ライフサイエンスコーパス: intracellular signaling

1 ossibility that morphogenesis itself affects intracellular signaling.

2 as microdomains for protein interactions and intracellular signaling.

3 plored whether CC2D1A controls male-specific intracellular signaling.

4 ction as the catalytic subunits that mediate intracellular signaling.

5 (+) T cells and the subsequent triggering of intracellular signaling.

6 al ABC transporters and their regulation via intracellular signaling.

7 n, the common structural change that enables intracellular signaling.

8 fate commitment, depends almost entirely on intracellular signaling.

9 ich scavenges human chemokines and modulates intracellular signaling.

10 receptors (GPCRs) are intimately involved in intracellular signaling.

11 ard to G protein and beta-arrestin-dependent intracellular signaling.

12 ase, thereby serving as crucial mediators of intracellular signaling.

13 e increasingly emerging as critical hubs for intracellular signaling.

14 2)) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling.

15 riving polarization of membrane proteins and intracellular signaling.

16 surface receptors and subsequently activates intracellular signaling.

17 molecular events coupling ligand binding to intracellular signaling.

18 relationships between caveolae structure and intracellular signaling.

19 operties as an often-overlooked modulator of intracellular signaling.

20 itted across the T-cell membrane to initiate intracellular signaling.

21 lar myocytes were studied for morphology and intracellular signaling.

22 dent cell adhesion properties from canonical intracellular signaling.

23 ation, stable ligand binding, and subsequent intracellular signaling.

24 causing conformational changes that trigger intracellular signaling.

25 on but did not induce RANKL, suggesting that intracellular signaling activated by the low affinity in

26 We found that adropin(34-76) enhances major intracellular signaling activities in the liver that are

27 ctivities associated with receptor dependent intracellular signaling activity.

28 ria are vital for cellular energy supply and intracellular signaling after stress.

29 be fully understood by genetic mutations or intracellular signaling alone.

30 te [PI(4,5)P2] is a well-known precursor for intracellular signaling and a bona fide regulator of act

31 ate how this MAPK-phosphatase might regulate intracellular signaling and cardiac growth dynamics in v

32 In the absence of lysis, MAC may induce intracellular signaling and cell activation, responses i

33 gest a direct Hh-mediated regulation of both intracellular signaling and cell adhesion through Ihog.

34 expressed the IL-5 receptor, which triggered intracellular signaling and changed gene expression.

35 act as hotspots for optimal coordination of intracellular signaling and clathrin-mediated endocytosi

36 herin adhesion complexes communicate through intracellular signaling and contribute to the integrity

37 ults show that total body irradiation alters intracellular signaling and epigenetic pathways regulati

38 tor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic

39 ction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of si

40 omplications in the brain, thereby affecting intracellular signaling and gene expression that underli

41 r energy status and nutrient availability to intracellular signaling and metabolic pathways.

42 tor linking extracellular physical cues with intracellular signaling and potentially facilitate the d

43 7-expressing LNCaP cell clone showed altered intracellular signaling and reduced spheroid formation p

44 y (meSPIM) for imaging and quantification of intracellular signaling and submicrometer cellular struc

45 ools have revealed fundamental principles of intracellular signaling and suggest paths forward for th

46 on and clustering is a prerequisite for TNFR intracellular signaling, and as m4-1BBL can only recruit

47 complex to phosphorylate the ITAMs, initiate intracellular signaling, and drive CD4(+) T cell fate de

48 ace of cells to mediate motility, transport, intracellular signaling, and environmental sensing.

49 n factors that are activated by receptor and intracellular signaling, and microRNAs which are small n

50 Purkinje cell dendritic development, altered intracellular signaling, and motor coordination deficits

51 ls that regulate Ag recognition, kinetics of intracellular signaling, and the selectivity and efficie

52 otein of cadherin-based cell-cell junctions, intracellular signaling, and tissue homeostasis and repa

53 hanges tapping into cell membrane signaling, intracellular signaling, and transcriptional regulations

54 Intracellular signaling antibody array analysis revealed

55 as metabolite exchange (Ca(2+) and lipids), intracellular signaling, apoptosis, and autophagy.

56 Mechanistically, ICAM-1-mediated intracellular signaling appeared to support neutrophil R

57 mechanically induced membrane damage and/or intracellular signaling are evaluated.

58 Conversely, cytoskeletal reorganization and intracellular signaling are sensitive to the pillar dime

59 vents such as polarization, endocytosis, and intracellular signaling, but challenging to quantify usi

60 ted that efficient HIV entry also depends on intracellular signaling, but this remains controversial.

61 phosphorylation events that characterize the intracellular signaling by activated TLRs.

62 LPS-induced NF-kappaB reporter activity and intracellular signaling by NF-kappaB and MAPK pathways w

63 on in three of seven donors, suggesting that intracellular signaling by p17 may lead to genomic insta

64 ned Y705 STAT3 phosphorylation, outlining an intracellular signaling cascade activated by antiviral a

65 ma membrane of macrophages that activate the intracellular signaling cascade in response to pathogeni

66 myr-Akt mouse model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) a

67 We discovered that the intracellular signaling cascade requires activation of t

68 We further examined the intracellular signaling cascade triggered by Sema4D and

69 acellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the produc

70 , and CSF3), silencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p

71 alpha (TNF-alpha) by initiating a variety of intracellular signaling cascades and is considered to be

72 hemical signals via adhesion, and integrates intracellular signaling cascades associated with cytoske

73 Toll-like receptors (TLRs) coupled to intracellular signaling cascades function as central ele

74 ce suggests PRR can also act in a variety of intracellular signaling cascades independently of RAS in

75 y to assess the role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nic

76 However, the intracellular signaling cascades that mediate the osteob

77 these results show that OXT recruits several intracellular signaling cascades to induce protein synth

78 1R hypersensitivity, a shift from PKA to ERK intracellular signaling cascades upon D1R activation, an

79 mbrane receptors P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin al

80 ract with extracellular ligands to transduce intracellular signaling cascades, modulate target gene e

81 nstream of cell-surface receptors to control intracellular signaling cascades.

82 ive conformations to regulate a multitude of intracellular signaling cascades.

83 degradation, and act as scaffolds to enhance intracellular signaling cascades.

84 The inflammasome is an intracellular signaling complex, which on recognition of

85 Inflammasomes are intracellular signaling complexes that are assembled in

86 tification of many recognition receptors and intracellular signaling components of efferocytosis, its

87 tributions of neurotransmitter receptors and intracellular signaling components.

88 isualize the intricate relationships between intracellular signaling, cytoskeletal organization and d

89 ta signaling domain (CAR) and one lacking an intracellular signaling domain (DeltaCAR).

90 cellular ligand binding domain but lacks the intracellular signaling domain.

91 nonstimulating control CAR construct lacking intracellular signaling domains termed CAR-Stop.

92 This allows SPRY2 to inhibit intracellular signaling downstream of other receptor tyr

93 static tumors is, in part, driven by altered intracellular signaling downstream of receptor tyrosine

94 Intracellular signaling during oxidative stress is compl

95 ify the receptor tyrosine kinase Axl and its intracellular signaling effectors as important for MLC1

96 However, the intracellular signaling effectors transducing its activa

97 at bud off from the cell surface to generate intracellular signaling endosomes.

98 ormation is due to direct inhibition of Dsg, intracellular signaling events causing desmosome destabi

99 model system that allows for observation of intracellular signaling events during collagen matrix as

100 membrane depolarization into precisely timed intracellular signaling events in the mammalian brain.

101 sed by receptors at the surface that trigger intracellular signaling events modulating the cytoskelet

102 n CD11b with such lectins results in altered intracellular signaling events that inhibit TEpM and dif

103 e pathogens and initiate a series of complex intracellular signaling events that result in various im

104 ortant role in controlling receptor-mediated intracellular signaling events, which have a central rol

105 oss talk between extracellular ATP and JA in intracellular signaling events.

106 ufficient to couple extracellular stimuli to intracellular signaling events.

107 cell polarity determinant, orchestrates the intracellular signaling for normal forgetting.

108 Here we sought to investigate the intracellular signaling from cannabinoid 2 receptor (CB2

109 s including cell motility, intercellular and intracellular signaling, gene expression, and membrane i

110 anismal functions such as neuronal activity, intracellular signaling, gene expression, cell prolifera

111 The fidelity of intracellular signaling hinges on the organization of dy

112 o four broad categories-DNA damage response, intracellular signaling, immune engagement, and genetic

113 Our findings show that CC2D1A regulates cAMP intracellular signaling in a male-specific manner in the

114 A is not a pure BCR mimic but rather rewires intracellular signaling in EBV-infected B cells that opt

115 e modulation of spatiotemporal regulation of intracellular signaling in intact cells and multicellula

116 lation of MsrB1 did not preclude LPS-induced intracellular signaling in macrophages, but resulted in

117 ulated protein kinases are key components of intracellular signaling in plants that mediate rapid str

118 etic strategy highlights the impact of Nlgn1 intracellular signaling in synaptic differentiation and

119 ity and female-specific resilience impacting intracellular signaling in the brain.

120 -10)) act as molecular checkpoints mediating intracellular signaling induced by 19 mammalian, secrete

121 ytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uP

122 ors (CRTCs) are a newly discovered family of intracellular signaling integrators that serve as the co

123 d CyclinD1, as well as the activation of the intracellular signaling kinases Akt and GSK3beta was per

124 Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of

125 oxyester-linked ubiquitylation is used as an intracellular signaling mechanism.

126 t evolutionarily-conserved intercellular and intracellular signaling mechanisms critical for learning

127 The intracellular signaling mechanisms involved in different

128 nal discharge properties, and elucidated the intracellular signaling mechanisms involved.

129 A presynaptic mechanism mediated by distinct intracellular signaling mechanisms may account for this

130 Understanding the intracellular signaling mechanisms that govern growth co

131 Little is known about intracellular signaling mechanisms that persistently exc

132 eceptors on the platelet surface and through intracellular signaling mechanisms that remain systemati

133 to reduce the computational complexity of an intracellular signaling mechanistic model.

134 Our results identify a novel intracellular signaling module that synergistically regu

135 These data position CD2AP as a major intracellular signaling molecule coordinating NGF signal

136 The intracellular signaling molecule cyclic di-GMP (c-di-GMP

137 lr), Apolipoprotein receptor 2 (Apoer2), and intracellular signaling molecule Disabled-1 (Dab1).

138 olecule-associated protein (SAP), a critical intracellular signaling molecule for T-B lymphocyte inte

139 This report implicates calcineurin as an intracellular signaling molecule responsible for immune

140 nosine monophosphate (c-di-GMP) is a dynamic intracellular signaling molecule that plays a central ro

141 in a deficiency of ARHGEF1, a hematopoietic intracellular signaling molecule that transmits signals

142 as a result of variegated surface receptor, intracellular signaling molecule, and transcription fact

143 Moreover, we identified a novel intracellular signaling molecule, cAMP-response element

144 ts, ERK was the most significantly activated intracellular signaling molecule.

145 Very few studies addressed how intracellular signaling molecules differentially specify

146 at the P2X7 receptor may also activate other intracellular signaling molecules or other ion channels.

147 TGFBIp also induced phosphorylation of intracellular signaling molecules SRC, FAK, AKT, JNK and

148 1 and -2 (Barr1 and Barr2, respectively) are intracellular signaling molecules that regulate many imp

149 ween an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1

150 ng as adaptors for various transmembrane and intracellular signaling molecules.

151 through membrane-bound receptors and related intracellular signaling molecules.

152 n multiple stimuli, including the binding of intracellular signaling molecules.

153 ized, the connection of the enzymes with the intracellular signaling network and thus their regulatio

154 l model for the activation of the CD8 T cell intracellular signaling network by mono- or dual-costimu

155 An intracellular signaling network largely initiated by thr

156 AKAPbeta as a nodal regulator in the myocyte intracellular signaling network.

157 n of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosp

158 of the kinetics, cellular distribution, and intracellular signaling networks of cosignaling molecule

159 The intracellular signaling networks regulated by the p75 ne

160 A high-dimensional analysis of intracellular signaling networks revealed immune system-

161 Atrial function is regulated by a variety of intracellular signaling networks that facilitate rapid c

162 or human cancer cells is largely mediated by intracellular signaling networks that regulate viral rep

163 reonine protein kinase and a key node in the intracellular signaling networks that transduce and ampl

164 Migratory immune cells use intracellular signaling networks to generate and orient

165 The activation of complex intracellular signaling networks underlies these respons

166 ersible fashion, hold promise for modulating intracellular signaling networks with high spatial and t

167 GF receptor and previously indistinguishable intracellular signaling networks, only TGF-alpha stimula

168 Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in

169 erstood, including their potentially diverse intracellular signaling networks, their roles in the tum

170 g extracellular growth factor stimulation to intracellular signaling networks.

171 environment by relaying external inputs via intracellular signaling networks.

172 Additive/competitive assays indicate that intracellular signaling-networks for multiple ligands ut

173 ecular understanding of signaling as well as intracellular signaling nodes in Arabidopsis.

174 ic response based on a mathematical model of intracellular signaling of activator and inhibitor.

175 er integrity and mechanisms of heme-mediated intracellular signaling of human lung microvascular endo

176 YK2 is a mediator of type 3 immunity through intracellular signaling of IL-23.

177 t defense mediated through activation of the intracellular signaling of jasmonate (JA), a well-charac

178 ermore, we found that the fumarase-dependent intracellular signaling of the B. subtilis DDR is achiev

179 the endosomal residence time and subsequent intracellular signaling of the beta2AR.

180 mmon architecture and structurally conserved intracellular signaling partners.

181 d within AKT1, a member of the PI3K/AKT/MTOR intracellular signaling pathway activated in endometrial

182 ufficient to initiate the complex pattern of intracellular signaling pathway and gene expression prof

183 The ERK/MAPK intracellular signaling pathway is hypothesized to be a

184 The Nox2/TRX-1/NF-kappaB intracellular signaling pathway is involved in the patho

185 ging secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded pr

186 lthough dependent on CD44, is mediated by an intracellular signaling pathway rather than as a competi

187 CD2AP with TrkA and p85 suggests a distinct intracellular signaling pathway regulating growth of non

188 There is decreased expression of the intracellular signaling pathway spleen tyrosine kinase (

189 entify a hitherto unrecognized Nox2-mediated intracellular signaling pathway that contributes to hype

190 The effects of these proteins converge on an intracellular signaling pathway that depends on a protei

191 eptor potential canonical 6 (TRPC6)-mediated intracellular signaling pathway that regulates the stabi

192 ntegrated stress response (ISR), a universal intracellular signaling pathway that responds to a varie

193 However, the intracellular signaling pathway that senses dietary fat

194 However, the intracellular signaling pathway triggering Src activatio

195 ally, we show that RET drives a multifaceted intracellular signaling pathway, including key signaling

196 king are mediated via activation of the PI3K intracellular signaling pathway, providing an insight on

197 permits the design of rational cytokine and intracellular signaling pathway-targeted therapeutics, r

198 ing systems biology approaches to analyze an intracellular signaling pathway.

199 NFR ligands, CD70 has been shown to initiate intracellular signaling pathways (CD70 reverse signaling

200 Inhibitors for components of intracellular signaling pathways activated by CD44, incl

201 ssion, particularly in genes involved in key intracellular signaling pathways and genes mediating fea

202 pecific biological effects through different intracellular signaling pathways and has a complex prote

203 isoforms use similar receptors but different intracellular signaling pathways and have different effe

204 ceptors, which classically activate distinct intracellular signaling pathways and responses.

205 h for new therapeutics aimed at manipulating intracellular signaling pathways and/or transcriptional

206 pes depending on their environment and which intracellular signaling pathways are activated.

207 Cytokine-mediated intracellular signaling pathways are fundamental for the

208 nisms connecting cell polarity proteins with intracellular signaling pathways are largely unknown.

209 Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex wi

210 Tight junctions (TJ) act as hubs for intracellular signaling pathways controlling epithelial

211 Conversely, activation of intracellular signaling pathways coupled to mGluRI in D1

212 receptors on myelin, and the integration of intracellular signaling pathways emanating downstream fr

213 d understanding of the complex regulation of intracellular signaling pathways in CLL, currently a maj

214 activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosi

215 stablished, and the molecular mechanisms and intracellular signaling pathways involved are not known.

216 However, the intracellular signaling pathways involved are unknown.

217 from sphingomyelin as a second messenger in intracellular signaling pathways involved in cell prolif

218 Although many of the intracellular signaling pathways involved in the proinfl

219 guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP.

220 , we quantified the effect of the flicker on intracellular signaling pathways known to regulate cytok

221 l studies on MOR gene have not addressed how intracellular signaling pathways mediate extracellular m

222 homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear.

223 by miR-200/Zeb1-dependent EMT that activate intracellular signaling pathways responsible for tumor c

224 -activated protein kinase 1 (MSK1)-ranges of intracellular signaling pathways similar to those activa

225 at is largely regulated by extracellular and intracellular signaling pathways that are central to cel

226 the gene targets of which were enriched for intracellular signaling pathways that are important to c

227 However, the intracellular signaling pathways that control these proc

228 ression of MOR gene requires the activity of intracellular signaling pathways that have been implicat

229 identified an RvD2/DRV2 axis that activates intracellular signaling pathways that increase phagocyto

230 the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell

231 small molecules and dramatically stimulating intracellular signaling pathways to determine cell fate.

232 tage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential b

233 ggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce representati

234 ive oxygen species, autophagy activation and intracellular signaling pathways were analyzed in Mincle

235 exploring the role and impact of modulating intracellular signaling pathways with more direct myocar

236 sequent activation of inhibitory (Gi-linked) intracellular signaling pathways within the basolateral

237 ion of cell membrane fluidity, regulation of intracellular signaling pathways, and production of bioa

238 Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed th

239 mbination with agents that target oncogenic, intracellular signaling pathways, diagnostic pathologist

240 erabilities in receptor tyrosine kinases and intracellular signaling pathways, epigenetics, metabolis

241 strocytes regulate behavior through multiple intracellular signaling pathways, including G-protein co

242 Autophagy is intricately linked with many intracellular signaling pathways, particularly nutrient-

243 increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transdu

244 The scaffold protein IQGAP1 regulates intracellular signaling pathways, such as the mitogen-ac

245 n the surface of immune cells and activating intracellular signaling pathways, thereby resulting in i

246 ell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost

247 ow and fast neurotransmitter systems through intracellular signaling pathways-and may unify a number

248 nrichment in genes that regulate kinases and intracellular signaling pathways.

249 SR, which was associated with alterations in intracellular signaling pathways.

250 FRs reside and how they control such diverse intracellular signaling pathways.

251 mes play critical roles in a wide variety of intracellular signaling pathways.

252 ansmitted through the glycocalyx to initiate intracellular signaling pathways.

253 by the host innate immune system and related intracellular signaling pathways.

254 e and polarity to coordinate the activity of intracellular signaling pathways.

255 by aberrant activation of several well-known intracellular signaling pathways.

256 ss, cells must activate a series of adaptive intracellular signaling pathways.

257 rases (PKMTs), is a key player in regulating intracellular signaling pathways.

258 and exhibits pleiotropic effect on multiple intracellular signaling pathways.

259 r understanding of how mitochondria serve as intracellular signaling platforms with a particular emph

260 g been established as a major contributor to intracellular signaling, primarily by virtue of its role

261 In response, the ER evokes a set of intracellular signaling processes, collectively known as

262 act to regulate membrane properties and many intracellular signaling processes.

263 The intracellular signaling protein regulator of presynaptic

264 zinc finger (PLZF), as well as expression of intracellular signaling proteins FcepsilonRgamma, spleen

265 actor-beta (TGF-beta) network of ligands and intracellular signaling proteins is a subject of intense

266 ed many extracellular guidance molecules and intracellular signaling proteins that regulate axonal ou

267 monoamine modulation with phosphorylation of intracellular signaling proteins.

268 APOL1 risk variant-induced dysregulation of intracellular signaling relevant for cell survival.

269 olved in resolution and tissue repair, whose intracellular signaling remains of interest.

270 nding events trigger receptor activation and intracellular signaling remains unclear.

271 en the orthosteric drug binding site and the intracellular signaling surface, revealing strong intera

272 othesis that opioid tolerance is mediated by intracellular signaling that can be selectively targeted

273 etween thymocytes and APCs, while monitoring intracellular signaling, this study reveals that distinc

274 ltikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisp

275 Attachment triggers intracellular signaling to change gene expression from t

276 q acts as a functional hNSC ligand, inducing intracellular signaling to control cell behavior.

277 itates a strict spatiotemporal regulation of intracellular signaling to ensure the cues are detected

278 ogical synapse affects synapse formation and intracellular signaling to impact the downstream T cell

279 ltering G(alphai) protein-mediated MAPK/MMP9 intracellular signaling to increase nAR-negative BCa cel

280 nize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial

281 ic splenocytes require MerTK transmission of intracellular signaling to suppress the production of in

282 t subcellular organization, and consequently intracellular signaling, to control information flow nee

283 The abnormal intracellular signaling underlying TSC has been the focu

284 histocompatibility complex (MHC), and induce intracellular signaling via a TCR-like signal after bind

285 othesized that the Cys23Ser alters 5-HT(2C)R intracellular signaling via changes in subcellular local

286 c extracellular matrix and are the origin of intracellular signaling via FAK and paxillin.

287 a RGD-independent manner and is involved in intracellular signaling via interacting with integrin be

288 tions of TIMP-1 are mediated by induction of intracellular signaling via its cell surface receptor CD

289 activated protein C), independently modulate intracellular signaling via partially distinct receptors

290 This reduction required intracellular signaling via second messengers-cytosolic

291 ls EGFR protein levels, thereby impinging on intracellular signaling, viability, and response to targ

292 Inhibition of intracellular signaling was measured by Western blot ana

293 To explore the role of intracellular signaling, we performed a kinome screen us

294 hesis and degradation, chromatin remodeling, intracellular signaling), which are linked to alteration

295 time-dependent changes in intercellular and intracellular signaling, which can be interrogated by ma

296 (EC) triggers proliferative and prosurvival intracellular signaling, which is implicated in the proc

297 e ROP1 Rho GTPase signaling and coordinating intracellular signaling with cell wall mechanics.

298 of aging and oxidative stress on chondrocyte intracellular signaling, with a specific focus on oxidat

299 Altered intracellular signaling within the immune system may int

300 nternalized by endothelial cells, leading to intracellular signaling without the need for priming as