ライフサイエンスコーパス: interferon regulatory factor-3

1 ding kinase 1, inducible IkappaB kinase, and interferon regulatory factor 3.

2 acid-inducible gene I (RIG-I) and downstream interferon regulatory factor 3.

3 cifically, these pathogens directly suppress interferon regulatory factor 3.

4 pressing constitutively active NF-kappaB and interferon regulatory factor 3.

5 al responses including activation of PKR and interferon regulatory factor 3.

6 IRF3 (interferon regulatory factor 3), a proinflammatory trans

7 r double-stranded RNA-mediated activation of interferon regulatory factor 3, a transcription factor t

8 al for innate immune signaling of downstream interferon regulatory factor 3 activation and interferon

9 RIG-I binds PAMP RNA and signals interferon regulatory factor 3 activation to induce the

10 ng NF-kappaB, TLR3/4 pathways also stimulate interferon regulatory factor 3 activation.

11 sion of the shRNA results in dimerization of interferon regulatory factor-3, activation of IFN promot

12 Rip1 expression stimulates NF-kappaB but not interferon regulatory factor 3 activity.

13 anscription factors was increased, including interferon regulatory factor 3 and 7 (IRF-3 and IRF-7) a

14 pter-inducing interferon-beta), and affected interferon regulatory factor 3 and 7 (IRF3-IRF7).

15 ciated with increased baseline expression of interferon regulatory factor 3 and 7 mRNAs and productio

16 dent and -independent pathways that activate interferon regulatory factor 3 and cytokine expression.

17 985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiprolifer

18 r and blocking downstream activation of both interferon regulatory factor 3 and nuclear factor kappa

19 on and decreased the nuclear accumulation of interferon regulatory factors 3 and 7 (IRF3 and -7) and

20 ase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factors 3 and 7, and rhinovirus in

21 ctivation of the transcription factors IRF3 (interferon regulatory factor 3) and IRF7.

22 ator of interferon genes-TANK-binding kinase-interferon regulatory factor 3 (cGAS-STING-TBK1-IRF3) si

23 ic inhibition of viral replication, which is interferon regulatory factor 3 dependent.

24 PAK1 knockdown did not reduce interferon regulatory factor 3-dependent gene expression

25 e via the restoration of host immunity in an interferon regulatory factor 3-dependent manner.

26 Interferon regulatory factor 3 does not appear to be pre

27 l28ra(-/-)), and mice with disruption of the interferon regulatory factor 3 gene (Irf3(-/-)), with or

28 including E6AP, ERC55, paxillin, hDlg, p300, interferon regulatory factor 3, hMCM7, Bak, and E6TP1.

29 s showed greater activation of NF-kappaB and interferon regulatory factor 3 in response to LPS and po

30 ded protein response before transcription of interferon regulatory factor 3 induced genes.

31 directed by a constitutively active form of interferon regulatory factor 3 (IRF-3 5D), and IRF-3 is

32 was associated with nuclear translocation of interferon regulatory factor 3 (IRF-3) and IRF-7.

33 the signal through the transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

34 the early IFN-beta and -alpha1 response are interferon regulatory factor 3 (IRF-3) and nuclear facto

35 The transcription factors interferon regulatory factor 3 (IRF-3) and nuclear facto

36 ng pathways that lead to viral activation of interferon regulatory factor 3 (IRF-3) and synthesis of

37 DRAF1 is composed of interferon regulatory factor 3 (IRF-3) and the transcrip

38 ponents of DRAF1 have now been identified as interferon regulatory factor 3 (IRF-3) and the transcrip

39 sponses mediated by the transcription factor interferon regulatory factor 3 (IRF-3) are often vital f

40 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3) at a step subsequ

41 Inhibition of phosphorylation of interferon regulatory factor 3 (IRF-3) by the Ebola VP35

42 e models, the antiviral transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus

43 s found to restore the responsiveness of the interferon regulatory factor 3 (IRF-3) in cells containi

44 3, during chronic virus infection.IMPORTANCE Interferon regulatory factor 3 (IRF-3) is a critical com

45 Interferon regulatory factor 3 (IRF-3) is a key transcri

46 Interferon regulatory factor 3 (IRF-3) is essential for

47 It is now known that neither STAT1 nor interferon regulatory factor 3 (IRF-3) play essential ro

48 Interferon regulatory factor 3 (IRF-3) plays a central r

49 ltimeric transcription factor containing the interferon regulatory factor 3 (IRF-3) protein and one o

50 The transcription factor interferon regulatory factor 3 (IRF-3) regulates genes i

51 Interferon regulatory factor 3 (IRF-3) undergoes phospho

52 Interferon regulatory factor 3 (IRF-3) was identified as

53 protease, Sendai virus-induced activation of interferon regulatory factor 3 (IRF-3), a key antiviral

54 ron response by inhibiting the activation of interferon regulatory factor 3 (IRF-3), a key regulator

55 Nile virus NY (WNV-NY) delays activation of interferon regulatory factor 3 (IRF-3), a transcription

56 us-induced phosphorylation and activation of interferon regulatory factor 3 (IRF-3), a transcription

57 e interaction between gammaherpesviruses and interferon regulatory factor 3 (IRF-3), a ubiquitously e

58 the latent transcription factors NF-kappaB, interferon regulatory factor 3 (IRF-3), and ATF-2, which

59 n in vitro, class II transactivator (CIITA), interferon regulatory factor 3 (IRF-3), and interferon r

60 yxovirus infection induces apoptosis through interferon regulatory factor 3 (IRF-3), but the exact me

61 actors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF-3), classically indu

62 ocation of the IFN-beta transcription factor interferon regulatory factor 3 (IRF-3), MHV did not indu

63 ponse, as characterized by the activation of interferon regulatory factor 3 (IRF-3), production of in

64 -beta (TRIF), TRIF-related adaptor molecule, interferon regulatory factor 3 (IRF-3), receptor-interac

65 NF-kappaB and interferon regulatory factor 3 (IRF-3), the two major tr

66 ating signaling that activates NF-kappaB and interferon regulatory factor 3 (IRF-3), thereby inducing

67 hibited poly(I.C)-induced phosphorylation of interferon regulatory factor 3 (IRF-3), which is the key

68 key proapoptotic protein in this pathway is interferon regulatory factor 3 (IRF-3), which upon activ

69 inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promote

70 uently, binding of IFI44L to FKBP5 decreased interferon regulatory factor 3 (IRF-3)-mediated and nucl

71 to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3).

72 HSV-1, we isolated HFs depleted of STAT-1 or interferon regulatory factor 3 (IRF-3).

73 ssembly of a complex between ATF-2-c-jun and interferon regulatory factor 3 (IRF-3).

74 viral activation of the transcription factor interferon regulatory factor 3 (IRF-3).

75 olic RIG-I pathway, requires the presence of interferon regulatory factor 3 (IRF-3).

76 response by sequestration and degradation of interferon regulatory factor 3 (IRF-3).

77 Interferon regulatory factor-3 (IRF-3) activation direct

78 involves activation of transcription factors interferon regulatory factor-3 (IRF-3) and NF-kappaB, re

79 and suppressed the downstream activation of interferon regulatory factor-3 (IRF-3) and nuclear facto

80 Here, we show that the human interferon regulatory factor-3 (IRF-3) gene promoter con

81 Interferon regulatory factor-3 (IRF-3) has been implicat

82 this study we have defined the mechanisms of interferon regulatory factor-3 (IRF-3) signaling in prim

83 Interferon regulatory factor-3 (IRF-3) was found to spec

84 s the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular a

85 HeLa cells, EV68 inhibits poly(I.C)-induced interferon regulatory factor 3 (IRF3) activation and bet

86 e, we report that exogenous IL-1beta induces interferon regulatory factor 3 (IRF3) activation in huma

87 We have identified potential pathways, via interferon regulatory factor 3 (IRF3) activation or Hoxa

88 (IFN-I) production through inhibition of the interferon regulatory factor 3 (IRF3) activation pathway

89 1 and -2 was required for phosphorylation of interferon regulatory factor 3 (IRF3) and accumulation o

90 sed S. pneumoniae induced phosphorylation of interferon regulatory factor 3 (IRF3) and activating tra

91 ar translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent ind

92 onse to microbial components, TBK1 activates interferon regulatory factor 3 (IRF3) and cytokine expre

93 f cytokines via TANK binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3) and inhibitor of n

94 s) required for initiating the activation of interferon regulatory factor 3 (IRF3) and interferon (IF

95 Interferon regulatory factor 3 (IRF3) and IRF7 are close

96 The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are

97 stimulator 1 (IPS-1)-mediated activation of interferon regulatory factor 3 (IRF3) and NF-kappaB sign

98 ents and activation of transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB, STI

99 tion of two inducible transcription factors, interferon regulatory factor 3 (IRF3) and NF-kappaB.

100 tested the impact of ISG15 and ISGylation on interferon regulatory factor 3 (IRF3) and NFkappaB signa

101 in turn activates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor

102 It is known that STING utilizes interferon regulatory factor 3 (IRF3) and nuclear factor

103 r proteins leading to activation of both the interferon regulatory factor 3 (IRF3) and nuclear factor

104 nscription via transcription factors such as interferon regulatory factor 3 (IRF3) and nuclear factor

105 this leads to sequential phosphorylation of interferon regulatory factor 3 (IRF3) and p65/RelA.

106 h promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of I

107 gomerization of STING and phosphorylation of interferon regulatory factor 3 (IRF3) and STING.

108 phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent exp

109 ds to activation of the transcription factor interferon regulatory factor 3 (IRF3) and subsequent tra

110 -dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

111 TBK1 phosphorylates the transcription factor Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquit

112 then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recrui

113 Interferon regulatory factor 3 (IRF3) and type I interfe

114 ls by preventing not only phosphorylation of interferon regulatory factor 3 (IRF3) but also degradati

115 d not bind MDA5 efficiently, did not inhibit interferon regulatory factor 3 (IRF3) dimerization or IF

116 Because the absence of interferon regulatory factor 3 (IRF3) does not increase

117 Within our dataset, Interferon regulatory factor 3 (IRF3) emerged as a leadi

118 nse to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject o

119 of the immune signaling transcription factor interferon regulatory factor 3 (IRF3) in response to cyt

120 ndrial antiviral signaling protein (MAVS) or interferon regulatory factor 3 (IRF3) in the IFN inducti

121 on of ZAP occurs under the direct control of interferon regulatory factor 3 (IRF3) independent of int

122 Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transc

123 Interferon regulatory factor 3 (IRF3) is a transcription

124 Interferon regulatory factor 3 (IRF3) is an important tr

125 interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a ma

126 Interferon regulatory factor 3 (IRF3) is known to partic

127 Interferon regulatory factor 3 (IRF3) is known to regula

128 nd the TLR2 and TLR3 mediated signalling.The interferon regulatory factor 3 (IRF3) pathway remained u

129 ria associated 1 (AIFM1)-caspase-6-caspase-3-interferon regulatory factor 3 (IRF3) pathway, and caspa

130 e also induced directly by pathogens via the interferon regulatory factor 3 (IRF3) pathway.

131 ic acid (S386D) in ANDV N robustly inhibited interferon regulatory factor 3 (IRF3) phosphorylation an

132 y and confirmed that these miRNAs potentiate interferon regulatory factor 3 (IRF3) phosphorylation an

133 (iii) delivery of the viral genome triggers interferon regulatory factor 3 (IRF3) phosphorylation, a

134 nduction of TBK1 alone is not sufficient for interferon regulatory factor 3 (IRF3) phosphorylation.

135 the interferon beta (IFN-beta) promoter and interferon regulatory factor 3 (IRF3) phosphorylation.

136 Interferon regulatory factor 3 (IRF3) plays a central ro

137 Interferon regulatory factor 3 (IRF3) regulates hepatocy

138 n cyclic GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3) signaling.

139 activation of the TANK-binding kinase (TBK1)-interferon regulatory factor 3 (IRF3) signalling axis to

140 tiviral interferon antagonist which degrades interferon regulatory factor 3 (IRF3) through the protea

141 ntly phosphorylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interfe

142 antagonist capable of blocking activation of interferon regulatory factor 3 (IRF3) via the retinoic a

143 ta but not IFN-gamma, and both NF-kappaB and interferon regulatory factor 3 (IRF3) were required.

144 sible for HIV-1 targeting and degradation of interferon regulatory factor 3 (IRF3), a central transcr

145 Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for th

146 Interferon regulatory factor 3 (IRF3), a key signal medi

147 Interferon regulatory factor 3 (IRF3), a key transcripti

148 cells causes partial proteolytic cleavage of interferon regulatory factor 3 (IRF3), a key transcripti

149 Liver expression of interferon regulatory factor 3 (IRF3), a MyD88-independe

150 N(pro) also targets interferon regulatory factor 3 (IRF3), a transcription f

151 ng cause, we determined the effect of E3L on interferon regulatory factor 3 (IRF3), a transcription f

152 N-lambda) via activating caspase-3 to cleave interferon regulatory factor 3 (IRF3), and caspase-3 inh

153 at least in part, of the recently identified interferon regulatory factor 3 (IRF3), but it does not c

154 luding nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3), leading to profou

155 eic acid-sensing pathways by down-regulating interferon regulatory factor 3 (IRF3), leading to resist

156 hondrial antiviral signaling protein (MAVS), interferon regulatory factor 3 (IRF3), or Interferon-alp

157 uit TANK-binding kinase 1 (TBK1) to activate interferon regulatory factor 3 (IRF3), resulting in prod

158 epatitis C virus (HCV) genomic RNA activates interferon regulatory factor 3 (IRF3), thereby inducing

159 E) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essentia

160 paB, commonly activated by several TLRs, and interferon regulatory factor 3 (IRF3), which was found t

161 s alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3),a transcription fa

162 rom the site of inoculation independently of interferon regulatory factor 3 (IRF3)-, IRF7-, and IFNAR

163 We identify an interferon regulatory factor 3 (IRF3)-dependent but type

164 ation of toll-like receptor 4 (TLR4) and its interferon regulatory factor 3 (IRF3)-dependent downstre

165 Interferon regulatory factor 3 (IRF3)-dependent IFN prof

166 identifies both inhibitors and activators of interferon regulatory factor 3 (IRF3)-mediated gene indu

167 R OF INTERFERON GENES (STING), activating an INTERFERON REGULATORY FACTOR 3 (IRF3)-mediated immune re

168 f the beta interferon gene via activation of interferon regulatory factor 3 (IRF3).

169 F-kappaB), TANK-binding kinase 1 (TBK1), and interferon regulatory factor 3 (IRF3).

170 by distinct innate immune signaling through interferon regulatory factor 3 (IRF3).

171 tically, CTPS1 interacts with and deamidates interferon regulatory factor 3 (IRF3).

172 rylation of TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3).

173 factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3).

174 ne system by facilitating the degradation of interferon regulatory factor 3 (IRF3).

175 hways that activate the transcription factor interferon regulatory factor 3 (IRF3).

176 lities to modulate apoptosis, NF-kappaB, and interferon regulatory factor 3 (IRF3).

177 a cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3).

178 but is dependent on the transcription factor interferon regulatory factor 3 (IRF3).

179 IFN-beta promoter when it was stimulated by interferon regulatory factor 3 (IRF3)/5D or its upstream

180 ctivates the transcription factors NFkappaB, interferon regulatory factor-3 (IRF3) and CCAAA/enhancer

181 increased PTEN/TLR4 (Toll-like receptor 4), interferon regulatory factor-3 (IRF3), nuclear factor ka

182 in an MyD88-independent manner that involves interferon regulatory factor-3 (IRF3).

183 lasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of

184 We also demonstrated that interferon-regulatory factor 3 (IRF3) is transiently rec

185 articular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in E

186 Immediately upon entry, viruses activate interferon-regulatory factor 3 (IRF3), as well as nuclea

187 However, activation of interferon regulatory factor 3 is only essential for ind

188 ion in endotoxin-tolerized cells as shown in interferon regulatory factor-3 knock-out mice.

189 nished alcohol-induced hepatic steatosis and interferon regulatory factor 3-mediated apoptosis.

190 endent of the retinoic acid-inducible gene I/interferon regulatory factor 3 pathway.

191 f interferon genes - tank-binding kinase 1 - interferon regulatory factor 3) pathway, shedding light

192 Furthermore, C. jejuni induced interferon regulatory factor 3 phosphorylation and IFN-b

193 etion of the downstream transcription factor interferon regulatory factor 3 resulted in reduced induc

194 plex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has bee

195 1)-AKT (AKT serine/threonine kinase 1)-IRF3 (interferon regulatory factor 3) signaling cascade leadin

196 activated IFN-inducing transcription factor interferon regulatory factor 3 that collaborates with P3

197 hatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription fa

198 We propose that EBNA3A limits the binding of interferon regulatory factor 3 to the IFNbeta promoter,

199 ding activation of the TANK binding kinase 1/interferon regulatory factor 3 type I interferon pathway

200 Here we report that the virus-encoded interferon regulatory factor 3 (vIRF3) latent viral gene

201 s in which it activated STING and its target interferon regulatory factor 3, which directly induced m