ライフサイエンスコーパス: intraepidermal

1 Although most vulvar EMPD cases were intraepidermal (1247/1773 [70.3%]), radical surgeries we

2 A low correlation between intraepidermal and corneal fiber loss was found with bot

3 Intraepidermal and corneal nerve fiber lengths were redu

4 Intraepidermal and corneal nerve fibers both detected ne

5 and hair follicle palisades as well as some intraepidermal and free myelinated nerve endings.

6 ity scores, were observed when comparing the intraepidermal and superficially invasive portions with

7 phils, resulting in formation of subcorneal, intraepidermal, and subepidermal pustules.

8 higus, IgG4-predominant autoantibodies cause intraepidermal blistering by direct interference with de

9 disorders of skin fragility characterized by intraepidermal blistering upon mild mechanical trauma.

10 a mechano-bullous disorder characterized by intraepidermal blistering within the basal keratinocytes

11 inheritable skin disorders characterized by intraepidermal blistering, epidermal hyperkeratosis, or

12 ents with epidermolysis bullosa simplex with intraepidermal blistering.

13 une blistering skin disease characterized by intraepidermal blisters and circulating autoantibodies d

14 /7 inhibitor, protected mice from developing intraepidermal blisters and clinical disease induced by

15 At 2 days of age, mutant animals exhibit intraepidermal blisters and erosions at sites of trauma,

16 TUNEL-positive epidermal cells appear before intraepidermal blisters.

17 Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcin

18 squamous cell carcinoma or Bowen's disease (intraepidermal carcinoma) present and confirmed in the b

19 of CD4+ T cells revealed CD69 expression by intraepidermal CD4+ as well as CD8+ T cells.

20 hat contains a unique population of immature intraepidermal dendritic cells (DCs) called Langerhans c

21 cted not only on many thin-caliber axons and intraepidermal endings but also on many large-caliber ax

22 n barrier defects, immunopathology including intraepidermal eosinophils, mast cell activation, increa

23 independent and is associated with increased intraepidermal expression of IL-22 and the presence of g

24 Advances in the analysis of intraepidermal fiber densities could shorten the time co

25 roduct) 9.5 were used, with the exception of intraepidermal fibres which were not detected in the maj

26 induced increases in PGP 9.5 immunoreactive intraepidermal fine nerve endings that were normalized a

27 e, we show that macromolecular aggregates of intraepidermal gammadelta T cell antigen receptors (TCRs

28 harboring altered compartments of dendritic intraepidermal gammadelta T cells (DETCs), a prototypic

29 Intraepidermal (IENFD), sweat gland (SGNFD), and pilomot

30 vation and proliferation, we discovered that intraepidermal immunocytes, including both CD4 and CD8+

31 ous cytokines and chemokines responsible for intraepidermal inflammation independent of TNFalpha.

32 pathway and mediates chemokine induction and intraepidermal inflammation independently.

33 r, inhibiting AP-1 in vivo does not abrogate intraepidermal inflammation.

34 osis in transgenic skin, but only TPA evokes intraepidermal inflammation.

35 y volunteers of both sexes rated pain due to intraepidermal injections of different concentrations an

36 Intraepidermal innervation using PGP 9.5 immunostaining

37 ty, reduced paw grip strength, and a loss of intraepidermal innervation.

38 presence of basal melanocyte hyperplasia and intraepidermal Langerhans cells.

39 rficial spreading melanoma, characterized by intraepidermal large nests.

40 ized by extensive neutrophil accumulation in intraepidermal lesions accompanied by a mononuclear infi

41 nd marker expression mimicking that of human intraepidermal MCC.

42 o regenerate anagen hair follicles in AA and intraepidermal melanocytes in vitiligo.

43 protein shifts from nuclear localization in intraepidermal melanoma cells to nuclear and cytoplasmic

44 A572V disease is epidermotropic and produces intraepidermal microabscesses.

45 ific for melanocytes and nerve fibers showed intraepidermal nerve endings in contact with melanocytes

46 m underlying keratinocyte communication with intraepidermal nerve endings remains poorly understood.

47 thought to be exclusively transduced by the intraepidermal nerve endings.

48 pathological changes using the technique of intraepidermal nerve fiber (IENF) assessment and the nov

49 Intraepidermal nerve fiber (IENF) density was most sever

50 landin content, markers of inflammation, and intraepidermal nerve fiber (IENF) density were measured

51 erformed in patients and carriers to measure intraepidermal nerve fiber (IENF) density, sweat gland i

52 nced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density.

53 normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in th

54 nts [73%; 95% CI, 44% to 92%]; P < .001) and intraepidermal nerve fiber density (4 patients [27%; 95%

55 FN in rat foot pads by quantification of the intraepidermal nerve fiber density (IENFD) after multipl

56 nd 2 neurological scores were used to depict intraepidermal nerve fiber density (IENFD) and clinical

57 ther alterations in cutaneous LC density and intraepidermal nerve fiber density (IENFD) are present i

58 dorsal root ganglion (DRG) inflammation and intraepidermal nerve fiber density (IENFD) loss.

59 ion of diabetes, where skin biopsy assessing intraepidermal nerve fiber density (IENFD) plays an impo

60 e, and nerve conduction studies, and reduced intraepidermal nerve fiber density (IENFD) plus abnormal

61 Intraepidermal nerve fiber density (IENFD) was assessed

62 Intraepidermal nerve fiber density (IENFD) was reduced a

63 Reduced intraepidermal nerve fiber density (IENFD) was seen in a

64 The intraepidermal nerve fiber density (IENFD) was significa

65 nitored by serial skin biopsies to determine intraepidermal nerve fiber density (IENFD).

66 urophysiology, QST, corneal sensitivity, and intraepidermal nerve fiber density (IENFD).

67 Taken together, our findings suggest that intraepidermal nerve fiber density and changes in NCV an

68 ht-based equivalent of human dose, increased intraepidermal nerve fiber density and improved multiple

69 Secondary outcomes included intraepidermal nerve fiber density and nerve conduction

70 es, quantitative sudomotor axon testing, and intraepidermal nerve fiber density are useful tools to e

71 Low-dose Metanx increased intraepidermal nerve fiber density but did not prevent m

72 270 mg/dl), with a significant reduction of intraepidermal nerve fiber density by 25% at 5 weeks com

73 All patient groups showed a decreased intraepidermal nerve fiber density compared with control

74 Intraepidermal nerve fiber density declined maximally by

75 Valuable markers of neuropathy such as intraepidermal nerve fiber density from skin biopsies ha

76 altered sensory nerve action potentials and intraepidermal nerve fiber density had a shorter CNFL (P

77 e total number of regenerating axons and the intraepidermal nerve fiber density in the skin were redu

78 ies in the same participants showed that the intraepidermal nerve fiber density is lower in the finge

79 on and electrochemical skin conductance) and intraepidermal nerve fiber density quantification.

80 gh-fat diet; nerve conduction velocities and intraepidermal nerve fiber density were restored.

81 Comparison of intraepidermal nerve fiber density with automated wide-f

82 els in the sciatic nerve and reduced loss of intraepidermal nerve fiber density.

83 myelin changes accompanied by a reduction in intraepidermal nerve fiber density.

84 subjects had skin biopsies for evaluation of intraepidermal nerve fiber density.

85 Unraveling human intraepidermal nerve fiber ensheathment and potential in

86 ns did not impair axon regeneration into the intraepidermal nerve fiber layer.

87 V and alleviation of thermal hypoalgesia and intraepidermal nerve fiber loss but not tactile allodyni

88 a, and thermal hypoalgesia in the absence of intraepidermal nerve fiber loss or axonal atrophy.

89 iculum stress, peripheral nerve dysfunction, intraepidermal nerve fiber loss, and sciatic nerve and s

90 Intraepidermal nerve fiber loss, axonal degeneration, im

91 hyperexcitability, and alleviated peripheral intraepidermal nerve fiber loss.

92 ial nerve myelinated fiber diameter, but not intraepidermal nerve fiber loss.

93 ity, thermal hypoalgesia, and a reduction in intraepidermal nerve fiber profiles.

94 onduction velocity, thermal hypoalgesia, and intraepidermal nerve fiber profiles.

95 cal allodynia, spontaneous pain, and loss of intraepidermal nerve fibers (IENF) in the paw.

96 to small-diameter peripheral nerve axons and intraepidermal nerve fibers (IENF).

97 The density of intraepidermal nerve fibers and intrapapillary myelinate

98 Intraepidermal nerve fibers and intrapapillary myelinate

99 All of the drugs ablated intraepidermal nerve fibers and produced axonopathy, wit

100 Since many intraepidermal nerve fibers are afferent nerves that act

101 ypothesize that patients with SFN would lose intraepidermal nerve fibers at the distal leg more quick

102 ceptive sensations, tightly interacting with intraepidermal nerve fibers at the neuro-cutaneous unit.

103 ciated with severe DRG pathology and loss of intraepidermal nerve fibers in SIV-infected macaques.

104 urodegeneration in type 2 diabetes, but only intraepidermal nerve fibers were associated with clinica

105 stimuli) and pathological (transient loss of intraepidermal nerve fibers) signs of peripheral neuropa

106 nd a remarkable ( approximately 78%) loss of intraepidermal nerve fibers.

107 xon terminal sensory arbors in the skin (the intraepidermal nerve fibers; IENFs) and induce abnormal

108 nerve conduction studies and skin biopsy for intraepidermal nerve fibre assessment.

109 Intraepidermal nerve fibre densities at the index finger

110 ction studies, quantitative sensory testing, intraepidermal nerve fibre density (thigh), computerised

111 rial biopsies revealed a partial recovery of intraepidermal nerve fibre density [fibres/mm epidermis

112 l assessments, quantitative sensory testing, intraepidermal nerve fibre density and serum neurofilame

113 members and revealed in six of them reduced intraepidermal nerve fibre density consistent with small

114 Evaluation of intraepidermal nerve fibre density showed a striking los

115 tive sprouting was assessed by the return of intraepidermal nerve fibre density through regenerative

116 The intraepidermal nerve fibre density was markedly reduced

117 gp120 and/or ddC and there is a reduction in intraepidermal nerve fibre density, comparable to that s

118 nt neuropathies lead to a clear reduction in intraepidermal nerve fibre density, which was independen

119 skin biopsy showed a significant decrease in intraepidermal nerve fibre density.

120 ed reversal of neuropathy and an increase in intraepidermal nerve fibre.

121 nd nerve action potential amplitude, loss of intraepidermal nerve fibres and significant degeneration

122 eversible SARM1 inhibitors prevented loss of intraepidermal nerve fibres induced by paclitaxel and pr

123 velocity, mechanical allodynia, and loss of intraepidermal nerve fibres.

124 s expression was associated with recovery of intraepidermal nerve fibres.

125 nt aspects of nerve degeneration, where only intraepidermal nerves appear to reflect the clinical sta

126 Our findings indicate that corneal and intraepidermal nerves likely mirror different aspects of

127 Corneal and intraepidermal neuronal loss is more pronounced in advan

128 erproliferation, acanthosis, hyperkeratosis, intraepidermal neutrophil microabscesses, and increased

129 Intraepidermal neutrophilic IgA dermatosis, a rare skin

130 glein 3 is identified as a target antigen in intraepidermal neutrophilic IgA dermatosis.

131 -PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong ep

132 K5-PKCalpha transgenic mice exhibit severe intraepidermal neutrophilic inflammation and disruption

133 pressing PKCalpha in the skin exhibit severe intraepidermal neutrophilic inflammation and keratinocyt

134 5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic ne

135 hemokines regulated by PKCalpha that promote intraepidermal neutrophilic inflammation, a condition th

136 ly benign lesions, intermediate lesions, and intraepidermal or invasive melanomas.

137 complex disorders that are characterized by intraepidermal (pemphigus) and subepidermal blistering (

138 ancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and

139 In two patients, intraepidermal resident CD8+ T cells were induced to pro

140 eficit was greater compared to reductions in intraepidermal sensory innervation of adjacent epidermis

141 yndrome which is characterized by a specific intraepidermal separation of layers of the skin.

142 Changes in the density of intraepidermal small fibers, the ultrastructure of Remak

143 d prolonged mechanical allodynia and loss of intraepidermal small nerve fibers in WT mice.

144 Intraepidermal T cell migration and related lesion forma

145 ided in a temporal fashion with depletion of intraepidermal T cells in all five patients studied.

146 state physiology, normality sensing licensed intraepidermal T cells to respond rapidly to subsequent

147 An intraepidermal Wnt signal is necessary and sufficient fo

148 We hypothesized that intraepidermal Wnt signaling might influence LC developm