ライフサイエンスコーパス: intimal thickening

1 olar hyalinosis, and 32.9% abnormal vascular intimal thickening).

2 by day 30, and associated with a decrease in intimal thickening.

3 h mononuclear cell infiltration and preceded intimal thickening.

4 eficient recipients had increased concentric intimal thickening.

5 al antibody resulted in marked diminution of intimal thickening.

6 on and activity in a model of injury-induced intimal thickening.

7 ter infectious exposure prevents accelerated intimal thickening.

8 beta1 ceased by 4 weeks, the time of maximal intimal thickening.

9 pearance of arterial lesions with concentric intimal thickening.

10 h muscle cells and subsequent development of intimal thickening.

11 levels and activity in relation to flow and intimal thickening.

12 nd lymphatic disruption and resulted in mild intimal thickening.

13 ing in-stent thrombus and obstruction due to intimal thickening.

14 en studied 10 normal coronaries with diffuse intimal thickening.

15 a pigmented (yellow) or nonpigmented (white) intimal thickening.

16 llografts, associated with a 65% increase in intimal thickening.

17 inine could enhance NO generation and reduce intimal thickening.

18 nted human and murine hearts as a concentric intimal thickening.

19 ering arteries susceptible to thrombosis and intimal thickening.

20 uppressed the effect of LTSN cell seeding on intimal thickening.

21 ive medial layer destruction associated with intimal thickening.

22 acterized by diffuse and concentric coronary intimal thickening.

23 lial cell injury, inflammation, and arterial intimal thickening.

24 y high prevalence of segmental and eccentric intimal thickening.

25 mic ascorbic acid reduces VSMC apoptosis and intimal thickening.

26 ity, as indicated by the loss of Eph-B4, and intimal thickening.

27 SMC) proliferation and migration and thereby intimal thickening.

28 th, it is not required for the initiation of intimal thickening.

29 on and analyzed for cellular infiltrates and intimal thickening.

30 m traditional SMCs are major contributors to intimal thickening.

31 n the number of adventitial fibroblasts, and intimal thickening.

32 eling T lymphocyte recruitment and preceding intimal thickening.

33 ry arteries allowed quantification of vessel intimal thickening.

34 rotid arteries to induce vascular injury and intimal thickening.

35 th mononuclear cell recruitment and preceded intimal thickening.

36 h mononuclear cell recruitment, and precedes intimal thickening.

37 ial function are associated with progressive intimal thickening.

38 fter stenting and virtually eliminated later intimal thickening.

39 e gene expression, cellular infiltration, or intimal thickening.

40 , leukocytes are recruited as a precursor to intimal thickening.

41 ant recipients with EBD demonstrated greater intimal thickening (0.59 +/- 0.1 vs. 0.32 +/- 0.2 mm; p

42 patterns are observed: (1) shear stabilized intimal thickening, (2) tension induced wall thinning an

43 ram of tissue per hour; P < .01) and reduced intimal thickening 4 weeks later (intima/ media ratio: L

44 : grade I = normal (44 patients); grade II = intimal thickening (52 patients); grade III = atheroma <

45 By day 30, there was concentric intimal thickening, accumulation of alpha-smA+ cells, an

46 ries, in concert with a twofold reduction in intimal thickening after 14 days, compared with arteries

47 mmune response also plays a cardinal role in intimal thickening after acute arterial-wall injury.

48 in the inhibitory effect of T lymphocytes on intimal thickening after arterial injury.

49 the initiation of cellular events leading to intimal thickening after balloon injury in the rat.

50 y artery lesions were classified as adaptive intimal thickening (AIT), pathologic intimal thickening

51 This revealed variable, fluctuating intimal thickening along the length of the vessel.

52 cipients showed severe chronic arteriopathy (intimal thickening, alpha-smooth muscle actin+ cell prol

53 grafted hearts expressed similar amounts of intimal thickening (analysis of variance, P=0.4826).

54 Furthermore, 30% of diffuse intimal thickening and 22% of medial samples showed cont

55 ly, restenosis after angioplasty, vein graft intimal thickening and atherogenesis.

56 r, and reduced shear predisposes arteries to intimal thickening and atherosclerosis.

57 day 24 posttransplantation and analyzed for intimal thickening and cellular infiltration.

58 d thrombosis and dramatically inhibited both intimal thickening and endogenous bFGF mobilization.

59 Intimal thickening and I:M were reduced significantly by

60 vity in SMCs from nonatherosclerotic diffuse intimal thickening and in the overlying endothelial cell

61 tation: early lumen loss primarily caused by intimal thickening and late lumen loss caused by EEM are

62 are the major correlates of coronary artery intimal thickening and luminal stenosis.

63 jury is a critical determinant of consequent intimal thickening and mural thrombus.

64 -microCi stent groups, characterized by both intimal thickening and negative arterial remodeling.

65 emodeling, as suggested by the inhibition of intimal thickening and outward arterial remodeling.

66 ic inflammation is associated with increased intimal thickening and stenosis after arterial allograft

67 rol allografts, which also developed greater intimal thickening and stenosis than hGSTA4-4 transduced

68 itors were shown to decrease coronary artery intimal thickening and stenosis.

69 necrosis and of capillary damage, including intimal thickening and vascular thrombosis.

70 nges in coronary artery structure, including intimal thickening and vessel remodeling, occur early af

71 as indicated by plaque size (plaque area and intimal thickening) and stage of development.

72 on the two time scales of thrombosis and of intimal thickening, and by using local protein release t

73 ty of the tissue, including lack of elastin, intimal thickening, and calcium deposition.

74 led only mild perivascular fibrosis, minimal intimal thickening, and preserved myocardial architectur

75 s during infiltration of inflammatory cells, intimal thickening, angiogenesis and plaque rupture whic

76 Single balloon injury produced limited intimal thickening at 3 weeks (intimal area, 0.40+/-0.05

77 Vasculopathy was graded for degree of intimal thickening based on the involvement of vascular

78 Intimal thickening became evident at 14 days.

79 evealed patent ductus arteriosus with normal intimal thickening but dilated cardiac chambers.

80 ate that adventitial angiogenesis stimulates intimal thickening but does not initiate it.

81 as in both recipient groups developed florid intimal thickening by 4 to 10 weeks, with marked lipid d

82 duction with an iNOS inhibitor increased the intimal thickening by 57.2%, indicating that NO suppress

83 ere histologically stained and evaluated for intimal thickening by deriving a neointimal index (NI) u

84 year, 4 with consecutive biopsies developed intimal thickening by intravascular ultrasound.

85 ing of the lumen primarily due to concentric intimal thickening caused by proliferation of alpha-smoo

86 ts undergoing chronic rejection was arterial intimal thickening comprising smooth muscle cell prolife

87 in graft failure is the result of medial and intimal thickening consequent upon medial vascular smoot

88 ether angiographically silent early coronary intimal thickening could predict long-term morbidity and

89 ophy, arteriolar hyaline thickening, fibrous intimal thickening (CV), and fraction of sclerotized glo

90 s infiltrate the donor heart before vascular intimal thickening develops, but the specific mediators

91 , whereas arteriolar hyalinosis and vascular intimal thickening did not.

92 exhibited prolonged graft survival, reduced intimal thickening, diminished immune cell infiltration,

93 r smooth muscle cells (VSMCs) contributes to intimal thickening during atherosclerosis and restenosis

94 sitive than coronary angiography and detects intimal thickening (early CAV) in the coronary arteries

95 s were classified as lesions with pathologic intimal thickening, fibrous-cap atheromas with cores in

96 Finally, a method was devised to quantitate intimal thickening from a sampling of three tissue cross

97 reduced abdominal aorta lipid deposition and intimal thickening from aortic arch throughout the abdom

98 The intimal thickening generated significant luminal narrowi

99 ever, separation of normal aorta and minimal intimal thickening (grades I and II) from more complex a

100 CAV was defined as an intimal thickening >/= 0.5 mm in the follow-up with rega

101 lticenter study suggests that progression of intimal thickening >/=0.5 mm in the first year after tra

102 nd specificity of 81% and 75% to detect CAV (intimal thickening >0.5 mm), whereas the PPV and NPV wer

103 P< or =0.0239) decrease in coronary arterial intimal thickening (GVD) of approximately 43%.

104 In a rabbit model, arterial intimal thickening has been induced by direct intravascu

105 of the coronary segments with progression of intimal thickening have compensatory dilation of the ves

106 ing inflammatory cells on the development of intimal thickening in a heterotopic mouse transplant mod

107 T lymphocyte and macrophage recruitment, and intimal thickening in a murine model of CAV.

108 L-749,329, was evaluated as an inhibitor of intimal thickening in a porcine balloon/stent model of c

109 luated for their ability to inhibit vascular intimal thickening in a porcine coronary artery model of

110 the effect of GA-induced VSMC apoptosis and intimal thickening in a TET2-dependent manner.

111 ith mononuclear cell recruitment and precede intimal thickening in cardiac allograft vasculopathy (CA

112 , an inhibitor of NO synthesis, enhanced the intimal thickening in injured vessels in adult rats but

113 uishable from values obtained by analysis of intimal thickening in multiple sections covering the ent

114 We used OCT to investigate coronary intimal thickening in pediatric transplant recipients an

115 Intimal thickening in PPH was most prominent in small pu

116 ntranasal C pneumoniae infection accelerates intimal thickening in rabbits given a modestly cholester

117 that this defect contributes to the enhanced intimal thickening in response to injury in old animals.

118 Vitamin supplementation failed to prevent intimal thickening in the carotid or iliac arteries.

119 Intimal thickening in the coronary arteries of murine ca

120 Dietary arginine reduced intimal thickening in the injured vessels of hypercholes

121 id artery, Ang II is not a major mediator of intimal thickening in the pig coronary artery.

122 found that Met-RANTES significantly reduced intimal thickening in this model of chronic rejection an

123 reduced CD4(+) T lymphocyte infiltration and intimal thickening in this model.

124 In 2 weeks, the formation of intimal thickening in tk-expressing grafts was significa

125 o the coronary circulation, LITA grafts show intimal thickening, increased intima/media ratio, and ma

126 ities were present in all children including intimal thickening (intima/lumen cross-sectional area ra

127 recipients, angiography was normal; however, intimal thickening (intima/media cross-sectional area ra

128 The degree of intimal thickening is correlated with abnormalities in c

129 Intimal thickening is driven by damage to the endotheliu

130 Vascular remodeling rather than intimal thickening is the most important determinant of

131 Intimal thickening is usually attributed to the migratio

132 PSV is less than 125 cm/sec and no plaque or intimal thickening is visible; (ii) <50% stenosis when I

133 CA PSV is less than 125 cm/sec and plaque or intimal thickening is visible; (iii) 50%-69% stenosis wh

134 equela of heart transplant in which arterial intimal thickening limits coronary blood flow.

135 the MAC-related arterial wall stiffening and intimal thickening, MAC fundamentally alters central and

136 4% vs. 32.7 +/- 9.7%, p = 0.01) at day 7 and intimal thickening (maximal intimal area 0.61 +/- 0.09 v

137 The severity of intimal thickening measured as the percentage of luminal

138 ially drive the various vascular phenotypes (intimal thickening, media hypertrophy, adventitial thick

139 However, dramatic intimal thickening (neointimal area 2.1+/-0.3) and media

140 These results suggest that the intimal thickening observed in transplant atherosclerosi

141 stents give equally profound suppression of intimal thickening, obviating the need for precise size

142 l ultrasound study revealed that most of the intimal thickening occurred during the first year after

143 Intimal thickening of allograft arteries progressed to l

144 Luminal occlusion as a consequence of intimal thickening of graft coronary arteries developed

145 e, changes in right ventricular pressure and intimal thickening of pulmonary small artery are a littl

146 Fourteen days after transplantation, intimal thickening of the allografts in each of the thre

147 Cs together with fibrosis provoke concentric intimal thickening of the coronary arteries, which is th

148 The average scores of arterial intimal thickening on day 45 after transplantation were

149 ger than 400 micrometer showed a significant intimal thickening only in CTED.

150 (plaque erosion), most often on pathological intimal thickening or fibroatheromas.

151 d iron were found in lesions with pathologic intimal thickening or fibrous-cap atheromas with cores i

152 transplantation in the group with pigmented intimal thickening (p < 0.05).

153 ntly smaller than control vessels because of intimal thickening (P=0.003).

154 LITA showed a significant intimal thickening (P=0.05) and a nonsignificant medial

155 daptive intimal thickening (AIT), pathologic intimal thickening (PIT), or intimal xanthoma (IXA).

156 Lesions were classified into pathological intimal thickening (PIT), VH-IVUS-derived thin-capped fi

157 we propose and study a mathematical model of intimal thickening, posed as a free boundary problem.

158 ted with increased aortic external diameter, intimal thickening, preserved vascular smooth muscle cel

159 Intimal thickening prevalence and severity measures did

160 re significantly correlated with severity of intimal thickening (R = 0.54, P < 0.0001).

161 ealed intact global architecture and minimal intimal thickening, respectively.

162 is disease which is characterized by diffuse intimal thickening resulting from smooth muscle cell mig

163 of normal medial samples and 31% of diffuse intimal thickening samples also were skewed toward one X

164 he two angioscopic groups revealed increased intimal thickening, serum cholesterol, low density lipop

165 lates most strongly with venous and small IV intimal thickening, similar to the pattern observed in P

166 ute rejection as an independent predictor of intimal thickening suggests that mechanisms beyond those

167 tion ensues within 4 weeks, characterized by intimal thickening, T-cell infiltrates, and vascular cel

168 Vascular injury induced intimal thickening that was largely composed of vascular

169 29 mice into the CD40L(-/-) mice reduced the intimal thickening to the level comparable to the thicke

170 various vascular changes ranging from focal intimal thickening to total vascular lumen blockade due

171 , v score, allograft glomerulopathy, fibrous intimal thickening, tubular atrophy, and interstitial fi

172 we show that outward vascular remodeling and intimal thickening, two manifestations of arterioscleros

173 The coronary arteries were analyzed for intimal thickening using a neointimal index (NI) derived

174 Consequently, intimal thickening was diminished, thrombotic occlusion

175 Intimal thickening was enhanced 3.4-fold in Csrp2(-/-) c

176 CD40 ligand knockout (CD40L(-/-)) mice, the intimal thickening was increased 3-fold compared with th

177 on of allograft myointimal proliferation and intimal thickening was induced directly by IGF-I.

178 Intimal thickening was observed after 1 week only in CCA

179 Intimal thickening was quantitated morphometrically.

180 helium in preventing vascular thrombosis and intimal thickening, we designed a series of experiments

181 nificant clinical predictors of nonpigmented intimal thickening were advanced donor age and lower mea

182 tery intimal thickness and the prevalence of intimal thickening were lower in the patients receiving

183 bFGF mobilization, medial repopulation, and intimal thickening were measured.

184 The scores of intimal thickening were significantly reduced to 0.97+/-

185 ver, the control allografts developed marked intimal thickening, whereas Ad3rsFas-transduced allograf

186 rafts (without MSCs) resulted in significant intimal thickening, whereas cellular grafts (with MSCs)

187 c rejection characterized by circumferential intimal thickening with partial disruption of the elasti

188 typically characterized by diffuse coronary intimal thickening with pathological vessel remodeling,

189 CCR1-deficient recipients, it increased GAD intimal thickening with SMLC proliferation in only the w

190 cimens comprised an undiseased portion (thin intimal thickening with the underlying media) and a dise

191 s harvested at day 30 showed circumferential intimal thickening, with accumulation of alpha-smA+ cell