ライフサイエンスコーパス: intervertebral

1 alism, including an increase in the width of intervertebral articular facets from the upper to lower

2 , DAPS maintained their structure, prevented intervertebral bony fusion, and matched native disc mech

3 Intervertebral bridging bone was consistently observed o

4 t the protein is required for maintenance of intervertebral, carpal and sternal joints, and the joint

5 From nucleus pulposus of the intervertebral disc (in which the bulk collagen monomer

6 r understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate

7 mplicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis.

8 l loads are important for homeostasis of the intervertebral disc (IVD) cell matrix, with physiologic

9 ithout pro-inflammatory cytokine IL-1beta in intervertebral disc (IVD) cells such as human annulus fi

10 dies have demonstrated biologic responses of intervertebral disc (IVD) cells to loading, although the

11 Intervertebral disc (IVD) degeneration activates the dif

12 Intervertebral disc (IVD) degeneration and associated sp

13 Intervertebral disc (IVD) degeneration and consequent lo

14 Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain

15 Intervertebral Disc (IVD) degeneration has been associat

16 of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicat

17 ommon cause of low back pain, the cascade of intervertebral disc (IVD) degeneration is initiated by t

18 Intervertebral disc (IVD) degeneration is often associat

19 The aetiology of intervertebral disc (IVD) degeneration remains poorly un

20 on of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-

21 Back pain is linked to intervertebral disc (IVD) degeneration, but clinical stu

22 ain is extremely high and is often linked to intervertebral disc (IVD) degeneration.

23 ted the role of HTRA1 in the pathogenesis of intervertebral disc (IVD) degeneration.

24 The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial chang

25 Role of cilia and IFT80 protein in intervertebral disc (IVD) development, maintenance, and

26 Intervertebral disc (IVD) disease (IDD) is a complex, mu

27 Intervertebral disc (IVD) disorder and age-related degen

28 embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturation.

29 Its incidence is closely related to intervertebral disc (IVD) failure, which is likely cause

30 sues also require interactions for postnatal intervertebral disc (IVD) growth and maintenance is less

31 The intervertebral disc (IVD) has long been considered uniqu

32 The main pathogenesis of intervertebral disc (IVD) herniation involves disruption

33 Recurrence of intervertebral disc (IVD) herniation is the most importa

34 anical signals can either promote or disrupt intervertebral disc (IVD) homeostasis, the molecular mec

35 The biomechanical function of the intervertebral disc (IVD) is a critical indicator of tis

36 A targeted injury to the mouse intervertebral disc (IVD) is often used to recapitulate

37 The central region of the intervertebral disc (IVD) is rich in proteoglycans, lead

38 anabolic and anti-catabolic growth factor on intervertebral disc (IVD) matrix and cell homeostasis.

39 Degeneration of the intervertebral disc (IVD) results in a range of symptoma

40 Narrowed intervertebral disc (IVD) space is a characteristic of I

41 -derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and t

42 flammatory cytokine expression in pathologic intervertebral disc (IVD) tissues.

43 al bodies were only mildly affected, but the intervertebral disc (IVD) was reduced or missing.

44 breakdown of the extracellular matrix of the intervertebral disc (IVD), disc height loss, and inflamm

45 commonly implicated in this condition is the intervertebral disc (IVD), which frequently herniates, r

46 s (NP), the central gelatinous region of the intervertebral disc (IVD).

47 commonly associated with pathologies of the intervertebral disc (IVD).

48 atic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs i

49 e commonly used to diagnose prolapsed lumbar intervertebral disc (PLID).

50 f this study was that Chd synthesized in the intervertebral disc accumulates in the vertebral body.

51 Sensory afferent nerve fiber growth into the intervertebral disc after injury-induced inflammation ma

52 y has correlated macroscopic and microscopic intervertebral disc alterations starting in the second d

53 how that the loss of residual strains in the intervertebral disc alters the microenvironment and inst

54 The physiologically hypoxic intervertebral disc and cartilage rely on the hypoxia-in

55 It is characterized by asymmetric intervertebral disc and facet joint degeneration, leadin

56 hich only revealed a protrusion of the L5-S1 intervertebral disc and no apparent cause for the patien

57 low back pain is degenerative disease of the intervertebral disc and other structures of the lumbar s

58 e a novel mechanism of NGF regulation in the intervertebral disc and potentially other pathogenic con

59 Pathologic processes affecting the intervertebral disc are affected by genetic factors and

60 Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extra

61 Intervertebral disc calcification is a rare condition in

62 n our study, we present a case of idiopathic intervertebral disc calcification within the cervical se

63 we investigated LPP action in rabbit primary intervertebral disc cells cultured ex vivo in a three-di

64 CHST3 mRNA was significantly reduced in the intervertebral disc cells of human subjects carrying the

65 In intervertebral disc cells, hypoxia promotes expression o

66 Low-dose NVP-BGJ398 treatment reduced intervertebral disc defects of lumbar vertebrae, loss of

67 enitors also caused severe short stature and intervertebral disc defects.

68 Intervertebral disc degeneration (IDD) causes chronic ba

69 Intervertebral disc degeneration (IDD) contributes to ba

70 pulposus (NP) has been observed in cases of intervertebral disc degeneration (IDD).

71 wn, studies on the effects and mechanisms of intervertebral disc degeneration (IVDD) are still lackin

72 Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause o

73 Intervertebral disc degeneration (IVDD) is a primary con

74 Intervertebral disc degeneration (IVDD) is linked to low

75 Intervertebral disc degeneration (IVDD) is mainly caused

76 The intervertebral disc degeneration (IVDD)-related diseases

77 or for several chronic conditions, including intervertebral disc degeneration and associated back pai

78 ales, and thickening of the skin, as well as intervertebral disc degeneration and extensive synovial

79 e therapeutic strategy for the prevention of intervertebral disc degeneration and its associated morb

80 ative connective tissue pathologies, such as intervertebral disc degeneration and osteoarthritis.

81 ation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely.

82 was to assess the prevalence and timeline of intervertebral disc degeneration in mice homozygous for

83 The finding of premature onset of intervertebral disc degeneration in this mouse model may

84 Intervertebral disc degeneration is a leading cause of c

85 Intervertebral disc degeneration is highly prevalent wit

86 Intervertebral disc degeneration is linked to loss of ex

87 Intervertebral disc degeneration is the leading cause of

88 Intervertebral disc degeneration was also detected, with

89 ioral phenotype in a rodent model of chronic intervertebral disc degeneration which provides a means

90 (12.5 mo old) showed increased incidence of intervertebral disc degeneration with a concomitant decr

91 a future therapeutic intervention to retard intervertebral disc degeneration, partial inhibition of

92 ges consistent with anatomic signs of OA and intervertebral disc degeneration.

93 e to the changes occurring in the ECM during intervertebral disc degeneration.

94 on of innervating sensory neurons in chronic intervertebral disc degeneration.

95 ic mechanisms of nociceptive pain in chronic intervertebral disc degeneration.

96 represents a promising strategy for treating intervertebral disc degeneration.

97 osis for several spinal disorders, including intervertebral disc degenerative changes in T1w and T2w

98 defects in caudal vertebrae due to abnormal intervertebral disc development, although with higher pe

99 The nucleus pulposus (NP) of the intervertebral disc develops from the notochord.

100 arrow signal changes, and abnormal signal in intervertebral disc did not necessarily indicate worseni

101 thin a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonfe

102 ents for diseases such as osteoarthritis and intervertebral disc disease.

103 is a promising avenue for treating advanced intervertebral disc disease.

104 nking sulfate homeostasis with back pain and intervertebral disc disorder, our study identifies SLC26

105 [1.01-1.06]), arthrosis (1.15 [1.09-1.21]), intervertebral disc disorders (1.13 [1.09-1.17]), and sp

106 IX collagen is an important component of the intervertebral disc extracellular matrix.

107 d ADAMTS-4 messenger RNA expression in human intervertebral disc fibrochondrocytes.

108 We obtained 34 control samples of intervertebral disc from previously healthy individuals

109 sures in the central nucleus pulposus of the intervertebral disc generate prestrain in the outer annu

110 Nerve ingrowth deeper into diseased intervertebral disc has been reported, but how common th

111 Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but does

112 painful neuroinflammation that can accompany intervertebral disc herniation, is associated with local

113 likely to have low back pain or symptoms of intervertebral disc herniation, with secondary problems

114 utic potential of TARPs for the treatment of intervertebral disc herniation.

115 g to increased susceptibility of spontaneous intervertebral disc herniations in a clinically relevant

116 We examined nerve growth into the intervertebral disc in the pathogenesis of chronic low b

117 an important role for nerve growth into the intervertebral disc in the pathogenesis of chronic low b

118 from the dorsal root ganglia in animals with intervertebral disc injury demonstrated altered TRPV1 ac

119 e outer third of the annulus fibrosus of the intervertebral disc is innervated.

120 to hypoxia in nucleus pulposus cells of the intervertebral disc is regulated by the hypoxia-inducibl

121 hondrocytes in knee joint and in NP cells in intervertebral disc led to the decrease in CTGF expressi

122 obtained from healthy and pathological human intervertebral disc matrices.

123 study to assess the therapeutic benefits of intervertebral disc matrix repair and regeneration by ev

124 ned peptide therapy with LfcinB and BMP7 for intervertebral disc matrix repair and to understand cell

125 he alterations in the range of motion (ROM), intervertebral disc pressure (IDP), articular cartilage

126 patients: dyspnoea, headache, hypertension, intervertebral disc protrusion, and malignant lung neopl

127 ting potential for future studies related to intervertebral disc replacement therapy.

128 Unilateral disc puncture of one lumbar intervertebral disc revealed a bilateral behavioral phen

129 Thirty-six formalin-fixed embedded intervertebral disc samples of varying grades of degener

130 h varying anatomic corridors to approach the intervertebral disc space and implanted materials have e

131 CT images at the level of the L4-5 intervertebral disc space were extracted from the medica

132 expression of Notch signaling components in intervertebral disc tissue from mature rats and from hum

133 the PKC pathways, specifically PKCdelta, in intervertebral disc tissue homeostasis.

134 anases other than ADAMTS-8 was identified in intervertebral disc tissue, as was mRNA for TIMP-3.

135 ell type than BM-MSCs for use in engineering intervertebral disc tissue.

136 aggrecanase activities were also detected in intervertebral disc tissue.

137 r of metalloproteinases 3 (TIMP-3), in human intervertebral disc tissue.

138 n clock phase and amplitude in cartilage and intervertebral disc tissues in vivo and in tissue explan

139 biosynthesis towards maintenance of healthy intervertebral disc tissues.

140 grecan-rich hydrated tissue that permits the intervertebral disc to resist compressive loads.

141 a CV2-dependent flow of Chd protein from the intervertebral disc to the vertebral body.

142 content in biological tissues (i.e., porcine intervertebral disc).

143 worsening destruction of vertebral body and intervertebral disc, abnormal vertebral marrow signal ch

144 of vertebral body height, abnormal signal in intervertebral disc, and loss of disc height.

145 pain is associated with degeneration of the intervertebral disc, but specific mechanisms of pain gen

146 tochord gives rise to the middle part of the intervertebral disc, called the nucleus pulposus.

147 Interestingly, lubricin was prominent in the intervertebral disc, especially in the nucleus pulposus.

148 Nucleus pulposus, the central zone of the intervertebral disc, is gel-like and has a similar colla

149 proteins in articular cartilages, meniscus, intervertebral disc, rib, and tracheal cartilages on sam

150 n nucleus pulposus (NP) cells of the healthy intervertebral disc, the mechanisms that control express

151 (alpha1) XI protein both localize within the intervertebral disc-vertebral junction region encompassi

152 TS activity in nucleus pulposus cells of the intervertebral disc.

153 ten the direct result of degeneration of the intervertebral disc.

154 yme regulating GAG synthesis in cells of the intervertebral disc.

155 uctures, such as the articular cartilage and intervertebral disc.

156 cornea, and successive lamellar rings in an intervertebral disc.

157 en a result of a degenerative process in the intervertebral disc.

158 agnosed with large calcifications within the intervertebral disc.

159 y neuron changes to a single affected lumbar intervertebral disc.

160 ogically hyperosmotic environment within the intervertebral disc.

161 adaptation to diurnal osmotic loading of the intervertebral disc.

162 Intervertebral discs (IVD) are essential components of t

163 ures of nucleus pulposus (NP) cells from the intervertebral discs (IVD) of bovine tails were transfec

164 reporter genes and injected in isolated goat intervertebral discs (IVD).

165 o-vanillin and RG-7112, remove SnCs in human intervertebral discs (IVDs) and reduce SASP release, but

166 uloskeletal (MSK) tissues like cartilage and intervertebral discs (IVDs) but require long acquisition

167 al bodies were only moderately affected, the intervertebral discs (IVDs) were either missing or incom

168 en associated with the degeneration of human intervertebral discs (IVDs).

169 th circumferentially aligned fibers, such as intervertebral discs and arteries, are abundant in natur

170 ithin the developing annulus fibrosis of the intervertebral discs and increased apoptosis of chondroc

171 es were taken at lumbar vertebrae L1-L5 plus intervertebral discs and the thigh (midthigh, 10 cm dist

172 hat express substance P deep within diseased intervertebral discs and their association with pain sug

173 Articular cartilage (AC) and intervertebral discs are cartilaginous tissues with a si

174 Intervertebral discs are important structural components

175 pression of Sca1 in mesenchymal cells of the intervertebral discs during development of the spinal co

176 n in vivo mechanical responses of the lumbar intervertebral discs during functional tasks.

177 We collected 46 samples of intervertebral discs from 38 patients during spinal fusi

178 Nerve growth into degenerate intervertebral discs has been linked with the developmen

179 orphometry and deformation of lumbar (L2-S1) intervertebral discs in 10 healthy participants while pe

180 f senescent cells taken from the degenerated intervertebral discs of aged humans.

181 Immunohistochemical staining of intervertebral discs of Ccn2 null embryos shows a decrea

182 ry responses associated with degeneration of intervertebral discs that cause chronic back pain, and w

183 Aggrecan extracted from human lumbar intervertebral discs was incorporated into tissue cultur

184 a murine organ culture model in which intact intervertebral discs were cocultured with peritoneal mac

185 of the spine and hips, and deterioration of intervertebral discs with characteristic radiographic ch

186 nt of anterior elements, relative sparing of intervertebral discs, and cold abscesses.

187 ading of the lower back with degeneration of intervertebral discs, and experiments on cadaver spines

188 tebrae, zygapophyseal and sacroiliac joints, intervertebral discs, and neurovascular structures) are

189 f a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and ster

190 Degeneration of the intervertebral discs, bulging, and facet joint arthropat

191 In injured intervertebral discs, disruptions in fibre organization

192 ures including cortical and cancellous bone, intervertebral discs, ligaments, and cartilage directly

193 Indeed, entire intervertebral discs, normally composed by nucleus pulpo

194 sforming growth factor can be transferred to intervertebral discs, resulting in increased proteogylca

195 g signaling is required for formation of the intervertebral discs.

196 cular mechanisms responsible for forming the intervertebral discs.

197 CCN3 was expressed in embryonic and adult intervertebral discs.

198 lcium phosphate-like whitlockite crystals in intervertebral discs.

199 perichondrium, and mesenchymal cells of the intervertebral discs.

200 directly by forming the nucleus pulposus of intervertebral discs.

201 re necessary for the resorption of herniated intervertebral discs.

202 us fibrosus in 48 (60%) of the 80 samples of intervertebral discs.

203 ome, which later comprises the vertebrae and intervertebral discs.

204 nges in achieving functional regeneration of intervertebral discs.

205 ing rise to the cells that form and maintain intervertebral discs.

206 premature degeneration and calcification of intervertebral discs.

207 ignaling mechanisms control this response in intervertebral discs.

208 and water content in the nucleus pulposus of intervertebral discs.

209 of alternating vertebral bodies (centra) and intervertebral discs.(1) Recent studies in zebrafish hav

210 spine alters the osmotic environment in the intervertebral disk (IVD) as interstitial water is expre

211 gulatory role of PN-1 in the pathogenesis of intervertebral disk (IVD) degeneration.

212 Degeneration of the intervertebral disk (IVD) is a major pathological proces

213 yD88 pathway has yet to be elucidated in the intervertebral disk (IVD).

214 The lumbosacral intervertebral disk angle (LSIVDA), defined as the angle

215 ant role in the development of back pain and intervertebral disk degeneration in adults.

216 other widespread pathology related to GAG is intervertebral disk degeneration.

217 e for HTRA1 in the pathogenesis of joint and intervertebral disk degeneration.

218 The images obtained in the excised intervertebral disk demonstrated a signal intensity vari

219 had ligamentous injuries, three patients had intervertebral disk edema, and one patient had a cord co

220 rs; 42% women) with imaging-confirmed lumbar intervertebral disk herniation and persistent signs and

221 cal candidates with imaging-confirmed lumbar intervertebral disk herniation who were treated at 13 sp

222 ctures, vertebral body and facet contusions, intervertebral disk herniations, ligamentum nuchae strai

223 Magnetic resonance (MR) images of a lumbar intervertebral disk in a healthy volunteer were obtained

224 cord contusion, a ligamentous injury, and an intervertebral disk injury.

225 A well-formed, complete S1-2 intervertebral disk is associated with LSTVs, but altera

226 ee-dimensional reconstruction of lamellae of intervertebral disk is presented.

227 -dimensional rAMIRA imaging at four cervical intervertebral disk levels.

228 rids by systemic immunization with cartilage/intervertebral disk proteoglycan (PG).

229 s, of which 24 resulted from misplacement of intervertebral disk space markers.

230 n 10-week-old dKO mice showed replacement of intervertebral disk structures (annulus fibrosus and nuc

231 A complete S1-2 intervertebral disk was associated with LSTVs (P = .004)

232 Thin-section spin-echo images of an excised intervertebral disk were obtained with a horizontal fiel

233 ium (from the occiput to the second cervical intervertebral disk) may be radiographically obscure due

234 The results suggest that MR imaging of the intervertebral disk, using sodium imaging and T2 mapping

235 n the literature this year include herniated intervertebral disk-associated radiculopathy, facet join

236 fate of cells of the nucleus pulposus in the intervertebral disk.

237 ation of facet joints, sacroiliac joints, or intervertebral disks (combination trial, 202 participant

238 rtilage, muscle, bone, connective tissue and intervertebral disks (IVDs) as drivers of AIS susceptibi

239 The magic angle effect in intervertebral disks will be observed with vertical magn

240 onal procedures involving bone, soft tissue, intervertebral disks, and joints are safe and sufficient

241 ation of facet joints, sacroiliac joints, or intervertebral disks, radiofrequency denervation combine

242 tomy and the relationship of nerve roots and intervertebral disks.

243 l spinal cord were collected parallel to the intervertebral disks.

244 r this retrospective study, 41 patients (243 intervertebral disks; overall mean age, 68 years; 24 wom

245 Intervertebral flexion translations from L2-S1 were dete

246 for 5-7 d by L-shaped rods inserted into the intervertebral foramina.

247 The method involves the installation of an intervertebral fusion mount to reduce spinal movement, a

248 Similar intervertebral joint defects and fusions occurred in Col

249 The unique birds dorsal intervertebral joint evolved from this dinosaur joint.

250 aset, we traced the evolution of the amniote intervertebral joint through ancestral character state r

251 res, scoliosis, and altered cartilage in the intervertebral joints of the spinal column.

252 The MRI slice at the intervertebral level between the lumbar (L) 2 and 3 vert

253 nal adipose tissue compartments at the L2-L3 intervertebral level by MRI is an acceptably reliable an

254 fidus muscles in a region of interest at the intervertebral level of L4 through L5.

255 onance imaging (MRI) slices taken at various intervertebral levels from the 12th thoracic to 1st sacr

256 Spinal control at intervertebral levels is dependent on interactions betwe

257 Furthermore, compared with other intervertebral levels, the L2-L3 level had a higher amou

258 e height of disk space was measured at 3,568 intervertebral levels.

259 bnormal collagen fibrillogenesis in skin and intervertebral ligaments and ectopic bone formation on t

260 This study is the first to quantify intervertebral MC in the cervical spine in asymptomatic

261 ponsive to hypoxia, we speculate that in the intervertebral niche, notch proteins participate in the

262 ypoxia on degenerating resident cells in the intervertebral niche.

263 The same is true for the intervertebral ramules of the recurrent facial ramus, wh

264 al development, Smad1 phosphorylation in the intervertebral region was decreased in the Cv2 mutant, e

265 vels of Chd/BMP complexes diffusing from the intervertebral region.

266 ine, which form due to mineralization across intervertebral segments.

267 iote tree revealed preservation of different intervertebral soft tissue types (cartilage, probable no

268 sensitivity included decreased height of the intervertebral space (n = 23, 52.3% sensitivity) and dis

269 bra in 85% of subjects and crossed the L2-L3 intervertebral space or the L2 vertebra for 15% of subje

270 Its cells became removed first from intervertebral spaces and then from vertebral bodies, an

271 ents are sometimes offered fusion surgery if intervertebral translation, measured from static, end of