ライフサイエンスコーパス: intracerebroventricular

1 eneficial effects is demonstrated here in an intracerebroventricular Abeta(42) infusion mouse model o

2 Finally, we demonstrate that BCAA intracerebroventricular administration ameliorates abnor

3 Finally, exogenous Dkk1 replacement via intracerebroventricular administration completely revers

4 55041 was soluble in an aqueous vehicle, and intracerebroventricular administration of 31 to 316 nmol

5 acological depletion of serotonin (5-HT) via intracerebroventricular administration of 5,7 dihydroxyt

6 Intracerebroventricular administration of alpha-klotho s

7 Scavenging endogenous NPY by intracerebroventricular administration of anti-NPY antib

8 We found that repeated daily intracerebroventricular administration of BDNF attenuate

9 Furthermore, intracerebroventricular administration of BDNF triggered

10 Intracerebroventricular administration of BMP7 to mice l

11 Intracerebroventricular administration of CSF3, 24 h aft

12 A 14-day intracerebroventricular administration of CYCLO to 8-mon

13 ally, the HPA-axis response to peripheral or intracerebroventricular administration of dexamethasone

14 Chronic intracerebroventricular administration of FGF9 increased

15 First, we showed that intracerebroventricular administration of glucose in rat

16 Intracerebroventricular administration of insulin increa

17 Intracerebroventricular administration of kisspeptin-10

18 Intracerebroventricular administration of KW-6002 into f

19 adrenoceptors directly in the brain (chronic intracerebroventricular administration of metoprolol) at

20 Intracerebroventricular administration of NPQ 53-70 prod

21 Since the intracerebroventricular administration of NPY increases

22 We found that intracerebroventricular administration of NPY inhibits b

23 cessary to mediate the stimulatory effect of intracerebroventricular administration of NPY on VLDL-TG

24 In dependent rats, intracerebroventricular administration of oxytocin or th

25 Intracerebroventricular administration of Rac1 antisense

26 Intracerebroventricular administration of saline, oxytoc

27 sgenic rat model of sporadic AD generated by intracerebroventricular administration of streptozotocin

28 A single intracerebroventricular administration of the antisense

29 Intracerebroventricular administration of the CRF antago

30 coneogenic enzymes were abolished in rats by intracerebroventricular administration of the K(ATP) cha

31 In Experiment 2 chronic intracerebroventricular administration of the selective

32 y determined that oral, intraperitoneal, and intracerebroventricular administration of this flavonoid

33 We previously reported that intracerebroventricular administration of three anti-Tau

34 me (1 microL) of pre-subarachnoid hemorrhage intracerebroventricular administration of two dosages (0

35 oximately 10 mg/kg/d, 4 months), followed by intracerebroventricular administration of vehicle or div

36 Intracerebroventricular administration to rats of a sing

37 teome), ex vivo (brain slices), and in vivo (intracerebroventricular administration) using activity-b

38 decreasing T(b) in rats than intrathecal or intracerebroventricular administration, indicating a per

39 es, but this effect was modest compared with intracerebroventricular administration.

40 ignificantly decreased feeding in mice after intracerebroventricular administration.

41 severe SMA mice, much more effectively than intracerebroventricular administration; subcutaneous inj

42 hippocampal pyramidal neurons 4 weeks after intracerebroventricular amyloid injection.

43 ng-term potentiation was abolished following intracerebroventricular amyloid injection.

44 ed peripherally (intravenous) and centrally (intracerebroventricular and intra-PFC) (n = 10-12/experi

45 ts that the amnesia resulting from systemic, intracerebroventricular and intrahippocampal injections

46 protein administration (parenteral, central intracerebroventricular and intraparenchymal, intranasal

47 Intracerebroventricular and VMH injection of the nonsele

48 Intracerebroventricular apoE significantly decreased foo

49 a model, we established a unique protocol of intracerebroventricular application of diphtheria toxin

50 An intracerebroventricular application of insulin promoted

51 (MER) by disabling astrocytic functions via intracerebroventricular application of l-aminoadipic aci

52 Intracerebroventricular ASO injection in neonatal mice r

53 A single embryonic or neonatal intracerebroventricular ASO injection strikingly rescued

54 Lastly, intracerebroventricular blockade of the purinergic recep

55 Chronic FGF-2 infusions (intracerebroventricular) blocked the deficit in SCT caus

56 e exhibited light aversion in response to an intracerebroventricular CGRP injection.

57 eritoneal CGRP injection, but was seen after intracerebroventricular CGRP injection.

58 In addition, as with intracerebroventricular CGRP, there was no general incre

59 dark only, similar to motility changes after intracerebroventricular CGRP.

60 Intracerebroventricular CMT- 3 infusion was also investi

61 Further, intracerebroventricular CMT-3 attenuated increased mean

62 Intracerebroventricular CMT-3 significantly inhibited An

63 Intracerebroventricular CNTF(Ax15) decreased 24 h food i

64 monstrated that reinstatement in response to intracerebroventricular CRF administration is heightened

65 Intracerebroventricular CRF impaired intradimensional se

66 Intracerebroventricular dAG also increased FM at the hig

67 Furthermore, intracerebroventricular dAG failed to regulate FM and in

68 erinsulinemic-euglycemic clamp suggests that intracerebroventricular dAG impairs glucose clearance wi

69 hat increased levels of 24,25-EC in vivo, by intracerebroventricular delivery in WT mice or by overex

70 In addition, intracerebroventricular delivery of (Met)CCL5 interrupte

71 g inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wild-type mic

72 Moreover, intracerebroventricular delivery of CRH rescued the cond

73 We tested the hypothesis that intracerebroventricular delivery of GAS6 directly into t

74 Intracerebroventricular delivery of scAAV9-STMN1 in SMA

75 e reduced seizure frequency were mimicked by intracerebroventricular delivery of the NMDA receptor (N

76 Intracerebroventricular delivery of ZT-1a decreases infl

77 treated beagle dogs using intracisternal or intracerebroventricular delivery.

78 e restored to normal levels following weekly intracerebroventricular dosing with rhbeta-Gal.

79 Intracerebroventricular E(2) infusion also increased PI3

80 Intrahippocampal or intracerebroventricular E(2) infusion in middle-aged fem

81 as increased 5 min after intrahippocampal or intracerebroventricular E(2) infusion in middle-aged, bu

82 dial, nucleus of the amygdala reproduced the intracerebroventricular effect.

83 They further suggest that intermittent intracerebroventricular enzyme replacement therapy dosin

84 cerebroventricular Ex4 to GLP-1r antagonism, intracerebroventricular Ex4 failed to reduce food intake

85 Despite the insensitivity of intracerebroventricular Ex4 to GLP-1r antagonism, intrac

86 Intracerebroventricular Ex4 was 100-fold more potent tha

87 GLP-1r dependence of the anorectic effect of intracerebroventricular Ex4 was assessed in GLP-1r(-/-)

88 nchanged body fat content, rats treated with intracerebroventricular FGF21 displayed a robust increas

89 Intracerebroventricular GCV infusion for 28 days nearly

90 Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased f

91 In rats, intracerebroventricular ghrelin decreased odor detection

92 Intracerebroventricular ghrelin treatment can influence

93 AND In this study, the anorectic effects of intracerebroventricular GLP-1 and Ex4, and the sensitivi

94 ere measured in MCT1-inhibited animals after intracerebroventricular glucose administration following

95 The anorectic effect of intracerebroventricular glucose and the insulin secretor

96 Intracerebroventricular glucose infusion reduced severe

97 required for intravenous (i.v.) but not for intracerebroventricular (i.c.v.) activity.

98 Intracerebroventricular (i.c.v.) administration of CDP-c

99 Following intracerebroventricular (i.c.v.) administration of GALC

100 We previously demonstrated that intracerebroventricular (i.c.v.) administration of prote

101 In lean mice, intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration of SR-33

102 Intracerebroventricular (i.c.v.) administration of the t

103 ciception that was ~100-fold greater than by intracerebroventricular (i.c.v.) administration.

104 e assessed Fos-expression in rat brain after intracerebroventricular (i.c.v.) injection of a newly de

105 Intracerebroventricular (i.c.v.) injection of an adipone

106 aluated the effect of intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of HE in a ra

107 f action of these growth factors, we perform intracerebroventricular (i.c.v.) injections of recombina

108 Here, we show that intracerebroventricular (i.c.v.) leptin increases lumbar

109 In addition, intracerebroventricular (i.c.v.) NPS evoked a significan

110 , we assessed the safety and tolerability of intracerebroventricular (i.c.v.) rhPDGF-BB administratio

111 Here, we compared the effects of prolonged intracerebroventricular (i.c.v.) versus systemic deliver

112 essor with IL-1 receptor antagonist (10 mug, intracerebroventricular (i.c.v.), 24 and 48 h after the

113 Intracerebroventricular (i.c.v.)-GnRH restores mating in

114 3 mg/kg s.c.) as well as central (0.3-3 nmol intracerebroventricular, i.c.v.) administration of this

115 e in SMA mice, either by intravenous (IV) or intracerebroventricular (ICV) administration at very ear

116 Intracerebroventricular (ICV) administration of ouabain,

117 We found that intracerebroventricular (icv) administration of TTR in n

118 ly blocked the effects of morphine following intracerebroventricular (icv) administration.

119 d in the RVLM of normal rabbits infused with intracerebroventricular (ICV) Ang II.

120 e 5CSRTT and then each was implanted with an intracerebroventricular (ICV) cannula.

121 Expression of BDNF and noggin via intracerebroventricular (ICV) delivery in an adenoviral

122 Here, we show that periodic intracerebroventricular (ICV) delivery of this AO result

123 Moreover, use of intracerebroventricular (ICV) galanin receptor antagonis

124 Intracerebroventricular (icv) improgan (40-80 mug) produ

125 First, intracerebroventricular (icv) infusion (5 mul/10 min) of

126 This was followed by leptin intracerebroventricular (ICV) infusion and bone histomor

127 The approach of intracerebroventricular (ICV) infusion of cytosine arabi

128 Here, we report that intracerebroventricular (icv) infusion of leptin reverse

129 Intracerebroventricular (icv) infusion of NPY (1 nmol/2

130 ract (NTS) preproglucagon (PPG), and chronic intracerebroventricular (ICV) infusion of the GLP-1 rece

131 tral Glp1r stimulates HGP, we tested whether intracerebroventricular (ICV) infusion of the Glp1r anta

132 nce stable responding was observed, received intracerebroventricular (ICV) infusions of the KOR agoni

133 Using intracerebroventricular (ICV) infusions, we examine the

134 mice, Sim1 neuron ablation was performed by intracerebroventricular (ICV) injection of diphtheria to

135 tic hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast gr

136 nt models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast gr

137 of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast gr

138 In vivo, intracerebroventricular (icv) injection of IL1beta or TN

139 s of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-

140 SMA pups (Smn-/-, SMN2+/+, SMNDelta7+/+) by intracerebroventricular (ICV) injection.

141 n antibody to mouse GM-CSF was introduced by intracerebroventricular (ICV) injections into the brains

142 nal populations following either systemic or intracerebroventricular (icv) prolactin administration.

143 A single intracerebroventricular (ICV)-administered dose of rhBet

144 Finally, EAE mice treated with intracerebroventricular IL-1ra showed normal glutamaterg

145 aged 11beta-HSD1(-/-) mice before and during intracerebroventricular infusion (10 d) of spironolacton

146 in treatment by intraperitoneal injection or intracerebroventricular infusion could normalize myocard

147 ist, leptin (0.62 microg/h) was added to the intracerebroventricular infusion for 10 days.

148 rotein-CIP (AAV9-GFP-CIP) to brain cells via intracerebroventricular infusion in amyloid precursor pr

149 bitor, delivered directly to the brain using intracerebroventricular infusion in an aged transgenic m

150 for in vivo imaging of myelination following intracerebroventricular infusion in the rat brain.

151 IgG brain distribution after intrathecal or intracerebroventricular infusion into the cerebrospinal

152 body weight were retained at least 1 d after intracerebroventricular infusion into the left ventricle

153 Finally, intracerebroventricular infusion of 5-HT stimulated base

154 In Experiment 1, pups receiving intracerebroventricular infusion of 50 ng of the anti-in

155 Direct intracerebroventricular infusion of a dominant-negative

156 In OVX rats, 5-min intracerebroventricular infusion of a PAK inhibitor pept

157 nt with the in vitro findings, we found that intracerebroventricular infusion of a specific PPARdelta

158 Direct activation of TLR3 by intracerebroventricular infusion of a TLR3 ligand impair

159 d memory impairment in mice that received an intracerebroventricular infusion of AbetaOs.

160 As expected, intracerebroventricular infusion of AG in mice increased

161 Chronic intracerebroventricular infusion of AG or dAG increased

162 Intracerebroventricular infusion of an adenosine A1 rece

163 food intake without causing malaise, whereas intracerebroventricular infusion of apoE antiserum stimu

164 Results showed that long-term intracerebroventricular infusion of BDNF accelerated the

165 acute carbon monoxide poisoning followed by intracerebroventricular infusion of brain-derived neurot

166 oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurot

167 A1 and mPFC spine density observed 2 h after intracerebroventricular infusion of E2 was blocked by DH

168 In parallel, mice were given an intracerebroventricular infusion of farnesoid X receptor

169 monoxide + hyperbaric oxygen with additional intracerebroventricular infusion of Fc fragment of tyros

170 Compared with vehicle, continuous intracerebroventricular infusion of FGF21 increased both

171 Intracerebroventricular infusion of GDNF improved behavi

172 Intracerebroventricular infusion of GLP-1 in mice direct

173 Intracarotid or intracerebroventricular infusion of hypertonic NaCl evok

174 Intracerebroventricular infusion of indomethacin, an ant

175 Antagonizing the NPY1 receptors by intracerebroventricular infusion of its antagonist large

176 -administration paradigm to demonstrate that intracerebroventricular infusion of NPS reinstates extin

177 Similarly, an intracerebroventricular infusion of OLZ resulted in a tr

178 Furthermore, intracerebroventricular infusion of PF4800567 increased

179 n-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human Tr

180 nd then blocked central EC signaling with an intracerebroventricular infusion of rimonabant while ass

181 allenged with a brief high-fat diet or acute intracerebroventricular infusion of saturated fatty acid

182 Intracerebroventricular infusion of the BACE1 inhibitor

183 To accomplish these goals, intracerebroventricular infusion of the KOR antagonist n

184 Intracerebroventricular infusion or forced expression of

185 -sODN-Ran; we then delivered these probes by intracerebroventricular infusion or intraperitoneal inje

186 In this study, we discovered that intracerebroventricular infusion or local OVLT injection

187 (1 microg Fe in 2 microl) was delivered via intracerebroventricular infusion to the left cerebral ve

188 tudy, we examined the effect of BDNF chronic intracerebroventricular infusion versus K252a (a Trk rec

189 rats, we examined if PACAP (.25-1.0 microg, intracerebroventricular infusion) affects motivation as

190 ipopolysaccharide and later provided IL-4 by intracerebroventricular infusion.

191 and memory impairment in mice that received intracerebroventricular infusions of AbetaOs.

192 id fluxes in male Sprague-Dawley rats during intracerebroventricular infusions of either WIN55,212-2

193 ularly concentrated in the hypothalamus, and intracerebroventricular infusions of nanomolar amounts o

194 Similarly, intracerebroventricular infusions of oligomeric Abeta pr

195 After UVN and one-month intracerebroventricular infusions of saline, GABA(A)R ag

196 y the eIF4E-transgenic mice are corrected by intracerebroventricular infusions of the cap-dependent t

197 lateral ventricle of Sprague-Dawley rats for intracerebroventricular infusions, and arterial and veno

198 Finally, both DOI and estrogen (intracerebroventricular) inhibited feeding in ovariectom

199 t, ghrelin (1 nmol) was administered through intracerebroventricular injection at 5 hrs after CLP.

200 ASO was administered by intracerebroventricular injection at postnatal day 2, fo

201 thelium-derived amyloid and tau proteins via intracerebroventricular injection exhibit a learning and

202 When administered by an intracerebroventricular injection in mice, M119 caused 1

203 ), AgRP, and ghrelin were investigated after intracerebroventricular injection in neural-specific POM

204 A single intracerebroventricular injection in the relatively seve

205 ed reinstatement behavior was measured after intracerebroventricular injection of 10 nM oxytocin in d

206 ped an in vivo model using CD-1 mice with an intracerebroventricular injection of 17-AAG for 24 h.

207 Intracerebroventricular injection of 26RFa and its C-ter

208 It has been reported that intracerebroventricular injection of a mu receptor antag

209 Importantly, intracerebroventricular injection of Abeta oligomers tri

210 Intracerebroventricular injection of Abeta1-42 oligomers

211 d restored the neuroprotection of gAD, while intracerebroventricular injection of AdipoR1 small inter

212 We evaluated the effect of intracerebroventricular injection of AICP.

213 One intracerebroventricular injection of amylin induces a mo

214 Using an acute model of AD induced by the intracerebroventricular injection of amyloid-beta oligom

215 Intracerebroventricular injection of an adeno-associated

216 In addition, intracerebroventricular injection of an IL-6 neutralizin

217 Changes in feeding behavior after intracerebroventricular injection of apoE, the regulatio

218 ubdivided into groups either administered an intracerebroventricular injection of artificial cerebros

219 versive behavior that is greatly enhanced by intracerebroventricular injection of CGRP and blocked by

220 METHODS AND Selective depletion of PVM using intracerebroventricular injection of clodronate abrogate

221 In addition, intracerebroventricular injection of DRB not only signif

222 of estrogens or their synthesis by a single intracerebroventricular injection of estrogen receptor a

223 We report that a single intracerebroventricular injection of FGF1 at a dose one-

224 Intracerebroventricular injection of ghrelin decreased s

225 Oral and intracerebroventricular injection of glycine elevated cu

226 Intracerebroventricular injection of Gpr17 agonists indu

227 Intracerebroventricular injection of GPR17 agonists indu

228 obtained following social defeat stress, and intracerebroventricular injection of IL-1 receptor antag

229 We found that a single intracerebroventricular injection of IL-1beta caused anx

230 , and global microglia activation induced by intracerebroventricular injection of IL-1beta were not o

231 Intracerebroventricular injection of insulin led to a gr

232 and cellular inflammatory changes induced by intracerebroventricular injection of interleukin-1beta w

233 at toll-like receptor 2 (TLR2) activation by intracerebroventricular injection of its ligand, Pam3CSK

234 A single intracerebroventricular injection of LMW AbetaOs (10 pmo

235 Intracerebroventricular injection of mu-p75-sap produced

236 Similarly, intracerebroventricular injection of NOX antagonists pre

237 Intracerebroventricular injection of NPQ/spexin produced

238 A single intracerebroventricular injection of NPY increased TG se

239 (NPY) signaling in the CNS was modulated by intracerebroventricular injection of NPY, receptor antag

240 Intracerebroventricular injection of PGDPs reduces body

241 hesis, we examined the therapeutic effect of intracerebroventricular injection of plasminogen activat

242 The intracerebroventricular injection of RG108 (20 nmol/day

243 lacking B cells and antibody production) and intracerebroventricular injection of streptozotocin (ICV

244 Intracerebroventricular injection of thrombin (20U) was

245 Moreover, intracerebroventricular injection of two antisense oligo

246 In vivo, intracerebroventricular injection of VEGF increased brai

247 After delivery by intracerebroventricular injection to ATXN2-Q127 mice, AS

248 ce coupled with flow cytometric analyses and intracerebroventricular injection to determine the contr

249 on pre-mRNA in the cortex and striatum after intracerebroventricular injection.

250 stores SMN expression in motor neurons after intracerebroventricular injection.

251 es, ex vivo as tissue explants or in vivo by intracerebroventricular injection.

252 r to aversion seen previously after central (intracerebroventricular) injection.

253 t all neurons, a result that was verified by intracerebroventricular injections of colchicine into ad

254 volume in mature adult female is reversed by intracerebroventricular injections of IGF-1 receptor ant

255 We determined here, by acute intracerebroventricular injections of specific agonists

256 Using acute intracerebroventricular injections of specific agonists

257 ical studies in mice exposed to stress or to intracerebroventricular injections of this inflammatory

258 We show that neonatal bilateral intracerebroventricular injections with AAV9 carrying CL

259 Obese rodents were treated by intracerebroventricular injections, with immunoneutraliz

260 cogenesis in vivo, we performed transuterine intracerebroventricular injections.

261 tivation and neuroinflammation in the CNS by intracerebroventricular inoculation of TLR7 and/or TLR8

262 (CpG-ODN) to induce neuroinflammation after intracerebroventricular inoculation.

263 asured in response to fasting and refeeding, intracerebroventricular insulin and leptin, and Tub anti

264 Intracerebroventricular insulin increased sympathetic ne

265 We investigated whether intracerebroventricular insulin infusion increases SNA m

266 Irs1 or Irs2 mediated suppression of HGP by intracerebroventricular insulin infusion.

267 administered via three different routes, by intracerebroventricular, intratracheal, and intraperiton

268 late alcohol consumption and the efficacy of intracerebroventricular KOR antagonism to reduce such dy

269 Locus coeruleus activation was eliminated by intracerebroventricular kynurenic acid.

270 potent glucose-lowering effect of continuous intracerebroventricular leptin infusion was not impacted

271 Cell-specific gene deletion experiments and intracerebroventricular leptin infusions reveal that ser

272 rts and was normalized by intraperitoneal or intracerebroventricular leptin.

273 gh-fat (HF)-diet had no anorexic response to intracerebroventricular leptin.

274 f COX-1 in the neuroinflammatory response to intracerebroventricular lipopolysaccharide (LPS) was inv

275 ring normal development, we demonstrate that intracerebroventricular macrophages arrive from embryoni

276 the arrival of both primitive microglia and intracerebroventricular macrophages was eliminated, wher

277 nervous system beta1-adrenoceptor blockade (intracerebroventricular metoprolol, 25 microg) to achiev

278 ion of the conserved brain CDC42 activity by intracerebroventricular ML141 injection caused acute anx

279 e subcutaneous low-dose SMN-ASO and a single intracerebroventricular Ncald-ASO3 or control-ASO inject

280 nsequence of these differences revealed that intracerebroventricular NPS reversed the hyperanxiety of

281 ts received an intravenous (OLZ-IV group) or intracerebroventricular (OLZ-ICV group) infusion of OLZ

282 Three days later, animals received daily intracerebroventricular or intra-VMN injections of eithe

283 We first demonstrated that intracerebroventricular or intrahippocampal E(2) infusio

284 FGF1 was administered via a single intracerebroventricular or multiple subcutaneous injecti

285 F1 injections to the cisterna magna mimicked intracerebroventricular outcomes, pointing to a novel th

286 We found that intracerebroventricular PACAP treatment induced anxiety-

287 ed NO during sleep deprivation (SD), we used intracerebroventricular perfusion in rats of the cell me

288 Intracerebroventricular PTN infusions prevented neuron l

289 Vagotomy, systemic haloperidol, or intracerebroventricular raclopride (a type 2 dopamine re

290 Additionally, we report that intracerebroventricular resistin increased plasma FGF21

291 We show that chronic intracerebroventricular resistin infusion downregulated

292 is effect is abolished in CB1-KO mice and by intracerebroventricular rimonabant treatment, suggesting

293 al of SPION-labeled fosB probe delivered via intracerebroventricular route was elevated in both acute

294 Intraperitoneal vs. intracerebroventricular routes of IL-18 administration h

295 nzyme replacement therapy via intrathecal or intracerebroventricular routes or with fusion proteins,

296 We describe the first reported intracerebroventricular transfections mediated by polyme

297 Intracerebroventricular transfer of activated ILC2 revit

298 Intraperitoneal and intracerebroventricular treatment also normalized circul

299 The combined acute and repeated intracerebroventricular treatment with FGF2 and 8-OH-DPA

300 Furthermore, intracerebroventricular treatment with neuronostatin inc