ライフサイエンスコーパス: intracellular domain

1 n or deletion tend to be enriched within the intracellular domain.

2 are conducted through narrow tunnels in the intracellular domain.

3 amma-secretase to generate a cytosolic TNFR1 intracellular domain.

4 , translocation-associated (Notch1) receptor intracellular domain.

5 ophosphorylation of tyrosine residues at the intracellular domain.

6 es formed by distant portions of the cyclase intracellular domain.

7 ing with talin for binding to beta1-integrin intracellular domain.

8 ptor contains only one tyrosine motif in the intracellular domain.

9 long or short isoforms with respect to their intracellular domain.

10 action to the NH2-terminal region of the APP intracellular domain.

11 f Dachs, similar to overexpression of the Ft intracellular domain.

12 distinct from the amyloid precursor protein intracellular domain.

13 ubule dynamics through RUVBL proteins at its intracellular domain.

14 -mimetic of the beta4 sodium channel subunit intracellular domain.

15 crucial for mural cell recruitment, via its intracellular domain.

16 her processed into a small, rapidly degraded intracellular domain.

17 lex with the amyloid precursor protein (APP) intracellular domain.

18 diminished in cells overexpressing the CD44 intracellular domain.

19 y and does not require signaling through its intracellular domain.

20 fragment comprising most of L1's C-terminal, intracellular domain.

21 t not mutants with deletion of its extra- or intracellular domain.

22 pts a preexisting conformation of the BTN3A1 intracellular domain.

23 assessed by immunohistochemistry for Notch1 intracellular domain.

24 with transgenic overexpression of the Notch intracellular domain.

25 Rather, it was dependent on the size of the intracellular domains.

26 stabilizing interactions between the VS and intracellular domains.

27 pment of inhibitors at the extracellular and intracellular domains.

28 f10 and Notch1 interact via their respective intracellular domains.

29 beta-APP carboxyl-terminal fragments and APP intracellular domain accumulate in EVs over time and amy

30 cretase-dependent but RBPj-independent Notch intracellular domain activity operating in the first hai

31 processes via two separate domains, the APP intracellular domain (AICD) and the soluble secreted APP

32 Evidence suggests that APP intracellular domain (AICD) could regulate synapse funct

33 ort that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldric

34 nitiated by the APP transcriptionally active intracellular domain (AICD) in response to 27-hydroxycho

35 Pbeta and also the amyloid precursor protein intracellular domain (AICD).

36 This activity requires the intracellular domain and apparently the dimerization of

37 ffects of Serrate ligand forms that lack the intracellular domain and are therefore incapable of endo

38 mTOR)-Akt, accumulation of HIF1alpha, Notch3 intracellular domain and beta-catenin, deficiency of pro

39 Furthermore, AIB1 interacted with Notch intracellular domain and Mastermind-like 1 and was recru

40 udy shows that residues 956-1154 of the HER2 intracellular domain and residue 83 of S100A14 are essen

41 es the direct binding of both the RBPJ/Notch intracellular domain and SOXF transcription factors.

42 Vamana also associates with the Dachsous intracellular domain and with a region of the Fat intrac

43 opening may occur through a rotation of the intracellular domains and calmodulin may prevent this ro

44 iced variants of ADAM15 that differ in their intracellular domains and demonstrated correlation of th

45 R1 and IFNAR2 promotes proximity between the intracellular domains and that differential signaling is

46 mide ketone inhibits formation of N-terminal intracellular domains and the corresponding secreted C-p

47 antigen-binding domain but differed in their intracellular domains and their in vivo antitumor effica

48 S4-S5 linker allow calmodulin to bind to the intracellular domains and to close the potassium pore, i

49 edicted allosteric pocket unique to the CD45 intracellular domain, and validated inhibitors by in vit

50 al fragment containing the transmembrane and intracellular domains, and this processing is dependent

51 recent years it became apparent that the APP intracellular domain (APP-ICD) might play a role in regu

52 led that amino acids 327-334 of the ephrinB1 intracellular domain are critical for the interaction wi

53 We demonstrate that the Eag1 intracellular domains are not required for voltage-depen

54 ic domain, indicating that the alphaIIbbeta3 intracellular domains are primed for activation while th

55 we report that the amyloid precursor protein intracellular domain associated-1 protein (AIDA-1), whic

56 ucleus messengers, amyloid precursor protein intracellular domain associated-1 protein, cAMP response

57 he sensitivity of AXL to 17-AAG required its intracellular domain because an AXL intracellular domain

58 se, resulting in the generation of a soluble intracellular domain, beta1-ICD, which modulates transcr

59 The intracellular domain binds, directly or indirectly, diff

60 cells decreased the production of the Notch intracellular domain but not the production of amyloid b

61 Mutations in the intracellular domain can have profound effects on recept

62 revealed a strong correlation between Notch1 intracellular domain, CD133, and p-p38 mitogen-activated

63 echanical stress-induced enhancement of CD44-intracellular domain (CD44-ICD) production plays an impo

64 ne cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell su

65 expression and nuclear localization of Notch intracellular domain compared with ECs of AVFs in pair-f

66 attributed to haploinsufficiency but not to intracellular domain composition.

67 )(-/-) with the overexpression of the Notch1-intracellular domain, confirming the role of Notch signa

68 Binding of extracellular signals stabilizes intracellular-domain conformations that selectively acti

69 embrane domain (TMD) and extended C-terminal intracellular domain containing a degron.

70 istically direct transmembrane receptors-the intracellular domain contains a transcriptional regulato

71 and gamma-secretase, and the released CX3CL1 intracellular domain (CX3CL1-ICD) would translocate into

72 mplement receptor CD46, and specifically its intracellular domain CYT-1, was required for induction o

73 ired its intracellular domain because an AXL intracellular domain-deleted mutant was insensitive to t

74 ar-domain) or IGF1R(extracellular domain)/IR(intracellular-domain) demonstrate homodimer IRalpha enha

75 e pluripotent stem cell line increased NOTCH intracellular domain-dependent (NICD-dependent) activati

76 tch1 intracellular domain expression, Notch1 intracellular domain-dependent CD133-mediated mitogen-ac

77 Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gl

78 discrete membrane subdomains, and the Gpr125 intracellular domain directly interacted with Dvl in pul

79 endowed the substituted thyrotropin receptor intracellular domain elements with spatial constraints a

80 espite their highly diverged sequences, each intracellular domain elicits repulsion via a common path

81 Intracellular domains engage in extensive interactions t

82 rimeric complexes with their ligands and the intracellular domains engage in higher-order oligomeriza

83 We identified the GB(1a) intracellular domain essential for the presynaptic homeo

84 Andrographolide inhibits Notch1 intracellular domain expression, Notch1 intracellular do

85 An endogenous intracellular domain fragment of p75(NTR) (p75(ICD)) con

86 cific 29-amino acid peptide derived from the intracellular domain fragment of p75(NTR) interacts with

87 containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-prod

88 ong the entire length of Ecadherin, with the intracellular domains having a surprisingly strong favor

89 nts and at two -sites to release human EPCAM intracellular domain HEPICD, which is efficiently degrad

90 EphA3 independently of ligand to generate an intracellular domain (ICD) fragment that reverses axon d

91 at can signal via a proteolytically released intracellular domain (ICD) in addition to classical rece

92 phenocopy deleting a specific portion of the intracellular domain (ICD) of Ft that regulates both gro

93 and knockdown experiments indicate that the intracellular domain (ICD) of HyFatl affects actin organ

94 vious studies have shown that the N-terminal intracellular domain (ICD) of teneurins can be cleaved a

95 s study, we investigated the function of the intracellular domain (ICD) of the Notch ligand Delta-lik

96 IgG to HER2 intracellular domain (ICD), HER2-ECD, p53, IGFBP2, CEA,

97 The intracellular domain (ICD), however, has been orphaned i

98 goes cleavage at the membrane and the Notch4-intracellular domain (ICD), translocates to the nucleus

99 nt phosphorylation of alpha3GlyRs within the intracellular domain (ICD), which decrease the GlyR-asso

100 , we show that Fra is cleaved to release its intracellular domain (ICD), which shuttles between the c

101 -mediated p75NTR cleavage and release of its intracellular domain (ICD).

102 xtracellular (ECD), transmembrane (TMD), and intracellular domain (ICD).

103 In this regard, RTK intracellular domains (ICD) are of interest due to their

104 that this is achieved by cleavage-regulatory intracellular-domain (ICD)-modifications of the precurso

105 -secretase cleavage of NOTCH3 to release its intracellular domain (ICD3), and sequenced the negative

106 However, the intracellular domains (ICDs) of ADAM10 and -17 can be re

107 Unexpectedly, we also found that the intracellular domains (ICDs) of DSCAM and DSCAML1 specif

108 ation by using chimeric ligands with swapped intracellular domains (ICDs), demonstrated that the Jagg

109 ransfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into an E

110 one, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A,

111 show that constitutive expression of Notch1 intracellular domain impairs secretory function of mouse

112 g by promoting the degradation of the Notch1 intracellular domain in cardiomyocytes.

113 xpression of the constitutively active NOTCH intracellular domain in CD11c-expressing cells.

114 on in clinical CRPC, tumors driven by Notch1 intracellular domain in combination with multiple pathwa

115 n strongly promotes dimerization of the TLR4 intracellular domain in MAPPIT.

116 of serine residue S1163 of the alphaE chain intracellular domain in polarization of CD103 and recrui

117 ALCAM shedding, defined as detection of the intracellular domain in the absence of the corresponding

118 RP8, revealing an unprecedented role for its intracellular domain in the regulation of synaptically g

119 that detects both the extracellular and the intracellular domains in formalin-fixed tissue.

120 Notch1 intracellular domain induced genes associated with stemn

121 ne-inducible genetic system (inducible Notch intracellular domain [iNICD]).

122 accumulate in SMC mitochondria, and the Fat1 intracellular domain interacts with multiple mitochondri

123 We also determined that the ROBO intracellular domain interacts with the Myo9b RhoGAP dom

124 asmic domain of CD44, we determined that the intracellular domain interfered with anchoring of the fu

125 The data suggest that release of the CD44 intracellular domain into the cytoplasm of cells such as

126 n of TH17 cells with a CAR encoding the ICOS intracellular domain is a promising approach to augment

127 by transcription, suggesting that the Notch intracellular domain is acting through a novel mechanism

128 Mouse neogenin lacking the intracellular domain is also capable of mediating BMP si

129 lar directional switches, suggested that the intracellular domain is critical for the directional rev

130 ation is unclear as studies suggest that its intracellular domain is dispensable for some AdV infecti

131 roteins, suggesting that generation of Notch intracellular domain is dispensable for this function.

132 specific ion conduction pathway through the intracellular domain is less clear.

133 to aberrant Notch trafficking and the Notch intracellular domain is stalled in sorting endosomes.

134 k analysis reveals that communication in the intracellular domains is greatly weakened during activat

135 nsmembrane core domain of TRPV1, but not the intracellular domains, is responsible for sensing these

136 c reverse signaling via its nuclear-targeted intracellular domain Jag1-ICD.

137 , upon ligand stimulation, is coupled to its intracellular domain kinase activation.

138 binds to growth factors, is coupled with the intracellular domain kinase activation.

139 d transmembrane (TMD) domains, as well as an intracellular domain known as the common region (CR).

140 Intracellular domains likely play a similar modulatory r

141 Coupling between the extracellular and intracellular domains may involve a switch between alter

142 How the intracellular domain modification communicates with the

143 We propose that substrate intracellular domain modification induces a relative rot

144 ive by specific intracellular signal-induced intracellular domain modifications of the substrates, wh

145 ngth (defined here as the ultimate number of intracellular domain molecules reaching the nucleus, int

146 Also, most pore mutations--in contrast to intracellular domain mutations--were found to have sever

147 s associated with decreased levels of Notch1 intracellular domain (N1ICD) and impaired regenerative r

148 tors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely red

149 e by conditionally overexpressing the Notch1 intracellular domain (N1ICD) in the reproductive tract d

150 e examined in detail mice in which the Notch intracellular domains (N1ICD and N2ICD) were swapped.

151 , leading to the increased expression of the intracellular domain (N3IC), finally enhancing Notch3-de

152 f autophagy required ligand-dependent, Notch intracellular domain (NIC) activity, which controlled mi

153 tase dependent and releases the active Notch intracellular domain (NIC).

154 that mutant p53 formed a complex with Notch1 intracellular domain (NICD) and antagonized p63/p73-medi

155 trate that ERG directly interacts with Notch intracellular domain (NICD) and beta-catenin and is requ

156 resulted in an increase of activated NOTCH1 intracellular domain (NICD) and c-MYC protein levels as

157 trengthens the association between the Notch intracellular domain (NICD) and CBF1, resulting in incre

158 by hydrodynamic tail vein injection of notch intracellular domain (NICD) and myr-Akt.

159 f the bivalent interaction between the Notch intracellular domain (NICD) and the transcription factor

160 y by nuclear translocation of cleaved Notch1 intracellular domain (NICD) and upregulation of target m

161 PT, to inhibit cleavage and release of Notch Intracellular Domain (NICD) blocked cardiac architectura

162 ng because inducible expression of the Notch Intracellular Domain (NICD) can reverse the effect.

163 that overexpression of either her12 or Notch intracellular domain (NICD) increases the number of immo

164 ata showed that over-expression of the Notch Intracellular Domain (NICD) significantly induced the ex

165 of its neighboring cell, releasing the Notch Intracellular Domain (NICD) that activates many downstre

166 ependent increase in the abundance of Notch1 intracellular domain (NICD) that depended on ADAM10 and

167 nse pathway through recruitment of the Notch intracellular domain (NICD) transcriptosome to a conserv

168 In the case of Notch, the intracellular domain (NICD) transduces the signal direct

169 nd in vitro assays, we show that the Nephrin intracellular domain (NICD), a disordered protein, drive

170 Tak1 deletion also down-regulated Notch intracellular domain (NICD), but increased the levels of

171 the transcription factor RBPJ and the Notch intracellular domain (NICD), but not Mastermind-like pro

172 e half-life of the positive regulator, Notch intracellular domain (NICD), can lead to elevated NICD l

173 In contrast, overexpression of Notch1 intracellular domain (NICD), to constitutively activate

174 avage and nuclear translocation of the Notch intracellular domain (NICD), which associates with Epste

175 ion and enhancing nuclear transport of Notch intracellular domain (NICD).

176 ancer by directly interacting with the Notch intracellular domain (NICD).

177 ctivation and nuclear translocation of Notch intracellular domain (NICD).

178 ed form of the Notch receptor (cleaved Notch intracellular domain, NICD)].

179 ieved by increased recruitment of the NOTCH1 intracellular domain (NICD1) to nuclear and mitochondria

180 in, which facilitates the cleavage of NOTHC1 intracellular domain (NICD1).

181 overexpressing a version missing part of the intracellular domain (NL1DeltaC).

182 Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the n

183 y gamma-secretase, which releases the active intracellular domain (Notch1(NIC)).

184 disequilibrium, and are located in the PRLR intracellular domain, occurred with significantly higher

185 We constructed functional mimetics of the intracellular domain of a model GPCR, the thyrotropin re

186 a global conformational change in the B30.2 intracellular domain of BTN3A1 induced by pAg binding.

187 es called phosphoantigens, which bind to the intracellular domain of butyrophilin 3A1, triggering ext

188 Here we report that the intracellular domain of Caenorhabditis elegans BMP type

189 e mediated via the gamma-secretase-regulated intracellular domain of CD44, which promoted aggressive

190 Here we show that the WDD interacts with the intracellular domain of cytokine receptors to regulate t

191 we show that this element is present in the intracellular domain of cytokine receptors.

192 In contrast, overexpression of the intracellular domain of DLL1 in adult murine pancreatic

193 of a highly conserved serine cluster in the intracellular domain of E-Cadherin is essential for bind

194 at App promotes growth by palmitoylating the intracellular domain of Fat, and that palmitoylation neg

195 Multiple regions of the intracellular domain of Ft have been implicated in regul

196 All 10 cysteines in the intracellular domain of IA-2 were modified to serine by

197 Receptors with the intracellular domain of IGF1R show increased activation

198 Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphor

199 he IQ region of IQGAP1 binds directly to the intracellular domain of IR.

200 Mutation of tyrosine 1138 in the intracellular domain of LepRb that mediates signaling th

201 mal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic clea

202 ts are mediated via interactions between the intracellular domain of LOX-1 and AT1 that activate AT1.

203 We show that the intracellular domain of Lrp1 interacts with the nuclear

204 lar hair cells was found to interact with an intracellular domain of microfibril interface-located pr

205 MPL and that 3 tyrosine residues within the intracellular domain of MPL are required to activate sig

206 the specific adsorption of the His(6)-tagged intracellular domain of Neuroligin-2 (His-cytNL2) were p

207 port that CaMKII robustly phosphorylates the intracellular domain of NL-1.

208 nd binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the

209 enewal by Notch1 cleavage, and the generated intracellular domain of Notch1 (NICD) induced the expres

210 of OS based on conditional expression of the intracellular domain of Notch1 (NICD).

211 t mice constitutively expressing the active, intracellular domain of NOTCH1 (NICD1) in Sertoli cells.

212 er overexpression of a constitutively active intracellular domain of NOTCH1.

213 nts harbor gain-of-function mutations in the intracellular domain of Notch1.

214 e show that liver-specific expression of the intracellular domain of Notch2 (N2ICD) in mice is suffic

215 that expression of the constitutively active intracellular domain of Notch4 (N4ICD) in melanoma cells

216 ee-dimensional NMR solution structure of the intracellular domain of p45 and characterized its intera

217 er sST2 levels in the GWAS and mapped to the intracellular domain of ST2, which is absent in sST2.

218 response begins with sensing of pAg via the intracellular domain of the butyrophilin 3A1 (BTN3A1) mo

219 Posttranslational modifications to the intracellular domain of the EGFR are known to regulate E

220 vels.SIGNIFICANCE STATEMENT We show that the intracellular domain of the inhibitory glycine receptor

221 s kinase 1 (JAK1) bound to a fragment of the intracellular domain of the interferon-lambda receptor 1

222 A prominent example is the intracellular domain of the Notch receptor (NICD), which

223 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides w

224 d by Box1 and Box2 motifs located within the intracellular domain of the receptor chains.

225 The intracellular domain of the serotonin type 3A receptor,

226 We now show that the N-terminal intracellular domain of the type II transmembrane protei

227 ath domain regulates RIP1 recruitment to the intracellular domain of TNFR1.

228 the light-inducible homo-interaction of the intracellular domain of TrkB in the cytosol or on the pl

229 membrane recruitment and homo-interaction of intracellular domain of TrkB is most efficient in activa

230 ite long-standing evidence that the specific intracellular domains of AMPA-type glutamate receptor (A

231 ring was modulated by both extracellular and intracellular domains of ApoER2.

232 CD28, whereas T cell functions depend on the intracellular domains of both CD28 and CD3epsilon, with

233 rgic receptor (alpha2AAR) that occurs at the intracellular domains of both proteins.

234 e various studies is that the association of intracellular domains of CCR5 with the signaling machine

235 Cherry nanobodies fused to transmembrane and intracellular domains of cytokine receptors that phenoco

236 rs of Notch signaling that interact with the intracellular domains of DLL1 and DLL4.

237 OsSERK2 interacts with the intracellular domains of each immune receptor in the yea

238 Ras-related protein 5A) bind directly to the intracellular domains of GABAARs, validating our proteom

239 Analysis of the extracellular and intracellular domains of Kirrel2 revealed that it is cle

240 The intracellular domains of many ion channels are important

241 Moreover, none of the intracellular domains of p75NTR demonstrated a propensit

242 Switching the intracellular domains of the gamma2 and gamma1 subunits

243 reating chimeras using the extracellular and intracellular domains of three different Drosophila repu

244 Analogous "anchor" peptides within intracellular domains of vertebrate KCNQ2, KCNQ3, and Na

245 cade to release its transcriptionally active intracellular domain, on force to unfold a protective do

246 g chimeras of IR(extracellular domain)/IGF1R(intracellular-domain) or IGF1R(extracellular domain)/IR(

247 K(v)10.1 or Eag1 also has three intracellular domains: PAS, C-linker, and CNBHD.

248 on of a vector encoding for the active Notch intracellular domain prevented H19-induced mineralizatio

249 ly complex fluorescence changes within these intracellular domains, providing clues as to how posttra

250 ion and reporter assays revealed that Notch1 intracellular domain regulates CD133 expression at the t

251 The release of the active intracellular domain requires the enzymatic activity of

252 risingly, a single lysine residue within the intracellular domain rescues shedding of Tim-3.

253 M and I338T, located in the transmembrane or intracellular domain, respectively, have no influence on

254 in-of-function transgene encoding the Notch1 intracellular domain resulted in lymphoproliferation, ex

255 ther show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB

256 ar domains and transducing signals via their intracellular domains, resulting in changes in direction

257 se cleavage and nuclear translocation of its intracellular domain (Ryk-ICD).

258 Chromatin immunoprecipitation of the NOTCH intracellular domain showed increased binding to two spe

259 Indeed, gain of function of Ryk intracellular domain signaling regulates SST and PV fate

260 ed by two distinct, structurally disordered, intracellular domains spanning amino acids 584-734 ("mid

261 than wild-type tumors on the basis of Notch1 intracellular domain staining ( P = .004).

262 The intracellular domain starts with a short loop after the

263 e component of the WAVE complex, through its intracellular domain, suggesting a role in the control o

264 expressing either full-length Dchs1b or its intracellular domain, suggesting that Dchs1b affects mic

265 enhance the repulsive activity of all three intracellular domains, suggesting that repulsion by Unc5

266 ific gamma-secretase complexes following the intracellular domain swap.

267 we examined the responses elicited by their intracellular domains systematically.

268 alysis showed that only a core region of the intracellular domain that exhibits at least some conserv

269 domain, a transmembrane (TM) domain, and an intracellular domain that includes a juxtamembrane (JM)

270 1 induces a conformational change within the intracellular domain that involves the JM region and is

271 cellular domain and with a region of the Fat intracellular domain that is essential for controlling H

272 ression in Fat1(KO) cells of a modified Fat1 intracellular domain that localizes exclusively to mitoc

273 or transmembrane helix 5 (TM5), TM6, and TM7 intracellular domains that are essential elements for GP

274 external stimuli and transmit information to intracellular domains through a single transmembrane (TM

275 Most mutations located in the large intracellular domain (TM3-4 loop) of the GlyRalpha1 impa

276 Exposing the intracellular domain to a denaturing agent increases the

277 ffects the NSC fate by signaling through its intracellular domain to regulate beta-catenin signaling

278 nuclear localization of the activated NOTCH4 intracellular domain to the apical cytoplasm of neoplast

279 water channels and their redistribution from intracellular domains to the plasma membrane via vesicul

280 lizes presenilin1 and releases N1ICD (Notch1 intracellular domain) to promote EC proliferation.

281 roviding evidence that signaling via the DCC intracellular domain triggers DCC recruitment to the pla

282 and TACE (ADAM17), which releases the Trop2 intracellular domain (Trop2 ICD).

283 The butyrophilin 3A1 intracellular domain undergoes a conformational change i

284 Conformational coupling between membrane and intracellular domains via poorly understood mechanisms i

285 0) of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after P

286 the N-glycosylation dependence, whereas the intracellular domain was not involved.

287 xpression of a mutant E-cadherin lacking the intracellular domain was sufficient for efficient L. mon

288 Truncated Sema6B lacking the intracellular domain was unable to rescue the loss-of-fu

289 llele 008, with an altered transmembrane and intracellular domain, was not affected by mutation of th

290 Minimal amounts of the Notch intracellular domain were sufficient for rescue, which w

291 rther reveal much of the architecture of the intracellular domain, where mutagenesis experiments and

292 t dimer interfaces in the BTN3A1 full-length intracellular domain, which are stable in MD simulations

293 rface results in the generation of the Notch intracellular domain, which associates with several tran

294 luence the cytoskeleton directly through its intracellular domain, which can bind and localize Ena/VA

295 5a stimulates the release of the tagged Ptk7 intracellular domain, which can translocate into the nuc

296 ger is regulated by binding of Ca(2+) to its intracellular domain, which contains two structurally ho

297 ulting in the cytoplasmic release of a Notch intracellular domain, which translocates to the nucleus

298 sing mutations localize to these specialized intracellular domains, which underlie the unique gating

299 educing PI3K activity destabilizes the Notch intracellular domain, while the constitutive activation

300 DCC dominant negative that replaces the DCC intracellular domain with mCherry, consistent with netri