ライフサイエンスコーパス: interstrand crosslink

1 and Bloom's complexes at the site of the DNA interstrand crosslink.

2 -distorting DNA damage and the repair of DNA interstrand crosslinks.

3 be informative about the metabolism of other interstrand crosslinks.

4 modification and repair of bulky adducts and interstrand crosslinks.

5 the stimulation of DNA synthesis by psoralen interstrand crosslinks.

6 fficient in vitro DNA resynthesis induced by interstrand crosslinks.

7 NA polymerase-helicase involved in repair of interstrand crosslinks.

8 s, including monoadducts and intrastrand and interstrand crosslinks.

9 links were preferred targets for the ER over interstrand crosslinks.

10 ms, Pol theta also promotes tolerance of DNA interstrand crosslinks.

11 f different types of DNA damage, such as DNA interstrand crosslinks.

12 y covalently modifying the template DNA with interstrand crosslinks.

13 activity of enzymes acting on DNA and causes interstrand crosslinks.

14 f damage, such as double-stranded breaks and interstrand crosslinks.

15 and facilitates replication traverse of DNA interstrand crosslinks.

16 tion, an essential step in the repair of DNA interstrand crosslinks.

17 ncreased activity of DNA2 and WRN at the DNA interstrand crosslinks.

18 core complex that mediates the repair of DNA interstrand crosslinks.

19 that senses and repairs damage caused by DNA interstrand crosslinks.

20 interfere with normal cellular processing of interstrand crosslinks.

21 A core complex to chromatin in repairing DNA interstrand crosslinks.

22 hor complex that recognizes damage caused by interstrand crosslinks, a multisubunit ubiquitin ligase

23 nts cause defective cellular response to DNA interstrand crosslinking agent and telomere maintenance,

24 diazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine

25 n, knockdown of NONO sensitizes cells to the interstrand crosslinking agent, cisplatin, whereas knock

26 Upon exposure to ionizing radiation or an interstrand crosslinking agent, the number of cells exhi

27 characterized by cellular sensitivity to DNA interstrand crosslinking agents and a high risk of cance

28 en shown to be specifically sensitive to DNA interstrand crosslinking agents but not sensitive to mon

29 y can result in a marked hypersensitivity to interstrand crosslinking agents, such as mitomycin C.

30 ty and sensitivity to ionizing radiation and interstrand crosslinking agents.

31 omal instability and hypersensitivity to DNA interstrand crosslinking agents.

32 omal instability and hypersensitivity to DNA interstrand crosslinking agents.

33 disorder characterized by sensitivity to DNA interstrand crosslinking agents.

34 d recombinational exchanges during repair of interstrand crosslinks and closely opposed lesions.

35 Here we generate acetaldehyde-induced DNA interstrand crosslinks and determine their repair mechan

36 and repair of DNA double-strand breaks, DNA interstrand crosslinks and DNA damage during DNA replica

37 erphase, TRAIP helps replisomes overcome DNA interstrand crosslinks and DNA-protein crosslinks, where

38 fective in promoting replication traverse of interstrand crosslinks and is also inefficient in promot

39 involved in the recognition or repair of DNA interstrand crosslinks and perhaps other forms of DNA da

40 re rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellul

41 damage, including DNA double-strand breaks, interstrand crosslinks, and DNA gaps.

42 Because interstrand crosslinks are believed to be repaired throu

43 stards selectively formed two base-staggered interstrand crosslinks between the 5'G and the G opposit

44 Notably, 8MOP-induced DNA interstrand crosslinks, but not 8MOP mono-adducts, produ

45 as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts

46 ke MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be inde

47 was presumed to be a defect in the repair of interstrand crosslinks by homologous recombination.

48 se results define the repair pathways of DNA interstrand crosslinks caused by an endogenous and alcoh

49 nalogous to the mechanism used to repair the interstrand crosslinks caused by the chemotherapeutic ag

50 Inappropriate repair of interstrand crosslinks causes genomic instability, leadi

51 ified NEIL1 protein bound stably to psoralen interstrand crosslink-containing synthetic oligonucleoti

52 DNA interstrand crosslinks covalently link the two strands o

53 e FA repair pathway being overwhelmed by DNA interstrand crosslink damage caused by alcohol and tobac

54 onoaziridinyl-1,4-benzoquinones were able to interstrand crosslink DNA after reduction and were cytot

55 yamide 1-Chl conjugate (1-Chl) alkylates and interstrand crosslinks DNA in cell-free systems.

56 otoxic agents that generate alkylated bases, interstrand crosslinks, DNA-protein crosslinks, and doub

57 acted doses of 14 alkylating and similar DNA interstrand crosslinking drugs from medical records.

58 this groove for efficient digestion past DNA interstrand crosslinks, facilitating the key DNA repair

59 ifference in the extent of N-alkyl purine or interstrand crosslink formation in the N-ras, c-myc or C

60 The levels of N-alkyl purine and DNA interstrand crosslink formation, produced by the clinica

61 lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes.

62 resolution of non-B DNA structures including interstrand crosslinks, G quadruplexes and DNA triplexes

63 e phosphodiester backbone that surrounds the interstrand crosslink, generating a double-strand-break

64 roduces a number of DNA adducts with the DNA interstrand crosslink (ICL) considered to be the critica

65 pression, abrogation of BRIP1 foci after DNA interstrand crosslink (ICL) damage and hypersensitivity

66 and Rev1 are essential for the repair of DNA interstrand crosslink (ICL) damage.

67 HES1, to form complexes that participate in interstrand crosslink (ICL) DNA repair and MEC different

68 The interstrand crosslink (ICL) presents a challenge to both

69 other key cellular processes, including DNA interstrand crosslink (ICL) repair and DNA double-strand

70 DNA interstrand crosslink (ICL) repair requires a complex ne

71 s roles in nucleotide excision repair (NER), interstrand crosslink (ICL) repair, homologous recombina

72 During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonu

73 that MUS312 has a MEI-9-independent role in interstrand crosslink (ICL) repair.

74 ng (NHEJ), homologous recombination (HR) and interstrand crosslink (ICL) repair.

75 The FA proteins function primarily in DNA interstrand crosslink (ICL) repair.

76 s in any of at least 16 genes regulating DNA interstrand crosslink (ICL) repair.

77 ynthesis (TLS) past a nitrogen mustard-based interstrand crosslink (ICL) with an 8-atom linker betwee

78 date factors affecting TFO-directed psoralen interstrand crosslink (ICL)-induced recombination, we co

79 gulated target acting as one defense against interstrand crosslink (ICL)-inducing agents.

80 oligonucleotides (TFOs) conjugated to a DNA interstrand crosslinking (ICL) agent, psoralen (pTFO-ICL

81 (FA) patients are extremely sensitive to DNA interstrand crosslinking (ICL) agents, but the molecular

82 nd FANCD2, is required for the repair of DNA interstrand crosslinks (ICL) and related lesions(1).

83 d by increased sensitivity to agents forming interstrand crosslinks (ICL) in DNA.

84 Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NE

85 ssor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly toxic lesion that

86 (FA) pathway is essential for repairing DNA interstrand crosslinks (ICL).

87 ) pathway is important for the repair of DNA interstrand crosslinks (ICL).

88 ential for the recognition and repair of DNA interstrand crosslinks (ICL).

89 ous cancers sensitizes a cancer cell line to interstrand-crosslinking (ICL) agents.

90 s time points, suggested an unexpected, late interstrand-crosslinking (ICL) repair pathway response t

91 During the repair of interstrand crosslinks (ICLs) a DNA double-strand break

92 tients and mouse models are sensitive to DNA interstrand crosslinks (ICLs) and FA mice are moderately

93 ay plays a central role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular res

94 CA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chr

95 Interstrand crosslinks (ICLs) are a type of covalent les

96 DNA interstrand crosslinks (ICLs) are among the most cytotox

97 Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the ge

98 DNA interstrand crosslinks (ICLs) are critical lesions for t

99 DNA interstrand crosslinks (ICLs) are cytotoxic lesions that

100 DNA interstrand crosslinks (ICLs) are extremely cytotoxic le

101 DNA interstrand crosslinks (ICLs) are generated by endogenou

102 DNA interstrand crosslinks (ICLs) are highly cytotoxic lesio

103 DNA interstrand crosslinks (ICLs) are highly toxic because t

104 Interstrand crosslinks (ICLs) are highly toxic DNA lesio

105 DNA interstrand crosslinks (ICLs) are the most toxic lesions

106 Interstrand crosslinks (ICLs) are toxic DNA lesions that

107 DNA interstrand crosslinks (ICLs) are toxic DNA lesions whos

108 esolving double-strand DNA breaks (DSBs) and interstrand crosslinks (ICLs) by homologous recombinatio

109 ins thought to function in the repair of DNA interstrand crosslinks (ICLs) comprise what is known as

110 Photoreactive psoralens can form interstrand crosslinks (ICLs) in double-stranded DNA.

111 The repair mechanisms acting on DNA interstrand crosslinks (ICLs) in eukaryotes are poorly u

112 tively resolve Holliday junctions and repair interstrand crosslinks (ICLs) in mammalian cells.

113 ed that fludarabine enhanced accumulation of interstrand crosslinks (ICLs) in specific regions of the

114 DNA interstrand crosslinks (ICLs) pose a major obstacle for

115 DNA interstrand crosslinks (ICLs) represent a severe form of

116 Repair of interstrand crosslinks (ICLs) requires the coordinated a

117 not essential for cells to survive toxic DNA interstrand crosslinks (ICLs), although MMR proteins bin

118 Drugs that produce DNA interstrand crosslinks (ICLs), between the two complemen

119 otein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism

120 Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical effici

121 DNA-DNA crosslinks, especially interstrand crosslinks (ICLs), cause cytotoxicity via bl

122 DNA interstrand crosslinks (ICLs), highly toxic lesions that

123 le-deficient cells are hypersensitive to DNA interstrand crosslinks (ICLs), indicating that BRCA1 has

124 DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by

125 r hypersensitivity to agents that induce DNA interstrand crosslinks (ICLs), such as mitomycin C (MMC)

126 When facing interstrand crosslinks (ICLs), the ICL-repair protein FA

127 agents used in cancer chemotherapy cause DNA interstrand crosslinks (ICLs), which covalently link bot

128 However, interstrand crosslinks (ICLs), which preclude DNA unwind

129 itin are required for localizing SLX4 to DNA interstrand crosslinks (ICLs), yet how SLX4 is targeted

130 accumulate 4N DNA content in response to DNA interstrand crosslinks (ICLs).

131 and for survival of cells in response to DNA interstrand crosslinks (ICLs).

132 cative stress, as well as to the response to interstrand crosslinks (ICLs).

133 poptotic death in response to unresolved DNA interstrand crosslinks (ICLs).

134 cterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs).

135 lites which promote DNA damage, specifically interstrand crosslinks (ICLs).

136 (DSBs), angelicin monoadducts and trioxsalen interstrand crosslinks (ICLs).

137 c nuclease involved in the processing of DNA interstrand crosslinks (ICLs).

138 ndependent function during the repair of DNA interstrand crosslinks (ICLs).

139 rticipates in a pathway of resistance to DNA interstrand crosslinks (ICLs).

140 NEIL1 recognizes specifically and distinctly interstrand crosslinks in DNA, and can obstruct the effi

141 es or a novel tetrafunctional mustard caused interstrand crosslinks in the target DNA and were more m

142 differentially process UV mimetic damage and interstrand crosslinks in vitro.

143 that EcoR124I can translocate past covalent interstrand crosslinks, inconsistent with an obligatory

144 veloped a mammalian cell free assay in which interstrand crosslinks induce DNA synthesis in both dama

145 e DSBs and show defects in the resolution of interstrand crosslink-induced DSBs.

146 ovarian cancer often include the use of DNA interstrand crosslink-inducing agents (e.g., platinum dr

147 cts, the collision of replication forks with interstrand crosslinks initiates two distinct repair pat

148 th biomolecules, including DNA base adducts, interstrand crosslinks, intrastrand crosslinks, and DNA-

149 No interstrand crosslinking is observed.

150 the cellular level, hypersensitivity to DNA interstrand crosslinks is the defining feature in Fancon

151 es profound cellular hypersensitivity to DNA interstrand crosslink lesions in vivo, highlighting the

152 itutional genomic disorders, suggesting that interstrand crosslinks may play a pathogenic role in suc

153 UVA irradiation also induces DNA interstrand crosslinking of S(4)TdR-containing duplex ol

154 to aid replication machines to traverse DNA interstrand crosslinks prior to post-replication repair.

155 emonstrated that neither mismatch repair nor interstrand crosslink repair affects the production of t

156 la MUS308, which is essential for normal DNA interstrand crosslink repair and is unique in that it co

157 ing replication and its participation in DNA interstrand crosslink repair and/or heteroduplex rejecti

158 CM participates in recombination-independent interstrand crosslink repair by facilitating recruitment

159 esults suggest that FAN1 has a minor role in interstrand crosslink repair compared with true FA genes

160 otifs, SLX4 SIMs are dispensable for its DNA interstrand crosslink repair functions.

161 roper RAD51 function is important during DNA interstrand crosslink repair outside of homologous recom

162 the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred t

163 protein families, namely the PSO2 (SNM1) DNA interstrand crosslink repair proteins and the 73-kD subu

164 nstability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome bre

165 ce that BRCA1 plays an important role in DNA interstrand crosslink repair that is distinct from its e

166 be important for nucleotide excision repair, interstrand crosslink repair, and DNA double-strand repa

167 including nucleotide excision repair (NER), interstrand crosslink repair, and meiotic recombination.

168 connected to a pathway that is deficient in interstrand crosslink repair, and that at least one othe

169 genetic complementation groups implicated in interstrand crosslink repair, FANCJ encodes a DNA helica

170 found the depletion of reduced both HDR and interstrand crosslink repair, phenocopying the loss of t

171 ty-DNA double-strand break (DSB) repair, DNA interstrand crosslink repair, repair of stalled replicat

172 monoubiquitinated FANCD2 and is required for interstrand crosslink repair, suggesting that mutation o

173 lication-dependent and transcription-coupled interstrand crosslink repair, while SNM1B/Apollo is requ

174 e marrow failure disorder with defective DNA interstrand crosslink repair.

175 nconi anemia (FA) pathway is responsible for interstrand crosslink repair.

176 caused by mutations in genes controlling DNA interstrand crosslink repair.

177 role(s) in homologous recombination and DNA interstrand crosslink repair.

178 functions in nucleotide excision repair and interstrand crosslink repair.

179 n endo- and exo-nuclease involved in DNA and interstrand crosslink repair.

180 of its E3 ubiquitin ligase activity and DNA interstrand crosslink repair.

181 ng error-prone replicative lesion bypass and interstrand crosslink repair.

182 tion and Fanconi anemia complex-mediated DNA interstrand crosslink repair.

183 he two known pathways of replication-coupled interstrand-crosslink repair.

184 were exposed to chemicals that generate DNA interstrand crosslinks (repaired by FA proteins), but no

185 Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for

186 Repair of DNA interstrand crosslinks requires action of multiple DNA r

187 by ATR activates Fanconi anemia signaling at interstrand crosslink-stalled replication forks by recru

188 n in vitro assay in which the presence of an interstrand crosslink stimulates the incorporation of ra

189 alter the accumulation of NEIL1 at sites of interstrand crosslinks, suggesting distinct recognition

190 leotides (TFOs) that target a psoralen (pso) interstrand crosslink to a specific chromosomal site in

191 n C, which is consistent with the ability of interstrand crosslinks to induce homologous recombinatio

192 d for repair of DNA double-strand breaks and interstrand crosslink tolerance.

193 When two replisomes converge at an interstrand crosslink, TRAIP ubiquitylates the replicati

194 ntral and crucial step for the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway.

195 to oxidative DNA damage and psoralen-induced interstrand crosslinks was differentially affected by th

196 repair (BER) proteins in the response to DNA interstrand crosslinks, which block replication and tran

197 Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the