ライフサイエンスコーパス: intermembrane

1 of c-SWNTs, was 4.74% intramembrane and 6.3% intermembrane.

2 Intermembrane [(14)C]cholesterol transfer was strongly e

3 f thicker (7-8 nm) swelled films with weaker intermembrane adhesion ( approximately 0.13 mJ/m(2)) on

4 to form a compact film (3-4 nm) with strong intermembrane adhesion ( approximately 0.36 mJ/m(2)), in

5 Close proximity of these two classes of intermembrane bonds would require significant membrane b

6 The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understo

7 ariability in reported values for intra- and intermembrane cholesterol transport rates.

8 nd comparative protein studies, allowing for intermembrane comparisons with high sensitivity and repr

9 These intermembrane contact sites constitute important intrace

10 e endoplasmic reticulum (ER) makes extensive intermembrane contacts with the plasma membrane (PM), co

11 two events are coordinated through a dynamic intermembrane coupling between two distinct membrane pro

12 They are fully reconstituted via intermembrane coupling of the Ca(2+)-selective Orai chan

13 annels are gated through a unique process of intermembrane coupling with the Ca(2+)-sensing STIM prot

14 e, the receptor-ligand complex spans a short intermembrane distance (15 nm) compared to long surface

15 By increasing the equilibrium intermembrane distance on binding, we show that intermem

16 espectively) is achieved for a fixed 120 mum intermembrane distance stack (without movement of the me

17 Based on crystal structures, the intermembrane distance would be approximately 15 nm for

18 This setup that fixes the intermembrane distance, and thereby the transient states

19 to an increase in adhesion at a much-reduced intermembrane distance.

20 ein complexes to cope with variations in the intermembrane distance.

21 composition and membrane morphology, not in intermembrane distance.

22 water and seawater compartments have a fixed intermembrane distance.

23 ange due to the high pressure drops at small intermembrane distance.

24 electrodialysis stack by varying in time the intermembrane distance.

25 ed for different membrane conductivities and intermembrane distances simulating high performance memb

26 Cytochrome c (cyt c), a mitochondrial intermembrane electron shuttle between complexes III and

27 le neutron scattering to measure cholesterol intermembrane exchange and intramembrane flipping rates,

28 Although it catalyzes the intermembrane exchange of phosphatidylcholines in vitro,

29 ex, amino acids 141 to 146 interact with the intermembrane-exposed Tim50 protein, forming a large com

30 the protein are located on the mitochondrial intermembrane-facing surface, with six membrane-spanning

31 vesicle trafficking machinery that mediates intermembrane fusion.

32 the release of cytochrome c (cyt c) from the intermembrane gap and subsequent cell death.

33 The intermembrane gap is separated by a distance ranging fro

34 along the entire length of the pores that no intermembrane gap is visible.

35 esence correlates with the appearance of the intermembrane gap.

36 rin interactions that occur within confined, intermembrane gaps but not in solution.

37 nd the HOPS complex, are required for stable intermembrane interactions and that the three vacuolar Q

38 ermembrane distance on binding, we show that intermembrane interactions become negligible for the bin

39 ropose a simple model that describes how the intermembrane interactions tilt the free energy landscap

40 ab proteins and effectors are sufficient for intermembrane interactions.

41 gratory and antigen recognition occurs at an intermembrane junction where the T cell physically conta

42 aterally fluid receptor-ligand complex at an intermembrane junction.

43 S transport, to illustrate key challenges in intermembrane lipid trafficking.

44 y for another function of Nm23-H4, selective intermembrane lipid transfer.

45 plast envelopes, respectively, necessitating intermembrane lipid transfer.

46 The intermembrane lipid transport processes play important r

47 sertional mutagenesis in the first predicted intermembrane loop eliminated MFT function, but the intr

48 e of insertion of the c-myc epitope into the intermembrane loops and of a series of site-directed mut

49 embrane-spanning regions interspersed by two intermembrane loops and three matrix-facing loops.

50 es it to "sense" mitochondrial stress in the intermembrane mitochondrial space and convey these signa

51 exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells.

52 es to determine the mechanistic basis of the intermembrane movement and identify the interactions res

53 This intermembrane movement of lipid-modified proteins is a f

54 the potential pathways for intracellular and intermembrane movement of molecules.

55 e-binding affinities and consequent rates of intermembrane movement.

56 However, tools available to evaluate the intermembrane organization of the synapse are limited.

57 that the Mla pathway constitutes a bacterial intermembrane PL trafficking system.

58 een Scythe and the apoptogenic mitochondrial intermembrane protein AIF (apoptosis-inducing factor).

59 Stable expression of the mitochondrial intermembrane protein IMS-RP was established in human br

60 the Trx1 reductant, as well as mitochondrial intermembrane proteins AIF and Mia40.

61 e proton pumping from the matrix (N-side) to intermembrane region (P-side) in mitochondria; the resul

62 n FP domains and contributes to reduction of intermembrane separation between FPs.

63 We reconstituted this intermembrane signaling geometry between live EphA2-expr

64 how they function to mediate this remarkable intermembrane signaling process controlling Ca(2+) signa

65 encoded protein, ERIS (endoplasmic reticulum intermembrane small protein), is also shown to localize

66 luorescent protein-based redox sensor to the intermembrane space (IMS) and matrix of yeast mitochondr

67 d by misfolded proteins in the mitochondrial intermembrane space (IMS) and mediated by the estrogen r

68 tochondrial membrane translocases facing the intermembrane space (IMS) and that this interaction prom

69 beta-barrel fold consisting of an N-terminal intermembrane space (IMS) domain and a C-terminal 16-str

70 ner membrane, the dynamic association of its intermembrane space (IMS) domain with the outer membrane

71 The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery

72 ast to matrix proteins, many proteins of the intermembrane space (IMS) lack presequences and are impo

73 stitute the largest group of proteins in the intermembrane space (IMS) of mitochondria.

74 logy of the mitochondria and accumulation of intermembrane space (IMS) proteins.

75 dent sulfhydryl oxidase in the mitochondrial intermembrane space (IMS) that functions in the import o

76 hatase that is targeted to the mitochondrial intermembrane space (IMS) where it interacts with the mi

77 ause Cu,Zn-SOD is found in the mitochondrial intermembrane space (IMS), we hypothesized that mitochon

78 ied to map the proteome of the mitochondrial intermembrane space (IMS), which can freely exchange sma

79 oid dehydrogenase type 2 (3betaHSD2) via its intermembrane space (IMS)-exposed charged unstructured l

80 transacylase tafazzin, which associates with intermembrane space (IMS)-facing membrane leaflets.

81 e oxidizing environment of the mitochondrial intermembrane space (IMS).

82 mbrane proteins facing the matrix versus the intermembrane space (IMS).

83 nner membrane (IM) protein facing toward the intermembrane space (IMS).

84 le is known about folding of proteins in the intermembrane space (IMS).

85 mostly on the outer membrane and inside the intermembrane space (IMS).

86 chondrial membranes surround the hydrophilic intermembrane space (IMS).

87 m (lfALR) which resides in the mitochondrial intermembrane space (IMS).

88 phospholipid metabolism in the mitochondrial intermembrane space (IMS).

89 ria, where it localizes predominantly in the intermembrane space (IMS).

90 reduced proteins entering the mitochondrial intermembrane space (IMS).

91 anslocated through the inner membrane to the intermembrane space (IMS).

92 may inhibit respiration directly within the intermembrane space (IMS).

93 ensitive cysteine residues reside within the intermembrane space (IMS).

94 m a structural disulfide bond exposed to the intermembrane space (IMS).

95 al matrix (Mito-RoGFP), or the mitochondrial intermembrane space (IMS-RoGFP), allowing assessment of

96 to acidification, whereas the mitochondrial intermembrane space (trans) side barely responded to pH

97 ectron transport chain and released into the intermembrane space - is the cellular oxygen signal resp

98 expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting mis

99 The presence of this peptidoglycan in the intermembrane space allows the refinement of a model for

100 localization of Prx1: a soluble form in the intermembrane space and a form in the matrix weakly asso

101 cytochrome c release from the mitochondrial intermembrane space and apoptosis.

102 rosomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex

103 motif mitochondrial protein localized in the intermembrane space and associated with the inner membra

104 ed both by their presence in the constrained intermembrane space and by the 2D environment of membran

105 ive literature on proteins released from the intermembrane space and consider genetic evidence for an

106 reases in ROS signaling in the mitochondrial intermembrane space and cytosol, and it abrogated hypoxi

107 10 is a mitochondrial protein located in the intermembrane space and enriched at cristae junctions.

108 ein that exposes its carboxy-terminus to the intermembrane space and exists in several complexes of 6

109 approach to express SOD1 exclusively in the intermembrane space and found that mitochondrial SOD1 is

110 it was reported that mHTT is present in the intermembrane space and inhibits mitochondrial protein i

111 isoenzyme is expressed in the mitochondrial intermembrane space and is mutated in reticular dysgenes

112 ation-prone proteins enter the mitochondrial intermembrane space and matrix after heat shock, and som

113 y the Mia40 oxidative-folding pathway in the intermembrane space and probably stabilize the membrane

114 alization of mu-calpain to the mitochondrial intermembrane space and provides new insight into the po

115 8's and Pam16's N termini interacting in the intermembrane space and the matrix, respectively.

116 er membrane, which in turn is bounded by the intermembrane space and the outer membrane.

117 When calcium levels in the intermembrane space are high, the N-terminus of the amph

118 ia demonstrated that DSP18 is located in the intermembrane space as a peripheral membrane protein of

119 ria accommodates the essential mitochondrial intermembrane space assembly (MIA) machinery that cataly

120 The mitochondrial intermembrane space assembly (MIA) pathway is generally

121 ydryl oxidase Erv1, termed the mitochondrial intermembrane space assembly (MIA) pathway.

122 the intermembrane space by the mitochondrial intermembrane space assembly pathway that couples their

123 f DAG in the leaflets facing the chloroplast intermembrane space by DAGK impairs plant growth.

124 mbrane and is subsequently released into the intermembrane space by proteolytic removal of a hydropho

125 Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane s

126 chondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10

127 Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the smal

128 , to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10.

129 Cox19 isolated from the mitochondrial intermembrane space contains variable quantities of copp

130 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

131 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

132 The intermembrane space domain of Mic60 has a lipid-binding

133 Ablation of the intermembrane space domain of the translocase subunit, a

134 We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 A reso

135 Notably, the transmembrane and intermembrane space domains are separated from the main

136 he central region of Tim23, which enters the intermembrane space first, may serve to nucleate the bin

137 The mitochondrial intermembrane space has an analogous pathway with the ox

138 Expression of Opa1 CTFs in the intermembrane space has no effect on mitochondria morpho

139 ane space via the redox-driven mitochondrial intermembrane space import and assembly (MIA) pathway.

140 Mitochondrial intermembrane space import and assembly protein40, a pro

141 component of a redox-sensitive mitochondrial intermembrane space import machinery.

142 ls, allowing K(+) to enter the mitochondrial intermembrane space in a controlled regulated fashion.

143 dative protein import into the mitochondrial intermembrane space in yeast and mammals.

144 d through these pores from the mitochondrial intermembrane space into the cytoplasm where they initia

145 otic factors including cytochrome c from the intermembrane space into the cytoplasm, where they initi

146 orine causes translocation of DSP18 from the intermembrane space into the cytosol similar to other ap

147 sults suggest that SOD1 in the mitochondrial intermembrane space is fundamental for motor axon mainte

148 The functional significance of SOD1 in the intermembrane space is unknown.

149 We show that Prx1 sorting into the intermembrane space likely involves the release of the p

150 ilitated by Mrs2, and point mutations in the intermembrane space loop limits (m)Mg(2+) uptake.

151 mine-conjugated dextran in the mitochondrial intermembrane space of digitonin-permeabilized hepatocyt

152 The oxidative folding mechanism in the intermembrane space of human mitochondria underpins a di

153 The intermembrane space of mitochondria accommodates the ess

154 containing metalloprotein is located in the intermembrane space of mitochondria and released into bl

155 and biogenesis of proteins localized to the intermembrane space of mitochondria.

156 ides drives import of many proteins into the intermembrane space of mitochondria.

157 g the efficiency of oxidative folding in the intermembrane space of mitochondria.

158 trols proteostasis at the inner membrane and intermembrane space of mitochondria.

159 We found that CPS-6 relocates from the intermembrane space of paternal mitochondria to the matr

160 h a chaperone had not been identified in the intermembrane space of plastids and we propose that Tic2

161 firmed that POTRA domains are located in the intermembrane space of the chloroplast envelope.

162 osome in which m-IL-1beta resides within the intermembrane space of the double-membrane structure.

163 t, but it localizes to the cytoplasm and the intermembrane space of the mitochondria.

164 ther cellular compartments especially in the intermembrane space of the mitochondrial to avoid irreve

165 We show that this lipase is located in the intermembrane space of the mitochondrion and is imported

166 is inserted between two bilayers in a tight intermembrane space of ~3 nm, implying direct interactio

167 is unclear whether loss of the enzyme in the intermembrane space or cytosol is important in this resp

168 her complex I subunits as a substrate of the intermembrane space oxidoreductase CHCHD4 (also known as

169 eric Tim9-Tim10 complex of the mitochondrial intermembrane space plays an important role during impor

170 sible for the transfer of disulfide bonds to intermembrane space precursor proteins, causing their ox

171 ndria, suggesting that OPA1 is cleaved by an intermembrane space protease which is regulated by activ

172 observed with knockdown of the mitochondrial intermembrane space protease Yme1.

173 in we report that the so-far-uncharacterized intermembrane space protein Mix23 is considerably up-reg

174 x activation and pro-apoptotic mitochondrial intermembrane space protein release, which are required

175 ond is the CHCHD3 homologue, CHCH-3, a small intermembrane space protein that may act as a chaperone.

176 is a developmentally regulated mitochondrial intermembrane space protein that undergoes processive cl

177 thermore, the protease Prd1, misannotated as intermembrane space protein, could be re-assigned and ch

178 and D sphingosine potentiate the release of intermembrane space proteins by long-chain ceramide and

179 ismutase (Sod1) requires a growing number of intermembrane space proteins containing a twin Cx(9)C mo

180 ge assembly defect and emphasize the role of intermembrane space proteins for the efficient assembly

181 y, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm.

182 , the Mia40/Erv1 pathway for import of small intermembrane space proteins participates in CCS mitocho

183 The release of mitochondrial intermembrane space proteins to the cytosol is a key eve

184 membrane permeabilization and the release of intermembrane space proteins, such as cytochrome c, are

185 n the permeability transition and release of intermembrane space proteins, the mitochondrial Ca(2+)-i

186 e, we investigated the role of the conserved intermembrane space proteins, Ups1p and Ups2p, and an in

187 In this study, we report that two homologous intermembrane space proteins, Ups1p and Ups2p, control c

188 ed to the transport and oxidative folding of intermembrane space proteins.

189 sociates with the small alpha subunit on the intermembrane space side of the inner membrane.

190 d plants, Toc75 N terminus is located on the intermembrane space side, not the cytosolic side, of the

191 PNPase localization to the mitochondrial intermembrane space suggests a unique role distinct from

192 lectron acceptor couple in the mitochondrial intermembrane space that seems to function in both aerob

193 in yet another subcellular compartment: the intermembrane space that separates forespores from mothe

194 ther apoptotic factors are released from the intermembrane space through these pores, initiating down

195 e recruitment of molecular chaperones in the intermembrane space to facilitate membrane transport.

196 membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands

197 nsported across two membranes and an aqueous intermembrane space to the cell surface.

198 0 and Tim23 transfer preproteins through the intermembrane space to the inner membrane.

199 cation for proteins that are targeted to the intermembrane space via the redox-driven mitochondrial i

200 ifunctional hemoprotein in the mitochondrial intermembrane space whereby its participation in electro

201 cal hexameric complexes in the mitochondrial intermembrane space with phosphotransfer activity using

202 and poly-A polymerase, in the mitochondrial intermembrane space, a location lacking resident RNAs.

203 lipid transfer proteins in the mitochondrial intermembrane space, allowing formation of PE by Psd1 in

204 n, a sulfhydryl oxidase of the mitochondrial intermembrane space, and a larger protein containing the

205 whose hydrophilic domains are located in the intermembrane space, and Cox20 remains associated with m

206 , localized to the cytosol and mitochondrial intermembrane space, and Grx2, localized primarily to th

207 d in the major compartments (outer membrane, intermembrane space, and the matrix) of the organelle is

208 ropose that a set of stacked rings spans the intermembrane space, as has been found for type III secr

209 g in both neuronal cytosol and mitochondrial intermembrane space, calpain I was found to be activated

210 vely reside in the cytosol and mitochondrial intermembrane space, can engage negatively charged bilay

211 interact via their C-terminal domains in the intermembrane space, consistent with their in vivo topol

212 e oxidation takes place in the mitochondrial intermembrane space, delivering electrons to the respira

213 -Tim13 complex, located in the mitochondrial intermembrane space, functions in the TIM22 import pathw

214 P-independent chaperone of the mitochondrial intermembrane space, involved in transport of polytopic

215 whose extracellular domain is located in the intermembrane space, is a substrate of StoA.

216 denine nucleotide interconversion within the intermembrane space, is markedly induced during adipocyt

217 protons from the mitochondrial matrix to the intermembrane space, it builds up an electrochemical pot

218 the MOM and entering into the mitochondrial intermembrane space, making it highly unlikely that mHTT

219 ompartments: outer membrane, inner membrane, intermembrane space, or matrix.

220 estined for the outer or inner membrane, the intermembrane space, or the matrix, proteins begin the i

221 locase complex, located in the mitochondrial intermembrane space, plays an essential chaperone-like r

222 o replenish protons from the matrix into the intermembrane space, sustaining mitochondrial membrane p

223 n mitochondria, huntingtin is located in the intermembrane space, that mHTT binds with high-affinity

224 s are by nature transient and located in the intermembrane space, this determination is generally a v

225 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to

226 the translocase of the outer membrane to the intermembrane space, where divergent pathways sort them

227 otein Opa1 is localized to the mitochondrial intermembrane space, where it facilitates fusion between

228 argeted to mitochondria and localizes in the intermembrane space, where it participates in an approxi

229 ) promotes transport of the precursor to the intermembrane space, whereas the sorting and assembly ma

230 III is also released into the mitochondrial intermembrane space, which contains a recently identifie

231 sistant fold, associates non-integrally with intermembrane space-facing membranes and assembles in a

232 ) forms the membrane anchor, which binds the intermembrane space-localized alpha-subunit (Psd1alpha).

233 ty in which cytoplasmic Ca(2+) regulation of intermembrane space-localized MICU1/2 is controlled by C

234 s the respiratory chain to the mitochondrial intermembrane space-localized, ubiquitous, and ancient S

235 cysteine-rich proteins in the mitochondrial intermembrane space.

236 arding how lipids transit across the aqueous intermembrane space.

237 ial proteins, including many proteins of the intermembrane space.

238 e of mitochondria with its C terminus in the intermembrane space.

239 dase (Ccp1) is targeted to the mitochondrial intermembrane space.

240 terminal end of the protein localized to the intermembrane space.

241 associated (POTRA) domain extending into the intermembrane space.

242 membrane with the C and N termini facing the intermembrane space.

243 which reduce i-AAA protease activity in the intermembrane space.

244 brane a second time to finally reside in the intermembrane space.

245 lipids in a lipid-specific manner across the intermembrane space.

246 ner membrane, and matrix or trap them in the intermembrane space.

247 rane protease following translocation to the intermembrane space.

248 ch protein substrates into the mitochondrial intermembrane space.

249 ated by a highly conserved linker facing the intermembrane space.

250 the mitochondrial inner membrane facing the intermembrane space.

251 is a peripheral protein of the IM facing the intermembrane space.

252 freely between the cytosol and mitochondrial intermembrane space.

253 ome c and smac/DIABLO from the mitochondrial intermembrane space.

254 urolastin is imported into the mitochondrial intermembrane space.

255 tase, but is also found in the mitochondrial intermembrane space.

256 isoforms were predicted to be soluble in the intermembrane space.

257 (wtHTT) and mHTT reside in the mitochondrial intermembrane space.

258 ane, whereas the C-terminal domain faces the intermembrane space.

259 ns in the maintenance of proteostasis in the intermembrane space.

260 he small Tim proteins into the mitochondrial intermembrane space.

261 one the hydrophobic Tim23 across the aqueous intermembrane space.

262 ed in the cytoplasm and in the mitochondrial intermembrane space.

263 ugh partially localized to the mitochondrial intermembrane space.

264 tive protease localized in the mitochondrial intermembrane space.

265 te-binding site is open to the mitochondrial intermembrane space.

266 DP to AMP by adenylate kinase located in the intermembrane space.

267 brane helices, shielding it from the aqueous intermembrane space.

268 the mitochondrial inner membrane facing the intermembrane space.

269 small molecules pass between the cytosol and intermembrane space.

270 e with the beta-folded P0-cyt located at the intermembrane space.

271 mu-calpain, are present in the mitochondrial intermembrane space.

272 e, suggesting its functional role within the intermembrane space.

273 al quality control mechanisms present in the intermembrane space.

274 ondrial matrix and the N-terminus facing the intermembrane space.

275 aggregation as the preprotein traverses the intermembrane space.

276 mitochondria with the C-terminus facing the intermembrane space.

277 membrane with it's C-terminus exposed to the intermembrane space.

278 phobic carrier substrates across the aqueous intermembrane space.

279 l of Lyn and Syk reside in the mitochondrial intermembrane space.

280 ion or by artificially targeting XIAP to the intermembrane space.

281 ysteine-rich proteins into the mitochondrial intermembrane space.

282 study was used to reveal the relative matrix/intermembrane space/outer membrane (85:6:9) distribution

283 Here, we show that the conserved intermembrane-space dynamin-related GTPase Mgm1 is requi

284 olipid, cardiolipin (CL), is oxidized by the intermembrane-space haemoprotein, cytochrome c.

285 periplasms of bacteria and the mitochondrial intermembrane spaces of fungi.

286 e-protein adsorption mechanisms that affects intermembrane spacing and adhesion and has direct implic

287 ssion electron microscopy revealed increased intermembrane spacing at ID sites adjacent to gap juncti

288 as with planar bilayers demonstrated average intermembrane spacing of 12.8 nm with CD48-WT, 14.7 nm w

289 The relationship between intermembrane spacing, adhesion efficiency, and lateral

290 I-LHCII and LHCII-LHCII interactions and the intermembrane stacking interactions between these comple

291 of NPC2 on the rate and kinetic mechanism of intermembrane sterol transport, to model the movement of

292 thalene-8-sulfonic acid, and (iv) glycolipid intermembrane transfer activity monitored by Forster res

293 ation of the GLTP paralogs showed glycolipid intermembrane transfer activity only for 12q24.11 GLTP.

294 lten globule-like state inhibited glycolipid intermembrane transfer by the HET-C2 GLTP fold.

295 ble proteins that selectively accelerate the intermembrane transfer of glycolipids.

296 tidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine.

297 ansfer protein (GLTP) accelerates glycolipid intermembrane transfer via a unique lipid transfer/bindi

298 mol %) in C1P source vesicles depressed C1P intermembrane transfer.

299 inal domains, to promote STING dimerization, intermembrane translocation, and signaling.

300 Tic22 is a ubiquitous intermembrane translocon component that interacts with t