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1 fic CD8 T cells in comparison to gut mucosal intraepithelial lymphocytes.
2 uired a surface phenotype resembling that of intraepithelial lymphocytes.
3 e of gammadelta T cells and TCRgammadelta(+) intraepithelial lymphocytes.
4 ransforming growth factor beta production by intraepithelial lymphocytes.
5 imilar to that observed for mouse regulatory intraepithelial lymphocytes.
6 d subepithelial collagen plate and increased intraepithelial lymphocytes.
7 -expressing cells, including most intestinal intraepithelial lymphocytes.
8 ymphoid tissues tested, including intestinal intraepithelial lymphocytes.
9 nction as a homing or retention molecule for intraepithelial lymphocytes.
10 lls including gammadelta TCR-positive (TCR+) intraepithelial lymphocytes.
11 cells, CD8+ T lymphocytes, and TCRgammadelta intraepithelial lymphocytes.
12 e in intimate contact with subepithelial and intraepithelial lymphocytes.
13 nducing proliferation of cultured intestinal intraepithelial lymphocytes.
14 unity, including reduced type 1 alarmins and intraepithelial lymphocytes.
15 elta T cells, innate lymphoid cells, and gut intraepithelial lymphocytes.
16 is spatially matched by Nkrp1g on subsets of intraepithelial lymphocytes.
17 FD promoted a decreased in the proportion of intraepithelial lymphocytes.
18 ected statistically significant elevation in intraepithelial lymphocytes (49%; 95% CI: 9%, 105%) and
21 mmune response in the small intestine and by intraepithelial lymphocytes after a single intraperitone
22 T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus an
23 olecules involved in pathogen elimination by intraepithelial lymphocytes and changed the intestinal m
24 ions and artifacts, including distinguishing intraepithelial lymphocytes and differentiating villous
25 beta(7)(+) DC (alphaE-DC) were distinct from intraepithelial lymphocytes and distinguishable from CD1
26 eraction between integrin alpha(E)beta(7) on intraepithelial lymphocytes and E-cadherin on epithelial
27 al tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation thro
29 lpha E beta 7 is highly expressed on colonic intraepithelial lymphocytes and has been suggested to fu
30 found predominantly within the intestine as intraepithelial lymphocytes and have been shown to be in
31 EATL derives from a clonal proliferation of intraepithelial lymphocytes and is often disseminated at
33 opulations of anatomically distinct T cells, intraepithelial lymphocytes and lamina propria lymphocyt
34 D8alpha(+) T and natural killer cells in the intraepithelial lymphocytes and lamina propria lymphocyt
37 on most small intestinal lamina propria and intraepithelial lymphocytes and on a small subset of per
39 ratio [Vh:Cd]), and frequency of intestinal intraepithelial lymphocytes and peripheral gut-homing T
40 illus blunting, increased lamina propria and intraepithelial lymphocytes, and epithelial apoptosis, l
41 neutrophils with occasional crypt abscesses, intraepithelial lymphocytes, and goblet cells in the int
42 , CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate memory phenotype
43 , CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate memory phenotype
45 as the immunoscore (IS) or quantification of intraepithelial lymphocytes are only slowly being adopte
48 d 8), expressed predominantly by innate-like intraepithelial lymphocytes, as the ligand engaging epit
49 of CD8 alpha alpha homodimers in some of the intraepithelial lymphocytes, as well as low expression o
50 s, natural killer (NK) cells, and intestinal intraepithelial lymphocytes, as well as normalization of
51 significantly increased in cecal tonsil and intraepithelial lymphocytes at days 6 and 8, respectivel
54 y and follicular helper-like CD4(+) T cells, intraepithelial lymphocytes, CD8(+) and gammadelta T cel
55 is accompanied by a dramatic decrease in the intraepithelial lymphocyte CD8alpha(+)TCRgammadelta(+)/C
56 eta(+)CD4(-)CD8alpha(+)CD8beta(-) intestinal intraepithelial lymphocytes (CD8alphaalpha IELs) are an
57 f villous atrophy were numbers of gammadelta intraepithelial lymphocyte cells followed by age and hom
58 2.0 afterward; P = .0007; density of CD3(+) intraepithelial lymphocytes changed from 61 to 91 cells/
60 ound in intestinal tissues, primarily in the intraepithelial lymphocyte compartment and lamina propri
65 , a population of wild-type CD8alphaalpha(+) intraepithelial lymphocytes constitutively expressed gra
66 ion of the integrin CD103alpha(E)/beta(7) by intraepithelial lymphocytes controls the retention of ly
67 0.66); and the difference in change in total intraepithelial lymphocyte count was -12.73% (95% CI -77
68 umed oats, 0.24; 95% CI, 0.01-4.8; P = .35), intraepithelial lymphocyte counts (standardized mean dif
69 tween groups, morphologic changes and CD3(+) intraepithelial lymphocyte counts differed significantly
70 (villous height-to-crypt depth ratio; VHCD); intraepithelial lymphocyte counts; Marsh score; and pati
71 ased intraepithelial lymphocytes, markers of intraepithelial lymphocyte cytotoxicity, gliadin-specifi
76 C(lo) supports TCRalphabeta(+) CD8alphaalpha intraepithelial lymphocyte development; meanwhile, mTEC(
77 e dendritic epidermal T cells are prototypic intraepithelial lymphocytes, displaying an almost monocl
78 tains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate f
79 chronic inflammation, lymphocyte aggregates, intraepithelial lymphocytes, eosinophils, and villous bl
82 at CD8+ T-cell receptor alphabeta intestinal intraepithelial lymphocytes express and secrete this cyt
84 A subpopulation of isolated human intestinal intraepithelial lymphocytes expressed the fractalkine re
85 rveillance behavior, we investigated whether intraepithelial lymphocytes expressing the gammadelta T
86 rveillance behavior, we investigated whether intraepithelial lymphocytes expressing the yd T cell rec
88 The change in the proportion of aberrant intraepithelial lymphocytes from baseline to week 12 wit
89 pha) and gamma interferon (IFN-gamma), while intraepithelial lymphocytes from calves with cryptospori
90 x vivo reverse transcriptase PCR of RNA from intraepithelial lymphocytes from control calves showed a
91 ce within the intestine through retention of intraepithelial lymphocytes, functional redistribution o
94 ists of both resident populations-gammadelta intraepithelial lymphocytes (gammadelta IELs)-and transi
96 ables were addressed in the small intestine: intraepithelial lymphocyte (IEL) and lamina propria lymp
99 tinal mucosa was significantly lower and the intraepithelial lymphocyte (IEL) count (x 100 enterocyte
100 both exhibit abnormal thymic and intestinal intraepithelial lymphocyte (IEL) development, but the de
101 ion, results in marked changes in intestinal intraepithelial lymphocyte (IEL) function and phenotype.
102 (CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or functio
105 is study, we investigate how obesity impacts intraepithelial lymphocyte (IEL) persistence and functio
107 specifically promotes a distinct CD8aa+CD4+ intraepithelial lymphocyte (IEL) population that acquire
108 mice appear normal, we demonstrated that the intraepithelial lymphocyte (IEL) populations of small (S
109 st selection of TCRalphabeta(+)CD8alphaalpha intraepithelial lymphocyte (IEL) progenitors (IELps), ev
110 D4(+) T helper functions and induction of an intraepithelial lymphocyte (IEL) program that included e
111 e reported that the pathogens induce a rapid intraepithelial lymphocyte (IEL) response important for
112 Peyer's patch (PP), lamina propria (LP), and intraepithelial lymphocyte (IEL) T cell populations were
115 is crucial for the development of intestinal intraepithelial lymphocytes (IEL) and delivery is mediat
116 aracterize the phenotype of large intestinal intraepithelial lymphocytes (IEL) and lamina propria leu
119 ro studies have demonstrated that intestinal intraepithelial lymphocytes (IEL) are constitutively cyt
127 ntrol mice, TCR gammadelta and TCR alphabeta intraepithelial lymphocytes (IEL) developed efficiently
129 estinal lamina propria lymphocytes (LPL) and intraepithelial lymphocytes (IEL) during primary SIV inf
130 xpress CD8 alphabeta, whereas TCR alphabeta+ intraepithelial lymphocytes (IEL) express CD8 alpha alph
132 opment of signature, murine TCRgammadelta(+) intraepithelial lymphocytes (IEL) in gut and skin depend
134 tead, there were twice as many CD8alphaalpha intraepithelial lymphocytes (IEL) in mice that were reco
135 ession of IL-10 was produced specifically by intraepithelial lymphocytes (IEL) in the small intestine
137 aggregates in the development of intestinal intraepithelial lymphocytes (IEL) is a matter of controv
138 TCR alphabeta(+), CD8alphabeta(+) intestinal intraepithelial lymphocytes (IEL) is dependent on MHC cl
144 eaks, intervillous spaces, and the number of intraepithelial lymphocytes (IEL) were measured before a
145 enriched lamina propria lymphocytes (LPL) or intraepithelial lymphocytes (IEL) were transferred into
146 both GCT and CD11c on PP lymphocytes (PPL), intraepithelial lymphocytes (IEL), and lamina propria ly
147 development of naive CD8 T cells, intestinal intraepithelial lymphocytes (IEL), and natural killer (N
148 ion of T cell receptor gammadelta-expressing intraepithelial lymphocytes (IEL), but these changes wer
149 opment occurs in the thymus, some intestinal intraepithelial lymphocytes (IEL), including TCR gamma d
155 dramatic decrease in extrathymic intestinal intraepithelial lymphocytes (IELs) and natural killer 1.
162 nt of TCRalphabeta+CD8alphaalpha+ intestinal intraepithelial lymphocytes (IELs) are not thoroughly un
167 amined the effects of interleukin (IL)-15 on intraepithelial lymphocytes (IELs) because they resemble
169 e show that, although mouse small intestinal intraepithelial lymphocytes (IELs) expressed the CD43 co
172 D134) in the activation of CD8(+) intestinal intraepithelial lymphocytes (IELs) has been studied usin
175 e of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classical B-,
176 selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, whi
182 his model of intestinal inflammation, CD8(+) intraepithelial lymphocytes (IELs) secrete transforming
183 urn modulate a distinct population of CD4(+) intraepithelial lymphocytes (IELs) that express CD8alpha
184 lial cells (ECs) is a population of resident intraepithelial lymphocytes (IELs) that provide host-pro
185 termine the contribution Vgamma1+ intestinal intraepithelial lymphocytes (IELs) vs systemic Vgamma1+
186 , no expansion of CD8 alpha alpha intestinal intraepithelial lymphocytes (IELs) was observed, despite
187 estine tissues were collected and intestinal intraepithelial lymphocytes (IELs) were measured; we als
188 elta T cells isolated from murine intestinal intraepithelial lymphocytes (IELs) were separated into g
189 of naturally occurring Vgamma4(+)/Vdelta1(+) intraepithelial lymphocytes (IELs) with innate cytolytic
191 , CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique
192 uding natural killer (NK) cells, NK T cells, intraepithelial lymphocytes (IELs), CD8 T cells, and gam
193 sical lymphoid cells, broadly referred to as intraepithelial lymphocytes (IELs), intercalate the inte
194 such as TCRalphabeta((+))CD8alphaalpha((+)) intraepithelial lymphocytes (IELs), require full-agonist
195 isolation and purification of rat intestinal intraepithelial lymphocytes (IELs), we previously identi
196 ion requirements of TCR-alphabeta intestinal intraepithelial lymphocytes (IELs), we utilized the 2C t
197 mall intestine, the types of T(RM) cells are intraepithelial lymphocytes (IELs), which contain high l
198 pulated by CD8(+) alpha beta and gamma delta intraepithelial lymphocytes (IELs), which monitor the in
210 celiac disease were villous atrophy with 40 intraepithelial lymphocytes (IELs)/100 enterocytes (ECs)
213 ole of IL-2 in the development of intestinal intraepithelial lymphocytes (iIEL), we evaluated IL-2(-/
216 in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the
217 T cell receptor (TCR) alpha beta intestinal intraepithelial lymphocytes (iIELs) using the 2C transge
220 sease, can result from expansion of aberrant intraepithelial lymphocytes in refractory celiac disease
221 T cells but constitute a major proportion of intraepithelial lymphocytes in the gastrointestinal muco
223 h) mice had normal numbers of TCR gammadelta intraepithelial lymphocytes in the intestines and did no
224 in spleen and intestine (lamina propria and intraepithelial lymphocytes), in suckling and juvenile m
225 nd CD8alpha(+) T cells in lamina propria and intraepithelial lymphocytes, in general, an increase of
226 se were included in the analyses of aberrant intraepithelial lymphocytes, including the primary analy
228 ming growth factor beta(1) production by the intraepithelial lymphocytes increased, as did Smad2 expr
229 ss-linking of the T cell receptor complex on intraepithelial lymphocytes increases the avidity of alp
231 ration and cytokine secretion in the spleen, intraepithelial lymphocyte inflammatory cytokines, and i
233 Although an increased number of intestinal intraepithelial lymphocytes is observed at the inception
234 of NK cell subsets in the lung, tonsils and intraepithelial lymphocytes isolated from healthy indivi
235 led developmental trajectories of intestinal intraepithelial lymphocytes, lamina propria lymphocytes,
236 ively expressed granzyme B and GzmB(-/-) cre intraepithelial lymphocytes likewise expressed granzyme
237 ace proteins that are involved in intestinal intraepithelial lymphocyte localization or function, cul
241 r and of abnormal morphology, and intestinal intraepithelial lymphocytes, normally containing a large
247 organization, and regulation of the adaptive intraepithelial lymphocytes, or IEL, which are key playe
248 villous height:crypt depth ratio, numbers of intraepithelial lymphocytes, or serologic markers of cel
249 he relative change from baseline in aberrant intraepithelial lymphocyte percentage was -4.85% (90% CI
251 CD8alphaalpha TCRalphabeta(+) intestinal intraepithelial lymphocytes play a critical role in prom
252 lts indicate that changes occur in the ileal intraepithelial lymphocyte population coincidently with
253 ble-positive cells present in the intestinal intraepithelial lymphocytes population can suppress T he
255 vious studies have suggested that intestinal intraepithelial lymphocytes prevent spontaneous intestin
256 ThPOK results in premature acquisition of an intraepithelial lymphocyte profile by mLN T(reg) cells,
257 of intestinal alphabeta(+) and gammadelta(+) intraepithelial lymphocytes purified from germ-free mice
259 in terms of the primary endpoint of aberrant intraepithelial lymphocyte reduction from baseline.
260 ma to 'educate' the natural, skin-associated intraepithelial lymphocyte repertoire to be of physiolog
262 ntramucosal Brunner's gland scores and lower intraepithelial lymphocyte scores than from the second o
263 Secondary end points included numbers of intraepithelial lymphocytes, serology test results (for
265 serum, nor did it induce IL-2R expression by intraepithelial lymphocytes, suggesting that GL3 inhibit
266 An important component of the disease is the intraepithelial lymphocyte that might become clonally ex
267 receptor (TCR)alphabeta+ cells and resident intraepithelial lymphocytes that are commonly enriched i
270 is role involves cell-cell interactions with intraepithelial lymphocytes that may also play a role in
271 In the epithelium, interleukin-15 activates intraepithelial lymphocytes that promote destruction of
272 eir anatomic location within the epithelium (intraepithelial lymphocytes), the interstitium between t
273 les (one in the AMG 714 group), and atypical intraepithelial lymphocytes (three in the AMG 714 group
274 -gamma is produced by both stromal cells and intraepithelial lymphocytes through all stages of the me
275 owel transplant, the number and the ratio of intraepithelial lymphocytes to enterocytes, as well as c
276 AM-15 is involved in heterotypic adhesion of intraepithelial lymphocytes to IEC as well as in homotyp
278 response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelia
279 cell receptor alphabeta(+) CD4(-)CD8beta(-) intraepithelial lymphocytes (unconventional iIELs), a ma
280 pithelium, long-term retention of intestinal intraepithelial lymphocytes was also alphaEbeta7 indepen
281 e gamma-region gene repertoire of intestinal intraepithelial lymphocytes was regulated by interleukin
283 from baseline to week 12 with respect to all intraepithelial lymphocytes was the primary endpoint and
284 elta T cells or gammadelta TCR(+) intestinal intraepithelial lymphocytes, we hypothesized that activa
291 illus height to crypt depth and densities of intraepithelial lymphocytes were the primary end points.
292 d Mucida discuss development and function of intraepithelial lymphocytes, which are found within the
293 CR alpha- and beta-chain usage by intestinal intraepithelial lymphocytes, which are predominantly CD8
295 Is, biopsies showed significant increases in intraepithelial lymphocytes, which were predominantly T
296 tration of a clonal population of neoplastic intraepithelial lymphocytes with an atypical immunopheno
297 n the AMG 714 and placebo groups in aberrant intraepithelial lymphocytes with respect to epithelial c
298 ondary endpoints were the change in aberrant intraepithelial lymphocytes with respect to intestinal e
299 pporting host immune function by stimulating intraepithelial lymphocytes within the epithelial barrie
300 owed by Peyer's patches, lamina propria, and intraepithelial lymphocyte yield with respiratory and in