenotype of intellectual disability, macrothrombocytopenia, camptoda

208 ith Takenouchi-Kosaki syndrome revealed that intellectual disability, macrothrombocytopenia, camptoda

209 B1 as a genetic etiology in individuals with intellectual disability, microcephaly, and epilepsy.

210 s have a speech delay, and most present with intellectual disability, motor delay, behavioral issues,

211 nts, who present with a clinical spectrum of intellectual disability, motor delay, speech delay, seiz

212 obal developmental delay, severe to profound intellectual disability, muscle weakness and abnormal to

213 for de novo mutations underlying autism and intellectual disability, mutations in the ADNP gene are

214 esenting with an X-linked syndrome involving intellectual disability, proportionate short stature, mi

215 We report a patient with intellectual disability, psychomotor development delay,

216 isk of neuropsychiatric disorders, including intellectual disability, schizophrenia, attention-defici

217 developmental disorder characterized by mild intellectual disability, seizures, behavioral abnormalit

218 xtrapolate the core phenotype, consisting of intellectual disability, short stature, microcephaly, li

219 viduals presenting with microcephaly, severe intellectual disability, simplification of cerebral gyra

220 comprising global developmental delay and/or intellectual disability, subtle facial dysmorphisms, beh

221 f neurological disorders, such as autism and intellectual disability, that are characterized by dendr

222 attention deficit hyperactivity disorder and intellectual disability, to later life, such as dementia

223 terized by global developmental delay and/or intellectual disability, variable axon pathfinding defec

224 me (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP func

225 This study reveals that a large set of intellectual disability-related genes contribute to ADHD

226 her forms of epilepsy associated with severe intellectual disability.

227 ders characterized by epilepsy with comorbid intellectual disability.

228 coexisting conditions, including autism and intellectual disability.

229 and neurodevelopmental defects are linked to intellectual disability.

230 activity recently identified in humans with intellectual disability.

231 sion program that is aberrantly expressed in intellectual disability.

232 Syndrome (FXS), the most prevalent inherited intellectual disability.

233 renia, and 63% versus 24% of individuals had intellectual disability.

234 n factor mutated in families with hereditary intellectual disability.

235 a (Dyrk1a) and mutations in both genes cause intellectual disability.

236 X syndrome (FXS), the most common inherited intellectual disability.

237 tein-truncating variants presented with mild intellectual disability.

238 o CTCF, including schizophrenia, autism, and intellectual disability.

239 ome (DS) is the most common genetic cause of intellectual disability.

240 h an overlapping phenotype of mild to severe intellectual disability.

241 tributes to trisomy-21/Down-syndrome-related intellectual disability.

242 ypical behaviours and high co-morbidity with intellectual disability.

243 X syndrome is rare but a prominent cause of intellectual disability.

244 (NDDs) such as autism spectrum disorder and intellectual disability.

245 nderstand the aetiology of Zbtb11-associated intellectual disability.

246 interactions in the pathogenesis of ASD and intellectual disability.

247 ntly described as a cause of severe X-linked intellectual disability.

248 -onset peripheral neuropathy with or without intellectual disability.

249 of Slack channels, resulting in epilepsy and intellectual disability.

250 isorders including often severe epilepsy and intellectual disability.

251 associated with autism spectrum disorder and intellectual disability.

252 that altered lipid metabolism contributes to intellectual disability.

253 own syndrome (DS) is the most common form of intellectual disability.

254 ll adhesion molecule NLGN4X result in ASD or intellectual disability.

255 cephaly, autism spectrum disorder (ASD), and intellectual disability.

256 llitus, sensorineural hearing loss, and mild intellectual disability.

257 missense variants associated with autism and intellectual disability.SIGNIFICANCE STATEMENT Here, we

258 neurodevelopmental condition associated with intellectual disability/developmental delay, autism spec

259 les from mothers of children with autism and intellectual disability; (2) an inflammatory cytokine mi

260 uals with autism spectrum disorder (ASD) and intellectual disability; however, its clinical significa

261 ns and exhibiting developmental delay and/or intellectual disability; the individuals are from 17 unr

262 tein 2 (MeCP2), is one of the most prevalent intellectual disorders without effective therapies.

263 for plastic changes in response to lifetime intellectual enrichment and potentially also a higher re

264 ng the imaging markers, and early to midlife intellectual enrichment to predict longitudinal cognitiv

265 After briefly introducing the field's intellectual foundations, we review recent basic researc

266 hreshold symptoms of psychosis, low baseline intellectual functioning and cognitive decline.

267 22q11.2 CNVs differentially modulate intellectual functioning and psychosis-related symptomat

268 Intellectual functioning is a critical determinant of ec

269 Age, gender, intellectual functioning, and country of study were asso

270 d intellectual disability (ID) or borderline intellectual functioning.

271 he proper practice of activities that foster intellectual growth, such as journal clubs, lab meetings

272 Fragile X syndrome (FXS) is an inherited intellectual impairment that results from the loss of fr

273 She presented with mild intellectual impairment, convergent strabismus, horizont

274 etraparesis, severe generalized dystonia and intellectual impairment, sharing a unique brain malforma

275 Paradoxically, even as technical and intellectual innovations bring us ever closer to a trans

276 ce statement must disclose all financial and intellectual interests related to health care from the p

277 and motor delay, and variable expression of intellectual or learning disability are common clinical

278 PRT was associated with more favorable intellectual outcomes in most domains compared with XRT,

279 ins of allergen immunotherapy share the same intellectual paradigm, and subsequent innovations in vac

280 e exon frequently lead to strikingly similar intellectual phenotypes in unrelated ASD probands.

281 also serve as a good strategy for developing intellectual properties which will be critical for produ

282 nancial data, due to regulatory limitations, intellectual property and privacy control, still hinder

283 Strengthened intellectual property protection manifested by the rise

284 Besides cost, other factors such as intellectual property protection, problem solving skills

285 Implications of strengthened intellectual property provisions for equitable access to

286 Intellectual property regimes, technology regulatory fra

287 ly valuable PET radiopharmaceuticals without intellectual property residing in regulatory limbo, with

288 ervices, honoraria, expenses, royalty/patent/intellectual property, and other disclosures.

289 , and acquire novel chemical space to secure intellectual property.

290 Intellectual disability (intellectual quotient < 70, cSDS < -2.0) was associated

291 ctious disease epidemiology has undergone an intellectual rebirth in recent years amid increasing rec

292 icant investment of financial, physical, and intellectual resources that catalyze impressive scientif

293 We examined the change in intellectual scores over time in patients with pediatric

294 rovides the strongest evidence to date of an intellectual sparing advantage with PRT in the treatment

295 tinct and generally scientifically-unrelated intellectual territory.

296 Much of the intellectual tradition of modern epidemiology stems from

297 Despite evolving from different intellectual traditions, both frameworks attest to the i

298 nowledge, this is the first study to compare intellectual trajectories between pediatric patients tre

299 sequences of excessive physical training and intellectual work into a single neuro-computational mech

300 and enriches, rather than replaces, people's intellectual work.