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1     She was diagnosed with acute sickle cell intrahepatic cholestasis.
2 irrhosis, primary sclerosing cholangitis and intrahepatic cholestasis.
3 ver damage in rat models of extrahepatic and intrahepatic cholestasis.
4 gands may be potential therapeutic drugs for intrahepatic cholestasis.
5 lation may result in bile acid retention and intrahepatic cholestasis.
6 Fic1 [Byler's disease]) and benign recurrent intrahepatic cholestasis.
7  gene of a patient with neonatal progressive intrahepatic cholestasis.
8 P domain of USP53 cause progressive familial intrahepatic cholestasis.
9 ts (DKOs) in mice liver leads to progressive intrahepatic cholestasis.
10 ysis of nontransplant surgical approaches to intrahepatic cholestasis.
11 inherited liver disease progressive familial intrahepatic cholestasis.
12 3R2 may contribute to the pathophysiology of intrahepatic cholestasis.
13 ATPase disrupted in three inherited forms of intrahepatic cholestasis.
14 d dysfunction despite increased fibrosis and intrahepatic cholestasis.
15 -null mice that are resistant to LCA-induced intrahepatic cholestasis.
16 ific beta-catenin knockout (KO) mice exhibit intrahepatic cholestasis.
17 cular morphology, bile secretory defect, and intrahepatic cholestasis.
18 SEP), ABCB11, is mutated in several forms of intrahepatic cholestasis.
19 eral and canalicular membranes, resulting in intrahepatic cholestasis.
20 GS patients, and PFIC patients with familial intrahepatic cholestasis 1 (FIC1) genotype, responded be
21 at ATPase class I type 8B member 1 [familial intrahepatic cholestasis 1 (FIC1)] posttranslationally a
22                         Progressive familial intrahepatic cholestasis 1 (PFIC1) results from mutation
23 h Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis-1 (FIC1), 18 with bile salt exp
24  of the FXR abrogated the effect of familial intrahepatic cholestasis-1 antisense oligonucleotides.
25 echanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (p
26                             Loss of familial intrahepatic cholestasis-1 leads to diminished nuclear t
27 e-mediated knock-down of endogenous familial intrahepatic cholestasis-1 led to up-regulation of apica
28 the farnesoid X receptor (FXR), and familial intrahepatic cholestasis-1 were studied in the ileum of
29                                  In familial intrahepatic cholestasis-1-negative Caco-2 cells, the ac
30 r but not cytoplasmic extracts from familial intrahepatic cholestasis-1-negative Caco-2 cells.
31                                  Sickle cell intrahepatic cholestasis, a potentially fatal complicati
32       We report a patient who presented with intrahepatic cholestasis, a rare and potentially lethal
33 ample in ATP8B1 causing progressive familial intrahepatic cholestasis, a rare inherited disorder prog
34      Mutations in BSEP result in progressive intrahepatic cholestasis, a severe liver disease that im
35 r, especially in enhancing the resolution of intrahepatic cholestasis after DDC injury.
36  liver transplantation for acute sickle cell intrahepatic cholestasis and a novel case of transplanta
37 autosomal-dominant disorder characterized by intrahepatic cholestasis and abnormalities of heart, eye
38 ids prolonged postnatal survival, alleviated intrahepatic cholestasis and intestinal malabsorption, r
39 amples from patients of progressive familial intrahepatic cholestasis and primary sclerosing cholangi
40 holangiopathies such as progressive familial intrahepatic cholestasis and primary sclerosing cholangi
41 n after the development of acute sickle cell intrahepatic cholestasis and renal failure requiring con
42 s, biliary atresia, and progressive familial intrahepatic cholestasis, and clinical trials of therapi
43  is used to treat primary biliary cirrhosis, intrahepatic cholestasis, and other cholestatic conditio
44  adult B-cell development, the prevention of intrahepatic cholestasis, and parturition, and is a new
45  diagnosis, 14 age-appropriate subjects with intrahepatic cholestasis as diseased controls and seven
46  Coincidently, we observed an improvement in intrahepatic cholestasis as seen by decreases in both se
47 presenting with features of benign recurrent intrahepatic cholestasis associated with a heterozygous
48 osis of a third type of neonatal progressive intrahepatic cholestasis associated with impaired bile a
49 nesis of primary biliary cirrhosis, familial intrahepatic cholestasis, biliary atresia, and primary s
50 s of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial
51 spectrum from intermittent (benign recurrent intrahepatic cholestasis; BRIC) to progressive familial
52 hildhood liver disease, progressive familial intrahepatic cholestasis, but cause and effect is less c
53 fferent genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account
54 ous and metabolic causes, including neonatal intrahepatic cholestasis caused by citrin deficiency (NI
55 aralixibat, and elobixibat are used to treat intrahepatic cholestasis, cholestatic pruritus, and obst
56 pha-1 antitrypsin deficiency (A1AT), chronic intrahepatic cholestasis (CIC), and Alagille syndrome (A
57                       Inherited syndromes of intrahepatic cholestasis commonly result from mutations
58 s with biliary atresia and six with neonatal intrahepatic cholestasis (diseased controls) and hybridi
59 apies for children and adults suffering from intrahepatic cholestasis due to BSEP deficiency.
60 accumulating toxic bile acids and developing intrahepatic cholestasis during the early stage of liver
61                             Benign recurrent intrahepatic cholestasis emanates from a partially funct
62 idered as an additional progressive familial intrahepatic cholestasis gene.
63  constitute the molecular defect in familial intrahepatic cholestasis I (Fic1 [Byler's disease]) and
64                                              Intrahepatic cholestasis (IHC) was observed in 4.9% of I
65  aggravating factor in the early CPZ-induced intrahepatic cholestasis in human hepatocytes.
66                   Disorders characterized by intrahepatic cholestasis in particular have now been sub
67 ns are known to cause hepatotoxicity such as intrahepatic cholestasis in susceptible women during pre
68  the Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis in the Childhood Liver Disease
69                                  Sickle cell intrahepatic cholestasis is a potentially catastrophic c
70                                  Sickle cell intrahepatic cholestasis is a potentially fatal end-orga
71                  Our study demonstrates that intrahepatic cholestasis leading to hepatocyte exposure
72  Alagille Ssyndrome and progressive familial intrahepatic cholestasis, leading to FDA and EMA approva
73  predisposed to adolescent development of an intrahepatic cholestasis-like condition with attendant h
74 asis characterized by a progressive familial intrahepatic cholestasis-like phenotype with normal seru
75 s in five patients with progressive familial intrahepatic cholestasis-like phenotype with normal seru
76 estasis (PFIC) is characterized by pruritus, intrahepatic cholestasis, low serum gamma-glutamyltransf
77                          In a mouse model of intrahepatic cholestasis, metformin treatment induced FX
78  not activate BSEP, whereas benign recurrent intrahepatic cholestasis mutants partially activated BSE
79                         Progressive familial intrahepatic cholestasis mutations were introduced into
80 isease with three different stages: neonatal intrahepatic cholestasis (NICCD), a relatively mild adap
81                                   In sepsis, intrahepatic cholestasis occurs frequently, suggesting i
82                                              Intrahepatic cholestasis of pregnancy (ICP) affects 1/14
83 nagement and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatmen
84                                              Intrahepatic cholestasis of pregnancy (ICP) can predispo
85                                              Intrahepatic cholestasis of pregnancy (ICP) causes incre
86                                              Intrahepatic cholestasis of pregnancy (ICP) is a liver d
87                                              Intrahepatic cholestasis of pregnancy (ICP) is a liver d
88                                              Intrahepatic cholestasis of pregnancy (ICP) is a pregnan
89                                              Intrahepatic cholestasis of pregnancy (ICP) is a pregnan
90                                              Intrahepatic cholestasis of pregnancy (ICP) is a pregnan
91                                              Intrahepatic cholestasis of pregnancy (ICP) is associate
92                                              Intrahepatic cholestasis of pregnancy (ICP) is the most
93                                              Intrahepatic cholestasis of pregnancy (ICP) is the most
94                                              Intrahepatic cholestasis of pregnancy (ICP) is the most
95                                              Intrahepatic cholestasis of pregnancy (ICP) is the most
96  pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to be
97                                   Women with intrahepatic cholestasis of pregnancy (ICP), a disorder
98                                              Intrahepatic cholestasis of pregnancy (ICP), marked by e
99 tch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP).
100 s, and outcomes of babies born to women with intrahepatic cholestasis of pregnancy (ICP).
101  volunteers with gallstone disease (n = 31), intrahepatic cholestasis of pregnancy (ICP, n = 16), cho
102  cirrhosis was independently associated with intrahepatic cholestasis of pregnancy (relative risk [RR
103 severity of acute and chronic complications, intrahepatic cholestasis of pregnancy [ICP]) were simila
104 n has been implicated in the pathogenesis of intrahepatic cholestasis of pregnancy and may induce cho
105 isk of stillbirth is increased in women with intrahepatic cholestasis of pregnancy and singleton preg
106     Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritu
107 e for the aggregate data meta-analysis (5557 intrahepatic cholestasis of pregnancy cases and 165 136
108    Stillbirth occurred in 45 (0.83%) of 4936 intrahepatic cholestasis of pregnancy cases and 519 (0.3
109  was three (0.13%; 95% CI 0.02-0.38) of 2310 intrahepatic cholestasis of pregnancy cases in women wit
110 165 136 controls), and 27 provided IPD (5269 intrahepatic cholestasis of pregnancy cases).
111                      Because most women with intrahepatic cholestasis of pregnancy have bile acids be
112                   Hyperemesis gravidarum and intrahepatic cholestasis of pregnancy have no relationsh
113 to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with incr
114                                              Intrahepatic cholestasis of pregnancy is associated with
115    BEST PRACTICE ADVICE 10: The diagnosis of intrahepatic cholestasis of pregnancy is based on a seru
116                                              Intrahepatic cholestasis of pregnancy is pruritus and el
117                          Recurrent prolonged intrahepatic cholestasis of pregnancy was followed by pe
118  reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile ac
119 to pregnancy include hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, acute fatty liver
120 hepatic cholestasis type 1, biliary atresia, intrahepatic cholestasis of pregnancy, and primary bilia
121 gement of acute fatty liver of pregnancy and intrahepatic cholestasis of pregnancy, and their impact
122                                              Intrahepatic cholestasis of pregnancy, characterised by
123 y cirrhosis, primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, or hereditary ped
124  cirrhosis; and important clinical trials in intrahepatic cholestasis of pregnancy, primary biliary c
125 ngitis, and clinical trials of therapies for intrahepatic cholestasis of pregnancy, primary biliary c
126                      We recruited women with intrahepatic cholestasis of pregnancy, who were aged 18
127 ces adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy.
128 naling in pathogenesis and how it relates to intrahepatic cholestasis of pregnancy.
129 characterizing the metabolic associations of intrahepatic cholestasis of pregnancy.
130 ow-phospholipid-associated cholelithiasis or intrahepatic cholestasis of pregnancy.
131 uce adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy.
132  to treat children with Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille syndrome (A
133                         Progressive familial intrahepatic cholestasis (PFIC) is characterized by prur
134 PFIC II is a subtype of progressive familial intrahepatic cholestasis (PFIC) that is associated with
135  of autosomal recessive progressive familial intrahepatic cholestasis (PFIC) with raised serum gamma-
136 ified in a patient with progressive familial intrahepatic cholestasis (PFIC), is located close to the
137 encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)--or "neonatal hepatitis"
138 c cholestasis; BRIC) to progressive familial intrahepatic cholestasis (PFIC).
139 c liver disease akin to progressive familial intrahepatic cholestasis (PFIC).
140 yD and ByS (subtypes of progressive familial intrahepatic cholestasis [PFIC]) represent one clinicopa
141 uestration, viral hepatitis, and sickle cell intrahepatic cholestasis (SCIC).
142 ing bile salt transport problems in familial intrahepatic cholestasis syndromes were some of the majo
143   PEX2 mutant liver has severe but transient intrahepatic cholestasis that abates in the early postna
144 ere biliary atresia and progressive familial intrahepatic cholestasis (three patients each).
145  cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), were previously
146 ille syndrome), ATP8B1 (progressive familial intrahepatic cholestasis type 1 [PFIC1]), ABCB11 (PFIC2)
147  ileum of children with progressive familial intrahepatic cholestasis type 1 and in Caco-2 cells.
148  cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown.
149 nto the pathogenesis of progressive familial intrahepatic cholestasis type 1, biliary atresia, intrah
150 cted in 3 patients with progressive familial intrahepatic cholestasis type 1.
151                         Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a result of m
152                         Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a severe hepa
153 atic liver diseases such as primary familial intrahepatic cholestasis type 2 (PFIC2).
154 f clinical evolution in progressive familial intrahepatic cholestasis type 2 patients and how they re
155 p (BSEP) deficiency, or progressive familial intrahepatic cholestasis type 2, is a genetic liver dise
156 rea cycle disorders and progressive familial intrahepatic cholestasis type 2.
157 cluded 22 children with progressive familial intrahepatic cholestasis type 2.
158 ously in a patient with progressive familial intrahepatic cholestasis type 3 (PFIC-3).
159 ary diseases, including progressive familial intrahepatic cholestasis type 3 (PFIC3), a rare disease
160                         Progressive familial intrahepatic cholestasis type 3 (PFIC3), an inherited ju
161 e the tumorigenicity of progressive familial intrahepatic cholestasis type 3 and, with further refine
162                         Progressive familial intrahepatic cholestasis type 3 is caused by biallelic v
163 ariations identified in progressive familial intrahepatic cholestasis type 3 patients.
164 el therapeutic tool for progressive familial intrahepatic cholestasis type 3 patients.
165 kout mouse, a model for progressive familial intrahepatic cholestasis type 3.
166 CB4 gene sequence cause progressive familial intrahepatic cholestasis type 3.
167  to the pathogenesis of progressive familial intrahepatic cholestasis type II (PFIC II).
168  deficiencies result in progressive familial intrahepatic cholestasis type III.
169 tations in ATP8B1 cause progressive familial intrahepatic cholestasis type1 in humans, which is chara
170              A total of 278 cases of genetic intrahepatic cholestasis were studied, with TJP2 deficie
171 a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the di
172       We describe a patient with sickle cell intrahepatic cholestasis who underwent liver transplanta
173 tations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including prurit

 
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