ライフサイエンスコーパス: intraflagellar

1 ton extrusion via Hv1 channels should induce intraflagellar alkalinisation and activate CatSper ion c

2 Here we demonstrate that intraflagellar Ca(2+) elevations act to directly regulat

3 Gliding motility induces mechanosensitive intraflagellar Ca(2+) elevations in trailing (dragging)

4 Highly compartmentalized intraflagellar Ca(2+) elevations initiate retrograde tra

5 tion potentiates CatSper current to increase intraflagellar calcium and induce sperm hyperactivation.

6 ortance, the mode of interaction between the intraflagellar ciliary transport (IFT) mechanism and its

7 usually result from disruption of retrograde intraflagellar (IFT) transport of the cilium.

8 her with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesi

9 Followed by downstream modules leading to intraflagellar pH (pHi), voltage and [Ca2+]i fluctuation

10 cilia structural proteins, polycystin-1 and intraflagellar protein-88.

11 ial spokes are required for Ca(2+)-initiated intraflagellar signaling, resulting in modulation of inn

12 oneme, which potentially mediates retrograde intraflagellar trafficking, runs through the entire axis

13 oducts from the flagellar tip is mediated by intraflagellar transport (IFT) , which is essential for

14 Here, we examine the role of intraflagellar transport (IFT) 20 (Ift20) during polariz

15 require the universally conserved process of intraflagellar transport (IFT) [1, 2].

16 per se of SAG1 is independent of anterograde intraflagellar transport (IFT) [13], but the rapid apica

17 arrier at the base of the organelle [3-8] by intraflagellar transport (IFT) [9-18].

18 aintenance of all cilia and flagella require intraflagellar transport (IFT) along the axoneme.

19 semble from basal bodies by a process called intraflagellar transport (IFT) and are associated with s

20 ins in primary cilia is thought to depend on intraflagellar transport (IFT) and diffusion.

21 crotubule-based organelles that assemble via intraflagellar transport (IFT) and function as signaling

22 Both intraflagellar transport (IFT) and lipidated protein int

23 GFP-tagged alpha-tubulin enters cilia as an intraflagellar transport (IFT) cargo and by diffusion.

24 Mutations in several genes affecting intraflagellar transport (IFT) cause SRPS but they do no

25 rily of HEAT repeats, may not be part of the intraflagellar transport (IFT) complex and is not requir

26 IFT80, a protein component of intraflagellar transport (IFT) complex B, is required fo

27 unction of Ift27, which encodes a subunit of intraflagellar transport (IFT) complex B.

28 The intraflagellar transport (IFT) complex is an integral co

29 Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex.

30 Intraflagellar transport (IFT) complexes A and B build a

31 Two intraflagellar transport (IFT) complexes, IFT-A and IFT-

32 ization (aCGH) covering 20 genes that encode intraflagellar transport (IFT) components and 74 ciliopa

33 ization of other ciliary proteins, including intraflagellar transport (IFT) components, sensory recep

34 very similar, but not identical, to that of intraflagellar transport (IFT) components.

35 aintenance of eukaryotic cilia and flagella, intraflagellar transport (IFT) consists of the bidirecti

36 Intraflagellar transport (IFT) depends on two evolutiona

37 Anterograde intraflagellar transport (IFT) employing kinesin-2 molec

38 Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogene

39 This is the first time an intraflagellar transport (IFT) gene is implicated in the

40 netic approach in mice identified a role for intraflagellar transport (IFT) genes in Shh signal trans

41 nal (anterograde and retrograde) motor-based intraflagellar transport (IFT) governs cargo transport a

42 least BBS1, -4, -5, -7, and -8 and undergoes intraflagellar transport (IFT) in association with a sub

43 n FLA15 and FLA17 show defects in retrograde intraflagellar transport (IFT) in Chlamydomonas.

44 Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist

45 toplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia.

46 Eukaryotic cilia are assembled via intraflagellar transport (IFT) in which large protein pa

47 Intraflagellar transport (IFT) is a bidirectional proces

48 Intraflagellar transport (IFT) is a motility process ope

49 Intraflagellar transport (IFT) is an active event in whi

50 Intraflagellar transport (IFT) is an ancient, conserved

51 Intraflagellar transport (IFT) is assumed to be the pred

52 Anterograde intraflagellar transport (IFT) is essential for photorec

53 Intraflagellar transport (IFT) is essential for the elon

54 Anterograde intraflagellar transport (IFT) is mediated by kinesin mo

55 Intraflagellar transport (IFT) is not essential for PKD-

56 Retrograde intraflagellar transport (IFT) is required for assembly

57 Intraflagellar transport (IFT) is required for proper fu

58 Intraflagellar transport (IFT) is required for the assem

59 Intraflagellar transport (IFT) is the bidirectional move

60 Intraflagellar transport (IFT) is the process by which p

61 a, tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 motors kinesin-

62 17 and kinesin-3 KLP-6 without affecting the intraflagellar transport (IFT) kinesin-II.

63 Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport

64 tmentalized ciliogenesis depends on the core intraflagellar transport (IFT) machinery and the associa

65 The intraflagellar transport (IFT) machinery consists of the

66 Intraflagellar transport (IFT) machinery is required for

67 ciliary membranes at rates comparable to the intraflagellar transport (IFT) machinery located between

68 Intraflagellar transport (IFT) machinery mediates the bi

69 kinesin-2 subunit Kif3a, a component of the intraflagellar transport (IFT) machinery used to generat

70 Cilia are assembled and maintained by the intraflagellar transport (IFT) machinery, which coordina

71 et-Biedl syndrome (BBS) proteins, and on the intraflagellar transport (IFT) machinery.

72 er centrioles, and IFT88, a component of the intraflagellar transport (IFT) machinery.

73 Intraflagellar transport (IFT) motor protein localizatio

74 y assembly and maintenance as an anterograde intraflagellar transport (IFT) motor.

75 Intraflagellar transport (IFT) motors assemble and maint

76 Characterization of previously described intraflagellar transport (IFT) mouse mutants has led to

77 Intraflagellar transport (IFT) moves IFT trains carrying

78 This phenotype is much less pronounced in intraflagellar transport (IFT) mutants and reveals that

79 e during flagellar resorption, especially in intraflagellar transport (IFT) mutants, suggesting that

80 s neurons depends on the kinesin-2-dependent intraflagellar transport (IFT) of ciliary precursors ass

81 Cilia are assembled via intraflagellar transport (IFT) of ciliary precursors; ho

82 rated that kinesin-II drives the anterograde intraflagellar transport (IFT) of protein complexes alon

83 Cilia and flagella are assembled by intraflagellar transport (IFT) of protein complexes that

84 umption is that proteins responsible for the intraflagellar transport (IFT) of tubulin are present in

85 Moreover, intraflagellar transport (IFT) particle components accum

86 Intraflagellar transport (IFT) particle composition was

87 examine the role of the IFT20 subunit of the intraflagellar transport (IFT) particle in photoreceptor

88 Conserved intraflagellar transport (IFT) particle proteins and IFT

89 -3-kinesin, which cooperate to move the same intraflagellar transport (IFT) particles along microtubu

90 Intraflagellar transport (IFT) particles are multiprotei

91 Chlamydomonas reinhardtii intraflagellar transport (IFT) particles can be biochemi

92 hlamydomonas genes that encode components of intraflagellar transport (IFT) particles involved in cil

93 rate, and the rate of entry into flagella of intraflagellar transport (IFT) particles is increased.

94 Intraflagellar transport (IFT) particles of Chlamydomona

95 HYLS-1 compromises the docking and entry of intraflagellar transport (IFT) particles, ciliary gating

96 is molecular architecture, two reservoirs of intraflagellar transport (IFT) particles, correlating wi

97 y activity and interact genetically with the intraflagellar transport (IFT) pathway to play a role in

98 may traffic to the primary cilium through an intraflagellar transport (IFT) pathway.

99 Highly conserved intraflagellar transport (IFT) protein complexes direct

100 -1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamyd

101 the transport adaptor ODA16, as well as the intraflagellar transport (IFT) protein IFT46, but the mo

102 lishing the first association of a defective intraflagellar transport (IFT) protein with human diseas

103 We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, S

104 ealed moderately altered expression of known intraflagellar transport (IFT) protein-encoding loci in

105 The highly conserved intraflagellar transport (IFT) proteins are essential fo

106 Intraflagellar transport (IFT) proteins are essential fo

107 Intraflagellar transport (IFT) proteins are essential fo

108 gulators of animal development and depend on intraflagellar transport (IFT) proteins for their format

109 The intraflagellar transport (IFT) proteins Ift172/Wimple an

110 d and maintained by evolutionarily conserved intraflagellar transport (IFT) proteins that are involve

111 ODA16 localization resembles that seen for intraflagellar transport (IFT) proteins, and flagellar a

112 Disruption of intraflagellar transport (IFT) results in loss of flagel

113 are unusual in that they do not require the intraflagellar transport (IFT) system for assembly of th

114 The intraflagellar transport (IFT) system is required for bu

115 Ciliogenesis is accomplished by the intraflagellar transport (IFT) system, a set of proteins

116 Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular

117 he kinesin-2-driven anterograde transport of intraflagellar transport (IFT) trains has long been susp

118 Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transpor

119 Intraflagellar transport (IFT) underpins many of the imp

120 s are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 coop

121 hog (Hh) signaling in vertebrates depends on intraflagellar transport (IFT) within primary cilia.

122 ntenance of primary cilia are facilitated by intraflagellar transport (IFT), a bidirectional protein

123 e assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mecha

124 Assembly of cilia and flagella requires intraflagellar transport (IFT), a highly regulated kines

125 Ciliary assembly requires intraflagellar transport (IFT), a motile system that del

126 Sensory cilia and intraflagellar transport (IFT), a pathway essential for

127 m Caenorhabditis elegans that is involved in intraflagellar transport (IFT), a process essential for

128 of proteins within the cilia is governed by intraflagellar transport (IFT), a process that facilitat

129 Cilia assembly is mediated by intraflagellar transport (IFT), and cilia defects disrup

130 Cilia formation requires intraflagellar transport (IFT), and mutations disrupting

131 y opsin to test whether the highly conserved intraflagellar transport (IFT), as driven by heterotrime

132 alcium levels and requires kinesin-II-driven intraflagellar transport (IFT), as well as BBS- and RAB8

133 oth the frequency and velocity of retrograde intraflagellar transport (IFT), but it does not eliminat

134 ined by kinesin-2 motors in a process termed intraflagellar transport (IFT), but they exhibit great v

135 rs that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along mic

136 Kif3a, a component of intraflagellar transport (IFT), is important in cilia ma

137 afficking of components within cilia, called intraflagellar transport (IFT), is powered by kinesin-2

138 onstruction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional moveme

139 ve been classified as putatively involved in intraflagellar transport (IFT), the bidirectional moveme

140 Intraflagellar transport (IFT), the bidirectional moveme

141 ance of eukaryotic flagella are regulated by intraflagellar transport (IFT), the bidirectional traffi

142 activator for an anterograde motor OSM-3 of intraflagellar transport (IFT), the ciliogenesis-require

143 Intraflagellar transport (IFT), the motor-dependent move

144 g flagellar shortening and in the absence of intraflagellar transport (IFT), the predominant protein

145 During intraflagellar transport (IFT), the regulation of motor

146 IFT88, essential for anterograde intraflagellar transport (IFT), was significantly reduce

147 ney disease 2 (PKD2) and its relationship to intraflagellar transport (IFT), we cloned the gene encod

148 built and maintained by continuous cycles of intraflagellar transport (IFT), where ciliary proteins a

149 Primary cilia are built and maintained by intraflagellar transport (IFT), whereby the two IFT comp

150 An essential component of ciliogenesis is intraflagellar transport (IFT), which is involved in IFT

151 Intraflagellar transport (IFT), which is the bidirection

152 n this category are known to be required for intraflagellar transport (IFT), which is the bidirection

153 he assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidir

154 system consists of three subcomplexes [i.e., intraflagellar transport (IFT)-A, IFT-B, and the BBSome]

155 ematical modeling of conserved components of intraflagellar transport (IFT)-mediated assembly and kin

156 large protein complexes in a process termed intraflagellar transport (IFT).

157 ins besides a possible role for motor-driven Intraflagellar Transport (IFT).

158 luding BBS4, that is cycled through cilia by intraflagellar transport (IFT).

159 Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT).

160 d to require both anterograde and retrograde intraflagellar transport (IFT).

161 ide repeat-containing protein related to the intraflagellar transport (IFT).

162 ssembled and maintained by the bidirectional intraflagellar transport (IFT).

163 cause B tubule defects that further disrupt intraflagellar transport (IFT).

164 ctural cores assembling from basal bodies by intraflagellar transport (IFT).

165 eostasis and are assembled and maintained by intraflagellar transport (IFT).

166 ed through a highly conserved process called intraflagellar transport (IFT).

167 equires an active transport process known as intraflagellar transport (IFT).

168 Cilia are assembled via intraflagellar transport (IFT).

169 siRNA inhibition of anterograde intraflagellar transport (IFT88) reduced cilia length an

170 gellar transport (IFT) and lipidated protein intraflagellar transport (LIFT) pathways are essential f

171 n three families, we identified mutations in Intraflagellar Transport 172 Homolog [IFT172 (Chlamydomo

172 Here, we identify intraflagellar transport 20 (IFT20) as a new target of t

173 Knockout of intraflagellar transport 88 (IFT88) confirmed that the c

174 Stable silencing of Intraflagellar Transport 88 (Ift88) or Kinesin Family Me

175 nsport [kinesin family member 3A (Kif3a) and intraflagellar transport 88 (Ift88)] and Cre drivers tha

176 so known as polaris or Tg737), which encodes intraflagellar transport 88 homolog, and Kif3a, which en

177 remodeling and centrosome migration, whereas intraflagellar transport 88's role seems to be restricte

178 vely, a recent finding has revealed that the intraflagellar transport 88/polaris protein, which is re

179 TTC26 (intraflagellar transport [IFT] 56/DYF13) is an atypical

180 conditional alleles for genes essential for intraflagellar transport [kinesin family member 3A (Kif3

181 INTU is essential for intraflagellar transport A complex assembly during cilio

182 Kinesin-2 motors, which are involved in intraflagellar transport and cargo transport along cytop

183 mselves, and show that crumbs genes modulate intraflagellar transport and cilia elongation.

184 esin II subunit Kif3A, which is required for intraflagellar transport and ciliogenesis.

185 Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human sk

186 Intraflagellar transport and kinesin-3 KLP-6 are require

187 nesin II motor complex, that is required for intraflagellar transport and the formation of cilia, was

188 Epistasis analyses indicate that DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channe

189 How might intraflagellar transport and the size of the trains be i

190 F3A/B, is a heterotrimeric motor involved in intraflagellar transport and vesicle motility in neurons

191 length-dependent signal produced to regulate intraflagellar transport appropriately?

192 ptures and releases its single effector, the intraflagellar transport B holocomplex, from the large p

193 entify the role of kinesin-II in anterograde intraflagellar transport by photoreceptor-specific delet

194 sive return of the kinesin motor that powers intraflagellar transport can play a key role in length r

195 affecting ciliary assembly, mutations in the intraflagellar transport complex A (IFT-A) paradoxically

196 ,5)P2)-dependent manner, ciliary delivery by intraflagellar transport complex A binding to the TULP3/

197 r characterization of specific components of Intraflagellar Transport complex A uncovered a cilia-ind

198 requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary

199 which encodes a component of the anterograde intraflagellar transport complex.

200 lia and flagella, and recent work shows that intraflagellar transport complexes - or trains - fall in

201 We observe sub-complexes in exocyst and intraflagellar transport complexes, which we validate bi

202 The intraflagellar transport component polaris localized to

203 imilarly, knockdown of ift22, an anterograde intraflagellar transport component, also suppresses the

204 In mutant OSNs, cilia base-anchoring of intraflagellar transport components IFT88, the kinesin-I

205 ents are not well understood, but defects in intraflagellar transport components, including Ift27 and

206 Mutants of daf-6 or intraflagellar transport constitutively upregulate tph-1

207 Ciliary dysfunction caused by intraflagellar transport defects results in branching de

208 genes encoding cytoplasmic assembly factors, intraflagellar transport factors, docking proteins, dyne

209 n et al. describe the necessity of Ift88 and intraflagellar transport for signal reception of the son

210 cription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polar

211 ephros fluid output through knockdown of the intraflagellar transport gene ift88, was not associated

212 ing ciliopathies and argue that mutations in intraflagellar transport genes cause their phenotypes be

213 ecause endothelial-specific re-expression of intraflagellar transport genes in respective mutants res

214 Embryos expressing mutant intraflagellar transport genes, which are essential and

215 ata suggest a tantalizing connection between intraflagellar transport in cilia and brain development.

216 Intraflagellar transport in cilia has been proposed as a

217 ns and implicate the molecular components of intraflagellar transport in degenerative disorders of th

218 ptor cells of the retina, we have focused on intraflagellar transport in photoreceptor sensory cilia.

219 Intraflagellar transport is a conserved delivery system

220 Intraflagellar transport is essential for the assembly a

221 Anterograde intraflagellar transport is sped up in lengthened cilia,

222 Intraflagellar transport is the rapid, bidirectional mov

223 e different measurements: 1) the quantity of intraflagellar transport machinery as a function of leng

224 We find that the quantity of intraflagellar transport machinery is independent of len

225 The intraflagellar transport machinery is required for the a

226 ecent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia

227 loading onto the constitutively trafficking intraflagellar transport machinery.

228 proteins such as GPCRs and links them to the intraflagellar transport machinery.

229 Hh receptor Patched-related factor DAF-6 and intraflagellar transport modulate serotonin production i

230 vation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal p

231 The Chlamydomonas anterograde intraflagellar transport motor, kinesin-2, is isolated a

232 mediate chain associated with the retrograde intraflagellar transport motor.

233 required for the functional coordination of intraflagellar transport motors and their cargoes.

234 lia and that Gli3 processing is defective in intraflagellar transport mutants.

235 nance and signaling via Tulp3, essential for intraflagellar transport of ciliary signaling receptors.

236 hancement of fluorescence signal in tracking intraflagellar transport particles, or reduction of phot

237 to an opening well suited for the passage of intraflagellar transport particles.

238 ignaling and adhesion molecules, and ciliary intraflagellar transport particles.

239 ivity to PIFTC3, encoding a component of the intraflagellar transport pathway.

240 tes cilia length through an Fgf8/Fgf24-Fgfr1-intraflagellar transport pathway.

241 ssociation of RPGR-ORF15 isoform(s) with the intraflagellar transport polypeptide IFT88 as well as mi

242 to differ significantly in length indicating intraflagellar transport processes in primary cilia may

243 Unlike zebrafish intraflagellar transport protein (IFT) mutants, cyst for

244 icing variants in WDR35, encoding retrograde intraflagellar transport protein 121 (IFT121), in three

245 of open brain (sopb), a null allele of mouse Intraflagellar transport protein 122 (Ift122).

246 howed that avc1 is a hypomorphic mutation of intraflagellar transport protein 172 (Ift172), required

247 Here, we provide evidence that intraflagellar transport protein 20 (IFT20) interacts wi

248 We showed previously that the intraflagellar transport protein 20 (IFT20), a component

249 icrotubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and cilio

250 Effect of the variant observed in the gene Intraflagellar Transport Protein 43 (IFT43) was studied

251 We show that SDCCAG3 interacts with the intraflagellar transport protein 88 (IFT88), a crucial c

252 kinesin family member 3A) or Ift88 (encoding intraflagellar transport protein 88), genes required for

253 iption requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are e

254 recent examples include the demonstration of intraflagellar transport protein and hedgehog contributi

255 e antenna-like structures are synthesized by intraflagellar transport protein complexes, IFT-B and IF

256 ions in TTC21B, which encodes the retrograde intraflagellar transport protein IFT139, cause both isol

257 gastric cilia, we conditionally deleted the intraflagellar transport protein Ift88 (Ift88(-/fl)).

258 ough mice with a hypomorphic mutation in the intraflagellar transport protein IFT88 (Ift88Tg737Rpw mi

259 formation and centriolar recruitment of the intraflagellar transport protein Ift88.

260 Elimination of the intraflagellar transport protein Kif3a leads to excessiv

261 , prenylated phosphodiesterase-6 (PDE6), and intraflagellar transport protein-88 (IFT88).

262 Intraflagellar transport proteins (IFT) are required for

263 performed shRNA-mediated knockdown of seven intraflagellar transport proteins (IFTs) and conditional

264 ges were associated with increased levels of intraflagellar transport proteins and accelerated ciliog

265 This pathway also includes genes encoding intraflagellar transport proteins and cyclic nucleotide

266 rotein content, including abnormal levels of intraflagellar transport proteins and proteins associate

267 germline stem cell populations, and require intraflagellar transport proteins for their formation.

268 C2cd3 is also required for recruiting the intraflagellar transport proteins Ift88 and Ift52 to the

269 The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedge

270 ncluding removal of CP110 and recruitment of intraflagellar transport proteins.

271 localization, in tight coordination with the intraflagellar transport system and vesicular traffickin

272 sport protein 20 (IFT20), a component of the intraflagellar transport system, controls polarized traf

273 the base of mature cilia and is required for intraflagellar transport trafficking.

274 in the cytoplasm, transported into cilia by intraflagellar transport, and bound to specific sites on

275 in isotype regulates ciliary ultrastructure, intraflagellar transport, and ciliary functions of extra

276 equires an active transport process known as intraflagellar transport, and previous measurements sugg

277 s to predict the relation between length and intraflagellar transport, and then compare the predicted

278 interaction (PPI) network analysis of known intraflagellar transport, BBSome, transition zone, cilia

279 ent due to the inherent length dependence of intraflagellar transport, whereas disassembly is length

280 Down-regulation of intraflagellar transport-88, a protein essential for cil

281 ated that the TTC21B gene product IFT139, an intraflagellar transport-A component, mainly localizes a

282 mbrane attachments before or coinciding with intraflagellar transport-dependent axoneme extension and

283 ioles at the plasma membrane but not for the intraflagellar transport-dependent extension of the cili

284 complete removal of cilia by inactivation of intraflagellar transport-related proteins.

285 t that a length-dependent feedback regulates intraflagellar transport.

286 eins transmit force for ciliary motility and intraflagellar transport.

287 ctural precursors delivered to their tips by intraflagellar transport.

288 n-2 family member best known for its role in intraflagellar transport.

289 ugh the degradation of proteins required for intraflagellar transport.

290 otein-coupled receptors GPCRs or by blocking intraflagellar transport.

291 t they show features of defective retrograde intraflagellar transport.

292 Shh signaling regulates this balance through intraflagellar transport.

293 ilia construction or maintenance, but not in intraflagellar transport.

294 lium morphology and provides a substrate for intraflagellar transport.

295 a novel ciliary gene required for retrograde intraflagellar transport.

296 ynein-2 complex are essential for retrograde intraflagellar transport.

297 nt data support a role in cilia function and intraflagellar transport.

298 (-/-) basal bodies, suggesting impairment of intraflagellar transport.

299 syndrome when mutated, in the triggering of intraflagellar transport.

300 sting 9+2 axonemes associated with decreased intraflagellar transport.