ライフサイエンスコーパス: intracellular protein

1 However, WT1 is a currently undruggable, intracellular protein.

2 ng possibility that NKG2E may function as an intracellular protein.

3 n (IFN)-alpha/beta-inducible, ubiquitin-like intracellular protein.

4 ubiquitous detection of MR1 transcripts and intracellular protein.

5 hat are classically associated with immature intracellular proteins.

6 apacity versus proteasome load of undegraded intracellular proteins.

7 tures, T-cell receptors (TCRs) can recognize intracellular proteins.

8 ignals from the extracellular environment to intracellular proteins.

9 fluenced by association with both inter- and intracellular proteins.

10 without knowledge of cell-surface markers or intracellular proteins.

11 main conformations that selectively activate intracellular proteins.

12 activity of DAT are regulated by a number of intracellular proteins.

13 responsible for the regulated degradation of intracellular proteins.

14 ck copolymer formulation as a tool to target intracellular proteins.

15 inked beta-N-acetylglucosamine (O-GlcNAc) on intracellular proteins.

16 ator for quantification of other surface and intracellular proteins.

17 interactions, and/or trafficking of numerous intracellular proteins.

18 that involves the recruitment and fusion of intracellular proteins.

19 C-terminus (GIPC) link RGS19 to a variety of intracellular proteins.

20 me pathway for the controlled degradation of intracellular proteins.

21 s single-cell measurement of 30+ surface and intracellular proteins.

22 to glial cells and cause the aggregation of intracellular proteins.

23 oteasome system catalyzes the degradation of intracellular proteins.

24 ly regulated by a number of cell surface and intracellular proteins.

25 ciated proteins, cell membrane proteins, and intracellular proteins.

26 uch interactions can alter the fates of many intracellular proteins.

27 ar machines for the regulated degradation of intracellular proteins.

28 well as acting as a molecular chaperone for intracellular proteins.

29 moieties that target enzymes, peptides, and intracellular proteins.

30 responsible for the regulated degradation of intracellular proteins.

31 identification of AX-mediated haptenation of intracellular proteins.

32 vealed 67 GalNAz-labeled proteins, including intracellular proteins.

33 beta has the capacity to interact with other intracellular proteins.

34 ation, lower autophagic capacity, and higher intracellular protein abundance phenotypes of aged and S

35 However, because temporal changes in intracellular protein abundances cannot be measured dire

36 modification that regulates the activity of intracellular proteins according to glucose availability

37 on of the targeted mRNA and of corresponding intracellular protein activity was achieved.

38 e CHMP2B, resulting in autophagy impairment, intracellular protein aggregate accumulation, unfolded p

39 Reactivation of intracellular protein aggregates after a severe stress i

40 Intracellular protein aggregates are a pathological hall

41 hibit reduced mitotic potential, and display intracellular protein aggregates as compared to cells fr

42 Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that effici

43 To avoid the build-up of potentially toxic intracellular protein aggregates, the timing and locatio

44 ation due to the rapid accumulation of large intracellular protein aggregates.

45 Intracellular protein aggregation is a common pathologic

46 n of wild-type, but not mutant, LSS prevents intracellular protein aggregation of various cataract-ca

47 s possible that any therapeutic that reduces intracellular protein aggregation will benefit all.

48 o digest the polyQ tract, which can initiate intracellular protein aggregation, preventing polyQ pept

49 variation in keratin-associated proteins and intracellular proteins, allowing body location different

50 ficantly higher in extracellular matrix than intracellular proteins, although a low amount was detect

51 is a well characterized system for degrading intracellular proteins, although many aspects remain poo

52 ve system to screen for molecules inhibiting intracellular protein amyloidogenesis in vivo, by testin

53 ll penetrating peptide applicable to achieve intracellular protein and gene delivery.

54 In this article, we show that Itfg2 is an intracellular protein and it plays a critical role in B

55 ved cellular process for bulk degradation of intracellular protein and organelles in lysosomes.

56 ication, web morphology, the distribution of intracellular protein and PI(4)P, along with cholesterol

57 oplasm inflicting hydroxyl radical attack on intracellular proteins and DNA.

58 mmune cell-derived exosomes are regulated by intracellular proteins and extracellular stimuli.

59 The E3-ubiquitin ligase parkin ubiquitinates intracellular proteins and induces mitophagy.

60 ) plays a critical role in removing unwanted intracellular proteins and is involved in protein qualit

61 ain as well as by its interaction with other intracellular proteins and lipids.

62 l extraction and quantitative measurement of intracellular proteins and mRNA from a variety of cell t

63 induced by starvation to capture and degrade intracellular proteins and organelles in lysosomes, whic

64 athway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes.

65 to actin filaments, the plasma membrane, and intracellular proteins and organelles, myosins can gener

66 hanisms, including physical association with intracellular proteins and post-translational modificati

67 n of cell-surface proteins to characterizing intracellular proteins and providing multiple different

68 ty of ligand-induced association of Ras with intracellular proteins and suggests it as a promising th

69 rowth and survival autonomously by recycling intracellular proteins and/or organelles.

70 r- survival, signaling, its interaction with intracellular proteins, and how melatonin regulates its

71 The 14-3-3 family of intracellular proteins are dimeric, multifunctional adap

72 In contrast, intracellular proteins are subjected to a simple version

73 ne localization, yet it is unclear how these intracellular proteins are targeted to sites of synaptic

74 P3, of the NOD-like receptor (NLR) family of intracellular proteins, are expressed in innate immune c

75 specific, live-cell, fluorescent labeling of intracellular proteins at high density for super-resolut

76 In this study, we identified intracellular protein ATP-binding cassette subfamily F m

77 up new opportunities for the development of intracellular protein-based anticancer treatment.

78 (CaMKII) in neuronal cells and recognize the intracellular protein biomarker tubulin.

79 riminate the extracellular proteins from the intracellular proteins by improving detection of activel

80 inciple, with refined extraction techniques, intracellular proteins can potentially be extracted with

81 ce of the FAST-DOSE assay system to quantify intracellular protein changes in blood leukocytes for ea

82 he role of mammalian thioredoxin (Trx) as an intracellular protein cofactor is widely appreciated, it

83 kine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome;

84 Intracellular protein complexes containing nucleic acids

85 Inflammasomes are intracellular protein complexes that drive the activatio

86 d biological PROTACs (bioPROTACs)-engineered intracellular proteins consisting of a target-binding do

87 MHC-I molecules expose the intracellular protein content on the cell surface, allow

88 following necrosis, GAPDH and numerous other intracellular proteins convert into an insoluble disulfi

89 amic simulations demonstrated that dimerized intracellular proteins cooperate in sensing HMBPP to enh

90 ition of 300 mOsm mannitol), which increases intracellular protein crowding.

91 em represents the major pathway of selective intracellular protein degradation in eukaryotes.

92 ypothesis that AMPK serves as a modulator of intracellular protein degradation in the heart.

93 Intracellular protein degradation is essential for the s

94 r, these methods involve the manipulation of intracellular protein degradation machinery and are ther

95 system is the major pathway of non-lysosomal intracellular protein degradation, playing an important

96 e report a bioconjugation-based approach for intracellular protein delivery by site-selectively attac

97 y to meet animals' nutritional needs through intracellular protein digestion while simultaneously all

98 monstrate a new technique that can determine intracellular protein distribution at nanometer spatial

99 alized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and

100 ceptor (GPCR) causes recruitment of multiple intracellular proteins, each of which can activate disti

101 al tags that can be used to covalently label intracellular proteins efficiently in living cells.

102 ss I molecules present peptides derived from intracellular proteins, enabling immune surveillance by

103 to elicit their bioactivity towards binding intracellular protein epitopes and inducing apoptosis.

104 cell populations based upon the presence of intracellular protein epitopes would enable many types o

105 TMEM176B is an intracellular protein expressed in ATDCs and initially i

106 P311, a conserved 8-kDa intracellular protein expressed in brain, smooth muscle,

107 precise mechanisms by which deficiency of an intracellular protein expressed primarily in the differe

108 discrete groups on the basis of high or low intracellular protein expression and virion release.

109 ant TGF-beta1 increased PAI-1 transcription, intracellular protein expression, and secretion.

110 However, unlike intracellular protein fate, intrinsic factors determinin

111 mediated proteolytic cleavage, releasing the intracellular protein fragment CD44-ICD, which transloca

112 aggregates, and an age-dependent transfer of intracellular protein from dilute to concentrated or con

113 that electroporation is capable of releasing intracellular proteins from adherent Chinese hamster ova

114 Extraction of intracellular proteins from cells is often an important

115 This is a unique mechanism for inhibiting an intracellular protein function and the structural contus

116 dality for engineering chemical control over intracellular protein function that is complementary to

117 Hs, can serve as inhibitors or activators of intracellular protein function, but functional testing o

118 ng existing antibody collections to modulate intracellular protein function.

119 opportunities to directly inhibit and study intracellular protein function.

120 Additionally, while several intracellular proteins function as c-di-AMP receptors in

121 Intracellular protein gradients are significant determin

122 Intracellular protein gradients underlie essential cellu

123 patial control of division site placement by intracellular protein gradients, under simplified condit

124 t to the application of 5ECdsAP1 aptamer for intracellular protein-guided imaging and modulation of g

125 poly-(ADP-ribose) polymerase 14 (PARP14), an intracellular protein highly expressed in lymphoid cells

126 The intracellular protein HMGB1 is released from cells and a

127 ranslational stress response to maintain the intracellular protein homeostasis.

128 her, we provide mechanistic insights of this intracellular protein in matrix mineralization.

129 or elucidating the structure and function of intracellular proteins in cell biology.

130 These numbers suggest that intramembrane and intracellular proteins in isolated oxygenic photosynthet

131 e showed that the probe specifically labeled intracellular proteins in live cells without and with wa

132 d extracellular spaces, and association with intracellular proteins in liver and kidney.

133 half-life and can readily label a variety of intracellular proteins in living cells.

134 Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and induces acute my

135 ariable levels of specificity to hundreds of intracellular proteins in vitro.

136 adducts enhance metal-catalyzed oxidation of intracellular proteins in vivo by use of live cell imagi

137 foundly affect interactions between ASOs and intracellular proteins in ways that are only beginning t

138 hock proteins are known to stabilize several intracellular proteins, including defense-related signal

139 t at only low levels in the serum and induce intracellular protein inclusions, causing lung emphysema

140 hallmark of PD pathology is the formation of intracellular protein inclusions, termed Lewy bodies (LB

141 Here we investigate the intracellular protein interaction network of the transme

142 aryotic cells and involved in a multitude of intracellular protein interactions.

143 y 3 domain-bearing protein Intersectin 1, an intracellular protein involved in synaptic vesicle cycli

144 Previous studies have used overexpression of intracellular proteins involved in GPCR trafficking, pat

145 omerization domain-like receptors (NLRs) are intracellular proteins involved in innate-driven inflamm

146 eracting protein 1 (TRIP-1), a predominantly intracellular protein is localized in the ECM of bone.

147 ound on the serine and threonine residues of intracellular proteins is an inducible post-translationa

148 Proteasome-mediated degradation of intracellular proteins is essential for cell function an

149 Alterations in O-GlcNAc modification of intracellular proteins is linked to diabetes, and the in

150 Post-translational palmitoylation of intracellular proteins is mediated by protein palmitoylt

151 Coupling of cellular prion protein to these intracellular proteins is modified by soluble amyloid-be

152 ivator of canonical WNT signaling and, as an intracellular protein, it helps to maintain precursor ce

153 ound that taurine enhanced K(V) channels via intracellular protein kinase C-mediated pathways.

154 extracytoplasmic domain (ectodomain) and an intracellular protein kinase domain involved in downstre

155 Focal adhesion kinase is an intracellular protein kinase that plays critical roles i

156 eins, generating hypotheses for differential intracellular protein kinases A and C signaling pathways

157 inction and reconsolidation are regulated by intracellular protein kinases and phosphatases, and inte

158 iotensin II activation of Tyk2 increased the intracellular protein level of Cx43 via STAT3.

159 e absence of TF oscillations under same mean intracellular protein level of TF.

160 Intracellular protein levels of diverse transcription fa

161 two-component systems and used them to drive intracellular protein levels to match user-defined refer

162 he technologies available for the control of intracellular protein levels with small molecules and co

163 ts expression was observed at transcript and intracellular protein levels.

164 the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting

165 In this protocol, surface and intracellular protein markers can also be stained with f

166 ParT is a unique example of an intracellular protein mART in bacteria and is the smalle

167 is was used to quantify changes in levels of intracellular proteins, measure reactive oxygen species

168 d-beta oligomer-triggered phosphorylation of intracellular protein mediators and impairment of synapt

169 r (Abetao) regulates the association between intracellular protein mediators and the synaptic recepto

170 e metabotropic glutamate receptor 5 with the intracellular protein mediators Homer1b/c, calcium/calmo

171 The intracellular proteins MMACHC and MMADHC play important

172 that functions in innate immunity both as an intracellular protein modifier and as an extracellular s

173 alpha1 subunit represents a multifunctional intracellular protein motif.

174 Intracellular protein motors have evolved to perform spe

175 However, little is known about the intracellular proteins necessary for channel function.

176 he novel markers identified in our study are intracellular proteins not previously identified in the

177 em are conformational epitopes of ubiquitous intracellular proteins not specific to brain tissue.

178 logous to protein phosphorylation; increased intracellular protein O-GlcNAc modification has been obs

179 fuel an indispensable dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T

180 r concentrations of UDP-GlcNAc and increased intracellular protein O-GlcNAcylation controlled by the

181 (GlcNAc) to serine and threonine residues of intracellular proteins (O-GlcNAc), regulates food intake

182 Intracellular proteins of interest were labeled with flu

183 Plants and animals use intracellular proteins of the nucleotide-binding domain,

184 signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton.

185 nsduction domain (PTD), to achieve effective intracellular protein or gene delivery in clinical pract

186 The intracellular protein p120 catenin aids in maintenance o

187 Association of GPCRs with intracellular protein partners might be one of the mecha

188 e extension and retraction processes through intracellular protein phosphorylation of numerous cytosk

189 PAMP responses include changes in intracellular protein phosphorylation, including the act

190 lent attachment of ubiquitin (Ub) to various intracellular proteins plays important roles in altering

191 Lipin1, an intracellular protein, plays critical roles in controlli

192 the pMHC I repertoire is a reflection of the intracellular protein pool.

193 osphorylation and OGlcNAcylation are dynamic intracellular protein post-translational modifications t

194 eceptor coactivator 4) is a widely expressed intracellular protein previously shown to mediate the au

195 onspecific weak attractive interactions with intracellular proteins prior to substrate recognition.

196 Surprisingly, despite these differences in intracellular protein processing, the T cell and antibod

197 human proteins, including those involved in intracellular protein-protein interactions (PPIs), are u

198 tor-sensed input signals affect and modulate intracellular protein-protein interactions (PPIs).

199 loping cyclic peptides for the inhibition of intracellular protein-protein interactions and of direct

200 ed a peptide-based therapy aimed at blocking intracellular protein-protein interactions during EGFR s

201 e therapeutics in general aimed at targeting intracellular protein-protein interactions for disease i

202 During the course of our efforts to target intracellular protein-protein interactions in cancer, we

203 of the alpha/beta-peptide approach to target intracellular protein-protein interactions.

204 nstrate robust and quantitative detection of intracellular protein-protein interactions.

205 de MCoTI-I an optimal scaffold for targeting intracellular protein-protein interactions.

206 n their target proteins, and thereby mediate intracellular protein-protein interactions.

207 ptides into potential therapeutics targeting intracellular protein-protein interactions.

208 ll-based technique to measure phosphorylated intracellular proteins, providing a more quantitative re

209 ologs function directly with 20S to maintain intracellular protein quality control.

210 recognition and clearance are essential for intracellular protein quality control.

211 nucleotide exchange factor system assists in intracellular protein (re)folding.

212 performed to assess changes in the levels of intracellular proteins, reactive oxygen species (ROS), a

213 Consistent with this pattern of intracellular protein redistribution, impaired nucleocyt

214 nipulate local membrane curvatures and probe intracellular protein responses, discussing surface coat

215 nsequence of impaired phosphorylation of key intracellular proteins responsible for regulating the SR

216 rane integrins link extracellular matrix and intracellular proteins, resulting in bidirectional signa

217 onical secreted subtilase [SBT5.2(a)] and an intracellular protein [SBT5.2(b)].

218 for single-cell studies to reliably identify intracellular proteins, secondary messengers, or metabol

219 tes with several transmembrane receptors and intracellular proteins serving as an anchoring molecule.

220 purpose of that technique was to reconstruct intracellular protein signaling networks.

221 x networks of biochemical reactions, such as intracellular protein signaling pathways and genetic net

222 The intracellular protein SOCS1 is known to downregulate cyt

223 d phenomena: a general age-dependent loss of intracellular protein solubility, a delayed and rapid ap

224 ptor protein-1 (AP-1) complex, implicated in intracellular protein sorting and packaging.

225 mer recognition core complex which regulates intracellular protein sorting and trafficking.

226 Membrane fusion is essential for intracellular protein sorting, cell growth, hormone secr

227 first tier involves a genetic selection for intracellular protein stability that is based on the fol

228 Three-dimensional colocalization of intracellular protein structures and the cell surface wi

229 tively, of N-acetylglucosamine (GlcNAc) from intracellular protein substrates.

230 n fluorescent protein (GFP) as a reporter of intracellular protein synthesis and degradation.

231 Y dye moiety as a component of probes for an intracellular protein target and highlight the importanc

232 The vast majority of intracellular protein targets are refractory toward smal

233 and synucleinopathies, the normally soluble intracellular proteins tau and alpha-synuclein become in

234 This phenomenon was more pronounced for intracellular proteins than for connective tissue.

235 PRAME is an intracellular protein that cannot currently be drugged.

236 Talin is an intracellular protein that is critical for linking integ

237 P311 is an 8-kDa intracellular protein that is highly conserved across sp

238 Mammalian Nod2 is an intracellular protein that is implicated in the innate i

239 ain-containing protein 2 (NOD2/Card15) is an intracellular protein that is involved in the recognitio

240 Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when relea

241 hough it can be secreted, vIL-6 is mainly an intracellular protein that is retained in the endoplasmi

242 Filamin A, an intracellular protein that stabilizes the actin cytoskel

243 olyamines is one of the few modifications of intracellular proteins that add positive charges.

244 ally described as self-peptides derived from intracellular proteins that are expressed at the cell su

245 ved that IL-32 is also able to interact with intracellular proteins that are involved in integrin and

246 associated with the plant biomass releasing intracellular proteins that contaminate the metasecretom

247 -polymerase (PARP)-14 belongs to a family of intracellular proteins that generate ADP-ribose posttran

248 ransmembrane integrin adhesion receptors and intracellular proteins that link integrins to the actin

249 nown about the interactions between ASOs and intracellular proteins that may alter cellular localizat

250 Fatty acid-binding proteins (FABPs) are intracellular proteins that mediate AEA transport to its

251 enewing divisions, but the extracellular and intracellular proteins that regulate this process are la

252 cNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma go

253 ands were synthesized to selectively deliver intracellular protein therapeutics into tumor cells via

254 The glutathionylation of intracellular protein thiols can protect against irrever

255 understand the contributions of secreted and intracellular protein to the VSV-induced immune response

256 ave been proposed that link the mechanics of intracellular proteins to cell shape maintenance.

257 rstand what determines the susceptibility of intracellular proteins to degradation by the UPS, we dev

258 y interact with a relatively small number of intracellular proteins to induce profound physiological

259 Defective endosomal intracellular protein trafficking due to biallelic mutat

260 functional studies of Rpgr suggest a role in intracellular protein trafficking through the connecting

261 regulator of axonal morphology as well as of intracellular protein trafficking to the lysosome compar

262 oss-of-function variants in AP-4 subunits on intracellular protein trafficking using patient-derived

263 Intracellular protein trafficking was pharmacologically

264 ike 1 (LEPROTL1) (two proteins that regulate intracellular protein trafficking) reduces GH receptor c

265 they participate in cell signaling including intracellular protein trafficking, cytoskeletal dynamics

266 nticipated role of physiological epoxides in intracellular protein trafficking.

267 cularly rich source of information regarding intracellular protein trafficking.

268 er a distinct role of LRP6 as a platform for intracellular protein trafficking.

269 cyclotides inside live yeast cells by using intracellular protein trans-splicing in combination with

270 two species triggered calcium signaling and intracellular protein translocation events, respectively

271 t may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exo

272 s a coatomer protein complex responsible for intracellular protein transport between the endoplasmic

273 otein with dual functions, being involved in intracellular protein transport, as well as cellular sig

274 nteraction controls different aspects of the intracellular protein triage decision, extending the fun

275 Spleen tyrosine kinase (SYK) is an intracellular protein tyrosine kinase involved in cell s

276 a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation.

277 ions by phosphorylating tyrosine residues of intracellular proteins upon extracellular ligand binding

278 amic and inducible enzymatic modification to intracellular proteins utilizes the end product of the n

279 We report that LRP1 binds intracellular proteins via its extracellular domain and

280 s is primarily ensured by the degradation of intracellular proteins via the ubiquitin-proteasome syst

281 the amplitude of the thermal denaturation of intracellular proteins was practically independent of fi

282 ase (p = 0.009), although levels of mRNA and intracellular protein were similar in aSS and healthy co

283 Intracellular proteins were quantified to monitor proteo

284 ze otherwise inaccessible disease-associated intracellular proteins when they are presented as proces

285 in interactome has lagged far behind that of intracellular proteins, where mass spectrometry and yeas

286 predominantly present peptides derived from intracellular proteins, whereas MHC-II predominantly pre

287 ract with a host of plasma, cell-surface and intracellular proteins which govern their therapeutic pr

288 growth factor homologous factors (FHFs) are intracellular proteins which regulate voltage-gated sodi

289 p120-catenin is a multidomain intracellular protein, which mediates a number of cellul

290 interactions with plasma, cell-surface, and intracellular proteins, which facilitates their tissue d

291 rk paves the way to extracting and analyzing intracellular proteins while keeping cells live.

292 ) revealed that 6AzGlcNAc exclusively labels intracellular proteins, while GlcNAz and GalNAz are inco

293 Intracellular proteins whose expression is altered by th

294 Actin is a major intracellular protein with key functions in cellular mot

295 m and integrin binding protein 1) is a small intracellular protein with numerous interacting partners

296 Post-translational modification of intracellular proteins with a single N-acetylglucosamine

297 ly, we presented evidence that suggests that intracellular proteins with high expression in cancer ce

298 Intracellular proteins with long lifespans have recently

299 samine (O-GlcNAc) transferase (OGT) modifies intracellular proteins with N-acetylglucosamine.

300 OGT and AMPK target a multitude of intracellular proteins, with the net effect to protect c