ライフサイエンスコーパス: intoxication

1 a model of binge drinking and acute ethanol intoxication).

2 f these were solely owing to the presence of intoxication.

3 micking the clinical situation of acute MDMA intoxication.

4 pects of Delta(9)-tetrahydrocannabinol (THC) intoxication.

5 ates akin to those reported for MDPV-induced intoxication.

6 ain tissue from a child that died of leucine intoxication.

7 ntribute to the cognitive effects of alcohol intoxication.

8 compounds in the treatment of acute alcohol intoxication.

9 omise in patients with glyphosate-surfactant intoxication.

10 njury, unintentional injuries, and substance intoxication.

11 d toxin export to the cytosol and blocked PT intoxication.

12 glets infected with STEC from fatal systemic intoxication.

13 increased oxidative stress and heavy metals intoxication.

14 inherent burdens, including the risk of self-intoxication.

15 efflux pump and protects cells against iron intoxication.

16 (VNA-Stx) protected mice from Stx1 and Stx2 intoxication.

17 pithelial cell line and subsequent host cell intoxication.

18 he role of these enzymes of TcdB in cellular intoxication.

19 the development of hyperthermia during acute intoxication.

20 100% survival following lethal acetaminophen intoxication.

21 methylmercury chloride, and thimerosal after intoxication.

22 ging diseases, such as infection and alcohol intoxication.

23 dent behaviors while conveying resistance to intoxication.

24 er tissue damage and regeneration after CCl4 intoxication.

25 erized by repeated episodes of heavy alcohol intoxication.

26 I in the RCK1 domain was highly resistant to intoxication.

27 loss and behavioral deficits following MPTP intoxication.

28 increased psychotic-like experiences during intoxication.

29 copBL and copAZ gene products to prevent Cu intoxication.

30 n ethanol, and are more sensitive to alcohol intoxication.

31 term effects of chronic intermittent ethanol intoxication.

32 ifetime approximately 10 ms) compatible with intoxication.

33 ly inhaled at high concentrations to produce intoxication.

34 without apparent damage until 24 hours post intoxication.

35 measurement of mental states elicited during intoxication.

36 with a marked increase in susceptibility to intoxication.

37 ivation may reflect subjective experience of intoxication.

38 l understood aspects of botulinum neurotoxin intoxication.

39 picting substantia nigra injury following CO intoxication.

40 al therapeutic targets for infants with MeHg intoxication.

41 tivity to the aversive properties of alcohol intoxication.

42 of up and down-regulated genes following Bt intoxication.

43 ation in fermented foods can cause histamine intoxication.

44 screte behavioral features characteristic of intoxication.

45 se to environmental and cellular cues during intoxication.

46 nd down-regulated transcripts in response to intoxication.

47 phyrins are also found in patients with lead intoxication.

48 immunity proteins that protect against self-intoxication.

49 iently high concentrations to pose a risk of intoxication.

50 rocytes during the recovery period after CPZ intoxication.

51 anisms under oxidative stress caused by lead intoxication.

52 Animals that wield toxins face self-intoxication.

53 xidative stress in live organisms under lead intoxication.

54 nse may be relatively preserved from arsenic intoxication.

55 as much as 17h, im 5.5h and tb 2h before the intoxication.

56 "zombielike" behavior reported in this mass intoxication.

57 rpose, greater anhedonia), and fewer days of intoxication.

58 f muscles due to botulinum neurotoxin (BoNT) intoxication.

59 l for treating the harmful effects of BoNT/A intoxication.

60 ulmonary failure after glyphosate-surfactant intoxication.

61 tensity of murine systemic organs after oral intoxication.

62 s used to treat severe glyphosate-surfactant intoxication.

63 pothesis, we compared the effects of alcohol intoxication (0.75 g/kg alcohol vs placebo) on brain glu

64 lled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults perfor

65 ts (46%; 22/48), showing alcohol use without intoxication (40%; 19/48), and providing clinical narrat

66 cute psychiatric symptoms (18.0% vs. 10.9%), intoxication (48% vs. 28%), and cardiovascular symptoms

67 circulation during moderate-to-heavy alcohol intoxication (50-100 mM) modify Ca(2+)- and voltage-gate

68 bsolute risk was 2.6% (95% CI, 2.3, 2.9) for intoxication, 7.7% (95% CI, 6.4, 7.9) for harmful use, a

69 nsensus for investigation: depicting alcohol intoxication (73%; 35/48), violating patient confidentia

70 s, rapid deceleration mechanism, chest pain, intoxication, abnormal alertness/mental status, distract

71 0.001), CVD (AHR, 0.70; P = 0.001), alcohol intoxication (AHR, 0.52; P = 0.003), and violence-relate

72 atory tract of mice 6h after pulmonary ricin intoxication allowed the rescue of 100% of intoxicated a

73 HlyA intoxication also stimulated caspase activation, which o

74 asure used for diagnosing the degree of lead intoxication, although it is unclear whether there is an

75 lated, perfused livers with and without CCl4 intoxication and (2) a set of in vivo experiments.

76 ty to stop cocaine seeking, even during drug intoxication and after a long history of cocaine self-ad

77 The primary outcome measures were subjective intoxication and alcohol craving.

78 egulates cellular defenses during xenobiotic intoxication and bacterial infection.

79 te crystal deposits in acute ethylene glycol intoxication and chronic calcium oxalate nephropathy mod

80 Here we demonstrate that after acute EtOH intoxication and CIE, upregulation of hippocampal alpha4

81 standing of their functional role in ethanol intoxication and consumption is very limited.

82 d public health costs associated with BoNT/A intoxication and could have potential biodefense implica

83 nducted on these drugs, and several cases of intoxication and deaths have been reported.

84 evelopment of novel therapeutics for alcohol intoxication and dependence.

85 r mechanism of DHM for counteracting alcohol intoxication and dependence.

86 ges accumulating in the liver following APAP intoxication and evaluated the role of galectin-3 (Gal-3

87 ovascular leakage following combined alcohol intoxication and hemorrhagic shock, in a dose-related ma

88 nized mAbs provide insight into C. difficile intoxication and hold promise as potential nonantibiotic

89 ions of the worm or human BK channel rescued intoxication and other BK channel-dependent behaviors in

90 exporter and aids GAS defenses against iron intoxication and oxidative stress.

91 ar potencies but different rates of cellular intoxication and pathology in a mouse model of botulism.

92 el of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricul

93 despite greater behavioral signs of alcohol intoxication and reduced anxiety, and are insensitive to

94 toxicity in the absence of episodes of acute intoxication and that duration of therapy and cumulative

95 of the central proteins that mediate alcohol intoxication and tolerance across species.

96 for the analysis of the kinetics of anthrax intoxication and ultimately drug discovery.

97 ac, and respiratory disorders, and substance intoxication and withdrawal-is imperative.

98 plex differences between the epithelial cell intoxication and, potentially, secretory outcomes induce

99 Cirrhotic (bile duct ligation/BDL; CCl4 intoxication) and non-cirrhotic (partial portal vein lig

100 medicines, counteracted acute alcohol (EtOH) intoxication, and also withdrawal signs in rats includin

101 wing prolonged exposure to cycles of alcohol intoxication, and is associated with persistent, wide-ra

102 o a variety of causes, including infections, intoxication, and ischemia.

103 greater alcohol-induced sedation, subjective intoxication, and lower alcohol craving on naltrexone, a

104 after partial hepatectomy and acetaminophen intoxication, and measured regenerative parameters and i

105 ity of illness, intubation status, recurrent intoxication, and several comorbidities.

106 icle focuses on the effects of cannabis use, intoxication, and withdrawal while also reviewing the de

107 rders; neoplasms; alcohol-intoxication; drug intoxication; and violence-related injury (note: the lat

108 elf-harm (aOR range, 3.9-4.2), and substance intoxication (aOR range, 3.0-4.0).

109 germination or downstream events in anthrax intoxication are also under investigation.

110 ociated with impaired cognition during acute intoxication as well as in the unintoxicated state in lo

111 up examinations in 4 patients with manganese intoxication associated with intravenous administration

112 n performed on rats did not show symptoms of intoxication associated with the administration of the g

113 and animal studies demonstrate that alcohol intoxication at the time of injury worsens postburn outc

114 developed to assess an individual's level of intoxication based on the presence of ethanol in sweat o

115 s derived from the Greek methuo (to drink to intoxication) because the hallmark of this form of cell

116 When combined with EtOH intoxication, burn injury significantly decreased IL-17

117 ate that an frvA mutant is sensitive to iron intoxication, but not to other metals.

118 osphogluconate dehydrogenase (GndA) leads to intoxication by 6-phosphogluconate, a potent inhibitor o

119 hannel, SLO-1, convey dramatic resistance to intoxication by ethanol.

120 producer Streptomyces azureus prevents self-intoxication by expressing the thiostrepton-resistance m

121 we demonstrate that ciA-C2 prevents BoNT/A1 intoxication by inhibiting its binding to neuronal recep

122 compound identified in the screen, inhibits intoxication by lethal toxin and blocks the entry of mul

123 th immunity proteins that protect cells from intoxication by neighboring siblings.

124 Intoxication by organophosphate (OP) nerve agents and pe

125 Successful cell entry and intoxication by TcdB are known to involve various confor

126 rapeutically for the treatment of acute iron intoxication, carries three hydroxamate groups and shows

127 activity by inhibiting the first step of the intoxication cascade.

128 Alcohol (EtOH) intoxication causes changes in the rodent brain gamma-am

129 We demonstrate that after cuprizone intoxication, CCR2-dependent infiltration of mouse bone

130 and susceptibility of colonic stem cells to intoxication compromises their function during infection

131 cal record is laden with evidence of mercury intoxication consistent with effects recognized today.

132 Self-reported ratings of intoxication correlated with striatal activation, sugges

133 ); respiratory disorders; neoplasms; alcohol-intoxication; drug intoxication; and violence-related in

134 Risks range from intoxication due to pathogen-contaminated edibles, to su

135 ntR null mutant is still sensitive to Mn(II) intoxication even if both of the import systems are abse

136 Our results show that alcohol intoxication exacerbated hemorrhagic shock and resuscita

137 Intoxication exacerbates postburn hepatic damage through

138 Consistent with the known intercellular self-intoxication exhibited by the T6S pathway, we observe th

139 Intoxication experiments showed that TeNT efficiently cl

140 receiving nabiximols did not report greater intoxication (F1,6 = 0.22; P = .97).

141 ith severe myocardial hypertrophy or cocaine intoxication facilitating a cardiac death without verifi

142 ed after 8 and 16 weeks carbon tetrachloride intoxication, following bile duct ligation, and in tissu

143 -was effective in preventing all symptoms of intoxication from Stx1 and Stx2 when coadministered with

144 Organophosphate (OP) intoxications from nerve agent and OP pesticide exposure

145 educed the sensitivity of the cells to ricin intoxication further confirming a role for this enzyme i

146 e 316 patients kept in a cervical collar for intoxication had no missed CSIs but were kept immobilize

147 dmission (12.3%); a combination of different intoxications had the lowest (6.3%).

148 tial hospital contact with alcohol problems (intoxication, harmful use, or dependence) during 1998-20

149 el of binge drinking as acute ethanol (EtOH) intoxication has become an alarming health problem.

150 le toxin A and B (TcdA and TcdB) to cellular intoxication has been studied extensively, but their imp

151 Existing strategies to negate BoNT/A intoxication have looked to antibodies, peptides, or org

152 Pharmacological attempts to ablate BoNT/A intoxication have sought to either nullify cellular toxi

153 he New Orleans Criteria findings (>60 years, intoxication, headache, vomiting, amnesia, seizure, or t

154 both mammalian and insect models of ethanol intoxication, high doses of ethanol induce motor impairm

155 Bonnet syndrome, Parkinson's disease, fever, intoxications, hypnagogic and hypnopompic states.

156 We directly investigated how alcohol intoxication impacts hemorrhagic shock and resuscitation

157 d demonstrates protection and rescue of BoNT intoxication in a human neuron model.

158 )-infected rhesus macaques and acute ethanol intoxication in a murine model were used.

159 educed signaling through D2 receptors during intoxication in active cocaine abusers regardless of cue

160 315C4 completely protected guinea pigs from intoxication in an in vivo lethality model, yielding an

161 and acetaldehyde levels after acute ethanol intoxication in both wild-type and ALDH2-deficient, ALDH

162 ced by cyanobacteria and are responsible for intoxication in humans and animals.

163 ncentrations just above the legal limits for intoxication in humans can inhibit alpha7 nAChRs in LDTg

164 nd assesses the potential role for Cu and Zn intoxication in innate immune function and their direct

165 manganese (hepatic encephalopathy, manganese intoxication in intravenous drug abusers).

166 determined by stereological tests after MPTP intoxication in mice pretreated with either VIPR1 or VIP

167 nravels its protective effect against severe intoxication in response to binge drinking.

168 ted to express CR3 and examined the steps in intoxication in the presence and absence of the integrin

169 ay be limited by variable protection against intoxication in vivo.

170 otassium permanganate, became a new cause of intoxications in Poland.

171 ing (peaking at ~8 min) during acute cocaine intoxication, in chronically treated mice D1R predominan

172 he TEM8 extracellular domain blocked anthrax intoxication, inhibited tumor-induced angiogenesis, disp

173 nsmission in MS/DB neurons are vulnerable to intoxication injury.

174 n the granulopoietic response, acute alcohol intoxication (intraperitoneal injection of 5 g alcohol/k

175 nate immunity proteins, indicating that self-intoxication is a general property of antibacterial T6SS

176 Alcohol (EtOH) intoxication is a risk factor for increased morbidity an

177 , reciprocity or retribution are impossible, intoxication is absent and when the "other" to be harmed

178 novel therapeutic strategies aimed at severe intoxication is apparent.

179 Although ricin intoxication is not transmittable from person to person,

180 ated BK channel activation causes behavioral intoxication is poorly understood.

181 ructural analyses also demonstrate that self-intoxication is prevented by the immunity protein throug

182 Zinc intoxication is prevented in S. pneumoniae by expression

183 or factor contributing to the persistence of intoxication is the long half-life of the catalytic ligh

184 Excessive drinking to intoxication is the major behavioral characteristic of t

185 Binding, an obligate event for cell intoxication, is believed to occur through the heavy-cha

186 ratory failure due to altered mental status (intoxication, ischemic brain injury), indirect lung inju

187 During the binge/intoxication stage, alcohol intoxication leads to a faster sleep onset, but sleep qu

188 Therefore, acute alcohol intoxication leads to decreased MRSA clearance in part b

189 beta-catenin-deficient hepatocytes, ethanol intoxication led to significant redox imbalance in the h

190 be capable of documenting and evaluating the intoxication levels of an individual based on sweat etha

191 These observations suggest that the dampened intoxication may contribute to the increased rates of al

192 Analyzing speech during intoxication may present a more direct, objective measur

193 Here, the intoxication mechanisms of CDTs from Escherichia coli (E

194 variants were investigated in mice in an SEB intoxication model, as well as in sepsis and deep-tissue

195 ory host response in both the sepsis and the intoxication models, which justifies further development

196 hages accumulate in the liver following APAP intoxication; moreover, Gal-3 plays a role in promoting

197 During intoxication, MRI revealed expansion of ventricles, but

198 rse effects, such as hyponatraemia and water intoxication necessitate a strict fluid intake, thus mot

199 2, 2016, a synthetic cannabinoid caused mass intoxication of 33 persons in one New York City neighbor

200 consistent with our results indicating that intoxication of Acanthamoeba by these exotoxins does not

201 B and subsequent molecular events leading to intoxication of cells.

202 id quality check of absorbed fluids to avoid intoxication of colonocytes.

203 GndA, PGI, or yeast Pho13 suppresses glucose intoxication of DeltacpgA cells, but not cold sensitivit

204 s, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol

205 exotoxin delivery into predator cells allows intoxication of predators that lack a cell surface recep

206 The intoxication of the cell is a consequence of a reductive

207 fic domains, allowing processing and thereby intoxication of the cell.

208 nt, including the effects of acute marijuana intoxication on driving abilities, unintentional ingesti

209 effects of Delta9-tetrahydrocannabinol (THC) intoxication on susceptibility to false memory in 64 hea

210 rotein member of the PDI family, in the cell intoxication operated by type 2 RIPs ricin and abrin.

211 nesis induced by either carbon tetrachloride intoxication or bile duct ligation and promote fibrosis

212 It is usually defined by characteristics of intoxication or by characteristics of withdrawal symptom

213 tion (BDL), CCl4 intoxication, thioacetamide intoxication or continuous AngII infusion.

214 npatient or outpatient treatment for alcohol intoxication or misuse (HR = 1.98, 95% CI 1.76-2.21, p <

215 fluence relapse, nor did it affect marijuana intoxication or most symptoms of withdrawal relative to

216 , there is no approved therapeutic for their intoxication or one that has even advanced to clinical t

217 g ethanol metabolism, sensitivity to ethanol intoxication, or continuous-access drinking.

218 proteins not previously implicated in the PE intoxication pathway were identified, including GPR107,

219 effects were mostly restricted to the acute-intoxication phase.

220 the microvascular leakage following alcohol intoxication plus hemorrhagic shock and resuscitation.

221 ubstrate for resting brain metabolism during intoxication (presumably shifting to acetate or other ke

222 Platelet intoxication prevents endothelial barrier repair and fac

223 which play distinct roles in the multi-step intoxication process, transforming from harmless, robust

224 l inhibitors targeting common steps of their intoxication process.

225 still critical gaps in information about the intoxication process.

226 Acute ethanol intoxication promotes fasting hypoglycemia through an in

227 nting renarcotization events in which opioid intoxication recurs following quick metabolism of naloxo

228 t not CD36(-/-) macrophages near the site of intoxication reduces dermonecrosis, IL-1beta production

229 r-impairing effects of ethanol contribute to intoxication-related injury and death.

230 n </= 5 y of age with severe paediatric lead intoxication reported to date to our knowledge.

231 MPTP intoxication resulted in severe insomnia with delayed sl

232 TcdA intoxication results in an apoptotic cell death that is

233 cond, we show that two previously described "intoxication reversers" raise Tc and counter ethanol's e

234 We discovered that both intoxication routes caused similar increases in serum cr

235 cant reduction in frequent past-year alcohol intoxication self-reported by men (adjusted odds ratio [

236 y each bacterium at the primary infection or intoxication sites.

237 elopment of drug-seeking habits in the binge/intoxication stage involve changes in dopamine and opioi

238 During the binge/intoxication stage, alcohol intoxication leads to a fast

239 cholera toxin A1 (CTA1) peptide, a critical intoxication step.

240 Alcohol intoxication strongly attenuates early visual responses

241 otal intoxicated population and for specific intoxication subgroups based on the Acute Physiology and

242 Alcohol intoxication suppressed ERK activation in granulopoietic

243 Acute ethanol intoxication suppresses the host immune responses agains

244 issue damage, resulting in infection-induced intoxication that can become fatal in the absence of ant

245 s could be precipitated by pesticide-induced intoxication that disrupts navigation.

246 es binge or heavy drinking to high levels of intoxication that leads to compulsive intake, the loss o

247 During alcohol intoxication, the human brain increases metabolism of ac

248 e the etiological agent responsible for BoNT intoxication, the LC protease.

249 In oral intoxication, the process by which the toxin transits ac

250 as induced by bile duct ligation (BDL), CCl4 intoxication, thioacetamide intoxication or continuous A

251 ge of concentrations in the brain, eliciting intoxication through to sedation.

252 anged from as few as 5 studies for bacterial intoxications through to 494 studies for diarrheal patho

253 ns, was optimized by toxin concentration and intoxication time, and the specificity of caspase activi

254 balance between D1R and D2R signaling during intoxication to a predominance of D1R (stimulatory) over

255 rged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pat

256 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication to render them parkinsonian and then local

257 lated behaviors in flies, ranging from acute intoxication to self-administration and reward, have bee

258 Repeated alcohol intoxications trigger inflammatory processes and sensiti

259 urea, bilirubin, biomarkers related to human intoxication, tumoural indicators, among several others)

260 C) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD).

261 o vaccine or therapeutic treatment for ricin intoxication, ultrasensitive analytical assays capable o

262 To avoid self-intoxication, V. cholerae expresses an anti-toxin encode

263 APAP intoxication was also associated with an accumulation of

264 In this study, alcohol or drug intoxication was common and resulted in significant dela

265 Intoxication was determined by serum alcohol levels and

266 Intoxication was identified in 632 of 1429 of patients t

267 proximity to target cells by centrifugation, intoxication was increased 4-fold.

268 dynamics of this attenuation during cocaine intoxication was longer lasting for D2R than for D1R.

269 T3SS effector intoxication was sufficient to generate cytotoxic amyloi

270 s in TcdB that are essential for target cell intoxication, we identified a region at the junction of

271 lances D1R over D2R signaling during cocaine intoxication, we used microprobe optical imaging to comp

272 ion, whereas subjective signs of progressive intoxication were confirmed as accurate predictors of ha

273 ted TcdB autoprocessing and delayed cellular intoxication, whereas E3 intrabody completely blocked th

274 queer" regarding moderate-to-severe alcohol intoxication, whereas subjective signs of progressive in

275 tR null mutant is highly sensitive to Mn(II) intoxication, which is attributed in part to the constit

276 (i.e., acetate) for resting activity during intoxication, which might persist through early sobriety

277 rotein release is a pre-requisite of colicin intoxication, which occurs on a timescale of minutes.

278 f Stx2a also exhibited a bimodal response to intoxication, while cells challenged with a hybrid toxin

279 y method and estimated deaths from drug self-intoxication whose manner was an "accident" or was undet

280 by flaccid paralysis, which can be caused by intoxication with any of the seven known serotypes of bo

281 terized by a cycle composed of drug seeking, intoxication with drug taking and withdrawal associated

282 t to generate cytotoxic amyloid release, yet intoxication with exoenzyme Y (ExoY) alone or together w

283 ndings provide evidence that (1) endothelial intoxication with ExoY is sufficient to elicit self-prop

284 We show that intoxication with GAP domain results in: (i) JNK1/2 acti

285 f environmental exposure of honeybees to and intoxication with neonicotinoid insecticides, namely, th

286 In vivo intoxication with PTX elicits a variety of immunologic a

287 as CD36 also limits dermonecrosis caused by intoxication with sterile bacterial supernatant or purif

288 n extended mean time to death, compared with intoxication with Stx2a only.

289 .9 mug, but no morbidity occurred after oral intoxication with up to 157 mug of Stx1a.

290 Intoxications with alcohol or antidepressants have a sig

291 The adjusted observed mortality showed that intoxications with street drugs and "other toxins" have

292 ke repressor (Fur) cooperate to prevent iron intoxication, with iron sequestration by the MrgA mini-f

293 motor function is most affected during acute intoxication, with some evidence for persistence in chro

294 the effects of cigarette smoking, marijuana intoxication, withdrawal, and relapse were assessed in d

295 tient laboratory studies assessing marijuana intoxication, withdrawal, and relapse were combined to a

296 ded period within a three-stage cycle: binge/intoxication, withdrawal/negative affect, and preoccupat

297 pendence induced by 1 month of alcohol vapor intoxication/withdrawal cycles, and prefrontal myelin wa

298 ed parkinsonism, compared with those with CO intoxication without parkinsonism or normal volunteers (

299 h poisoning (CFP) is the most common seafood intoxication worldwide, its burden has been difficult to

300 task immediately following learning (before intoxication) yet performance was better when tested the