ライフサイエンスコーパス: internalization

1 aggregation from cellular, receptor-mediated internalization.

2 thway by binding to EGFR and preventing EGFR internalization.

3 m, we investigated whether ALK regulates D2R internalization.

4 consequent activation, measured as receptor internalization.

5 ant for cell-cell communication and pathogen internalization.

6 ted Arp2/3 complexes are required for robust internalization.

7 no evidence for desensitization or receptor internalization.

8 nocytic machinery, and its involvement in NP internalization.

9 e the receptor's native behavior and trigger internalization.

10 and ligand identity on receptor binding and internalization.

11 tability and enhanced cellular activity upon internalization.

12 h PKC-mediated DAT-Rit2 dissociation and DAT internalization.

13 rrestin-dependent ERK1/2 phosphorylation and internalization.

14 actors, separately analyzing association and internalization.

15 ib completely inhibited dopamine-induced D2R internalization.

16 lectron tomography, contributes to endocytic internalization.

17 itor completely blocked dopamine-induced D2R internalization.

18 ocampal slices from AS mice by enhancing SK2 internalization.

19 nting beta-arrestin recruitment and receptor internalization.

20 ns as likely contributors for Abeta cellular internalization.

21 murine FAP with a rapid and almost complete internalization.

22 e cellular signals and is independent of MOR internalization.

23 ve allosteric modulation of mGlu(5) receptor internalization.

24 a PKC inhibitor blocked dopamine D2 receptor internalization.

25 uding generating membrane curvature to drive internalization.

26 hierarchy and exploit the rest, with no norm internalization.

27 CAV-1 and DNM2 diminishes LDL-mediated ALK-1 internalization.

28 ight compounds for modulators of ferroportin internalization.

29 he formation of CCPs without affecting their internalization.

30 d that high glucose suppressed membrane DMT1 internalization.

31 ein signaling but enable or promote receptor internalization.

32 an FPR2-dependent ERK1/2 phosphorylation and internalization.

33 grin expression facilitates efficient HAdV26 internalization.

34 nase domain and resulted in decreased VEGFR3 internalization.

35 facilitated NOP receptor desensitization and internalization.

36 1-independent actions involving Bbetaglucans internalization.

37 sites, where it regulates glutamate receptor internalization.

38 defining it as an EV ligand critical for EV internalization.

39 hich controls the speed of membrane and coat internalization.

40 y associate with antigen clusters to mediate internalization.

41 nase pathway and was independent of FcgammaR internalization.

42 ctional ACE2 expression as a result of viral internalization.

43 n aggregation, and that dynasore reduces tau internalization.

44 han females, suggesting greater CRF receptor internalization.

45 FM4-64 is also recycled back to the PM after internalization.

46 lemmal damage and connexin 43 redistribution/internalization.

47 hat this overlap further increases upon LRP1 internalization.

48 (VE-cadGGG/GGG) or decreased (VE-cadDEE/DEE) internalization.

49 Abeta-induced toxicity and of neuronal Abeta internalization.

50 s DAT surface expression by accelerating DAT internalization.

51 ptor (MOR) signaling via desensitization and internalization.

52 or or other host proteins critical for virus internalization.

53 ) Tf, which was suggested to facilitate TfR1 internalization; 3) H-ferritin; and 4) MARCH8, previousl

54 amely regulating CD22 surface expression and internalization after B cell activation, as well as prom

55 rface expression and clathrin-dependent CD22 internalization after BCR stimulation.

56 747 showed the best efficacy in blocking MOR internalization among the compounds tested.

57 , LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signalin

58 a protocol able to track the EVs for in vivo internalization analysis.

59 ve allosteric modulation of mGlu(5) receptor internalization and adds significant new knowledge about

60 ting G-protein coupling, triggering receptor internalization and affecting various downstream signall

61 urant were biased toward (affinity) receptor internalization and away (cooperativity) from the ERK1/2

62 ess enhanced green fluorescent protein after internalization and cell viability is unaffected by the

63 It modulates mesoderm internalization and controls a massive posterior infoldi

64 ron absorption and recycling by inducing the internalization and degradation of ferroportin(1).

65 ent and receptor endocytosis, promoting CCR3 internalization and degradation.

66 oupling, adenylyl cyclase activity, receptor internalization and desensitization, and post-endocytic

67 in endothelial cells disrupts VEGF-A/VEGFR2 internalization and downstream signaling.

68 BMP6 controls AMOT internalization and endosomal trafficking in epithelial

69 Slower viral internalization and faster immune-cell recruitment slow

70 derlying ethanol-induced alterations in GPCR internalization and implicate beta-arrestin as a potenti

71 C terminus of 5-HT(2A)R severely diminished internalization and infection, suggesting that beta-arre

72 In contrast, P. gingivalis internalization and intracellular survival in GFs remain

73 ound that the inactivation of Diaph1 blocked internalization and intracellular trafficking of TbetaRI

74 volves early adhesion to ARPE cell membrane, internalization and localization of Pg within single-mem

75 In particular, prolactin receptor internalization and localization was altered in STM KO m

76 Additionally, the efficient cellular internalization and low toxicity of DMNDC make it highly

77 g that is subsequently terminated in part by internalization and lysosomal degradation of CXCR4.

78 g epithelial cells, GSK3008348 induces rapid internalization and lysosomal degradation of the alphavb

79 nins are host cellular factors that mediated internalization and membrane fusion during B. pseudomall

80 tins, which act as adaptors to regulate AT1R internalization and mitogen-activated protein kinase (MA

81 iety of cells and its uptake by constitutive internalization and recycling of CCR2.

82 to mechanisms that mediate PKC-regulated DAT internalization and reveal unexpected region-specific di

83 key drawback of Laurdan linked to its rapid internalization and subsequent labeling of internal memb

84 t opioid tolerance is not dependent upon MOR internalization and support the novel hypothesis that op

85 iments confirmed that CD9 enhanced bacterial internalization and that CD81 inhibited MNGC formation.

86 opioid tolerance occurs independently of MOR internalization and that it is selectively mediated by p

87 1) to the cell surface after agonist-induced internalization and that L-PGDS overexpression had the o

88 at ethanol dose-dependently inhibits 5-HT1AR internalization and that MDM2 knockdown reverses this ef

89 xcept for DPD also caused subsequent TAS2R14 internalization and trafficking via early and late endos

90 targeted NPs significantly improved cellular internalization and transfection efficiency in macrophag

91 , a size selective process occurs during the internalization and translocation of these nanoparticles

92 p taken by the cells through label-free self-internalization and were sensed by SERS.

93 ex formation, betaarr1 recruitment, receptor internalization, and desensitization of G-protein activa

94 competitive binding to FAP, cellular uptake, internalization, and efflux of [(18)F]FGlc-FAPI in vitro

95 id receptor alters acute desensitization and internalization, and in measures of long-term tolerance

96 Polyomavirus binding, internalization, and infection are mediated by glycosphi

97 ntracellular Ca(2+), ERK1/2 phosphorylation, internalization, and NADPH oxidase activity, yet lack of

98 1/2 reduced IGF1R association with clathrin, internalization, and pathway activation by more than 50%

99 y enabling ubiquitination of CD226 by CBL-B, internalization, and proteasomal degradation.

100 ge display library was screened for binding, internalization, and transcytosis across iPSC-derived BM

101 e actin assembly to ensure proper phagocytic internalization, and translocate phagosomes or other car

102 events, which can only occur through enzyme internalization, and which occurred only in systems pois

103 this interaction and the mechanism of phage internalization are not well-understood.

104 otein that orchestrates CLATHRIN-independent internalization, as a critical mediator of endothelial c

105 a-arrestin 2 demonstrated its role in IFNAR1 internalization, as well as STAT1 and IRF3 activation.

106 fluorescence resonance energy transfer-based internalization assay to directly measure CaSR internali

107 novel highly efficient cell-based real-time internalization assay to show that calcium-sensing recep

108 A live-cell receptor internalization assay was used to test the ability of GR

109 Methods: In vitro radioligand binding and internalization assays and cell-cycle analysis were perf

110 1/2) phosphorylation, and real-time receptor internalization assays on rat mGlu(5) expressed in HEK29

111 Competitive cell binding assays and internalization assays were performed with C4-2 cells, a

112 ion, protein absorption, as well as cellular internalization barriers.

113 on of alphavirus release correlated with its internalization but did not involve NF-kappaB activation

114 9-EC2 significantly enhanced B. pseudomallei internalization, but MAb against CD81 and CD81-EC2 inhib

115 GluR activation causes LTD and AMPA receptor internalization, but no spine shrinkage in either wildty

116 e pathogens to HSPGs and stop their cellular internalization, but the anticoagulant effect of these a

117 types is counteracted by constant uptake and internalization by CCR2-expressing cells.

118 more, we found that tamalin regulates mGluR1 internalization by interacting with S-SCAM, a protein th

119 and mammalian host cells and to quantify EV internalization by mammalian cells.

120 PSMAs showed low nanomolar affinity and high internalization by PSMA-expressing cells when compared w

121 studies suggested that cargo ensures its own internalization by regulating either CME initiation rate

122 For antibody selection, we evaluated internalization by target cells using streptavidin-linke

123 After NF internalization by the cells, the intracellular RNase H

124 rm the essential role of Cubilin in nutrient internalization by the early visceral endoderm and highl

125 The bNAb-induced Env internalization can be decreased by blocking dynamin fun

126 ble to rescue defects in transferrin and EGF internalization caused by loss of endogenous GAPVD1.

127 However, internalization, choice of endocytic routes, and degrada

128 design an optimal framework for controlling internalization, clearance, and tissue penetration to ma

129 Nanoparticle internalization dynamics is size dependent and differs b

130 We find that T-NP internalization enables cellular uptake of bystander NPs

131 ., 2020) identify integrin alphavbeta5 as an internalization factor that increases susceptibility in

132 research co-opts this crosslinking-mediated internalization for efficient intracellular delivery of

133 erturbation of MT-nanotube formation and Tkv internalization from MT-nanotubes into hub cells both re

134 ex and apical brush border and mediated MHCI internalization from the basolateral domain, while myosi

135 ubiquitin conjugation to OAT1 leads to OAT1 internalization from the cell surface and subsequent deg

136 level of TIM-1 expression, but promotes its internalization from the plasma membrane and sequesters

137 ciated Env than nonpermissive cells, and Env internalization from the plasma membrane is less efficie

138 hibited l-glutamate-induced mGlu(5) receptor internalization, generally with a similar potency to IP(

139 g the process, and little is known as to how internalization happens in invertebrates.

140 lent binding properties (<=45% binding; >95% internalization), high affinity (half-maximal inhibitory

141 detect earlier roles of EAPs preceding cargo internalization; however, this approach has been limited

142 unal work to produce a public good, and norm internalization, i.e. a process where acting according t

143 f soluble antigen-induced BCR clustering and internalization in a cultured human B cell line using co

144 onists induced multisite phosphorylation and internalization in a dose-dependent and agonist-selectiv

145 er, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum

146 ochemical pathway for CI-M6PR-mediated cargo internalization in cell lines, and uncover the exocyst c

147 Following internalization in corticotropes, SSTR2 moves to a juxta

148 ated their receptor binding, cell uptake and internalization in HSC-3 cells.

149 F- and (68)Ga-labeled compounds showed rapid internalization in LS174T-PSMA cells.

150 , we investigated their transformations upon internalization in mesenchymal stem cells and as a funct

151 endothelial cells, ephrinB2 controls VEGFR2 internalization in neurons.

152 icipated, PSMA-EMs showed increased cellular internalization in PSMA positive PC cell lines (LNCaP an

153 ternalization assay to directly measure CaSR internalization in real-time.

154 form unbiased analyses of opioid-induced MOR internalization in the rat substantia gelatinosa.

155 Compound 101 blocked receptor internalization in tissue from both naive and morphine-t

156 We have then evaluated the nanoparticle internalization in two cell lines with a markedly differ

157 ma membranes of renal proximal tubule cells, internalization/inactivation of NHE-3 (sodium-hydrogen e

158 This restored natriuresis, Na(+) transporter internalization/inactivation, and Src and VASP phosphory

159 blocked tolerance without altering receptor internalization induced by either morphine or fentanyl.

160 iated with severe cytoskeleton damage, rapid internalization inside the neuronal cells, and mitochond

161 PS/TAC pre-treatment caused greater TAC internalization into a higher number of lung cells obtai

162 Lead candidates exhibited binding and internalization into BMECs as well as binding to both hu

163 lity in biological media and relatively good internalization into cells and for that they have emerge

164 The peptide internalization into cells by receptor-mediated endocyto

165 Following endocytosis and its internalization into endolysosomes, Tat must be released

166 particles and enhances virus attachment and internalization into host cells.

167 NSTI-SA and BSI-SA exhibited stronger internalization into human keratinocytes and myoblasts t

168 to liposomes demonstrated specific and fast internalization into moLCs.

169 PLY-MRC-1 interactions mediate pneumococcal internalization into non-lysosomal compartments and pola

170 iffness of the DNA nanostructure affect both internalization into plant cells and subsequent gene sil

171 that present tight and specific binding and internalization into PSMA(+) cells and that accumulate s

172 Virus internalization into the host cells occurs via multivale

173 Receptor internalization is a mechanism by which receptors are de

174 to show that calcium-sensing receptor (CaSR) internalization is beta-arrestin-dependent and sensitive

175 on, we provide compelling evidence that CaSR internalization is beta-arrestin-dependent while interes

176 This internalization is followed by retrograde trafficking of

177 Tkv internalization is required for the activation of the Sm

178 els in hippocampal neurons without affecting internalization, K552T and R553L mutations at distal hel

179 ng biological features such as high cellular internalization, low cytotoxicity, controllable pharmaco

180 ere, we probe the toxin membrane binding and internalization mechanisms by using a combination of sup

181 ells in this setting and elucidate potential internalization mechanisms with particular emphasis on t

182 : Radiolabeling, stability, cell uptake, and internalization of (111)In-DOTA-5D3 were performed by es

183 The same was observed for the internalization of (68)Ga- and (177)Lu-PSMA-I&F.

184 terol acyltransferase (ACAT) triggered rapid internalization of a biochemically defined fraction of c

185 We also found that inducing internalization of a SNX17 cargo receptor, low-density l

186 ology phosphatase 2 (SHP2) ensures selective internalization of activated IR.

187 Knockdown of CAV-1 reduces BMP-9-mediated internalization of ALK-1, BMP-9-dependent signaling and

188 alin plays a critical role in mGluR-mediated internalization of alpha-amino-3-hydroxy-5-methyl-4-isox

189 r alphaSacetyl and demonstrate that cellular internalization of alphaSacetyl is reduced significantly

190 tly decreased, without fully preventing, the internalization of antibody-bound receptors suggesting t

191 ed enhanced B(12) receptor-mediated cellular internalization of B(12)-targeted complexes, relative to

192 rate with CD18 integrins in trans to promote internalization of bacteria.

193 Internalization of C. neoformans by KCs is subsequently

194 ents may act in coordination to regulate the internalization of cellular receptors.

195 Overexpression of wild-type EHD1 accelerated internalization of Cx43 and exacerbated ischemia-induced

196 ns indicating that Abeta(25-35) causes rapid internalization of Cx43 gap junctions.

197 onstrate that knockdown of EHD1 impaired the internalization of Cx43, preserving gap junction-interce

198 s of serum CXCL1 in ethanol-fed mice induced internalization of CXCR2 receptor in circulating neutrop

199 Moreover, CHL1 inhibited agonist-triggered internalization of DRD2-S.

200 We analysed internalization of epidermal growth factor in patient ce

201 tion of these transient DRMs by inducing the internalization of extracellular cholesterol and its tra

202 Specifically, UPF2 modulates the internalization of GLUR1 and promotes its local synthesi

203 that increased alphavbeta3 integrin enhances internalization of HAdV26.

204 arrested IL-12-, IL-23-, or p40(2)-mediated internalization of IL-12Rbeta1, but neither IL-12Rbeta2

205 eceptor-mediated, actin-dependent process of internalization of large extracellular particles, such a

206 lays a critical role in the ligand-dependent internalization of mGluR1 and mGluR5, members of the gro

207 Myosin IIA promoted internalization of MHCI and myosin IIB drove CD59 uptake

208 lly localized in each of these tissues after internalization of midbody ring components.

209 s, confirming that GRK2 predominantly drives internalization of MOR in the cell lines we tested and u

210 to opioids was caused by desensitization and internalization of mu-opioid receptors (MORs).

211 Internalization of nanomaterials was confirmed by neutro

212 nts, but there is no direct evidence for the internalization of nanoplastics in terrestrial plants.

213 idic compartments, associated with increased internalization of Notch.

214 oAd/RLX-PCDP complex enhanced the internalization of oAd into hMSC, leading to superior vi

215 Our study demonstrates that AP-2-dependent internalization of PM proteins via the recognition of fu

216 nanoscale protein cages for the capture and internalization of protein or non-proteinaceous componen

217 result of antibody-mediated crosslinking and internalization of receptors.

218 The presence of SEB appeared to promote internalization of S aureus into mast cells.

219 mer interface mutants also failed to trigger internalization of SERINC5 and localization to Rab7(+) l

220 ctivation, and in turn, cofilin promotes the internalization of surface beta1-integrin.

221 logical interventions on the aggregation and internalization of tau and aSyn.

222 HS diminished both cell surface binding and internalization of tau.

223 The internalization of the central nervous system, termed ne

224 In this study we found that agonist-induced internalization of the dopamine D2 receptor is regulated

225 These mechanisms involve recognition and internalization of the extracellular molecules via endoc

226 to CASPR2-transfected HEK cells led to some internalization of the IgG, but with a trend towards hig

227 bound to rodent brain sections, and induced internalization of the LGI1-ADAM22/23 complex in both HE

228 g the involvement of megalin receptor in the internalization of the liposomes.

229 -dependent differences in the regulation and internalization of the mu-opioid receptor (MOR) have bee

230 e paroxetine or GSK180736A scaffold to block internalization of the mu-opioid receptor (MOR).

231 Our data indicate that CCG258747 blocked the internalization of the mu-opioid receptor most efficacio

232 effector protein CPn0678, which facilitates internalization of the pathogen by remodeling the target

233 , the allosteric modulators induced cellular internalization of the receptor and recruitment of beta-

234 1)-mediated cellular effects and prompts the internalization of the receptor leading to its functiona

235 gonist, dopamine, causes desensitization and internalization of the receptor.

236 se a measure of the prevalence and extent of internalization of the stereotype that "math is not for

237 lly, TCR ligation leads to clathrin-mediated internalization of the TCR-CD3zeta complex, while mainta

238 acellular tail in response to Wnt9a promotes internalization of the Wnt9a-Fzd9b-LRP signalosome and s

239 enous tamalin inhibited the ligand-dependent internalization of these two receptors.

240 tin cytoskeleton, thereby averting the rapid internalization of this channel variant.

241 rine and human leukocytes endocytose Pf, and internalization of this single-stranded DNA virus result

242 icits beta-arrestin-dependent inhibition and internalization of TRPV4.

243 In addition, these antibodies enhanced internalization of virions into human leukemia K562 cell

244 differences in shape preservation affect OMV internalization on long timescales: spherical nanopartic

245 BIIB059 administration led to BDCA2 internalization on pDCs, which correlated with circulati

246 were not required for either robust tetherin internalization or alphavirus inhibition.

247 vailability in the EZ might reflect receptor internalization or conformational changes in response to

248 Inhibiting GCGR internalization or disrupting endocytic trafficking prev

249 ith either morphine, which did not cause MOR internalization, or fentanyl, which did.

250 tein pathways over receptor phosphorylation, internalization, or interaction with other effectors, th

251 , biocompatibility, protein corona, cellular internalization pathway of EVG nanoformulation for its p

252 sion from the initiation phase of CME to the internalization phase.

253 results suggest that tetherin-mediated virus internalization plays an important role in the restricti

254 nase transactivated by D2R that promotes its internalization, possibly through activation of protein

255 ost cell cholesterol and caveolin-1 and that internalization proceeds via clathrin-independent, lipid

256 tween S aureus and mast cells, including the internalization process, and demonstrates a prominent ro

257 rface, as well as tracking of the receptors' internalization processes on the addition of fatty acid.

258 onist peptide, NGO-BBN-AF750 showed cellular internalization property.

259 s demonstrate that a smaller size and slower internalization rate enabled higher tissue penetration a

260 The cellular basis of high internalization rate in myoblasts was attributed to high

261 reduced affinity is counteracted by the high internalization rate of constructs with PEG(6)-DM1 ADCs

262 The in vitro binding and internalization rates of (111)In-nimotuzumab, (111)In-ni

263 (64)Cu-CA003 and (64)Cu-CA005 showed high internalization ratios (34.6% +/- 2.8 and 18.6% +/- 4.4,

264 S. aureus internalization reached over 30% in human myoblasts due

265 lly we confirmed expression of vitamin B(12)-internalization receptor (CD320) by Calu-3 cells of the

266 We also found that constitutive receptor internalization/recycling and ligand uptake are not univ

267 endocytosis upon ligand binding, HER2 is an internalization-resistant receptor.

268 aling by inducing P2Y(2) phosphorylation and internalization, resulting in the suppression of the cal

269 Macropinocytosis acts as the major internalization route for BMPRs at the synapse in a proc

270 ng a dual tyrosine motif (YDYCRV) that is an internalization signal for clathrin-mediated endocytosis

271 g to a greater extent than beta-arrestin and internalization signaling pathways.

272 Interestingly, BMP-9-mediated ALK-1 internalization strongly re-duces LDL transcytosis to le

273 Internalization studies strongly correlate intracellular

274 hY(1)R-expressing cells was demonstrated by internalization studies.

275 BR levels, TGF-beta treatment promoted TGFBR internalization, suggesting an overall amplification of

276 e that there is a significant degree of norm internalization, supporting large fractions of the popul

277 Next, we show that the physical mechanism of internalization switches in response to BCR cluster size

278 Here we show that, upon internalization, TCR continues to signal from a set of s

279 competes with acetylation-mediated receptor internalization that correlates with enhanced receptor s

280 MOR at the plasma membrane (before receptor internalization) that facilitates transient activation o

281 e and enables measurements of ligand-induced internalization through changes in cell-surface receptor

282 el future research interests in improving NP internalization through this pathway, and open a new ave

283 p75 in cell bodies and axons is required for internalization to a Rab5-positive signaling endosome an

284 Retrograde sterol internalization to STRIC is independent of endocytosis o

285 packages pDNA and shows exceptional cellular internalization, transgene expression, and low cytotoxic

286 also mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal degradati

287 ogenes (Lm) invades host cells, ruptures its internalization vacuole and reaches the cytosol for repl

288 suppresses TRPA1 channel activity by protein internalization via O(2)-dependent proline hydroxylation

289 Following attachment and internalization, virions traffic to late endosomes where

290 plore whether antigen fate upon CLR-mediated internalization was affected by antigen physical propert

291 NTCP-specific, ligand-dependent binding and internalization was confirmed in vitro.

292 We found that particle internalization was driven by formation of Arp2/3 and fo

293 ed from transient to sustained when receptor internalization was inhibited with drugs or mutations, o

294 s ability to form stable complexes following internalization was reduced, markedly impairing its abil

295 ys downstream of ALK that might regulate D2R internalization, we used pharmacological inhibitors of p

296 In vitro studies (IC(50), internalization) were performed on LNCaP cells.

297 epletion of human SNX9 significantly reduces internalization, whereas ectopic overexpression of CPn06

298 he loss of surface expression was because of internalization, which depended predominantly on the PI3

299 une signaling via suppression of IL-12Rbeta1 internalization, which may be beneficial in patients wit

300 o-Phe substitution in Y(898)KAI reduced BRI1 internalization without affecting its kinase activity.