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1 thmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposit
3 or against neurodegeneration associated with intracytoplasmic aggregate-prone protein accumulation as
4 er characterized by progressive weakness and intracytoplasmic aggregates in muscle that exert reducin
5 is neuronal loss, astrocytosis, and neuronal intracytoplasmic aggregates of abnormal neuronal IFs tha
6 pose that Hsp70 can be used as a vehicle for intracytoplasmic and intranuclear delivery of proteins o
7 l laser scanning microscopic images revealed intracytoplasmic and intranuclear punctate patterns of i
9 elop intestinal disease had increased T-cell intracytoplasmic antigen 1-positive cytotoxic T lymphocy
10 is no evidence of positive selection on the intracytoplasmic antigen PS120 despite low selective con
12 tron microscopy of invaded monolayers showed intracytoplasmic bacteria enclosed by membrane-bound vac
14 urine biosynthesis was unable to expand into intracytoplasmic bacterial communities over time, unless
15 e agent of epidemic typhus, is an obligately intracytoplasmic bacterium, a lifestyle that imposes sig
19 and these receptors were shown to induce an intracytoplasmic Ca(2+) flux and cellular chemotaxis fol
21 eotaxin caused a similar rise in eosinophil intracytoplasmic Ca2+ and complete cross-desensitization
23 two receptors produced a synergistic rise in intracytoplasmic calcium ([Ca2+]i) to levels not reached
24 eased and the TCR/CD3-induced increased free intracytoplasmic calcium concentration response was norm
25 /CD3 complex leads to a dramatic increase of intracytoplasmic calcium concentration, protein tyrosine
26 Overexpression of c-Jun led to increase in intracytoplasmic calcium flux following TCR stimulation.
28 glutamate release pathway that induces local intracytoplasmic calcium release and subsequent damage i
30 Maturation was monitored by the induction of intracytoplasmic casein and lipids and the membrane prot
31 ent of caspase-8 to the complex, followed by intracytoplasmic caspase cleavage of amyloid precursor p
34 ated in the ectodomains, suggesting that the intracytoplasmic components that mediate G protein bindi
36 l contamination of surrounding structures by intracytoplasmic contents of the damaged hair cells.
37 catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membrane
38 tes after priming or prime-boosting by using intracytoplasmic cytokine staining and assays for cytoki
39 an mast cell line, HMC-1, as demonstrated by intracytoplasmic cytokine staining and flow cytometry, a
41 ction by activated NK cells was confirmed by intracytoplasmic cytokine staining by three-color immuno
45 ex with men with mpox infection showed viral intracytoplasmic cytopathic changes, interface dermatiti
46 family of molecules, containing a conserved intracytoplasmic "death domain" that indirectly activate
48 that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins
49 L1 transcription in part through its cleaved intracytoplasmic domain (ICD), which bound to a regulato
51 with an atypical extracellular domain and an intracytoplasmic domain containing one typical ITIM and
54 residue in an artificial glycine and alanine intracytoplasmic domain was endocytosed and degraded in
55 e binds directly to a region within the Toll intracytoplasmic domain, providing the first evidence th
63 d in the synaptic cleft, connected via their intracytoplasmic domains to the presynaptic web on one s
66 T cells being labeled with 1 to 3 pg/cell of intracytoplasmic endosomal iron and 15 to 20 pg/cell of
67 ion that this pathogen replicates within the intracytoplasmic environment facilitating delivery of Ag
72 re determined by flow cytometry using stable intracytoplasmic fluorescent dye 5- and 6-carboxyfluores
75 gether, our data imply that the formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-
76 l hallmarks of SPG11 in neurons that include intracytoplasmic granular lysosome-like structures mainl
79 method has been developed for the isolation intracytoplasmic (ICM) vesicles (chromatophores) from Rh
80 d HIV-1-induced IFN-alpha production; and 3) intracytoplasmic IFN-alpha was detected in CD14+ cells.
81 We confirmed this hypothesis by detecting intracytoplasmic IFN-gamma in macrophages activated with
82 n expansion of IFN-gamma-producing cells and intracytoplasmic IFN-gamma levels was found in pregnant
84 and CD86 Ag by LC in overlying epidermis and intracytoplasmic IL-12 accumulation in a subpopulation o
85 the cell cycle expressed significantly more intracytoplasmic IL-2 as well as IL-2Rbeta and gamma pro
87 f the protein, leading to the development of intracytoplasmic inclusion bodies and eventually to neur
89 om 9 of 11 patients recognize antigen within intracytoplasmic inclusion bodies in ciliated bronchial
90 disorder characterized by the appearance of intracytoplasmic inclusions called Lewy bodies (LB) in d
92 sease (PD) patients progressively accumulate intracytoplasmic inclusions formed by misfolded alpha-sy
93 tification, we used laser microdissection of intracytoplasmic inclusions identified in patient muscle
94 g beta-sheet-rich fibrils that accumulate as intracytoplasmic inclusions in Parkinson disease and cer
95 ntotemporal cortices and ubiquitin-positive, intracytoplasmic inclusions in the granule cells of the
96 llmark of the disease is the accumulation of intracytoplasmic inclusions known as Lewy bodies that co
100 yn by nitration can promote the formation of intracytoplasmic inclusions that constitute the hallmark
101 y demonstrated pale pink, oval to crescentic intracytoplasmic inclusions with a predilection for peri
102 , and endomysial fibrosis, in the absence of intracytoplasmic inclusions, rimmed vacuoles, or any evi
103 On routine staining, there were numerous intracytoplasmic inclusions, which ranged from eosinophi
108 asmic endosomal iron and 15 to 20 pg/cell of intracytoplasmic iron in mesenchymal stem cells compared
110 hologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of whi
111 hologically characterized by the presence of intracytoplasmic Lewy bodies, the major components of wh
113 gical evidence of neurodegeneration and rare intracytoplasmic Lewy body-like inclusions in spinal ant
116 onic epithelial cells a striking increase in intracytoplasmic lipid droplets (LDs), a dynamic organel
118 organization and interstitial fibrosis, with intracytoplasmic lipid vacuoles identifiable by electron
120 P-bound RAS in vitro and in vivo through its intracytoplasmic loop domain, and this interaction was r
122 within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+
123 6 gene there is bio-assimilated synthesis of intracytoplasmic magnetic nanoparticles which can be ima
124 e ability was not associated with surface or intracytoplasmic markers or secretion of cytokines.
126 gnized ultrastructural complexity within the intracytoplasmic membrane (ICM) housing the photosynthet
129 hototrophic bacteria elaborate a specialized intracytoplasmic membrane (ICM) system for the conversio
130 ytochrome b and ISP is detected in membrane (intracytoplasmic membrane and air-aged chromatophore), a
133 s defining a heretofore unknown mechanism of intracytoplasmic membrane heme transport in Haemophilus.
135 acultatively phototrophic bacterium forms an intracytoplasmic membrane that houses the photochemical
136 the LH2 complexes, which assembles spherical intracytoplasmic membrane vesicles of approximately 53 n
137 ns correlated with the presence of elaborate intracytoplasmic membrane-bound compartments, including
139 c bacteria synthesize an extensive system of intracytoplasmic membranes (ICM) in order to increase th
141 R. rubrum puf interposon mutants do not form intracytoplasmic membranes and are phototrophically inco
142 appear to be required for the maintenance of intracytoplasmic membranes and cell survival in late sta
143 ically and show no bc(1) complex activity in intracytoplasmic membranes prepared from these mutant ce
148 basal pole lipid vacuoles, with perinuclear-intracytoplasmic migration of the inclusions promoting a
149 The TCR complex signals through a set of 10 intracytoplasmic motifs, termed immunoreceptor tyrosine-
156 igomerization domain (Nod)1, a member of the intracytoplasmic Nod-like receptor family, induced poten
157 hat wild-type Beclin 1 colocalizes with both intracytoplasmic organelles and nuclei in COS7 monkey ki
158 ed foamy macrophages with Diastase-resistant intracytoplasmic organisms that were further demonstrate
160 oximately 200-fold higher than the estimated intracytoplasmic paromomycin concentration, suggestive o
161 When ferumoxides-TA or MION-46L-TA was used, intracytoplasmic particles stained with Prussian blue st
163 s currently known regarding how professional intracytoplasmic pathogens, including Shigella, mediate
166 an attenuated cell wall, and less extensive intracytoplasmic (photosynthetic) membrane system compar
168 der that is associated with the formation of intracytoplasmic protein aggregates (Lewy-body inclusion
170 in are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a pat
172 rimary locus of CRAMP activity appears to be intracytoplasmic, rather than at the outer membrane, sug
173 uencing unexpectedly revealed that the third intracytoplasmic region (3ICR) of the sheep receptor has
174 covered, polyubiquitination of Lys225 in the intracytoplasmic region and subsequent endocytosis and p
176 hich assemble virus-like particles (VLPs) in intracytoplasmic ribonucleoprotein (RNP) complexes.
179 n linked to domains 3 and 4 of human CD4 and intracytoplasmic sequence from either CD4 or human P-sel
181 negatively regulates osteoclast formation by intracytoplasmic sequestration of FHL2 to blunt RANK act
182 , and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated b
184 CI, 0.90 to 1.26), and the odds ratios with intracytoplasmic sperm injection (ICSI) (139 defects, 9.
186 We report two children who were conceived by intracytoplasmic sperm injection (ICSI) and who develope
187 hildren born after in-vitro fertilisation by intracytoplasmic sperm injection (ICSI) are at increased
189 st was IVF, categorized according to whether intracytoplasmic sperm injection (ICSI) for male inferti
191 rategies aimed at improving success rates of intracytoplasmic sperm injection (ICSI) include binding
195 rm or somatic cell chromatin within 5 min of intracytoplasmic sperm injection (ICSI) or somatic cell
199 ls from adult mice generated with the use of intracytoplasmic sperm injection (ICSI), a type of ART.
201 s, such as in-vitro fertilisation (IVF) with intracytoplasmic sperm injection (ICSI), can be used as
213 , 2019, we randomly assigned 1064 couples to intracytoplasmic sperm injection (n=532) or conventional
214 nology (in vitro fertilization [n = 19 448], intracytoplasmic sperm injection [n = 13 417], and froze
215 uss two major advances in the ART laboratory-intracytoplasmic sperm injection and extended embryo cul
216 84 (35%) of 532 couples randomly assigned to intracytoplasmic sperm injection and in 166 (31%) of 532
219 rocedures such as in vitro fertilization and intracytoplasmic sperm injection are generally considere
220 e first births of rhesus monkeys produced by intracytoplasmic sperm injection at rates greater or equ
221 ne two or fewer previous conventional IVF or intracytoplasmic sperm injection attempts, have used an
222 specifically sperm retrieval techniques for intracytoplasmic sperm injection coupled with in-vitro f
223 has a normal total sperm count and motility, intracytoplasmic sperm injection did not improve the liv
224 rian tissue and the continued development of intracytoplasmic sperm injection for men with poor sperm
227 icular sperm extraction (TESE) combined with intracytoplasmic sperm injection has allowed many men wi
230 ts challenge the value of the routine use of intracytoplasmic sperm injection in assisted reproductio
231 able of producing normal offspring following intracytoplasmic sperm injection into wild-type ova and
235 re randomly assigned (1:1) to undergo either intracytoplasmic sperm injection or conventional IVF, us
236 r amplitude of Ca(2+) oscillations following intracytoplasmic sperm injection or expression of phosph
237 h any other cause, but treatment with either intracytoplasmic sperm injection or sperm donation remov
238 and 16 of 39 patients (41%) who underwent an intracytoplasmic sperm injection procedure for pronuclea
243 maintained, embryos can be generated by the intracytoplasmic sperm injection technique (ICSI) from s
244 age and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomall
245 uration (primary outcome), and fertilized by intracytoplasmic sperm injection with subsequent transfe
246 es of IVF (in vitro fertilization) and ICSI (intracytoplasmic sperm injection) cycles, there is ongoi
248 ale DNA decondensation that occurs following intracytoplasmic sperm injection, an assisted reproducti
249 re, embryo transfer, in vitro fertilization, intracytoplasmic sperm injection, and round spermatid in
250 rates were observed among women who received intracytoplasmic sperm injection, and who received AH wh
252 rility of TAL(-/-) sperm was circumvented by intracytoplasmic sperm injection, indicating that TAL de
253 fetuses produced by in vitro fertilization, intracytoplasmic sperm injection, or round spermatid inj
255 on (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its
256 y fivefold compared with conventional PNI or intracytoplasmic sperm injection-mediated transgenesis.
265 in the 2B domain severely disrupted the fine intracytoplasmic staining of desmin, causing clumping of
268 (IL-3), and IL-5 (GMRbetaC) with a truncated intracytoplasmic tail caused by deletion of a 104-bp exo
269 ole for even minor sequence variation of the intracytoplasmic tail in modulating the antigenicity of
270 te that mutations selected in Gag and Env TM intracytoplasmic tail influence the replication and cyto
272 , was abrogated by deleting the NH2-terminal intracytoplasmic tail of CD4, or by mutating the two cri
274 el mechanism by which point mutations in the intracytoplasmic tail of the transmembrane component (gp
275 highly conserved structural motif within the intracytoplasmic tail resulted in decreased binding of n
276 nce is provided for minor differences in the intracytoplasmic tail sequences of WC1.1 and WC1.2 that
277 ng feature of these isoforms: their distinct intracytoplasmic tails (FcgammaRIIa with an immunorecept
278 ation, prominent frontotemporal neuron loss, intracytoplasmic tau aggregates, paired helical tau fila
284 binding was localized to the pellicle and an intracytoplasmic tubulovesicular network in sporozoites.
286 later though, upon the discovery of CD31's 2 intracytoplasmic tyrosine residues called immunoreceptor
287 of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies).
289 The pathological hallmark of the disease is intracytoplasmic vacuoles containing autophagic material
290 (0.5 and 1.0 mg/kg) induced the formation of intracytoplasmic vacuoles in pyramidal neurons in layers
292 PPT of aged cats which included somata with intracytoplasmic vacuoles, darkened mitochondria, deplet
294 , within which virus buds predominantly into intracytoplasmic vesicles, in contrast to the plasmalemm
298 ns compared to POKA; extensive aggregates of intracytoplasmic viral particles were also observed.
299 MMTV), a mammalian retrovirus that assembles intracytoplasmic virus particles, commandeers the cellul
300 s of the evolutionarily conserved protein is intracytoplasmic, whereas the extracellular domain carri