ライフサイエンスコーパス: interferon regulatory factor

1 imics and decreased nuclear translocation of interferon regulatory factors.

2 surprisingly, transcriptional activation by interferon regulatory factors.

3 on and was associated with downregulation of interferon regulatory factor 1 (IRF-1) and decreased lev

4 ion and activity of the transcription factor interferon regulatory factor 1 (IRF-1) and expression of

5 ving inhibition of the transcription factors interferon regulatory factor 1 (IRF-1) and upstream stim

6 ion of type I interferon (IFN) signaling and interferon regulatory factor 1 (IRF-1) expression is req

7 The transcription factor interferon regulatory factor 1 (IRF-1) has a demonstrate

8 Interferon regulatory factor 1 (IRF-1) is a transcriptio

9 ion and joint-associated swelling.IMPORTANCE Interferon regulatory factor 1 (IRF-1) is a transcriptio

10 Interferon regulatory factor 1 (IRF-1) is a tumor suppre

11 Here we report that the transcription factor interferon regulatory factor 1 (IRF-1) is required for c

12 al deficiency of antiviral tumor-suppressive interferon regulatory factor 1 (IRF-1) selectively promo

13 growth factor beta (TGF-beta) signaling, and interferon regulatory factor 1 (IRF-1) transactivation.

14 of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcrip

15 b which has full enhancer activity and binds interferon regulatory factor 1 (IRF1) and nuclear factor

16 ransitioned cells are defective in inducible interferon regulatory factor 1 (IRF1) expression by occl

17 association in European Americans was at the interferon regulatory factor 1 (IRF1) locus on 5q31.1.

18 Forkhead box P3 (FOXP3) and interferon regulatory factor 1 (IRF1) showed higher meth

19 is highly dynamic at the STAT1 target gene, interferon regulatory factor 1 (IRF1), suggesting that a

20 ession of multiple antiviral ISGs, including interferon regulatory factor 1 (IRF1).

21 Tumor necrosis factor (TNF) and interferon regulatory factor 1 (IRFN1) were identified a

22 man herpesvirus 8 (HHV-8) gene product viral interferon regulatory factor 1 (vIRF-1) is targeted to m

23 Here, we show that HHV-8-encoded viral interferon regulatory factor 1 (vIRF-1) promotes mitocho

24 Viral interferon regulatory factor 1 (vIRF1), a Kaposi sarcoma

25 One such protein, viral interferon regulatory factor 1 (vIRF1), targets STING by

26 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from supp

27 rafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune r

28 effect is mediated in large part by the gene interferon regulatory factor 1.

29 The current study identifies interferon-regulatory factor 1 (IRF-1) to be one of such

30 lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription

31 expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in im

32 RPE) through STAT1-mediated up-regulation of Interferon Regulatory Factor-1 (IRF-1) and IRF-8.

33 Interferon regulatory factor-1 (IRF1) is a tumor suppres

34 The TNF receptors signaled through interferon regulatory factor-1 (IRF1) to induce interfer

35 ism by HCV NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrin

36 saccharide-induced nuclear factor-kappaB and interferon regulatory factor-1 activation in RAW 264.7 m

37 IRF1 (Interferon Regulatory Factor-1) is the prototype of the

38 nitric oxide synthase and cyclooxygenase-2, interferon regulatory factor-1, interferon-inducible pro

39 ConA induced nuclear translocation of interferon-regulatory factor-1 (IRF1) in hepatocytes in

40 Interferon regulatory factor 2 (IRF2) is a member of a f

41 network showing temporal specificity, and an interferon regulatory factor 2 (IRF2) transcription fact

42 ate that KRAS(*) represses the expression of interferon regulatory factor 2 (IRF2), which in turn dir

43 a-replication factor C3 (RFC3), FAM111A, and interferon regulatory factor 2 (IRF2)-were confirmed by

44 ess expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP

45 h ORF50, immediate early lytic K8, and viral interferon-regulatory factor 2 gene expression.

46 Viral sensing/interferon-regulatory factor 2 module expression and pla

47 ator of interferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-STING-TBK1-IRF3) si

48 The transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

49 sponses mediated by the transcription factor interferon regulatory factor 3 (IRF-3) are often vital f

50 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3) at a step subsequ

51 n in vitro, class II transactivator (CIITA), interferon regulatory factor 3 (IRF-3), and interferon r

52 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3), classically indu

53 -beta (TRIF), TRIF-related adaptor molecule, interferon regulatory factor 3 (IRF-3), receptor-interac

54 hibited poly(I.C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key

55 key proapoptotic protein in this pathway is interferon regulatory factor 3 (IRF-3), which upon activ

56 uently, binding of IFI44L to FKBP5 decreased interferon regulatory factor 3 (IRF-3)-mediated and nucl

57 HeLa cells, EV68 inhibits poly(I.C)-induced interferon regulatory factor 3 (IRF3) activation and bet

58 e, we report that exogenous IL-1beta induces interferon regulatory factor 3 (IRF3) activation in huma

59 (IFN-I) production through inhibition of the interferon regulatory factor 3 (IRF3) activation pathway

60 1 and -2 was required for phosphorylation of interferon regulatory factor 3 (IRF3) and accumulation o

61 f cytokines via TANK binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3) and inhibitor of n

62 s) required for initiating the activation of interferon regulatory factor 3 (IRF3) and interferon (IF

63 Interferon regulatory factor 3 (IRF3) and IRF7 are close

64 ents and activation of transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB, STI

65 It is known that STING utilizes interferon regulatory factor 3 (IRF3) and nuclear factor

66 r proteins leading to activation of both the interferon regulatory factor 3 (IRF3) and nuclear factor

67 in turn activates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor

68 this leads to sequential phosphorylation of interferon regulatory factor 3 (IRF3) and p65/RelA.

69 -dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

70 TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

71 then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recrui

72 Interferon regulatory factor 3 (IRF3) and type I interfe

73 Because the absence of interferon regulatory factor 3 (IRF3) does not increase

74 nse to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject o

75 of the immune signaling transcription factor interferon regulatory factor 3 (IRF3) in response to cyt

76 ndrial antiviral signaling protein (MAVS) or interferon regulatory factor 3 (IRF3) in the IFN inducti

77 Interferon regulatory factor 3 (IRF3) is a transcription

78 Interferon regulatory factor 3 (IRF3) is an important tr

79 e also induced directly by pathogens via the interferon regulatory factor 3 (IRF3) pathway.

80 ic acid (S386D) in ANDV N robustly inhibited interferon regulatory factor 3 (IRF3) phosphorylation an

81 y and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation an

82 the interferon beta (IFN-beta) promoter and interferon regulatory factor 3 (IRF3) phosphorylation.

83 Interferon regulatory factor 3 (IRF3) plays a central ro

84 Interferon regulatory factor 3 (IRF3) regulates hepatocy

85 n cyclic GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3) signaling.

86 ntly phosphorylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interfe

87 antagonist capable of blocking activation of interferon regulatory factor 3 (IRF3) via the retinoic a

88 sible for HIV-1 targeting and degradation of interferon regulatory factor 3 (IRF3), a central transcr

89 Interferon regulatory factor 3 (IRF3), a key signal medi

90 cells causes partial proteolytic cleavage of interferon regulatory factor 3 (IRF3), a key transcripti

91 hondrial antiviral signaling protein (MAVS), interferon regulatory factor 3 (IRF3), or Interferon-alp

92 uit TANK-binding kinase 1 (TBK1) to activate interferon regulatory factor 3 (IRF3), resulting in prod

93 E) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essentia

94 s alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription fa

95 rom the site of inoculation independently of interferon regulatory factor 3 (IRF3)-, IRF7-, and IFNAR

96 R OF INTERFERON GENES (STING), activating an INTERFERON REGULATORY FACTOR 3 (IRF3)-mediated immune re

97 rylation of TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3).

98 factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3).

99 ne system by facilitating the degradation of interferon regulatory factor 3 (IRF3).

100 hways that activate the transcription factor interferon regulatory factor 3 (IRF3).

101 lities to modulate apoptosis, NF-kappaB, and interferon regulatory factor 3 (IRF3).

102 a cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3).

103 F-kappaB), TANK-binding kinase 1 (TBK1), and interferon regulatory factor 3 (IRF3).

104 IFN-beta promoter when it was stimulated by interferon regulatory factor 3 (IRF3)/5D or its upstream

105 Here we report that the virus-encoded interferon regulatory factor 3 (vIRF3) latent viral gene

106 anscription factors was increased, including interferon regulatory factor 3 and 7 (IRF-3 and IRF-7) a

107 pter-inducing interferon-beta), and affected interferon regulatory factor 3 and 7 (IRF3-IRF7).

108 ciated with increased baseline expression of interferon regulatory factor 3 and 7 mRNAs and productio

109 985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiprolifer

110 ic inhibition of viral replication, which is interferon regulatory factor 3 dependent.

111 l28ra(-/-)), and mice with disruption of the interferon regulatory factor 3 gene (Irf3(-/-)), with or

112 ded protein response before transcription of interferon regulatory factor 3 induced genes.

113 etion of the downstream transcription factor interferon regulatory factor 3 resulted in reduced induc

114 ding activation of the TANK binding kinase 1/interferon regulatory factor 3 type I interferon pathway

115 f interferon genes - tank-binding kinase 1 - interferon regulatory factor 3) pathway, shedding light

116 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3) signaling cascade leadin

117 hatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription fa

118 s in which it activated STING and its target interferon regulatory factor 3, which directly induced m

119 e via the restoration of host immunity in an interferon regulatory factor 3-dependent manner.

120 nished alcohol-induced hepatic steatosis and interferon regulatory factor 3-mediated apoptosis.

121 cifically, these pathogens directly suppress interferon regulatory factor 3.

122 pressing constitutively active NF-kappaB and interferon regulatory factor 3.

123 on and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and

124 ase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factors 3 and 7, and rhinovirus in

125 We also demonstrated that interferon-regulatory factor 3 (IRF3) is transiently rec

126 articular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in E

127 this study we have defined the mechanisms of interferon regulatory factor-3 (IRF-3) signaling in prim

128 increased PTEN/TLR4 (Toll-like receptor 4), interferon regulatory factor-3 (IRF3), nuclear factor ka

129 plex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has bee

130 or B cell development and function, cellular interferon regulatory factor 4 (c-IRF4) directly regulat

131 Interferon regulatory factor 4 (IRF-4) is essential for

132 Interferon regulatory factor 4 (IRF4) and IRF8 regulate

133 Here, we identify interferon regulatory factor 4 (IRF4) as a dominant tran

134 es myeloid and B-cell leukemia by inhibiting interferon regulatory factor 4 (IRF4) but through distin

135 th of which are dependent on M2 induction of interferon regulatory factor 4 (IRF4) expression.

136 rtance of the oncogenic transcription factor interferon regulatory factor 4 (IRF4) in hematological m

137 Interferon regulatory factor 4 (IRF4) is a critical tran

138 Interferon regulatory factor 4 (IRF4) is a member of the

139 Interferon regulatory factor 4 (IRF4) is an IRF family t

140 Interferon regulatory factor 4 (IRF4) is central to the

141 Interferon regulatory factor 4 (IRF4) is induced upon th

142 The interferon regulatory factor 4 (IRF4) is known to be hig

143 d chemokine production, lung histopathology, interferon regulatory factor 4 (IRF4) mRNA expression, a

144 microbial products, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulator

145 Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcri

146 T) proteins and on the cooperative action of interferon regulatory factor 4 (IRF4) with activator pro

147 type is accompanied by a higher induction of interferon regulatory factor 4 (IRF4), a transcriptional

148 Here, we report that interferon regulatory factor 4 (IRF4), dispensable for e

149 et is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required

150 molecules, IL-2Ralpha, T-bet, IFNgammaR, and interferon regulatory factor 4 (IRF4).

151 y the expression of the transcription factor interferon regulatory factor 4 (IRF4).

152 ated STAT3 and reduced protein expression of interferon regulatory factor 4 and B-cell lymphoma 6 (BC

153 n and small molecule inhibition downregulate interferon regulatory factor 4 and MYC, and provides an

154 on loop mediated by the transcription factor interferon regulatory factor 4 and the chemokine recepto

155 induction of the transcription factors IRF4 (interferon regulatory factor 4) and Bcl6, driving both e

156 c deletion of the transcription factor IRF4 (interferon regulatory factor 4) in Tcl-1 transgenic mice

157 of lenalidomide are associated with reduced interferon regulatory factor 4, a downstream target of c

158 mide treatment resulted in downregulation of interferon regulatory factor 4, a transcription factor f

159 hemistry for MYC, BCL2, CD10, BCL6, and MUM1/interferon regulatory factor 4, and fluorescent in situ

160 sion of CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome prolifera

161 cluding CCAAT/enhancer-binding protein-beta, interferon regulatory factor 4, and peroxisome prolifera

162 tion was found to be driven by 2 variants of interferon regulatory factor 4-dependent dermal type 2 c

163 ough a mechanism that involves activation of interferon regulatory factor 4.

164 The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B

165 revious study found microglial expression of interferon regulatory factor 5 (IRF5) and IRF4 was relat

166 The transcription factor interferon regulatory factor 5 (IRF5) exerts crucial fun

167 Variation in the interferon regulatory factor 5 (IRF5) gene has been asso

168 Polymorphisms in the interferon regulatory factor 5 (IRF5) gene have been con

169 Transcription factor interferon regulatory factor 5 (IRF5) has been implicate

170 Similar to Puma, the transcription factor interferon regulatory factor 5 (Irf5) has been reported

171 hether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macroph

172 Interferon regulatory factor 5 (IRF5) is a key transcrip

173 Interferon regulatory factor 5 (IRF5) is a member of the

174 Interferon regulatory factor 5 (IRF5) is a molecule of i

175 Interferon regulatory factor 5 (IRF5) is a transcription

176 The transcription factor interferon regulatory factor 5 (IRF5) is essential for t

177 During infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for t

178 We show that interferon regulatory factor 5 (IRF5) mediates IAV-induc

179 f p53-mediated LMP1 expression, we find that interferon regulatory factor 5 (IRF5), a direct target o

180 4 kinase activity controls the activation of interferon regulatory factor 5 (IRF5), a transcription f

181 Interferon regulatory factor 5 (IRF5), associated with M

182 henotype due to decreased P-STAT1 (Y701) and interferon regulatory factor 5 compared with NOD mice.

183 Mechanistically, lack of IRAK4 resulted in interferon regulatory factor 5 homodimerization via redu

184 nanoparticles formulated with mRNAs encoding interferon regulatory factor 5 in combination with its a

185 crosis factor-alpha, the chemokine CCL2, and interferon regulatory factor-5 (IRF5), a marker of infla

186 Interferon regulatory factor 6 ( IRF6) acts as a tumor s

187 Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated wi

188 Mutations in interferon regulatory factor 6 (IRF6) account for approx

189 Interferon Regulatory Factor 6 (IRF6) and TWIST1 are tra

190 tor-interacting protein kinase 4 (RIPK4) and interferon regulatory factor 6 (IRF6) are critical regul

191 actor beta (TGFbeta) signaling molecules and interferon regulatory factor 6 (Irf6) have been identifi

192 Interferon Regulatory Factor 6 (Irf6)-deficient mice die

193 ion of canonical WNT signaling perturbed p63/interferon regulatory factor 6 (p63/IRF6) signaling, res

194 Mutations in IRF6 (Interferon Regulatory Factor 6) and GRHL3 (Grainyhead-li

195 N-lambda expression by hMPV was dependent on interferon regulatory factor 7 (IRF-7) expression but no

196 Interferon regulatory factor 7 (IRF-7) is a transcriptio

197 Interferon regulatory factor 7 (IRF-7) is an innate immu

198 interferon regulatory factor 3 (IRF-3), and interferon regulatory factor 7 (IRF-7) were not required

199 C in LMP1 signaling leading to NF-kappaB and interferon regulatory factor 7 (IRF7) activation has not

200 f (RHIM) domains of TRIF and RIP1 to disrupt interferon regulatory factor 7 (IRF7) activity, a critic

201 ander cells resist STAT1 phosphorylation and interferon regulatory factor 7 (IRF7) induction in respo

202 ly shown that ORF45 suppresses activation of interferon regulatory factor 7 (IRF7), a crucial regulat

203 Interferon regulatory factor 7 (IRF7), a key innate immu

204 nate antiviral immunity by downregulation of interferon regulatory factor 7 (IRF7), an immune factor

205 r MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interf

206 Furthermore, the interferon regulatory factor 7 (IRF7), but not IRF3, tra

207 n to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I i

208 specific target of LMP1-induced sumoylation, interferon regulatory factor 7 (IRF7).

209 anistically, IL-33 downregulated viperin and interferon regulatory factor 7 gene expression and rapid

210 mRNAs and production of distinct isoforms of interferon regulatory factor 7 protein.

211 Lastly translocation of interferon regulatory factor 7(IRF7) from the cytosol to

212 The transcription factor IRF7 (interferon regulatory factor 7) is a key regulator of ty

213 cated suppression of antiviral host factors (interferon regulatory factor 7, CXCL10 [gamma interferon

214 IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy

215 ce of hyperconnected hub nodes, most notably interferon regulatory factor 7, which was identified as

216 Foxp3(+) Tregs showed reduced expression of interferon regulatory factor 8 (IRF-8)/aldehyde dehydrog

217 cent epidemiological studies have identified interferon regulatory factor 8 (IRF8) as a susceptibilit

218 The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both deve

219 fied novel associations in the chromosome 16 interferon regulatory factor 8 (IRF8) gene (P-value = 2.

220 Interferon regulatory factor 8 (IRF8) is a key regulator

221 Interferon regulatory factor 8 (IRF8) is known to affect

222 The homozygous K108E mutation of interferon regulatory factor 8 (IRF8) is reported to cau

223 Here we show that interferon regulatory factor 8 (IRF8) is required for th

224 Interferon regulatory factor 8 (IRF8) protein plays a cr

225 ROCK2 directly phosphorylated interferon regulatory factor 8 (IRF8), a crucial mediato

226 Previously, we found that interferon regulatory factor 8 (IRF8), also known as int

227 epressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly e

228 eded the genome-wide significance threshold: interferon regulatory factor 8 (IRF8; rs11644034; p(meta

229 otein Pellino-1 and the transcription factor interferon regulatory factor 8.

230 k between Wnt/beta-catenin signaling and the interferon-regulatory factor 8 (Irf8).

231 Interferon regulatory factor-8 (IRF-8) is a transcriptio

232 rise from perturbations in the regulation of interferon regulatory factor-8 (IRF-8), an integral tran

233 ongest association for 3 SNPs located in the interferon regulatory factor-8 (IRF8) gene.

234 feron-stimulated gene factor 3 [ISGF3]) with interferon regulatory factor 9 (IRF9) and translocate to

235 d activator of transcription (STAT) 1 and 2, interferon regulatory factor 9, N-myc and STAT interacto

236 , thus preventing association of hSTAT2 with interferon regulatory factor 9.

237 In vitro, increased expression of interferon regulatory factor-9 and IRG1 and itaconic aci

238 miR93 inhibits interferon regulatory factor-9 to decrease IRG1-itaconic

239 ed that IRG1 is not an miR93 target but that interferon regulatory factor-9, which can regulate IRG1

240 were conducted to examine the role of miR93-interferon regulatory factor-9-immunoresponsive gene-1 (

241 ulator (NEMO), an essential adaptor bridging interferon-regulatory factor and NF-kappaB activation.

242 cally, we demonstrated that TRIM29 inhibited interferon-regulatory factors and signaling via the tran

243 iallelic mutations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK

244 ially regulated cell genes identified an ETS-interferon regulatory factor composite element motif tha

245 ent expression of DNA-dependent activator of interferon regulatory factors (DAI, also known as ZBP1 o

246 ceptor 9 (TLR-9), DNA-dependent activator of interferon-regulatory factors (DAI), and absent in melan

247 h these receptors stimulates, in most cases, interferon regulatory factor-dependent type I IFN synthe

248 tion factors from Nuclear Factor (NF)-kB and Interferon Regulatory Factor families.

249 gulators of type I and type III interferons, interferon regulatory factor (IRF) 3 and IRF7, were sign

250 kinase-1 (TBK1)-dependent phosphorylation of interferon regulatory factor (IRF) 3 and transcription o

251 rs TRAM and TRIF, resulting in activation of interferon regulatory factor (IRF) 3.

252 Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 an

253 e, using 6-week-old mice triply deficient in interferon regulatory factor (IRF) as a model, we show t

254 er of adipocyte inflammation, members of the interferon regulatory factor (IRF) family may also play

255 Interferon regulatory factor (IRF) family members have b

256 Members of the interferon regulatory factor (IRF) family of transcripti

257 Here, we showed that IRF2, a member of the interferon regulatory factor (IRF) family of transcripti

258 IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critic

259 We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also res

260 that secretes excess c-di-AMP activates the interferon regulatory factor (IRF) pathway with enhanced

261 Interferon regulatory factor (IRF) regulation of the typ

262 ex pattern of deregulated TFs, we discovered interferon regulatory factor (IRF) sites among the top e

263 riven by nuclear factor kappa B (NF-kappaB), interferon regulatory factor (IRF), and the signal trans

264 Notably, interferon regulatory factor (IRF)-3 and -7 are the key

265 The transcription factor interferon regulatory factor (IRF)-5 is an important mod

266 ctly targeting high mobility group box-1 and interferon regulatory factor (IRF)-5, preventing activat

267 iethylhexyl phthalate suppressed CpG-induced interferon regulatory factor (IRF)-7 expression by suppr

268 e shared genes showed sequences required for interferon regulatory factor (IRF)-mediated transcriptio

269 Further experiments identified interferon regulatory factor (IRF)7, a driver of type I

270 ith activation of the dsRNA sensor RIG-I and interferon regulatory factor (IRF)7.

271 gnaling pathways and cause activation of the interferon regulatory factor (IRF-3) transcription facto

272 Interferon regulatory factors (IRF) have critical functi

273 f transcription 1 [STAT1], protein kinase R, interferon regulatory factors (IRF) IRF-1, IRF-3, IRF-5,

274 These include the interferon regulatory factor, IRF1, and the chemokine, C

275 of the PD-L1 transcriptional repressors, the interferon regulatory factors IRF2 and IRF2BP2, which li

276 with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is me

277 s the activation of the transcription factor interferon regulatory factor (IRF4), which, along with t

278 The restrictive effects of IFN-I require the interferon regulatory factor IRF5, which upregulates gen

279 )-STING pathway and subsequent activation of interferon regulatory factors (IRFs) 3 and 7, type I int

280 ron (IFN) signalling, including upregulating interferon regulatory factors (IRFs) and downregulating

281 ron response that could be driven in part by interferon regulatory factors (IRFs) and increased NF-ka

282 ositive-feedback loops mediated by inducible interferon regulatory factors (IRFs) and retinoic acid i

283 Interferon regulatory factors (IRFs) are mediators of th

284 The interferon regulatory factors (IRFs) are transcription f

285 The key role of Interferon regulatory factors (IRFs) as controllers of t

286 Interferon regulatory factors (IRFs) play functionally d

287 y shown that three KSHV homologs of cellular interferon regulatory factors (IRFs), known as viral IRF

288 known to encode viral homologues to cellular interferon regulatory factors (IRFs), known as vIRFs.

289 at they express viral homologues to cellular interferon regulatory factors (IRFs), termed viral IRFs

290 eir expression of viral homologs of cellular interferon regulatory factors (IRFs), termed viral IRFs

291 ular patterns, and signal downstream through interferon regulatory factors (IRFs), transcription fact

292 tors; principal among these is the family of interferon regulatory factors (IRFs).

293 e, cyclooxygenase-2) and a MyD88-independent interferon regulatory factor-mediated pathway that regul

294 in melanoma 2 and DNA-dependent activator of interferon regulatory factor) opened a new paradigm: Nuc

295 MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulatory factor pathways.

296 Interferon regulatory factors play an important role in

297 thways involving CREB1, NF-kappaB, STAT, and interferon regulatory factor signaling.

298 ies, including beta-catenin, Ap-1, NFkappaB, interferon regulatory factors, STATs, JUN, and p53.

299 man herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs 1 to 4), all of whi

300 demonstrated that DNA-dependent activator of interferon regulatory factors/Z-DNA binding protein 1 (D