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2 sed case-control study, 2395 CCA cases (1169 intrahepatic, 995 perihilar, and 231 distal) seen at the
3 t that abnormal AAT protein conformation and intrahepatic accumulation have broad effects on metaboli
6 lectrin-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may
7 Moreover, the renal excretion kinetic and intrahepatic albumin binding affinity of CyG can further
8 ility of invasion and migration in vitro and intrahepatic and distal lung metastasis in vivo of HCC c
9 elial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute sub
10 dysplastic morphology and expansion of both intrahepatic and extrahepatic biliary cells, and ultimat
11 aphy (MRCP) is the best test to evaluate the intrahepatic and extrahepatic biliary tract, and MRI als
12 ession levels were measured in the following intrahepatic and extrahepatic cholangiocarcinoma (CCA) c
15 opancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine
17 nstrates vasculature changes associated with intrahepatic angiogenesis and portal hypertension during
22 R-dependent impaired bile secretion promotes intrahepatic bile accumulation, which contributes to hep
23 erozygous mice (Jag1(+/-) ) exhibit impaired intrahepatic bile duct (IHBD) development, decreased SOX
29 ression and MC presence or activation; large intrahepatic bile duct mass, inflammation and senescence
36 ompensatory proliferation of hepatocytes and intrahepatic biliary cells, thus impeding HCC developmen
37 nts with biliary atresia (BA), the extent of intrahepatic biliary fibrosis negatively correlates with
40 inistration of GnRH to normal rats increased intrahepatic biliary mass (IBDM) and hepatic fibrosis.
42 in increased cholangiocyte proliferation and intrahepatic biliary mass, liver damage, and inflammatio
43 e produced a crowded branching defect in the intrahepatic biliary network and influenced actin dynami
51 limp-1(hi)Hobit(lo) T cells found within the intrahepatic but not the circulating memory CD8 T cell p
52 olesterolemia induced the differentiation of intrahepatic, but not intrasplenic, Th17 cells in wild-t
53 iated with shorter survival of patients with intrahepatic CCA (HR, 4.2; 95% CI: 1.1-14.1; P = 0.04).
54 NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA).
56 Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is s
57 3 expression was increased in both hilar and intrahepatic CCA samples as well as in CCA cell lines.
58 of myeloid cell infiltration in HCC, NET and intrahepatic CCA tumors further established that the fre
64 re found in corresponding invasive PDACs and intrahepatic CCAs, as well as in matched pancreatic cyst
66 dd)PCR assays were used to quantify residual intrahepatic cccDNA in liver biopsies from 56 chronicall
68 t and retention and enhances polarization of intrahepatic CD4 cells toward Th17 cells via type 17 cyt
69 tabolism in NAFLD causes a selective loss of intrahepatic CD4(+) but not CD8(+) T lymphocytes, leadin
70 increased frequency of IL-17(+) cells among intrahepatic CD4(+) T cells and higher Th17/rTreg and Th
73 Liver disease elicits alterations in the intrahepatic CD4(+) T-cell compartment that suppress T-c
80 liver disease and nonspecific cirrhosis, to intrahepatic cholangiocarcinogenesis together with geogr
82 equencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, includ
85 rom combined hepatocellular liver cancer and intrahepatic cholangiocarcinoma (ICC) has increased and
91 232R) of PTPN3, a frequent mutation found in intrahepatic cholangiocarcinoma (ICC), disables its role
93 on and aggressive malignancy of mass-forming intrahepatic cholangiocarcinoma (ICC), we modeled ICC de
98 er comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and other rare t
99 markers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical comp
100 f cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined a
101 occur in approximately 13% of patients with intrahepatic cholangiocarcinoma, a relatively uncommon c
102 ondary glioblastoma, acute myeloid leukemia, intrahepatic cholangiocarcinoma, and chondrosarcomas, le
103 ly encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second l
108 itized both EHCs and the otherwise resistant intrahepatic cholangiocytes to the toxin, whereas replen
109 pha-1 antitrypsin deficiency (A1AT), chronic intrahepatic cholestasis (CIC), and Alagille syndrome (A
111 holangiopathies such as progressive familial intrahepatic cholestasis and primary sclerosing cholangi
113 the Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis in the Childhood Liver Disease
118 pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to be
121 cirrhosis was independently associated with intrahepatic cholestasis of pregnancy (relative risk [RR
122 isk of stillbirth is increased in women with intrahepatic cholestasis of pregnancy and singleton preg
123 Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritu
124 e for the aggregate data meta-analysis (5557 intrahepatic cholestasis of pregnancy cases and 165 136
125 Stillbirth occurred in 45 (0.83%) of 4936 intrahepatic cholestasis of pregnancy cases and 519 (0.3
126 was three (0.13%; 95% CI 0.02-0.38) of 2310 intrahepatic cholestasis of pregnancy cases in women wit
129 to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with incr
131 reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile ac
132 gement of acute fatty liver of pregnancy and intrahepatic cholestasis of pregnancy, and their impact
138 ary diseases, including progressive familial intrahepatic cholestasis type 3 (PFIC3), a rare disease
140 e the tumorigenicity of progressive familial intrahepatic cholestasis type 3 and, with further refine
143 tations in ATP8B1 cause progressive familial intrahepatic cholestasis type1 in humans, which is chara
144 fferent genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account
145 h Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis-1 (FIC1), 18 with bile salt exp
146 predisposed to adolescent development of an intrahepatic cholestasis-like condition with attendant h
147 asis characterized by a progressive familial intrahepatic cholestasis-like phenotype with normal seru
148 s in five patients with progressive familial intrahepatic cholestasis-like phenotype with normal seru
150 DXA) analysis was performed in children with intrahepatic cholestatic diseases who were enrolled in t
154 of murine liver with adenovirus, a model for intrahepatic cross-presentation, confirms hepatocytes di
158 and retaining functions of primary extra- or intrahepatic duct cholangiocytes within 2 weeks of isola
164 ther adjusted for weight loss, losing VAT or intrahepatic fat was independently associated with impro
166 eased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increa
167 ovel mechanism whereby coagulation-dependent intrahepatic fibrin(ogen) deposition drives platelet acc
173 nt was also associated with replenishment of intrahepatic glucose due to enhanced gluconeogenesis and
179 not negligible and transcriptionally active intrahepatic HBV reservoir (circular covalently closed D
180 ociated with an increase in the frequency of intrahepatic HBV-specific CD8(+) T cells and a transient
181 upport the prognostic importance of treating intrahepatic HCC even in patients with metastatic diseas
182 ular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE
183 intrahepatic biliary tree with left proximal intrahepatic hyperdensities, as well as a 3 cm hepatocel
184 A methylation of SLC22A1 were analyzed using intrahepatic (iCCA) and extrahepatic (eCCA) biopsies (Co
186 e important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poo
187 gt1 and gt3 infections do not elicit innate intrahepatic immune responses and remain highly sensitiv
189 , we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepa
190 e, proinflammatory microparticles that cause intrahepatic inflammation, vasoconstriction, and extrahe
191 ngraftment was associated with low levels of intrahepatic inflammatory cells and mediators of islet d
192 RIF) was a central mediator of the resulting intrahepatic inflammatory response that was independent
193 Herein, we describe an original method of intrahepatic injection into adult NOD.Cg-Prkdc(scid)Il2r
197 EV infections in humanized mice and modelled intrahepatic interferon stimulated gene (ISG) responses.
198 s superior to the low-fat diet in decreasing intrahepatic, intrapericardial, and pancreatic fats (P<0
202 crosis factor alpha and interleukin 2 at the intrahepatic level significantly more than HCV-specific
203 ally, the lack of stabilin-1 led to elevated intrahepatic levels of the profibrogenic chemokine CCL3
205 antly greater visceral adipose tissue (VAT), intrahepatic lipid (IHL), plasma free fatty acids, adipo
206 ter suppression rates of lipolysis and lower intrahepatic lipid and plasma triacylglycerol concentrat
207 estriction to allow an effective decrease of intrahepatic lipid component, and despite that evidence
208 show that Plin5 is an important modulator of intrahepatic lipid metabolism and suggest that the incre
210 emic control and a reduction in body weight, intrahepatic lipid, and visceral adipose tissue in patie
211 capacity have profound effects on regulating intrahepatic lipids and mediating susceptibility for hep
212 pared with caloric restriction on regulating intrahepatic lipids and steatosis risk; 3) the effects o
213 Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clinical problem assoc
214 vity of hepatic adipose triglyceride lipase, intrahepatic lipolysis, hepatic acetyl-CoA content and p
215 For colorectal liver metastasis (CRLM), intrahepatic lymph invasion and lymph node metastasis ar
218 th sofosbuvir and velpatasvir, we found that intrahepatic MAIT cells are activated by monocyte-derive
223 ens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues.
226 tumor progression, characterized by reduced intrahepatic numbers of invariant NKT and CD4(+) T cells
227 0.27-0.42), and 0.29 (95% CI 0.19-0.44) for intrahepatic, perihilar, and distal CCA, respectively (P
228 tients; 24 (15%), 124 (79%), and 9 (6%) with intrahepatic, perihilar, and distal CCA, respectively.
229 tients; 24 (15%), 124 (79%), and 9 (6%) with intrahepatic, perihilar, and distal CCA, respectively.
231 ibrinogen depletion with ancrod reduced both intrahepatic platelet accumulation and hepatocyte prolif
232 ntributes to liver regeneration by promoting intrahepatic platelet accumulation and identified the tr
235 nsation in patients undergoing Trans jugular intrahepatic Porto systemic shunts (TIPS) procedure (1).
237 e the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) as a treatment f
238 <12 mm Hg after placement of a transjugular intrahepatic portosystemic shunt (TIPS) correlates with
239 early liver failure (ELF) after transjugular intrahepatic portosystemic shunt (TIPS) creation in pati
241 e efficacy and complications of transjugular intrahepatic portosystemic shunt (TIPS) creation perform
242 of study patients who underwent transjugular intrahepatic portosystemic shunt (TIPS) creation, regard
243 covered stent and bare stent in transjugular intrahepatic portosystemic shunt (TIPS) for cirrhotic po
244 hnical success, and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in a series of p
245 The efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) in this populati
247 ex embolization with or without transjugular intrahepatic portosystemic shunt (TIPS) placement in pat
249 ta are available on the role of transjugular intrahepatic portosystemic shunt (TIPS) with covered ste
252 ative portal vein embolization, transjugular intrahepatic portosystemic shunt placement, balloon retr
253 controversy over the ability of transjugular intrahepatic portosystemic shunts (TIPS) to increase sur
254 controversy over the ability of transjugular intrahepatic portosystemic shunts (TIPS) to increase sur
256 2 largest liver metastases predicted time to intrahepatic progression (P = 0.013; HR, 0.21; 95% CI, 0
257 ival, progression-free survival, and time to intrahepatic progression after radioembolization for liv
258 ival, progression-free survival, and time to intrahepatic progression were among other factors correl
260 roscopic RFA (L-RFA) have been used to treat intrahepatic recurrent small hepatocellular carcinoma (H
261 erved that hypercholesterolemia elevated the intrahepatic regulatory T (Treg) cell population and inc
262 c infection, characterized by high levels of intrahepatic regulatory T cells and expression of inhibi
264 CC in male mice with substantially increased intrahepatic retention of hydrophobic BAs and decreased
267 lysis revealed a highly connected network of intrahepatic signaling and disruption of vascular signal
268 atic stellate cells (HSCs) serve as a hub of intrahepatic signaling via HSC-derived stellakines and t
269 ables were compared between tumors that were intrahepatic, small (<7 cm), and solitary (ISS) and thos
271 indicates that exercise powerfully regulates intrahepatic storage of fat and risk for steatosis.
274 y dual immunohistochemistry, we affirm human intrahepatic T cell infiltrate includes CCR6(+)CD4(+) an
277 ults elucidate a new mechanism that controls intrahepatic T-cell differentiation during atheroscleros
278 n hypercholesterolemic Ldlr(-/-) mice led to intrahepatic Th1 cell differentiation and CD11b(+)CD11c(
280 woodchucks; the identification of a baseline intrahepatic transcriptional signature associated with r
282 ys, a number comparable to that required for intrahepatic transplantation; in the absence of oxygen t
284 n in 3 groups: (a) lean subjects with normal intrahepatic triglyceride (IHTG) and glucose tolerance (
288 a high-fat diet, Plin5(LKO) mice accumulated intrahepatic triglyceride, without significant changes i
291 CI: 18, 47) of 40 completely ablated tumors, intrahepatic tumor recurrence was observed at 2-18 month
293 of (90)Y radioembolization in patients with intrahepatic tumors from pretherapeutic baseline paramet
295 aarterial administration for hepatic tumors, intrahepatic tumors, and uninvolved background organs (s
296 nts, which were mainly mediated by increased intrahepatic tumour-growth factor (TGF)-beta because blo
299 l resolution provides a means for monitoring intrahepatic virological events in chronic HBV infection