ライフサイエンスコーパス: intermolecular

1 Significantly, this intermolecular 2 + 2 carbonyl-olefin photocycloaddition

2 general platform for visible-light mediated intermolecular [2 + 2] cycloaddition of indoles with alk

3 e-2-carboxyesters as suitable motifs for the intermolecular [2 + 2] cycloaddition reaction.

4 Instead, decomposition or intermolecular [2 + 2] photocycloaddition reactions prev

5 and reusable scaffolds for homo- and hetero-intermolecular [2+2] photocycloadditions of 4-vinylbenzo

6 Intermolecular [2+2] photocycloadditions represent a pow

7 a well-defined helical structure to form an intermolecular 4-helix bundle with the E6AP AZUL, which

8 xazoline) catalysts promote enantioselective intermolecular [4 + 1]-cycloadditions of vinylidene equi

9 from Morus cell cultures, that catalyses an intermolecular [4+2] cycloaddition to produce the natura

10 y a one-pot straightforward POCl(3) mediated intermolecular (5 + 1) annulation of the beta-ketosulfon

11 An intermolecular 8.9 +/- 0.3 Hz (2h)J(NN) hydrogen bond is

12 ar interactions are highly influenced by the intermolecular accessibility of its regulatory domains,

13 lytic hydroamination(8,9), and no asymmetric intermolecular additions to such alkenes are known.

14 S domains has been proposed to occur through intermolecular amide-pai and alkene-pai interactions, bu

15 The development of an intermolecular and enantioselective aza-Wacker reaction

16 An intermolecular and highly enantioselective C-H arylation

17 The strong intermolecular and intramolecular interactions, combined

18 he investigation of charge transport through intermolecular and intramolecular paths in single-molecu

19 Intermolecular and intramolecular variants of the reacti

20 n and the solid state through double-helical intermolecular and transannular hydrogen bonding.

21 The first is an intermolecular approach, wherein we designed several str

22 efficient and highly selective approach for intermolecular arylthiocyanation/arylselenocyanation of

23 used by the conversion of intramoleclular to intermolecular associations is observed in droplets of t

24 etal/photo-redox-catalyzed C-H arylation and intermolecular atom-transfer radical addition through ox

25 gesting that adjuvants may weaken or disrupt intermolecular attractions between pesticide molecules a

26 Here we report a visible-light-mediated intermolecular aza Paterno-Buchi reaction that utilizes

27 yclobutanes, the synthesis of azetidines via intermolecular aza Paterno-Buchi reactions remains highl

28 erated from these distributions recapitulate intermolecular background coupling parameters even when

29 um calculations, the experimentally observed intermolecular bands can be assigned.

30 berrant BTB dimers that fail to stabilize an intermolecular beta-sheet around a highly divergent beta

31 was confirmed by the increasing formation of intermolecular beta-sheets, revealed by second derivativ

32 Moreover, the intermolecular binding and dissociation rate constants a

33 anges in conformation or show alterations in intermolecular binding capability in response to glucose

34 ults in conformational changes that optimize intermolecular binding.

35 Using intermolecular bioluminescence resonance energy transfer

36 ese C-H borylation reactions are preceded by intermolecular bond (both dative and covalent) formation

37 tural investigations reveals that Ru(II) has intermolecular bonding with functional groups of GO.

38 double cores that are strongly connected by intermolecular bonds has been developed.

39 An efficient method for intermolecular branch-selective allylic C-H amidation ha

40 Intermolecular C-C bond-forming reactions are underdevel

41 rene group transfer reagent are supported by intermolecular C-H amination and aziridination reactivit

42 The Co(II)-catalyzed intermolecular C-H amination, which operates under mild

43 l structure of an oxidase catalyzing direct, intermolecular C-H amination.

44 The complex underwent intermolecular C-H bond activation upon thermolysis and

45 studies indicate that the reaction shows no intermolecular C-H crossover.

46 rocatalysis is applicable in both intra- and intermolecular C-N bond-forming reactions.

47 transition-metal-based methods for catalytic intermolecular C-N coupling.

48 The enantioselective intermolecular C2-allylation of 3-substituted indoles is

49 Specifically, we used this strategy in the intermolecular carboformylation, anti-Markovnikov hydroa

50 myces sp. NRRL F-5053), which catalyzes both intermolecular carbon-carbon (C-C) and carbon-nitrogen (

51 The first intermolecular carbonyl arylations via transfer hydrogen

52 trifluoromethanesulfonate (TMSOTf)-promoted intermolecular cascade reaction of aromatic diazo ketone

53 f molecular dimers and (ii) enantioselective intermolecular CH...pai interactions between the dimers.

54 In addition, a long-lived (4.3 mus) intermolecular charge separation is observed, and a new

55 Benefiting from intermolecular charge transfer interactions, the two co-

56 The intermolecular charge transfer property of PT-TPA forms

57 The experimental investigation of intermolecular charge transport in pai-conjugated materi

58 We found that the ability for intermolecular charge transport through different single

59 eneration organic solar cells, this involves intermolecular charge-transfer (CT) states whose energie

60 hese liquid condensates mature via pervasive intermolecular charge-transfer and persistent backbone i

61 se to demonstrate that an unusual cascade of intermolecular charge-transfer coupled with a multitude

62 30 meV) exciplexes, the SOC generated by the intermolecular charge-transfer states shows large and sm

63 tion is observed, and a new excimer-mediated intermolecular charger-transfer mechanism is proposed.

64 the E1PT product followed by a slow, likely intermolecular chemical step involving a second proton t

65 aluminum dihydride catalyzed both intra- and intermolecular chemoselective hydroboration of nitriles

66 Notably, both intra- and intermolecular chemoselective hydrosilylation and hydrob

67 Increasing intermolecular cohesion using longer peptide sequences t

68 n-adiabatic dynamics simulations identify an intermolecular CoIn as the source of these unusual dynam

69 ctroscopy (2DES), we reveal the existence of intermolecular CoIns in molecular aggregates relevant fo

70 Our results indicate that intermolecular CoIns may effectively steer energy pathwa

71 rick base-pairing, molecular plasticity, and intermolecular connectivity.

72 /MS, we identified as yet unknown intra- and intermolecular contact sites of TatB and TatC.

73 characterized by formation of just a few key intermolecular contacts and was otherwise highly structu

74 rovide evidence for the presence of specific intermolecular contacts between BtuB monomers that could

75 Intermolecular contacts between NSD proteins and nucleos

76 d through induced-folding pathways (in which intermolecular contacts form before or concurrently with

77 unfolded and then refolded after additional intermolecular contacts formed.

78 These observations suggest that even after intermolecular contacts have formed, disordered regions

79 nein is regulated by autoinhibition, whereby intermolecular contacts limit motor activity.

80 l studies-is likely due to disruption of key intermolecular contacts necessary for stable HbS polymer

81 ions have distinct water accessibilities and intermolecular contacts, indicating that they alternate

82 among conformations with similar numbers of intermolecular contacts, those with less helical content

83 ed to conductive frameworks with significant intermolecular contacts.

84 spectra, which contain long-range intra- and intermolecular correlations.

85 Interatomic or intermolecular Coulombic decay (ICD) is a nonlocal elect

86 t the ice surface are attributed to enhanced intermolecular coupling and reduced rotational mobility,

87 For example, the intermolecular coupling of alkenes with alpha-halo carbo

88 reaction proceeds via cycloaromatization and intermolecular coupling of ortho-(alkynyl)styrenes with

89 An intermolecular coupling of primary alcohols and organotr

90 Such large intermolecular couplings resulting from good pai-stackin

91 cules plays an important role by setting the intermolecular couplings that determine the system energ

92 rticular, we provide an in-depth look at the intermolecular couplings used to physically connect a nu

93 Specifically, mtROS induced intermolecular covalent linkage of NEMO through disulfid

94 ion of fibrinogen hydrogels through covalent intermolecular crosslinking.

95 lateral phenyl rings and intramolecular and intermolecular CT transitions.

96 Remarkably, TbtD is competent to perform an intermolecular cyclization in addition to its cognate in

97 Catalyst-controlled intra- and intermolecular cyclizations are mainly described to give

98 rlyst 15-controlled one-pot easy-operational intermolecular cyclocondensation of substituted piperidi

99 re an increase in (a) the intramolecular and intermolecular deck-to-deck spacing compared to [2.2]par

100 eport the first example of enantioselective, intermolecular diarylcarbene insertion into Si-H bonds f

101 s-Alderase has been demonstrated to catalyse intermolecular Diels-Alder transformations.

102 Herein, we describe an intermolecular direct branched-selective alpha-alkylatio

103 for oxidative cyclization and the unexpected intermolecular displacement of the oxazine.

104 energy transfer in order to trace intra and intermolecular distance changes of protein domains.

105 oresis, gel filtration, and determination of intermolecular distances.

106 of its two cysteine residues, generating an intermolecular disulfide bond that promotes dimerization

107 tains seven cysteines involved in intra- and intermolecular disulfide bonding and protein folding.

108 cysteine-loop domain of neurexins by forming intermolecular disulfide bonds during transport through

109 nition and complement activation by cleaving intermolecular disulfide bonds in large ficolin-3 multim

110 protein system in which spontaneously formed intermolecular disulfide bonds initiate amyloid fibril f

111 dergoes oxidation, allowing the formation of intermolecular disulfide bonds that result in TFEB oligo

112 ytic cysteines in Cd-MsrB through intra- and intermolecular disulfide formation and S-mycothiolation.

113 Additionally, intermolecular disulfide formation between PKA type I re

114 lthough all tested compounds equally induced intermolecular disulfide formation in PKA-RI, only 1-nit

115 roxide, Cd-MsrB formed reversible intra- and intermolecular disulfides without losing its Cys-coordin

116 We find that intermolecular dityrosine crosslinks restrict alphaSyn m

117 switch that regulated HUalphaalpha dependent intermolecular DNA bundling.

118 ating enantiomers with hydrogen bonds as the intermolecular driving force.

119 gation of CntA variants indicated an unusual intermolecular electron transfer between the subunits of

120 imetic donor-acceptor systems that model the intermolecular electron transfer processes of Nature's p

121 eptor, is kinetically limited by diffusional intermolecular electron transfer, masking the KIE.

122 Consistent with this conclusion, lateral intermolecular electron transfer, parallel to a semicond

123 attributed to stronger pai-pai stacking and intermolecular electronic coupling between TPP(+) cation

124 ion energies of as low as 160/150 meV, large intermolecular electronic coupling integrals of 12.1-37.

125 dielectric properties of a water model whose intermolecular electrostatic interactions are entirely s

126 A Ni-catalyzed intermolecular enantioselective hydroamination of branch

127 tations and vibrations, thus restricting the intermolecular energy transfer and corresponding quenchi

128 localization, which leads to extremely rapid intermolecular enolate equilibration.

129 y important gene can be subjected to precise intermolecular fine-tuning.

130 n reactions involving alkyl-group migration, intermolecular fluoride attack is product- and enantio-d

131 In addition, the reasons for relatively weak intermolecular forces in perfluoroalkanes compared to al

132 phase, a difficult process hampered by weak intermolecular forces, is achieved through polaritons fo

133 Finally, using intermolecular FRET analysis, we demonstrate that SWG di

134 Here single-molecule intermolecular FRET measurements of wild-type E-cadherin

135 to the diboron moiety is achieved either via intermolecular H-abstraction with a CF(3)-radical or via

136 ieved to enhance separate intramolecular and intermolecular H-bond interactions.

137 -like supramolecular structure stabilized by intermolecular H-bonding.

138 To understand how the intermolecular heteroleptic complexation influenced the

139 t interchain excitation energy migration via intermolecular homo-Forster resonance energy transfer ca

140 Here we report a photoenzymatic intermolecular hydroalkylation of olefins catalyzed by f

141 n, the vast majority of alkenes that undergo intermolecular hydroamination have been limited to conju

142 ort a cationic iridium system that catalyses intermolecular hydroamination of a range of unactivated,

143 current examples of direct, enantioselective intermolecular hydroamination of any type of unactivated

144 We report ruthenium-catalyzed intermolecular hydroaminations of a variety of unactivat

145 ve synthesis of functionalized arenes by the intermolecular hydroarylation of terminal and internal 1

146 Polymerization occurs through successive intermolecular hydroarylation reactions to produce high

147 tal-catalyzed methods allowing the selective intermolecular hydrofunctionalization of allenes with N-

148 ket)guan)Co](mu-NH)(mu-N(3)) (5) formed from intermolecular hydrogen atom abstraction (HAA) of strong

149 To our surprise, the mechanism suggests intermolecular hydrogen atom transfer (HAT) chemistry is

150 ier and that this reaction is promoted by an intermolecular hydrogen bond from methanol to the carbon

151 be the result of the nucleus growing through intermolecular hydrogen bonding among molecular componen

152 atile molecular auxiliaries that form robust intermolecular hydrogen bonding and are tethered to naph

153 Intra- and intermolecular hydrogen bonding as well as electrostatic

154 The occurrence of FRET mechanism is due to intermolecular hydrogen bonding between ADD and AA, whic

155 ulations, revealing stabilization effects of intermolecular hydrogen bonding between the side-chain f

156 roduct to form AIE-active aggregates through intermolecular hydrogen bonding in aqueous media.

157 leogels caused to form new intramolecular or intermolecular hydrogen bonding, and improve the thermal

158 states) as well as an abundance of intra and intermolecular hydrogen bonds suppress internal conversi

159 s more slip-stacked than octyl-tpPDI and has intermolecular hydrogen bonds to its neighboring molecul

160 erts into the structure, breaks the existing intermolecular hydrogen bonds, and changes the adsorptio

161 enhanced by adding hydrotropic agent to form intermolecular hydrogen bonds.

162 produce 1,2-disubstituted benzimidazoles by intermolecular imino-transfer.

163 This sheds light on the weak intermolecular interaction acting between the paired bet

164 d alignment of beta-phase PVDF, where strong intermolecular interaction between the NH(2) groups on D

165 e, and a more rigid conformation with strong intermolecular interaction combined with the solubility

166 mulations with showing a stabilizing role of intermolecular interaction in the partitioned system.

167 sition state provided by the confinement and intermolecular interaction of alkanols with the transiti

168 the thermodynamic distribution but also the intermolecular interaction of extracted compounds inside

169 se that ability of an amine to form multiple intermolecular interactions (i.e., hydrogen bonds) in th

170 ed opportunities in the fundamental study of intermolecular interactions and molecular design for cry

171 ock copolymer can occur, determined by their intermolecular interactions and monomer exchange dynamic

172 ation can be used as a powerful tool to tune intermolecular interactions and thereby gain an extra le

173 ed crystal structure analysis suggested that intermolecular interactions are important for efficient

174 demonstrate that geometry-matching and weak intermolecular interactions are of paramount importance

175 articles is challenging, because nonspecific intermolecular interactions are used for encapsulation.

176 improved by adding XG and controlling their intermolecular interactions as a function of pH.

177 tries, which are increasingly unsuitable for intermolecular interactions as the carbon chain length i

178 l is driven by pai-pai stacking and multiple intermolecular interactions between C(2) H(2) molecules

179 However, the critical role of transient intermolecular interactions between the disordered polyp

180 le DFT calculations helped elucidate crucial intermolecular interactions between the HBD, organic aci

181 r faces are anti to each other to allow only intermolecular interactions between the nucleobases, an

182 ences can be attributed to the nature of the intermolecular interactions between the organic molecule

183 mic energies of reactions for each step, the intermolecular interactions between the substrates, and

184 lf-assemblies--shedding light on engineering intermolecular interactions for self-assembled lattice m

185 The nature of the intermolecular interactions formed by EapH1 with catheps

186 its binding partners depends not only on the intermolecular interactions formed in the bound state bu

187 Intermolecular interactions in bulk water are dominated

188 design of systems for photovoltaics in which intermolecular interactions in self-assembled structures

189 squaramide synthons, giving rise to stronger intermolecular interactions in the resultant supramolecu

190 -keto-enamine forms and the influence of the intermolecular interactions in their equilibrium.

191 At high pressure, as intermolecular interactions increase significantly, the

192 structure-property relationships in terms of intermolecular interactions is also provided that may pa

193 with theoretical modeling, the nature of the intermolecular interactions is unraveled.

194 to mix with different amount of P3HT, their intermolecular interactions led to distinctive TIPS pent

195 to supramolecular structures or non-specific intermolecular interactions like van der Waals forces.

196 em, to show that multiple intramolecular and intermolecular interactions modulate ZAR1 activity.

197 taste behavior of polyhydroxy compounds and intermolecular interactions occurring in ternary mixture

198 etect thermodynamic regions characterized by intermolecular interactions of different type and comple

199 post-translational modifications and diverse intermolecular interactions of kinases, it is the distin

200 ises from preferred binding of pairs through intermolecular interactions of substrate molecules on th

201 Intermolecular interactions play a fundamental role on t

202 ular chemistry exploits weak, yet effective, intermolecular interactions such as hydrogen bonding, me

203 ork interpenetration and other types of weak intermolecular interactions such as paipai interactions.

204 effects in the solid state often arise from intermolecular interactions that involve fully extended

205 n FUS assembly by disrupting both intra- and intermolecular interactions that maintain the amyloid co

206 asis of this link through exploration of the intermolecular interactions that underlie LLPS and aggre

207 also by their supramolecular structures and intermolecular interactions to a large extent.

208 w of the liquid using conformation-dependent intermolecular interactions to desolvate (denature) prot

209 hysiochemistry of certain proteins and their intermolecular interactions under physiological conditio

210 s of zeolite pores as well as by intraporous intermolecular interactions with other alkanols.

211 agnetic field sensitivities depending on the intermolecular interactions with the amplification of ri

212 rocesses, analyze conformational aspects and intermolecular interactions, and predict trends in serie

213 have the lowest boiling point and the lowest intermolecular interactions, can be adsorbed in this pol

214 rature, unfolded conformation and subsequent intermolecular interactions, revealed by the increase of

215 ir arrangement in the crystal structures via intermolecular interactions, such as the arene-perfluoro

216 , and force, which alter their intra- and/or intermolecular interactions, yielding unique electronic/

217 stable 3D supramolecular lattice via strong intermolecular interactions.

218 strength, indicating hydrophobically driven intermolecular interactions.

219 dous value to drug discovery and research of intermolecular interactions.

220 berrant IN multimerization by bridging IN-IN intermolecular interactions.

221 ease the crystal formation energy via strong intermolecular interactions.

222 nd physicochemical properties and intra- and intermolecular interactions.

223 by intracellular factors such as nonspecific intermolecular interactions.

224 rowded environments are markedly impacted by intermolecular interactions.

225 not conclusively establish the nature of the intermolecular interactions.

226 ed by tuning the catalytic conditions of the intermolecular-intramolecular Buchwald-Hartwig amination

227 A large, primary intermolecular kinetic isotope effect (KIE = 31.9 +/- 1.

228 . maintaining integrity of mucosal barriers, intermolecular (lattice-like) gluing within the extracel

229 We report here the intermolecular metal-free addition reaction of functiona

230 On top of all these advantages, intermolecular metal-ion translocation is a well-known f

231 65 kDa, through a combination of intra- and intermolecular metal-mediated self-assembly steps.

232 The new method is based on a regioselective intermolecular N-benzylation followed by intramolecular

233 e present here a highly efficient asymmetric intermolecular Ni-catalyzed reductive dicarbofunctionali

234 he first example of efficient metal-mediated intermolecular nitrene transfer to such substrates.

235 a process where enzymatic reactions control intermolecular noncovalent interactions for spatial orga

236 d, was found to self-assemble as a result of intermolecular noncovalent interactions into supramolecu

237 Longer polyP chains are more effective at intermolecular, noncovalent cross-linking of tau.

238 dition, cyclization, and termination through intermolecular nucleophile capture have tremendous utili

239 lic C-H borylation reactions that proceed by intermolecular O-B, S-B and P-B bond formation are also

240 plex constitutes a discrete entity with weak intermolecular orbital overlap between neighboring compl

241 The first isolated examples of intermolecular oxidative addition of alkenyl and alkynyl

242 The gold-catalyzed intermolecular oxyarylation of alkenes is reported.

243 s over O nucleophiles ensured the success of intermolecular oxyarylation, giving desired products wit

244 etallacyclic structures offer a platform for intermolecular packing beneficial for the formation of l

245 In solid films, the slipped stacked intermolecular packing of a thiophene-functionalized der

246 ks is observed, which is rationalized by (i) intermolecular pai-pai interactions between neighboring

247 ered 12-connected organic SBUs on its strong intermolecular pai-pai interactions.

248 X-ray crystallography indicates that intermolecular pai-pai stacking is completely suppressed

249 g fused aromatics exhibited a high degree of intermolecular pai-pai stacking.

250 multiple conformations because of intra- or intermolecular pairing.

251 Chemical shift perturbations and intra- and intermolecular paramagnetic relaxation enhancement (PRE)

252 chors transited from an intramolecular to an intermolecular path when the degree of conjugation incre

253 and spectroscopic studies in the absence of intermolecular perturbation, allowing characterisation o

254 An intermolecular, photocatalytic dicarbofunctionalization

255 s of binary cocrystal solvates to undergo an intermolecular photoreaction to generate ternary cocryst

256 ad to collapse also correlate with increased intermolecular polypeptide chain association and aggrega

257 formulating models based on proper effective intermolecular potentials describing physicochemical phe

258 lorins exhibit a hangman effect derived from intermolecular proton transfer.

259 in the inner solvation sheath promote their intermolecular proton/charge transfer reactions, which d

260 fully account for AIE, whereas the two-body intermolecular quantum mechanical interaction plays a cr

261 renaissance of synthetic radical chemistry, intermolecular radical alkene carboamination comprising

262 ntioselectivity as well as reactivity of the intermolecular radical C-H amination of carboxylic acid

263 Here we report a visible-light-induced intermolecular radical hydroalkylation of terminal alken

264 ns, the governing of asymmetric induction in intermolecular radical reactions still poses challenging

265 rolling reactivity and enantioselectivity in intermolecular radical reactions.

266 es a radical cyclization that is followed by intermolecular radical-radical coupling.

267 er surprisingly, C-C bond formation through "intermolecular" radical addition to internal ynamides ha

268 We demonstrate an intermolecular reaction cascade to control the force whi

269 um mechanical calculations shed light on the intermolecular reaction mechanism.

270 time a chain end alkyne is activated, rapid intermolecular reaction takes place with a different oli

271 tivity has cumbered the development of novel intermolecular reactions that directly engage the arene

272 Intermolecular reactions with simple, all-carbon tetrasu

273 ng the formation of dimers and oligomers via intermolecular reactions.

274 d to be thermodynamically stable (negligible intermolecular rearrangements over weeks), whereas compu

275 lar, RarA makes substantial contributions to intermolecular recombination and to recombination events

276 that the host is involved in both intra- and intermolecular recombination events and that hosts like

277 In wild type, apparent intermolecular recombination intermediates clustered nea

278 evidence-based mechanistic description of an intermolecular reductive C-N coupling of nitroarenes and

279 enes into azaheterocycles through sequential intermolecular reductive C-N cross coupling with boronic

280 This defines a function for eIF4A to limit intermolecular RNA-RNA interactions in cells.

281 Stress granules form in part through intermolecular RNA-RNA interactions, and to better under

282 ules form, in part, through the formation of intermolecular RNA-RNA interactions.

283 y observed RNA tertiary interactions such as intermolecular RNA-RNA kissing loop dimerization, RNA-pr

284 does not involve sequence-specific, ordered intermolecular RNA:RNA interactions, and is thus RNA seq

285 cerning intramolecular (ssRNA and ssDNA) and intermolecular (RNA-RNA, RNA-DNA, and DNA-DNA hybrids) i

286 ridge in UBC13 that competes with a critical intermolecular salt-bridge at the native UBC13/TRAF6(RIN

287 pling to both the intramolecular bending and intermolecular soft modes.

288 on motifs for fullerenes, facilitating novel intermolecular, solvent tunable ground state electronic

289 r spacing, fibril diameter, D-periodicity or intermolecular spacing between treated and untreated spe

290 ecules required lengthy routes and displayed intermolecular spin-spin coupling with limited dimension

291 donor torsion, acceptor wag, acceptor twist, intermolecular stretch, donor torsion overtone, and in-p

292 lower affinity binding site and promote the intermolecular sulfur transfer reaction from IscS to Isc

293 We describe a general strategy for the intermolecular synthesis of polysubstituted cyclopenteno

294 the behaviors of side reactions, such as the intermolecular thioaglycon transformation and N-glycosyl

295 lectronic properties are highly dependent on intermolecular through-space interactions.

296 Intermolecular transfer hydrogenation and hydrothiolatio

297 extends to the efficient and stereoselective intermolecular transfer of carbenes to olefins, heterocy

298 The substrate-mediated intermolecular van der Waals interactions provide a rout

299 An intermolecular version of the reaction was also establis

300 d into the anthracene derivative by a double intermolecular Wittig reaction under very mild condition