ライフサイエンスコーパス: intramembrane

1 MO-IgGs to AQP4 in separate tetramers versus intramembrane aggregates (orthogonal arrays of particles

2 ds, including the terminal most hydrophobic, intramembrane anchoring sequence.

3 ug.L(-1) concentration of c-SWNTs, was 4.74% intramembrane and 6.3% intermembrane.

4 These numbers suggest that intramembrane and intracellular proteins in isolated oxy

5 STRA6 has one intramembrane and nine transmembrane helices in an intri

6 gh nonprocessive cleavages by intracellular, intramembrane, and extracellular proteases) can be benef

7 nonproteolytic functions for members of the intramembrane aspartyl protease family.

8 ing metalloproteases and gamma-secretase, an intramembrane aspartyl protease involved in Alzheimer's

9 gamma-Secretase is an intramembrane aspartyl protease that cleaves the amyloid

10 rticle, we investigate the role of SPPL3, an intramembrane aspartyl protease, in murine NK cell biolo

11 The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group

12 of NK cell maturation and expand the role of intramembrane aspartyl proteases in innate immunity.

13 tide peptidase (SPP) and gamma-secretase are intramembrane aspartyl proteases that bear similar activ

14 In addition to their established intramembrane binding sites, both proteins were thus fou

15 ual and ubiquitous aspartyl protease with an intramembrane catalytic site that cleaves many type-I in

16 tructure, surrounding a large, water-filled, intramembrane chamber, capped by a zinc metalloprotease

17 Thus, the PAT complex is an intramembrane chaperone that protects TMDs during assemb

18 s of membrane proteins; however, ER-resident intramembrane chaperones are poorly defined.

19 n (TMD) helices and residues involved in the intramembrane charge displacement remain unknown.

20 However, intramembrane charge movement was only reduced in fibers

21 e amplitude or the voltage-dependence of the intramembrane charge movement.

22 alysis of CD81 indicates that it contains an intramembrane cholesterol-binding pocket and that intera

23 Ectodomain cleavage is followed by intramembrane cleavage (S2) to generate a soluble intrac

24 nhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic

25 Intramembrane cleavage by catalytically active SPP provi

26 in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to relea

27 L3 serves as a new substrate for consecutive intramembrane cleavage by SPPL2a/b.

28 sser extent, SPPL2b are responsible for this intramembrane cleavage event.

29 and a specific requirement for SPP-mediated intramembrane cleavage in protein turnover.

30 Intramembrane cleavage of Bri2 is triggered by an initia

31 Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-ne

32 By investigating the kinetics of intramembrane cleavage of the Alzheimer's disease-associ

33 gral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor pro

34 Intramembrane cleavage of the beta-amyloid precursor pro

35 c molecule in Alzheimer disease, through the intramembrane cleavage of the beta-carboxyl-terminal fra

36 This proteolysis was a prerequisite for the intramembrane cleavage of the C-terminal fragments of PT

37 Intramembrane cleavage of transmembrane proteins is a fu

38 of a GXXXG dimerization motif influences the intramembrane cleavage only to a minor extent.

39 Intramembrane cleavage sites are accessible and not part

40 teins via ectodomain shedding followed by an intramembrane cleavage.

41 ry structure of the Bri2 TMD and thereby its intramembrane cleavage.

42 main, followed by a gamma-secretase-mediated intramembrane cleavage.

43 gamma-Secretase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that c

44 The signal peptide peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in rel

45 ses that carry out these cleavages are named intramembrane cleaving proteases (I-CLips).

46 irst time the identification of five metallo-intramembrane cleaving proteases in Anabaena variabilis.

47 Peptide Peptidases (SPP) are members of the Intramembrane Cleaving Proteases, which are involved in

48 ne proteolysis, specifically cleavage by the intramembrane-cleaving aspartyl protease signal peptide

49 subunit of the gamma-secretase complex, are intramembrane-cleaving aspartyl proteases of the GxGD ty

50 SPPL) proteases are members of the family of intramembrane-cleaving aspartyl proteases of the GXGD-ty

51 ost proteases: signal peptidase (SP) and the intramembrane-cleaving protease signal peptide peptidase

52 gamma-Secretase is an intramembrane-cleaving protease that processes many type

53 gamma-Secretase is an intramembrane-cleaving protease that produces amyloid-be

54 Gamma-secretase is a multiprotein, intramembrane-cleaving protease with a growing list of p

55 the domain I was further processed by a host intramembrane-cleaving protease, signal peptide peptidas

56 One of the intramembrane-cleaving proteases (I-CLiPs), gamma-secret

57 the remaining stubs are further processed by intramembrane-cleaving proteases (I-CLiPs).

58 give deeper insights into the mechanisms of intramembrane-cleaving proteases and the impact on viral

59 sheds light on potential mechanisms by which intramembrane-cleaving proteases cleave their substrates

60 gamma-Secretases are a family of intramembrane-cleaving proteases involved in various sig

61 tark contrast to rhomboid--another family of intramembrane-cleaving proteases.

62 homboid family, which belong to the class of intramembrane-cleaving serine proteases.

63 The main intramembrane contact site is formed by a complex electr

64 within mitochondria to supply the Cu(A) and intramembrane Cu(B) sites of cytochrome oxidase, within

65 nal quality control scrutiny but displays an intramembrane defect.

66 Hrd1-dependent degradation of proteins with intramembrane degrons was largely unperturbed by ER stre

67 orthologue) has the capacity for recognizing intramembrane degrons, expanding its spectrum of substra

68 mera with the glycophorin A TM domain causes intramembrane dimerization and consequently operon activ

69 Consequently, the strength of the intramembrane dimerization of the glycophorin A domain c

70 saturating cytokine occupancy, we determined intramembrane dissociation constants (K(d,2D)) of 180 an

71 in the CD225 domain, consisting of the first intramembrane domain (intramembrane domain 1 [IM1]) and

72 onsisting of the first intramembrane domain (intramembrane domain 1 [IM1]) and a conserved intracellu

73 highlight the functional significance of the intramembrane domain and the CSD for defined caveolin-in

74 ar vesicles (GUVs) leads to the formation of intramembrane domains.

75 We conclude that RH421 detects intramembrane electric field strength changes arising fr

76 However, this intramembrane enzyme becomes insensitive to warfarin inh

77 Intramembrane enzymes are often difficult for biochemica

78 al biology methods are ideal for stabilizing intramembrane enzymes.

79 Norfluoxetine binds within intramembrane fenestrations found in only one of these t

80 t gains access to the channel cavity through intramembrane fenestrations.

81 asure cholesterol intermembrane exchange and intramembrane flipping rates, in situ, without recourse

82 ported by previous studies, particularly for intramembrane flipping where our measured rates are seve

83 This effect is attributed to an amplified intramembrane friction.

84 e chain at a principal interface between the intramembrane-gated pore and the cytoplasmic gating ring

85 Analysis of intramembrane gating charge movements and ionic tail cur

86 The authors examined the significance of an intramembrane glutamic acid conserved in all P/rds prote

87 Surprisingly, only one of the four conserved intramembrane glycine residues significantly affects the

88 leads into a lumenally-sealed, lipid-exposed intramembrane groove large enough to accommodate a singl

89 A gap between the cytosolic vestibule and intramembrane groove provides a potential path for subst

90 activate the ErbB2 receptors, suggesting an intramembrane-growth factor function for MUC4.

91 s affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, c

92 PG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER

93 tary spastic paraplegia encode proteins with intramembrane hairpin loops that contribute to the curva

94 drophobic segments and are proposed to adopt intramembrane helical hairpins that stabilize membrane c

95 r is approximately 13 degrees , showing that intramembrane helix-helix association forces dominate ov

96 rved when ClC-7 was truncated after the last intramembrane helix.

97 Finally, two highly conserved intramembrane histidines (His-171 and His-197) within Ap

98 -terminal LPS transport slide, a hydrophobic intramembrane hole and the hydrophilic channel of the ba

99 were obtained at the N-terminal domain, the intramembrane hole, the lumenal gate, the lumen of LptD

100 ogen bonding is typically weakened in water, intramembrane hydrogen bonding between native lipids has

101 eved to drive these changes by weakening the intramembrane lateral PSII-LHCII and LHCII-LHCII interac

102 netic data that support a prominent role for intramembrane ligand entry in both receptors, and sugges

103 Intramembrane lipid transport reactions utilize P-type A

104 tracellular to the selectivity filter are an intramembrane loop and an arginine residue, both highly

105 An intramembrane loop is found immediately after the select

106 ransmembrane regions and the less structured intramembrane loops undergo restricted submicrosecond ti

107 predictive mechanistic understanding of the intramembrane mechanisms by which influenza hemagglutini

108 Bacillus subtilis SpoIVFB is an intramembrane metalloprotease that cleaves Pro-sigma(K)

109 Intramembrane metalloproteases (IMMPs) are conserved fro

110 Intramembrane metalloproteases (IMMPs) control critical

111 of one large and diverse family of putative intramembrane metalloproteases are widely distributed in

112 Site-2 proteases (S2Ps) are intramembrane metalloproteases that cleave transmembrane

113 B are somewhat different from those of other intramembrane metalloproteases, perhaps reflecting diffe

114 odomain shedding at the juxtamembrane and/or intramembrane motif and to show that this is independent

115 mutagenesis demonstrated that similar polar intramembrane motifs are also important for assembly of

116 Electrogenic signals mediated by intramembrane movement of hydrophobic ions, such as hexy

117 helix (TM4) about a central hinge seals the intramembrane opening, preventing lipid block of the cav

118 n but not at lysines in the oligomerization, intramembrane, or C-terminal domains.

119 ing effects on vertical stacking and lateral intramembrane organization.

120 appear inadequate to account for the size of intramembrane particles (IMPs) expressed in the OHC memb

121 the smallest and had the most densely packed intramembrane particles (IMPs), whereas the PF-CwC synap

122 oscopy revealed disruption of the strands of intramembrane particles connecting bicellular and tricel

123 s Type V, Type VI, PVC and a novel PrsW-like intramembrane peptidase-dependent mechanism.

124 s converge at the inner leaflet to create an intramembrane pocket with additional electron density co

125 The intramembrane processes regulate the establishment and e

126 s Abeta40, Abeta42, and AICD production, nor intramembrane processing of Notch and N-cadherin.

127 content of the transmembrane domain nor its intramembrane processing.

128 1 (Ras and a-factor converting enzyme 1), an intramembrane protease (IMP) of the endoplasmic reticulu

129 signal transduction system in which a single intramembrane protease cleaves three anti-sigma factor s

130 gamma-secretase is an intramembrane protease complex that catalyzes the proteo

131 We show that the RseP intramembrane protease degrades weakly stable H-segments

132 de peptidase-like 2a (SPPL2a) is an aspartyl intramembrane protease essential for degradation of the

133 d range of papillomavirus types requires the intramembrane protease gamma secretase.

134 The intramembrane protease gamma-secretase is a key player i

135 Dysfunction of the intramembrane protease gamma-secretase is thought to cau

136 f the amyloid precursor protein (C99) by the intramembrane protease gamma-secretase.

137 Here, using the intramembrane protease GlpG of Escherichia coli as a mod

138 This intramembrane protease plays a major role in converting

139 eric core complex that includes the aspartyl intramembrane protease presenilin (PS).

140 urther processing, which requires the site 2 intramembrane protease RasP.

141 al fragment (NTF) of CD74 is mediated by the intramembrane protease signal peptide peptidase-like (SP

142 at mice with an inactivating mutation in the intramembrane protease signal peptide peptidase-like 2A

143 The mutation was mapped to the intramembrane protease signal peptide peptidase-like 2a

144 teases, including cathepsin S (CatS) and the intramembrane protease signal peptide peptidase-like 2a

145 on, which relieves inhibition of SpoIVFB, an intramembrane protease that cleaves Pro-sigma(K) , relea

146 Another intramembrane protease, signal peptide peptidase, predom

147 We investigate the folding of GlpG, an intramembrane protease, using perfectly funneled structu

148 vement of signal peptide peptidase (SPP), an intramembrane protease, which acts on substrates that ha

149 SP(UL40) by a signal peptide peptidase-type intramembrane protease.

150 Intramembrane proteases (IPs) cleave membrane-associated

151 sms and is carried out by different types of intramembrane proteases (IPs), including a large family

152 ins via the degradation of MucA by activated intramembrane proteases AlgW and/or MucP.

153 alized single molecules of multiple rhomboid intramembrane proteases and unrelated proteins in living

154 and the significance of rhomboids and other intramembrane proteases are discussed.

155 Intramembrane proteases are important enzymes in biology

156 rol processes, but little is known about how intramembrane proteases are regulated.

157 Intramembrane proteases are responsible for a number of

158 Rhomboid intramembrane proteases are the enzymes that release act

159 ill facilitate the characterization of other intramembrane proteases as well as non-protease membrane

160 Our work demonstrates that intramembrane proteases can be sequence specific and tha

161 Intramembrane proteases catalyse the signal-generating s

162 Members of the widespread rhomboid family of intramembrane proteases cleave transmembrane domain (TMD

163 To address this limitation, here we focus on intramembrane proteases containing domains known to exer

164 n though a number of structures of different intramembrane proteases have been solved recently, funda

165 Intramembrane proteases hydrolyze peptide bonds within t

166 Rhomboid intramembrane proteases occur throughout the kingdoms of

167 Intramembrane proteases regulate diverse processes by cl

168 Intramembrane proteases signal by releasing proteins fro

169 ich we identified as novel substrates of the intramembrane proteases signal peptide peptidase-like 2a

170 Rhomboid proteases are intramembrane proteases that play key roles in various d

171 Rhomboids are intramembrane proteases that use a catalytic dyad of ser

172 e most widespread and largest superfamily of intramembrane proteases, are known to play key roles in

173 Intramembrane proteases, which control many medically im

174 omboids, belongs to a unique class of serine intramembrane proteases; little is known about its funct

175 , we propose that IFITM3 is predominantly an intramembrane protein where both the N and C termini fac

176 Presenilins are ubiquitous, intramembrane proteins that function in Alzheimer's dise

177 he ERC and link ERC trafficking to regulated intramembrane proteolysis (RIP) and expression of megali

178 s the final step in the process of regulated intramembrane proteolysis (RIP) and has a significant im

179 certain transmembrane proteins by regulated intramembrane proteolysis (RIP) and regulated alternativ

180 on in B. subtilis is controlled by regulated intramembrane proteolysis (RIP) and requires the site 2

181 ToxR undergoes regulated intramembrane proteolysis (RIP) during late stationary p

182 Recently, regulated intramembrane proteolysis (RIP) has been recognized as a

183 Regulated intramembrane proteolysis (RIP) involves cleavage of a t

184 Regulated intramembrane proteolysis (RIP) involves cleavage of a t

185 Regulated intramembrane proteolysis (RIP) is a conserved mechanism

186 Regulated intramembrane proteolysis (RIP) is a mechanism of transm

187 Here, we show that FGF1 induces regulated intramembrane proteolysis (RIP) of FGFR3.

188 ility, but impaired functioning in regulated intramembrane proteolysis (RIP) of OASIS, ATF6 and SREBP

189 mulate Notch receptors by inducing regulated intramembrane proteolysis (RIP) to produce a transcripti

190 -step proteolytic pathway known as regulated intramembrane proteolysis (RIP), thereby inactivating th

191 otein expression, possibly through regulated intramembrane proteolysis (RIP), to increase intracellul

192 se proteolytic events are known as regulated intramembrane proteolysis (RIP).

193 tress signals release sigma(22) by regulated intramembrane proteolysis (RIP).

194 ecretase complex, a process called regulated intramembrane proteolysis (RIP).

195 ficking of ATF6 from the ER to the Golgi for intramembrane proteolysis and activation of ATF6.

196 n intracellular domain in p75(NTR)-regulated intramembrane proteolysis and apoptosis.

197 yroid signaling pathway that is regulated by intramembrane proteolysis and disrupted in cancer.

198 to the growing list of proteins that undergo intramembrane proteolysis and may shed light on the regu

199 main of an engineered receptor is cleaved by intramembrane proteolysis and releases a protein fragmen

200 o-Golgi trafficking and diminished regulated intramembrane proteolysis and transcriptional activity;

201 mbrane topology for the astrotactins, reveal intramembrane proteolysis as a feature of astrotactin ma

202 e present results validate S2P and regulated intramembrane proteolysis as novel therapeutic targets f

203 The intramembrane proteolysis by gamma-secretase of the amyl

204 vation of Notch receptor is executed through intramembrane proteolysis by gamma-secretase, which is a

205 elope protein (FVenv) as a new substrate for intramembrane proteolysis by human SPPL3 and SPPL2a/b.

206 Regulated intramembrane proteolysis by members of the site-2 prote

207 at Bri2 (itm2b) is a substrate for regulated intramembrane proteolysis by SPPL2a and SPPL2b.

208 This identifies intramembrane proteolysis by SPPL2a/b as a novel atherop

209 Subsequent intramembrane proteolysis catalysed by the gamma-secreta

210 little PAM-1/H3A was subjected to regulated intramembrane proteolysis followed by release of a small

211 evelopment through gamma-secretase-dependent intramembrane proteolysis followed by transcription of t

212 Intramembrane proteolysis governs many cellular control

213 Intramembrane proteolysis has emerged as a key mechanism

214 was cleaved to nuclear CREB3L2 by regulated intramembrane proteolysis in normal thyroid cells that e

215 Regulated intramembrane proteolysis is a central cellular process

216 Intramembrane proteolysis is a core regulatory mechanism

217 Regulated intramembrane proteolysis is a widely accepted concept d

218 Regulated intramembrane proteolysis is initiated by shedding, and

219 Astn2 intramembrane proteolysis is insensitive to replacement

220 proteins via ectodomain shedding followed by intramembrane proteolysis is involved in a wide variety

221 Thus, intramembrane proteolysis is naturally diffusion-limited

222 Intramembrane proteolysis is thought to require local un

223 Rhomboid intramembrane proteolysis is thus a slow, kinetically co

224 atability class II complex (MHCII) undergoes intramembrane proteolysis mediated by SPPL2a.

225 terior pharynx-defective 1 that mediates the intramembrane proteolysis of a large number of proteins

226 gamma-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (

227 sease-linked gene presenilin is required for intramembrane proteolysis of amyloid-beta precursor prot

228 strate of Sppl2a and suggests that regulated intramembrane proteolysis of CD74 by Sppl2a contributes

229 whether cerebral ischemia induces regulated intramembrane proteolysis of LRP and whether this proces

230 cate that gamma-secretase-mediated regulated intramembrane proteolysis of LRP results in cell death u

231 It mediates the intramembrane proteolysis of many type 1 proteins, plays

232 Regulated intramembrane proteolysis of membrane-embedded substrate

233 reveals its functional role in the regulated intramembrane proteolysis of p75 catalyzed by the gamma-

234 Thus, hypoxia-induced intramembrane proteolysis of p75(NTR) constitutes an api

235 e signal transduction that functions through intramembrane proteolysis of substrates.

236 ication within the host cell is regulated by intramembrane proteolysis of TgAMA1.

237 on of Insig-2a in hepatocytes led to reduced intramembrane proteolysis of the newly synthesized SREBP

238 eath via gamma-secretase-dependent regulated intramembrane proteolysis of the p75 neurotrophin recept

239 Subsequent gamma-secretase-mediated intramembrane proteolysis of the remaining membrane-teth

240 tional changes in the CCSSD enable regulated intramembrane proteolysis of the sigma regulator, ultima

241 Intramembrane proteolysis of transmembrane substrates by

242 -secretase protease and associated regulated intramembrane proteolysis play an important role in cont

243 ithin presenilin is necessary to mediate the intramembrane proteolysis reaction.

244 e processes through a mechanism of regulated intramembrane proteolysis that leads to cleavage of Trop

245 e cancer proliferation by blocking regulated intramembrane proteolysis through suppression of S2P cle

246 hetic genetic system based on ligand-induced intramembrane proteolysis to monitor cell-cell contacts

247 es from the ER to Golgi to undergo regulated intramembrane proteolysis to release a cytosolic domain

248 ol of Transcription) based on ligand-induced intramembrane proteolysis to reveal monosynaptic connect

249 showed that beta1 subunits undergo regulated intramembrane proteolysis via the activity of beta-secre

250 Regulated intramembrane proteolysis, a highly conserved process em

251 ces the amyloid beta-peptide (Abeta) through intramembrane proteolysis, and >100 presenilin mutations

252 ptor, or the transferrin receptor eliminates intramembrane proteolysis, as does leucine substitution

253 e active gamma-secretase complex, poised for intramembrane proteolysis, by cryo-electron microscopy.

254 ve been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding

255 ain that modulates gamma-secretase-dependent intramembrane proteolysis, particularly in differentiati

256 ce that Rgma promotes Neo1 glycosylation and intramembrane proteolysis, resulting in the production o

257 To determine whether intramembrane proteolysis, specifically cleavage by the

258 in shorter than 60 amino acids for efficient intramembrane proteolysis, SPPL3 cleaves mutant FVenv la

259 e, and reduced the extent of beta1-regulated intramembrane proteolysis, suggesting that the plasma me

260 commonly used for the enzymatic analyses of intramembrane proteolysis, the cleavage rate strongly de

261 y shown to undergo gamma-secretase regulated intramembrane proteolysis, this study examines the effec

262 To elucidate the function of TgAMA1 intramembrane proteolysis, we used a heterologous cleava

263 key step in Notch receptor activation is its intramembrane proteolysis, which releases an intracellul

264 We combined the previously described Notch1 intramembrane proteolysis-Cre (Nip1::Cre) allele with a

265 of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre(LO), that

266 ion risk factor TMEM106B undergoes regulated intramembrane proteolysis.

267 olytic processing by ectodomain shedding and intramembrane proteolysis.

268 rane-bound proteases that catalyze regulated intramembrane proteolysis.

269 cts galactolipid biosynthesis likely through intramembrane proteolysis.

270 a carboxyl-terminal fragment consistent with intramembrane proteolysis.

271 us membrane-bound proteins undergo regulated intramembrane proteolysis.

272 of the cognate extracellular ligand induces intramembrane proteolysis.

273 which promotes proliferation after regulated intramembrane proteolysis.

274 ity, which leads to suppression of regulated intramembrane proteolysis.

275 of proteins are activated by ligand induced intramembrane proteolysis.

276 These findings also suggest that ionizable intramembrane residues may serve regulatory roles for te

277 l in which the Hrd1p membrane domain employs intramembrane residues to evaluate substrate misfolding,

278 The mitochondrial intramembrane rhomboid protease PARL has been implicated

279 cessing pathway of APP through the mammalian intramembrane rhomboid protease RHBDL4.

280 gamma-secretase mediates proteolysis at the intramembrane S3 site.

281 cell membrane and bound to and inhibited the intramembrane sensor histidine kinase SGO_1180, thus pre

282 ss regulation domain located proximal to the intramembrane sequence within the cytoplasmic domain of

283 e proteins, including the canonical rhomboid intramembrane serine proteases and also others that have

284 rotein is a member of the rhomboid family of intramembrane serine proteases and is required for the p

285 Rhomboids are intramembrane serine proteases conserved in all kingdoms

286 ed subfamily of proteins related to rhomboid intramembrane serine proteases that lack key catalytic r

287 The rhomboids are a well-conserved family of intramembrane serine proteases, which are unrelated to t

288 homboid proteases are evolutionary conserved intramembrane serine proteases.

289 sing domain suggested that PilS may sense an intramembrane signal, possibly PilA.

290 eview highlights the molecular aspects of an intramembrane signaling mechanism in which a signal is p

291 h a substrate that we show is cleaved at two intramembrane sites within the previously defined Spitz

292 Recent work, however, supports an intramembrane topology for the helices with cytosolic or

293 erstanding of the trafficking, activity, and intramembrane topology of this important IFN-induced eff

294 steine at the mIFITM1 C terminus supports an intramembrane topology with mechanistic implications.

295 on in vivo, indicating the essential role of intramembrane trimerization in receptor activity.

296 Biosynthesis of ubiquinones requires the intramembrane UbiA enzyme, an archetypal member of a sup

297 In general, potassium channels have an intramembrane vestibule with a selectivity filter situat

298 Furthermore, we find the interplay between intramembrane viscous flow and the rate of induced curva

299 The intramembrane vitamin K epoxide reductase (VKOR) support

300 the higher polarity, and consequently higher intramembrane water concentration, at the protein-lipid