ライフサイエンスコーパス: interchromosomal

1 referred to as nuclear bodies, are discrete interchromosomal accumulations of several proteins inclu

2 be essential for DSB repair by conservative interchromosomal (allelic) gene conversion.

3 In addition, we were able to trace a likely interchromosomal Alu-mediated fusion between IGSF3 on 1p

4 of gamma-ray-induced DNA damage and on both interchromosomal and direct repeat heteroallelic recombi

5 These rearrangements occur via both interchromosomal and intrachromosomal exchange events be

6 Only one interchromosomal and two intrachromosomal rearrangements

7 entify a lineage-specific and stage-specific interchromosomal association between these two loci that

8 Strikingly, the interchromosomal association of DNA breaks also promotes

9 complex mechanism that involves monoallelic interchromosomal association, alterations in histone met

10 e findings demonstrate that CTCF mediates an interchromosomal association, perhaps by directing dista

11 Thanos describe how viral infection elicits interchromosomal associations between the interferon-bet

12 Interchromosomal associations can regulate gene expressi

13 entiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTC

14 e breakpoint data, we established that avian interchromosomal breakpoints appear in the regions of lo

15 t-clipped reads allows Bellerophon to detect interchromosomal breakpoints with high sensitivity, whil

16 Interchromosomal centromeric rearrangements may have fos

17 Interchromosomal changes have been extremely rare.

18 g all livestock ruminants) included multiple interchromosomal changes.

19 lycomb repressive complex 2 and by mediating interchromosomal chromatin contacts between Fab-7 and it

20 er, in all three cases, gene positioning and interchromosomal clustering are regulated.

21 genes to the nuclear pore complex (NPC) and interchromosomal clustering is mediated by transcription

22 Previously we proposed that the interchromosomal clustering of satellite DNAs into nucle

23 ene positioning at the nuclear periphery and interchromosomal clustering represent interdependent phe

24 to the NPC is independent of transcription, interchromosomal clustering requires transcription.

25 ote positioning at the nuclear periphery and interchromosomal clustering.

26 nct from the molecular mechanism controlling interchromosomal clustering.

27 ode to mediate both targeting to the NPC and interchromosomal clustering.

28 bridization experiments revealed monoallelic interchromosomal colocalization of miR-155 and miR-146a

29 alleles make independent stochastic choices, interchromosomal communication coordinates expression st

30 d that loss of chromosome alignment leads to interchromosomal compaction defects during anaphase, abn

31 al volumes) must be two in order to keep the interchromosomal concentrations unchanged.

32 gest that active DNA loci engage in physical interchromosomal connections that are an integral and pe

33 identified within the domains do not display interchromosomal conservation in terms of length, copy n

34 The previously reported interchromosomal conservation of synteny was confirmed,

35 hlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally reg

36 on (MZT) of Drosophila embryogenesis, stable interchromosomal contacts form between maternal and pate

37 range intrachromosomal contacts and specific interchromosomal contacts that are rarely seen in neuron

38 from 18 chromosomes make specific and robust interchromosomal contacts that increase with differentia

39 key contributions of low-frequency ('rare') interchromosomal contacts to accurately predicting the g

40 ed within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear

41 these rearrangements map to an ape-specific interchromosomal core duplicon that clusters at sites of

42 a subgroup of patients that map to the same interchromosomal core involved in the evolutionary forma

43 We find that interchromosomal crossover recombination with these shor

44 ver, such length variants may cause unequal, interchromosomal crossovers leading to MHC-associated di

45 structures such as a deletion-inversion and interchromosomal dispersed duplications.

46 The interchromosomal distribution of detection frequencies w

47 construct a paralogy map that delineated the interchromosomal distribution of duplicated segments thr

48 at a single gene resolution, we combined the interchromosomal DNA contacts in the yeast genome measur

49 In addition, the exact intra- and interchromosomal DNA duplications were analyzed using Mu

50 integrations of exogenous DNA and clustered interchromosomal DNA fragment rearrangements.

51 levated frequencies of forward mutations and interchromosomal DNA recombination.

52 Thus, while interchromosomal DNA repair does not result in genome in

53 vel mechanism of antibody diversification by interchromosomal DNA transposition and demonstrate the e

54 east 35 regions of the genome via intra- and interchromosomal duplication events.

55 r elucidation of the mechanism of intra- and interchromosomal duplication events.

56 was found to be 94.6%, suggesting that this interchromosomal duplication occurred within recent evol

57 provide molecular evidence for considerable interchromosomal duplication of genic segments during th

58 eat arrays, implicating these repeats in the interchromosomal duplication process.

59 thin the genome, we selected BACs containing interchromosomal duplications and characterized their du

60 Interchromosomal duplications are especially important f

61 somal duplications, but indicate that recent interchromosomal duplications at this centromere have in

62 rsity accompanied by an increasing number of interchromosomal duplications in proximity to the centro

63 the exact DNA duplications revealed that the interchromosomal duplications occurred prior to the intr

64 Recent interchromosomal duplications of ORs have also occurred,

65 Both intra- and interchromosomal duplications of regions of this chromos

66 Regions containing extensive interchromosomal duplications were observed, particularl

67 ysis of the sequence reveals many intra- and interchromosomal duplications, including segmental dupli

68 -exon and intra-exonic deletions, as well as interchromosomal duplications.

69 Our study provides observations of live interchromosomal dynamics during meiosis and illustrates

70 No evidence of an interchromosomal effect on aneuploidy was found by use o

71 We show that interchromosomal end joining is efficiently suppressed b

72 X-X incompatibilities and instead support an interchromosomal epistatic basis to hybrid female steril

73 what has been observed in vertebrates, where interchromosomal events are commonplace.

74 at any novel gene structures formed by these interchromosomal events would require relocation to a mo

75 solution, enabling examination of intra- and interchromosomal events, and providing a resource for fu

76 plex indels, retrotransposon insertions, and interchromosomal events.

77 ar identity of these arms suggests extensive interchromosomal exchange during evolutionary history.

78 ata are consistent with significant aberrant interchromosomal exchange events during meiosis I in the

79 gene, the mutation is not attributable to an interchromosomal exchange or to a chromosomal inversion.

80 a segment within Xq28 has resisted excessive interchromosomal exchange through great ape evolution, p

81 telomeres reflects their high rate of recent interchromosomal exchange.

82 omeric-directed mechanism for non-homologous interchromosomal exchange.

83 owed an unexpectedly high number of proximal interchromosomal exchanges between homologs, occurring i

84 ormal chromosome 22 in these probands showed interchromosomal exchanges in 2/15 informative meioses,

85 ister chromatid together in metaphase and an interchromosomal force that tethers broken sister chroma

86 RCC1 and HENMT1 located 80 Mbp apart and an interchromosomal fusion between RCC1 and ABHD12B.

87 ments and nuclear pore complexes to regulate interchromosomal gene clustering.

88 revertants of TX545 can be generated through interchromosomal gene conversion at the site of inactiva

89 y been observed in specific association with interchromosomal gene conversion in mammalian cells.

90 We also identified interchromosomal gene conversion involving HR and MMEJ a

91 rqh1(+) cells, are predominantly repaired by interchromosomal gene conversion, with HR between sister

92 ir gene rad16(+) were required for efficient interchromosomal gene conversion.

93 ir in this context was predominantly through interchromosomal gene conversion.

94 Rhp55 was required for interchromosomal gene conversion; however, an alternativ

95 loid wheat has undergone massive small-scale interchromosomal gene duplications compared to other gra

96 ver, unequivocal data required to prove that interchromosomal gene regulation truly represents anothe

97 chromosomes to facilitate cell-type-specific interchromosomal gene regulation.

98 mic distribution of gene families to analyze interchromosomal gene transposition in Drosophila.

99 rachromosomally spreading teleregulation and interchromosomal "gene kissing".

100 U2 genes is intrachromosomal homogenization; interchromosomal genetic exchanges are much rarer, and r

101 CDP-2 loss increases intra- and interchromosomal heterochromatic region interactions, wh

102 e distributed throughout the nucleus with an interchromosomal heterogeneity in size.

103 studies provide an in situ demonstration of interchromosomal heterogeneity in telomere lengths.

104 ling driven by mutated FLT3 and JAK2 confers interchromosomal homologous recombination (iHR), a prece

105 omosomal homologous recombination but not on interchromosomal homologous recombination.

106 romosome mobility per se, results in reduced interchromosomal homologous recombination.

107 when homologous chromosomes are aligned and interchromosomal homology-directed repair (HDR) mechanis

108 heterochromatic silencing and converge into interchromosomal hubs that assemble over the transcripti

109 BL resulted in enrichment for mega-loops and interchromosomal hubs that contain genes associated with

110 rearrangements were predicted by localizing interchromosomal identical repeated sequences along the

111 le-genome sequencing, we identified a 389-kb interchromosomal insertion at an extragenic palindrome s

112 ed translocation, balanced translocation, or interchromosomal insertion.

113 hod accurately predicted the presence of the interchromosomal insertions placed in our simulated data

114 in somatic cells provides the opportunity of interchromosomal interaction between homologous gene reg

115 ine demethylase, LSD1, in directing specific interchromosomal interaction loci to distinct interchrom

116 absence of a homolog partner and adjusts the interchromosomal interaction program accordingly.

117 ogression of DNA replication is modulated by interchromosomal interaction proteins.

118 We previously identified a high-frequency interchromosomal interaction within the Saccharomyces ce

119 iotic cells may involve "structure-dependent interchromosomal interaction" (SDIX) checkpoints.

120 Here, we report that ligand induces rapid interchromosomal interactions among subsets of estrogen

121 ions support the importance of both specific interchromosomal interactions and centromere clustering

122 rtly because there is no prior knowledge for interchromosomal interactions and the frequency of inter

123 However, the extent of interchromosomal interactions and the underlying mechani

124 idering the lack of computational methods on interchromosomal interactions and the unsurprisingly fre

125 rom diverse systems have shown that distinct interchromosomal interactions are a central component of

126 tween interacting chromatin partners whereby interchromosomal interactions are apparently lost in fav

127 es from diverse organisms show that distinct interchromosomal interactions are associated with many d

128 trates that the indiscriminate properties of interchromosomal interactions are consistent with the we

129 the principles governing their movements and interchromosomal interactions are currently under intens

130 ing such phenomena, our understanding of how interchromosomal interactions are initiated and regulate

131 OR enhancers are characterized by extensive interchromosomal interactions associated with OR transcr

132 identify regions with statistically frequent interchromosomal interactions at single-cell resolution.

133 trachromosomal interactions, we now describe interchromosomal interactions between the promoter regio

134 Reports of intra- and, remarkably, interchromosomal interactions between these regulatory e

135 rans-regulation of intrachromosomal loops by interchromosomal interactions during genome merger and s

136 Intra- and interchromosomal interactions have been implicated in a

137 Although the extent of the interchromosomal interactions have not been fully explor

138 The discovery of interchromosomal interactions in higher eukaryotes point

139 gulatory surveillance of normal and abnormal interchromosomal interactions in mitotic and meiotic cel

140 pport for the requirement and sufficiency of interchromosomal interactions in singular OR choice and

141 Finally, we discuss the role of intra- and interchromosomal interactions in the control of coregula

142 eb1 was recently shown to mediate long-range interchromosomal interactions in the nucleus through dim

143 hromosomal interactions and the frequency of interchromosomal interactions is much lower while the se

144 computational method dedicated to analyzing interchromosomal interactions of single-cell Hi-C with t

145 on intrachromosomal interactions and ignore interchromosomal interactions partly because there is no

146 Disruption of these interchromosomal interactions results in weak and multig

147 sophila activates transcription and mediates interchromosomal interactions such as transvection.

148 radial positioning and preferred patterns of interchromosomal interactions that are cell-type specifi

149 s a direct mediator of long-range intra- and interchromosomal interactions that can regulate transcri

150 t repressed Hox genes form mutual intra- and interchromosomal interactions with other genes located i

151 only intrachromosomal interactions, but also interchromosomal interactions, a less studied feature of

152 rocesses including transcription, intra- and interchromosomal interactions, and chromatin structure.

153 ediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an

154 hed measures, such as the ratio of intra- to interchromosomal interactions, and novel ones, such as Q

155 inance of intrachromosomal interactions over interchromosomal interactions, consistent with aggregati

156 result in large decreases in both intra- and interchromosomal interactions.

157 n of gene expression by mediating intra- and interchromosomal interactions.

158 translocation loci by triggering intra- and interchromosomal interactions.

159 to understand the fundamental properties of interchromosomal interactions.

160 the T(H)2 LCR developmentally regulate these interchromosomal interactions.

161 s1 serves as a negative regulator of meiotic interchromosomal interactions.

162 These constraints might limit interchromosomal interactions.

163 d enables formation of long-range intra- and interchromosomal interactions.

164 ctions from Hi-C data to identify functional interchromosomal interactions.

165 tein interactions, and are regulated through interchromosomal interactions.

166 d Hi-C data, particularly for long-range and interchromosomal interactions.

167 a useful tool for analyzing single-cell Hi-C interchromosomal interactions.

168 ovided increased understanding of intra- and interchromosomal interactions.

169 human cells that account for the majority of interchromosomal interactions.

170 ranslocations with integrated HBV DNA at the interchromosomal junctions.

171 nal genome-wide analyses and identified 1143 interchromosomal LCR substrate pairs, >5 kb in size and

172 To investigate the potential involvement of interchromosomal LCRs in recurrent chromosomal transloca

173 We replicated this pattern of interchromosomal LD between the genes in a separate bipo

174 We identified interchromosomal linkage disequilibrium (ILD) among loci

175 ker transmission ratio distortion (MTRD) and interchromosomal linkage disequilibrium in populations o

176 d explain how SMCs establish both intra- and interchromosomal links inside the cell and indicate that

177 rrelate with gene conversion, such as intra-/interchromosomal location, level of nucleotide divergenc

178 Thousands of intra- and interchromosomal loops are de novo established or disapp

179 PML nuclear bodies (PML-NBs) are dynamic interchromosomal macromolecular complexes implicated in

180 We found that RE exerted an effect on interchromosomal mating-type switching and on intrachrom

181 T alpha still influenced donor preference in interchromosomal mating-type switching, supporting a rol

182 SIR2 partially repressed interchromosomal meiotic ectopic recombination at RDN1,

183 Through Cre/loxP-mediated interchromosomal mitotic recombination of two reciprocal

184 Additional evidence for interchromosomal NAHR mediated translocation formation w

185 This interchromosomal network was drastically altered in CA1a

186 This probabilistic interchromosomal network was nearly completely different

187 hancers interact with each other, forming an interchromosomal network.

188 leus and form preferred-albeit probabilistic-interchromosomal networks.

189 us and form preferred -albeit probabilistic- interchromosomal networks.

190 omosome ends discourage error-prone NHEJ and interchromosomal NHEJ, preserving chromosome integrity o

191 ur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the

192 The interchromosomal organization of a subset of human chrom

193 Using MAP-C, we show that inducible interchromosomal pairing between HAS1pr-TDA1pr alleles i

194 Here, we demonstrate that interchromosomal pairing mediates this communication.

195 kpoints of one translocation to 24 bp within interchromosomal paralogous LCRs of approximately 130 kb

196 Interchromosomal paralogs of dispersed gene families and

197 It had lower levels of interchromosomal partners in 10A which increased strikin

198 alleles without parental genomes, leveraging interchromosomal phasing, mitochondrial and X chromosome

199 groups and we found only a few instances of interchromosomal rearrangement between the zebra finch a

200 lex structural variant must have involved an interchromosomal rearrangement creating fixed heterozygo

201 Sequence level analysis of an interchromosomal rearrangement during evolution has not

202 hylogenetic tree, we estimate the intra- and interchromosomal rearrangement history of all major vert

203 t region of the giant panda, suggesting that interchromosomal rearrangement may play a role in the ca

204 No interchromosomal rearrangement was identified in any spe

205 ecurrent type of genomic rearrangement, i.e. interchromosomal rearrangements (translocations or inser

206 manner, leading to the formation of multiple interchromosomal rearrangements and new telomeres, simil

207 athway supports the hypothesis that terminal interchromosomal rearrangements are common in regions un

208 They are implicated as truncated forms or interchromosomal rearrangements in a variety of tumors i

209 aim of this study was to (i) test if cryptic interchromosomal rearrangements of larger chromosomal bl

210 indicating a duplication and suggesting that interchromosomal rearrangements of maternal origin also

211 s been suggested to cause complex intra- and interchromosomal rearrangements on short timescales.

212 ge has a 30-fold difference in the number of interchromosomal rearrangements relative to felids, whil

213 Our findings indicate that interchromosomal rearrangements that generate chimeric c

214 ionary mechanisms, such as hybridization and interchromosomal rearrangements, that have shaped these

215 ations and two fusion transcripts created by interchromosomal rearrangements.

216 osomal rearrangements are more frequent than interchromosomal rearrangements.

217 e painting demonstrated there to be very few interchromosomal rearrangements.

218 ele (PA200(Delta)) through Cre-loxP-mediated interchromosomal recombination after targeting loxP site

219 kD zein locus in maize has been generated by interchromosomal recombination between chromosomes of tw

220 s with a transgene lacking the 3' enhancers, interchromosomal recombination between the transgenic VD

221 ology were constrained, we have now examined interchromosomal recombination between truncated but ove

222 ent with a translocation mechanism involving interchromosomal recombination by simple exchange of DNA

223 Thus, interchromosomal recombination can be efficiently progra

224 MADM reveals that interchromosomal recombination can be induced efficientl

225 ll cycle delay is insufficient to rescue the interchromosomal recombination defect of exo1Delta sgs1D

226 URA3-inverted repeats, increased intra- and interchromosomal recombination in the adjacent region 2,

227 oint, and therefore long-range resection, in interchromosomal recombination is due to a need to incre

228 now report the involvement of these genes in interchromosomal recombination occurring via crossovers

229 Interchromosomal recombination of subtelomeres is a pote

230 , RED1 and HOP1 do act in the normal meiotic interchromosomal recombination pathway; they reduce inte

231 romosomal recombination pathway; they reduce interchromosomal recombination to approximately 10% of n

232 ivation of the checkpoint partially restores interchromosomal recombination to exo1Delta sgs1Delta ce

233 However, the rate of interchromosomal recombination was increased in a rad59

234 duplication mutations, intrachromosomal and interchromosomal recombination, and required the wild-ty

235 expression of markers requires Cre-mediated interchromosomal recombination.

236 bility of RE to stimulate different forms of interchromosomal recombination.

237 ces in the chromosome and favors intra- over interchromosomal recombination.

238 ranslocations, some of which may result from interchromosomal recombination.

239 nsive breakage of nuclear DNA and stimulated interchromosomal recombination.

240 t mutants also show a defect specifically in interchromosomal recombination.

241 hich favours non-homologous end joining over interchromosomal recombination.

242 Interchromosomal recombinations between c-myc and immuno

243 ular machinery for generating characteristic interchromosomal recombinations can be found in all stra

244 ar stress, BCL9 is recruited adjacent to the interchromosomal regions, where it stabilizes the mRNA o

245 The results are in striking contrast with interchromosomal repair of a single DSB in an analogous

246 closely linked repeats, but are required for interchromosomal repeat recombination in Saccharomyces c

247 In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S.

248 uct arising from recombination between large interchromosomal ribosome-containing segmental duplicati

249 Both intra- and interchromosomal RNA polymerase-associated contacts invo

250 n subtelomeres are polymorphic patchworks of interchromosomal segmental duplications at the ends of c

251 Subtelomeres are concentrations of interchromosomal segmental duplications capped by telome

252 The duplication, among the largest interchromosomal segmental duplications described in hum

253 Interchromosomal segmental duplications including OR gen

254 ein-coding genes, and identified 8 new large interchromosomal segmental duplications.

255 t the nuclear volume can be divided into the interchromosomal space and the chromosome domains.

256 at they are unable to move freely within the interchromosomal space and thus unable to associate with

257 The interchromosomal spatial positionings of a subset of hum

258 short- and long-distance splicing, including interchromosomal splicing, in individual reads, using pr

259 vel measure of mapping ambiguity to discover interchromosomal SVs from mate-pair and pair-end sequenc

260 ever, MAT alpha donor preference is lost and interchromosomal switching is very inefficient.

261 In interchromosomal switching, with donors on chromosome II

262 e promotes chromatin loops that straddle the interchromosomal target sequences of this caRNA.

263 ncrease in accompanying mutations, including interchromosomal template switches (ICTS) involving high

264 HCC displayed frequent intra-chromosomal and interchromosomal templated insertion cycles (TIC), likel

265 Interchromosomal (trans) contacts have received much les

266 ealing extensive and preferential intra- and interchromosomal transcription interactomes.

267 ursting frequencies often occurred at shared interchromosomal transcriptional hubs.

268 Also, vpiT may have undergone interchromosomal translocation or may represent an indep

269 ntra-L1 rearrangements as well as a possible interchromosomal translocation.

270 Current methods can only identify interchromosomal translocations and long-range intrachro

271 her intrachromosomal (VDJ) rearrangements or interchromosomal translocations are a consistent feature

272 y with poor prognosis, and an association of interchromosomal translocations between GLIS3, GLIS1, an

273 d breakpoints involving intrachromosomal and interchromosomal translocations between three linkage gr

274 d switch region DNA double-strand breaks and interchromosomal translocations in the Igh locus.

275 promotes Alt-EJ-mediated CSR by suppressing interchromosomal translocations independent of end resec

276 4;11) and t(8;12) and potentially many other interchromosomal translocations throughout the human gen

277 n), which detects copy number variations and interchromosomal translocations within Hi-C data with br

278 lly, Cryptococcus genomes exhibited frequent interchromosomal translocations, including intercentrome

279 matin interactions induced by SVs, including interchromosomal translocations, large deletions and inv

280 at the MARs arose within the Arabis genus by interchromosomal transposition of a MAF1-like gene follo

281 xamine the two possible explanations of this interchromosomal uniformity: a common origin, such as ge

282 ation leads to increased aberrant intra- and interchromosomal V(D)J joining events.

283 There was some evidence for interchromosomal variation in the level of interference,

284 ate that mouse rearrangements are more often interchromosomal, whereas intrachromosomal rearrangement