ライフサイエンスコーパス: interleukin-7 receptor

1 Interleukin-7 receptor a (encoded by IL7R) is essential

2 ineage potential was largely associated with interleukin 7 receptor alpha (IL-7R(alpha)) expression a

3 Up-regulation of the B-cell line 2, interleukin 7 receptor alpha and interleuking 2 receptor

4 face expression and RNA levels of CD127, the interleukin 7 receptor alpha chain (IL-7Ralpha).

5 n of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significa

6 o1 deficiency resulted in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expressi

7 udy we show that increased expression of the interleukin 7 receptor alpha-chain (IL-7Ralpha) identifi

8 The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essen

9 nnate lymphoid cells (ILCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha).

10 only high levels of PD-1 but also decreased interleukin-7 receptor alpha (CD127), an exhausted pheno

11 factor receptor (G-CSFR); and were uniformly interleukin-7 receptor alpha (IL-7Ralpha(-)) AA4.1(Lo),

12 e memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, di

13 Interleukin-7 receptor alpha (IL-7Ralpha) is essential f

14 (Th) cell subsets, ILC subsets positive for interleukin-7 receptor alpha (IL-7Ralpha) produce distin

15 The interleukin-7 receptor alpha (IL-7Ralpha) signaling path

16 ular or to the transmembrane domain (TMD) in interleukin-7 receptor alpha (IL7R) or cytokine receptor

17 previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis "

18 elayed T cell responses and decreased CD127 (interleukin-7 receptor alpha [IL-7Ralpha] chain) convers

19 onstrated to regulate the gene expression of interleukin-7 receptor alpha chain (IL-7Ralpha) and post

20 t critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cel

21 Interleukin-7 receptor alpha chain (IL-7Ralpha) is induc

22 increased MS risk is the soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced

23 of CD45RB and upregulated expression of the interleukin-7 receptor alpha chain, indicating a transit

24 Furthermore, expression of the interleukin-7 receptor alpha chain, which has been propo

25 x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)

26 Moreover, we determined that dex upregulated interleukin-7 receptor alpha on CAR T cells and increase

27 , a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7Ralpha) emerged that h

28 pro-B cell stage due to a failure to express interleukin 7 receptor-alpha.

29 vitamin D(3), including genetic variants in interleukin-7 receptor-alpha (IL7RA*C), interleukin-2 re

30 ated STAT5 and high expression levels of the interleukin-7 receptor-alpha and interleukin-15 receptor

31 Functional studies validated interleukin-7 receptor-alpha as a Foxo1 target gene esse

32 Mechanistically, excessive surface interleukin-7 receptor-alpha sequestrates the common gam

33 D4+ T cells lacking autophagy show increased interleukin-7 receptor-alpha surface expression, while n

34 Interleukin-7 receptor-alpha, a cytokine receptor mostly

35 d- (CD62L-) CC chemokine receptor 7- (CCR7-) interleukin-7 receptor alphaLo (IL-7RalphaLo) phenotype.

36 cells had markedly reduced expression of the interleukin 7 receptor and exhibited shorter survival.

37 memory precursors (expressing high levels of interleukin-7 receptor and low levels of killer cell lec

38 cell expansion is driven by signals from the interleukin-7 receptor and the pre-B-cell receptor and i

39 w) cells express B cell leukemia/lymphoma 2, interleukin-7 receptor, and CD5.

40 Mice lacking interleukin-7 receptor are lymphopenic, due to a defect

41 ed fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response.

42 have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells

43 e show that neonatal thymi transplanted into interleukin 7 receptor-deficient hosts harbor population

44 Thus ligands of the interleukin-7 receptor deliver an extrinsic signal that

45 f PU.1 as a transcriptional regulator of the interleukin-7 receptor has established one mechanism by

46 haracterized by selective down-regulation of interleukin-7 receptor, heightened apoptosis, and poor a

47 We show that activating mutations in the interleukin-7 receptor identified in human pediatric ETP

48 set by the proper signaling function of the interleukin 7 receptor (IL-7R) and the pre-T-cell antige

49 The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the

50 he pre-B cell antigen receptor (pre-BCR) and interleukin 7 receptor (IL-7R) coordinate pre-B cell pop

51 t to express TCRs can be subdivided based on interleukin 7 receptor (IL-7R) expression.

52 Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cel

53 TCF1(hi)CD4(+) T cells expressing the interleukin 7 receptor (IL-7R) sustained vasculitis in s

54 (pre-BCR) and escape from signaling via the interleukin 7 receptor (IL-7R).

55 In interleukin 7 receptor (IL-7R)alpha-/- murine thymocytes

56 hed by progressively lower expression of the interleukin-7 receptor (IL-7R alpha) and by lower IL-7 r

57 sident memory (TRM) cells, but low levels of interleukin-7 receptor (IL-7R) and are functionally less

58 4(+) T cells and in reduced abundance of the interleukin-7 receptor (IL-7R) encoded by the NF-kappaB

59 Furthermore, we show that ectopic interleukin-7 receptor (IL-7R) expression can rescue pre

60 One unexpected result was the high level of interleukin-7 receptor (IL-7R) gene expression in HS-27a

61 The interleukin-7 receptor (IL-7R) is a crucial T-cell devel

62 Interleukin-7 receptor (IL-7R) levels are tightly contro

63 group is enriched for genes involved in the interleukin-7 receptor (IL-7R) pathway and T cell recept

64 Although the interleukin-7 receptor (IL-7R) plays a pivotal role in A

65 The interleukin-7 receptor (IL-7R), via its activation of th

66 Here, we show that c-Kit and interleukin-7 receptor (IL-7R)-mediated signals support

67 Expression of the interleukin-7 receptor (IL-7Ralpha) chain marks function

68 tes from mice lacking the alpha-chain of the interleukin-7 receptor (IL-7Ralpha).

69 There was downregulation of interleukin 7 receptor (IL7R) (P = .0001) and chemokine

70 Here, we show that interleukin 7 receptor (IL7R) interacts with the chemoki

71 The interleukin 7 receptor (IL7R), which contains a unique a

72 of normal and malignant thymocytes carrying interleukin-7 receptor (IL7R) gain-of-function mutations

73 apid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell

74 , effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effec

75 Activating mutations of interleukin-7-receptor pathway genes (IL-7Rp) play a pro

76 Accordingly, populations of CD62L(high) interleukin-7 receptor-positive progenitor central memor

77 ated polyfunctional T helper cells with high interleukin-7 receptor, rapid clonal expansion, and pote

78 ), a linchpin in the pre-B-cell receptor and interleukin 7 receptor signaling pathways critical to B-

79 Human soluble interleukin-7 receptor (sIL7R)alpha circulates in high m

80 ry receptors (inducible T-cell costimulator, interleukin 7 receptor), whereas inhibitory receptors (p