ライフサイエンスコーパス: interictal

1 nts are generally regarded as subclinical or interictal.

2 nd postoperative MRI scans coregistered with interictal (18) FDG-PET.

3 Dynamic (18)F-FMZ PET and static interictal (18)F-FDG PET scans were compared in healthy

4 11 +/- 4 y; age range, 6-18 y) who underwent interictal (18)F-FDG PET, followed by 2-stage epilepsy s

5 te areas of hypometabolism typically seen on interictal 18F-fluorodeoxyglucose PET imaging in patient

6 onvulsant 4-aminopyridine was used to induce interictal activity and seizures in rat neocortical slic

7 Interictal activity in rats sustaining febrile status ep

8 or low concentrations of RuBi-GABA, affected interictal activity or baseline electrical activity in n

9 Neither T2 changes nor interictal activity predicted epileptogenesis.

10 , synchronized bursts (< 500 ms in duration, interictal activity) were seen as described previously.

11 In whole-slice recordings prominent interictal activity, but fewer ictal events were observe

12 genesis and defining the predictive roles of interictal activity, MRI, and inflammatory processes are

13 the fraction of neurons that participate in interictal activity.

14 We conclude that the interictal and early preictal states are dominated by GA

15 These findings indicate that interictal and ictal activity can originate in the same

16 that GABA-mediated signalling contributes to interictal and ictal activity.

17 gone video-EEG monitoring, brain MR imaging, interictal and ictal brain perfusion SPECT, SISCOM, and

18 vitro isolated guinea pig brain during focal interictal and ictal discharges induced in the limbic ne

19 Interictal and ictal EEG/fMRI can provide helpful inform

20 togenetic specimens, where the occurrence of interictal and ictal epileptiform activity was confirmed

21 ings, we examined the cellular correlates of interictal and ictal HFO events.

22 with unpaired Student's t tests and between interictal and postictal epochs within epileptic patient

23 Ten epileptic men completed both interictal and postictal epochs.

24 This study evaluates the interictal and postictal secretion of luteinizing hormon

25 been encouraged to perform ictal scanning or interictal and postictal SPECT studies.

26 Data were provided to participants as 10-min interictal and preictal clips, with approximately half o

27 networks involved in the generation of both interictal and PSs in acute models of limbic cortex icto

28 more effective than routine EEG at detecting interictal and subclinical epileptiform activity.

29 ilepsy (TLE), there is evidence of ictal and interictal autonomic dysregulation, predominantly with s

30 To determine whether the interictal AV conduction blocks were of cardiac or neura

31 lobe epilepsy during two 24-hour epochs: an interictal baseline and a postictal interval initiated b

32 Interictal baseline epochs were compared to those of hea

33 In two monogenic models of absence epilepsy, interictal beta/gamma power is augmented in homozygous s

34 e characterized ictal (during a seizure) and interictal (between seizure) cardiac arrhythmogenesis fo

35 in dynamics of patients with epilepsy during interictal (between-seizures) activity.

36 ified as a volume-of-distribution (VD), with interictal binding and with binding changes in 14 health

37 provide a quantitative novel description of interictal brain activity of patients with epilepsy.

38 Interictal brain energy metabolism and glutamate-glutami

39 cal measurements, specifically for ictal and interictal brain networks.

40 ts of neurons during burst generation, while interictal bursts appear to be stochastic events with ce

41 In contrast, neuronal firing order during interictal bursts appeared homogeneous, with no particul

42 at rhythmic population discharges resembling interictal bursts can be induced in hippocampal slices f

43 model (in both sexes) that the frequency of interictal bursts increased after CBZ perfusion.

44 polarizing potentials (GDPs) and spontaneous interictal bursts recorded in bicuculline, a GABA(A) rec

45 the period of post-ictal suppression, during interictal bursts, and also at other times, through more

46 tors shortened the preictal phase, abolished interictal bursts, and attenuated the slow preictal depo

47 ates periodic population discharges known as interictal bursts.

48 ler again in the reduced model incorporating interictal but not ictal measures (R(2) 0.27; Area under

49 cna1-null mice display potentially malignant interictal cardiac abnormalities, including a fivefold i

50 oreover, we found that, regardless of age or interictal clinical status, all affected subjects had ob

51 Severe ictal-interictal continuum burden correlated with initial prog

52 14 yr; 88% male), 22 (14%) had severe ictal-interictal continuum including electrographic seizures i

53 Severe ictal-interictal continuum patterns, including electrographic

54 s "ictal-interictal continuum"; severe ictal-interictal continuum was defined as greater than or equa

55 or ictal patterns were referred to as "ictal-interictal continuum"; severe ictal-interictal continuum

56 meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalog

57 l biomarkers that might provide insight into interictal cortical function have been described.

58 a median baseline firing rate estimated from interictal discharge-free periods (Kruskal-Wallis one-wa

59 The different patterns of interictal discharge-modulated firing were classified in

60 e estimated in segments of scalp-EEG without interictal discharges (68 people with epilepsy, 38 contr

61 sly in extracellular field potentials during interictal discharges (IIDs) and also during pharmacolog

62 h-frequency activity was present both during interictal discharges and seizure onset.

63 Spontaneous interictal discharges are consequently mediated by GABAe

64 l disorders are more common among women with interictal discharges as well as women with abnormal hor

65 g rates of individual neurons changed during interictal discharges by determining whether the firing

66 re (VHC), with low frequencies that simulate interictal discharges has shown promising results, with

67 KCC1 Cl(-) cotransporters further controlled interictal discharges in 9 of 12 cases, revealing a Cl(-

68 als and single-unit action potentials during interictal discharges in patients with medically intract

69 Spontaneously occurring interictal discharges occur in human tissue in vitro, re

70 ileptogenic zone than the presence of either interictal discharges or ripples (100-250 Hz).

71 Analysis of these interictal discharges typically manifests as spike-wave

72 Interictal discharges were mapped using both EEG-fMRI he

73 Interictal discharges were sustained by GABAergic signal

74 hirty-six of 47 slices displayed spontaneous interictal discharges, along with a pattern specific to

75 8 slices in the areas generating spontaneous interictal discharges, with a transition to seizure invo

76 -positive interneurons in regions generating interictal discharges.

77 These data reveal interictal dysfunctional dynamics within pain pathways i

78 e seizures, neuroimaging findings, ictal and interictal ECoG measures were preoperatively obtained.

79 ts had frontotemporal as well as generalized interictal EEG abnormalities.

80 In these patients, the interictal EEG commonly shows interictal epileptiform di

81 uster patterns derived from the seizure-free interictal EEG data are higher in epileptogenic zones as

82 dels of absence epilepsy have shown that the interictal EEG displays augmented beta/gamma power in ho

83 of aberrant phase-amplitude coupling in the interictal EEG of both stg/stg and tg/tg mice, compared

84 nts at the site of injection which resembled interictal EEG spikes and rapidly propagated to adjacent

85 ional network of the brain, constructed from interictal EEG, combined with a computer model of the tr

86 To further evaluate the interictal EEG, we quantified phase-amplitude coupling (

87 ant BOLD changes in the area of resection on interictal EEG-fMRI in patients with TLE retrospectively

88 lassify focal and generalized epilepsy using interictal EEG.

89 Interictal electroencephalogram (EEG) was normal in all

90 n, family neuropsychiatric history, abnormal interictal electroencephalographic activity, and encepha

91 ; confidence interval = 1.5-6.3; P = 0.003), interictal electroencephalography abnormalities in the f

92 he potential for temporal lobectomy based on interictal electroencephalography and minimally invasive

93 We propose that interictal energetic deficiency in the epileptogenic hip

94 The increase in interictal epileptic activity before arousals suggests i

95 t in P20-22 or P17-18 mSMEI, indicating that interictal epileptic activity correlates with seizure su

96 istant epilepsy is associated with ictal and interictal epileptic activity.

97 Level Dependent (BOLD) signal correlates of interictal epileptic discharges (IEDs) in 63 consecutive

98 volvement of the hippocampus is suggested by interictal epileptic discharges, increased expression of

99 ileptic spikes were expertly identified, and interictal epileptic oscillations across the neural acti

100 In partial epilepsies, interictal epileptic spikes (IESs) and fast ripples (FRs

101 It reduced interictal epileptic spikes in vivo and drug-induced epi

102 Interictal epileptic spikes were expertly identified, an

103 We evaluated if interictal epileptifom activity and/or elevation of hipp

104 in a significant proportion of rats, and to interictal epileptifom EEG abnormalities in most others,

105 In all patients, the device recorded interictal epileptiform activity (IEA; >=6 months of con

106 01) localization of seizure onset, bilateral interictal epileptiform activity (p = 0.017), secondary

107 depolarizations resembling those typical of interictal epileptiform activity and proposed that there

108 rtex over the band heterotopia in generating interictal epileptiform activity and seizures in brains

109 The avalanches collected during interictal epileptiform activity had not only a stereoty

110 side the seizure onset zone, suggesting that interictal epileptiform activity in patients with epilep

111 severe disorders characterized by seizures, interictal epileptiform activity with a disorganized ele

112 n and larger avalanches, particularly during interictal epileptiform activity.

113 2DG (10mM) reduced interictal epileptiform bursts induced by 7.5mM [K(+)](o

114 alohippocampectomy (ATL), but the utility of interictal epileptiform discharge (IED) identification a

115 In two patients, local interictal epileptiform discharge frequencies correlated

116 lize with the seizure onset zone and surface interictal epileptiform discharges (IED).

117 ctroencephalography recordings, we show that interictal epileptiform discharges (IEDs) are significan

118 y retrieval processes.SIGNIFICANCE STATEMENT Interictal epileptiform discharges (IEDs) are thought to

119 Interictal epileptiform discharges (IEDs) identify epile

120 We assess dynamics of abGCs and mGCs during interictal epileptiform discharges (IEDs) in mice with T

121 ronous population activity characteristic of interictal epileptiform discharges (IEDs) to more prolon

122 Interictal epileptiform discharges (IEDs) were identifie

123 patients, the interictal EEG commonly shows interictal epileptiform discharges (IEDs).

124 e temporal relationship to the occurrence of interictal epileptiform discharges and may vary in relat

125 -frequency stimulation of the fornix reduces interictal epileptiform discharges and seizures in patie

126 ation have long been recognized to influence interictal epileptiform discharges and seizures.

127 Interictal epileptiform discharges are associated with h

128 ication may be challenging when seizures and interictal epileptiform discharges are infrequent or dis

129 FOs were commonly associated with widespread interictal epileptiform discharges but not with locally

130 n age 33 years, 6 males) with known frequent interictal epileptiform discharges had an [(18)F]GE-179

131 hip between cortisol levels and incidence of interictal epileptiform discharges in people with stress

132 Univariate analysis showed that localized interictal epileptiform discharges on scalp EEGs were as

133 Interictal epileptiform discharges were determined in th

134 In addition, interictal epileptiform discharges were recorded in 15 (

135 In these patients, interictal epileptiform discharges, also termed spikes,

136 hese large-scale events were associated with interictal epileptiform discharges.

137 Hbr), and light scatter (LS) associated with interictal epileptiform events with multiwavelength opti

138 ol, application of DC magnetic fields alters interictal epileptiform spike activity in five of ten pa

139 the temperature dependence and frequency of interictal epileptiform spike activity.

140 ocessing, local field potential dynamics and interictal epileptiform spike generation.

141 Interictal epileptiform spike rate correlated with spect

142 images there was a significant reduction in interictal epileptiform spike rate in the amygdala, hipp

143 on, which predicted significant reduction in interictal epileptiform spike rate.

144 mperature and age dependence of seizures and interictal epileptiform spike-and-wave activity in mSMEI

145 We conclude that interictal epileptiform spikes are modulated by the patt

146 frequency synchronization 200 ms before the interictal epileptiform spikes that arose during this pe

147 Interictal epileptiform spikes were manually marked and

148 at might result from decreased influences of interictal epileptogenic discharges on brain areas invol

149 Interictal events appear to be very similar to the pre-i

150 This included the elimination of interictal events that worsened during sleep.

151 izure initiation resembles the initiation of interictal events, and seizure propagation respects the

152 prolonged seizures (ictal events) and brief interictal events.

153 Interictal fast ripples proved a significantly more reli

154 Brain development and interictal function are unaffected in many paroxysmal ne

155 somatic pain transmission, shows evidence of interictal functional and structural abnormalities in mi

156 Properties of interictal functional networks from scalp EEG can be est

157 ed disorganised, slow background (n=10), and interictal generalised 2.5-3.0 Hz spike and slow waves (

158 le coupling may be an important mechanism of interictal global network dysfunction that could be targ

159 l cortex (metabolic "border zones") based on interictal glucose PET.

160 In the chronic epileptic state, interictal granule cell hyperinhibition extended to the

161 ly following SE, mice developed an increased interictal heart rate and heart rhythm abnormalities (i.

162 These results demonstrate that interictal HFOs are organized in networks and indicate a

163 Interictal HFOs were recorded from hippocampal microelec

164 Interictal high frequency oscillations (HFOs), in partic

165 delays, and studied the correlations between interictal hippocampal spike frequency during waking and

166 This study investigated whether interictal hippocampal spikes during sleep would impair

167 ocessing in migraine, variously described by interictal hyperexcitability, heightened responsiveness,

168 Although interictal hypoperfusion and ictal hyperperfusion are es

169 dicted subjects is similar to the pattern of interictal hypoperfusion and ictal hyperperfusion that h

170 We found that (a) interictal hypoperfusion was easier to demonstrate by SP

171 nderlie the pre-ictal discharges that govern interictal-ictal transitions.

172 s respond promptly to treatment, whereas the interictal impairments generally persist.

173 wo findings have been shown consistently: an interictal increasing lack of habituation of evoked pote

174 ld help localize the seizure onset zone from interictal intracranial recordings.

175 Here, we report on interictal levels of glutamate, glutamine, and GABA in e

176 ntal models of temporal lobe epilepsy (TLE), interictal-like activity (ILA) precedes SZ1 by several d

177 Interictal-like activity induced by incubation of hippoc

178 , and laminar profile of bicuculline-induced interictal-like activity on neocortical slices were anal

179 diated input to CA1 pyramidal neurons during interictal-like bursts.

180 Furthermore, we report that most interictal-like discharges originating in the overlying

181 pia does not constitute a primary origin for interictal-like epileptiform activity in vitro and is di

182 TTX blocked both ictal- and interictal-like epileptiform activity without affecting

183 saline result mainly in neuronal ictal- and interictal-like epileptiform activity, respectively.

184 t prevent the generation of either ictal- or interictal-like events.

185 he epileptic dentate gyrus display recurrent interictal-like network events with a high diversity in

186 Thus, these interictal-like recurrent macroscopic events are not nec

187 educed ictal activity was also observed when interictal-like responses were evoked by afferent stimul

188 ovides insights into the interpretation of 2 interictal markers observed in intracerebral electroence

189 he reduced model incorporating ictal but not interictal measures (R(2) 0.40; Area under the ROC curve

190 egression model incorporating both ictal and interictal measures [R(2) 0.44; Area under the receiver

191 episodes, many patients describe significant interictal memory difficulties.

192 d indicates that characteristic varieties of interictal memory disturbance co-occur with this form of

193 It is associated with novel forms of interictal memory disturbance: accelerated long-term for

194 er work is required to establish whether the interictal memory impairment is due to physiological or

195 We investigated the relationship between the interictal metabolic patterns, the extent of resection o

196 nance imaging in male and female age-matched interictal (migraine free) migraineurs and matched healt

197 hould be obtained to sufficiently sample the interictal network.

198 tive and motor milestones, neuroimaging, and interictal neurological status.

199 al correlates of human epilepsy, we recorded interictal neuronal activity from mesial temporal lobe (

200 have drawn no definite conclusions on either interictal or ictal changes in migraineurs compared with

201 severity does not provide information about interictal or sub-clinical epileptiform activity.

202 uromatrix during acute PH attacks and during interictal pain-free states off indomethacin that is dea

203 describe the prevalence and burden of ictal-interictal patterns, including electrographic seizures a

204 requent subtle differences between ictal and interictal patterns.

205 A total of 36 subtraction ictal and interictal perfusion studies were analysed in 31 consecu

206 nvestigate state specific (i.e. ictal versus interictal) perfusional limbic networks in patients with

207 s the epileptogenic focus, both in peri- and interictal period.

208 on of the epileptogenic temporal lobe in the interictal period.

209 us of 38 awake epileptic patients during the interictal period.

210 esynchronous events, both in comparison with interictal periods preceding the seizure without bursts

211 ant saturation effects are detectable during interictal periods with the PC-SIRS approach in patients

212 for normal function of these networks during interictal periods, a possibility that is eliminated by

213 d microdialysis samples were obtained during interictal periods.

214 normal cortical network states remain during interictal periods.

215 l high-frequency oscillations (pHFOs) during interictal periods.

216 th the presence of fear, laughter, or severe interictal personality changes) and an atypical group (4

217 ECT coregistered to MR imaging (SISCOM), and interictal PET with (18)F-FDG.

218 thalamocortical networks of patients in the interictal phase of migraine.

219 thalamocortical networks of patients in the interictal phase of migraine.

220 ignificantly longer in the ictal compared to interictal phase.

221 people: 20 without headache and 20 each with interictal photophobia from migraine with or without vis

222 res of epileptic networks (i.e., spontaneous interictal population spikes and seizures), the network

223 Interictal population spikes recorded from principal neu

224 Full synaptic recovery engendered interictal population spikes that spread via long-distan

225 in seizure generation, and whether discrete interictal, preictal, ictal and post-ictal physiologies

226 tely half of the 60 GB data bundle labelled (interictal/preictal) for algorithm training and half unl

227 gorithms and uploaded their classifications (interictal/preictal) for the unknown testing data, and a

228 aphy-electrocardiography revealed suppressed interictal resting heart-rate variability and episodes o

229 d brain network alterations, even during the interictal resting state (RS).

230 of functional connectivity (FC), even during interictal resting state (RS).

231 ionally, the pacemaker mechanisms underlying interictal rhythmicity remain conjectural.

232 elations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs;

233 we demonstrated that epileptic brains during interictal RS are associated with lower global excitabil

234 nation of the epileptic processes during the interictal RS period.

235 We used simultaneous interictal scalp EEG-fMRI to evaluate its value for pred

236 , during, and after migraine pain as well as interictal scans.

237 Subtraction ictal and interictal single photon emission computed tomography ca

238 Interictal slow activity was more frequently absent in c

239 -electroencephalographically (EEG) monitored interictal SPECT (IISPECT) and hyperperfusion in immedia

240 Ictal versus baseline interictal SPECT difference analysis was performed using

241 one or more ictal SPECT scans as well as an interictal SPECT scan.

242 ctroencephalography (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT c

243 Interictal spike activity was seen at normal body temper

244 Most P20-22 mSMEI had interictal spike activity with elevated body temperature

245 This indicates that interictal spike frequency may reflect the processing de

246 al in epilepsy surgery, we evaluated whether interictal spike frequency measures obtained from extrao

247 Seizure onset zone and interictal spike frequency measures on subdural ECoG rec

248 Yet, the additive clinical impact of interictal spike frequency measures to predict long-term

249 th emergence of multiple seizure phenotypes, interictal spike frequency, sleep dysfunction, and hyper

250 contralateral to the tumor was the dominant interictal spike generator and could initiate ictal acti

251 eptiform activity in these structures is the interictal spike, a synchronized burst of action potenti

252 mplete removal of seizure onset zone, higher interictal spike-frequency in the preserved cortex and i

253 nized, large amplitude potentials resembling interictal spikes (IIS) in epilepsy at just 5 weeks of a

254 Interictal spikes (IISs) were induced with iontophoresis

255 e pathways of propagation between sequential interictal spikes (IISs).

256 Rates of seizures (p < 0.01), interictal spikes (p < 0.001), and interictal spikes wit

257 limbic SLE that PS events are different from interictal spikes and are sustained by synchronous activ

258 c effects associated with decreased rates of interictal spikes and fast ripples in this MTLE model.

259 omplemented by the analysis of the impact of interictal spikes and fitting to the neuroimaging data.

260 orks are characterized by two outputs: brief interictal spikes and rarer, more prolonged seizures.

261 afish cerebellum, GABA release events during interictal spikes and seizures in awake mice, and found

262 suggesting that not only seizures, but also interictal spikes can have negative consequences.

263 ional at baseline, and support the idea that interictal spikes disrupt cognitive processes related to

264 By contrast, frequent interictal spikes during non-rapid eye movement sleep pr

265 We hypothesize that hippocampal interictal spikes during sleep interrupt hippocampal-neo

266 positively correlated with the frequency of interictal spikes during the last hour of wakefulness pr

267 icant correlation was found with hippocampal interictal spikes during waking.

268 Interictal spikes emerged predominantly during non-rapid

269 Ripples (80-200Hz) occurring outside of interictal spikes had higher rates in the PV-ChR2 group

270 Interictal spikes in models of focal seizures and epilep

271 By measuring interictal spikes in patients with a range of epilepsies

272 Our results show that activation of interictal spikes in the hippocampus during sleep and se

273 In animal studies, both seizures and interictal spikes induce synaptic potentiation.

274 The location of interictal spikes is used to aid surgical planning in pa

275 hese findings suggest that both seizures and interictal spikes may induce long-lasting changes in the

276 udy, we analysed the spatial distribution of interictal spikes over time in 20 adult and paediatric p

277 ike events (SLEs), but did generate periodic interictal spikes sensitive to the glutamatergic non-NMD

278 duration of the spike and wave components of interictal spikes were analyzed.

279 Interictal spikes were detected in the 24 h surrounding

280 Two types of interictal spikes were distinguished: type 1, with a spi

281 < 0.01), interictal spikes (p < 0.001), and interictal spikes with fast ripples (250-500Hz) (p < 0.0

282 Concomitantly, hippocampal interictal spikes, aberrant oscillations, and neuronal h

283 d that functional networks are unaffected by interictal spikes, corroborating previous experimental f

284 pective of brain state, were associated with interictal spikes, engaged distinct subnetworks of princ

285 s Kcnt1(+/R455H) animals revealed persistent interictal spikes, spontaneous seizures and a substantia

286 examine patterns of seizures and spontaneous interictal spikes, their relationship to each other, and

287 us and temporal neocortex promoted increased interictal spiking within these regions, whereas a nonhi

288 euronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased s

289 acute seizures with subsequent reduction in interictal spiking.

290 amine Oxime (Tc-99 m HMPAO) during ictal and interictal state confirmed by video-electroencephalograp

291 poral region and remaining cortex during the interictal state, followed by a surge of cross-correlate

292 Ictal and interictal studies were coregistered with patients' MRI

293 ns using automated software, and ictal minus interictal subtraction images were obtained.

294 neural network, and that the transition from interictal to ictal-like-sustained activity is preceded

295 In addition, the ensuing interictal up states of slow wave rhythms are more inten

296 Interictal very fast ripples (VFRs; 500-1,000Hz) were de

297 with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) betw

298 We hypothesized that interictal VHFOs are more specific biomarkers for epilep

299 INTERPRETATION: Interictal VHFOs are relatively frequent abnormal phenom

300 sodic (EMs) and 39 chronic migraineurs (CMs; interictal) were compared to 34 HCs for visual after-ima