ライフサイエンスコーパス: intramyocellular

1 scle insulin resistance may be aggravated by intramyocellular accumulation of fatty acid-derived meta

2 Intramyocellular accumulation of lipids directly attenua

3 er down-regulation, ceramide diminished both intramyocellular amino acid abundance and the phosphoryl

4 e children and adolescents with prediabetes, intramyocellular and intra-abdominal lipid accumulation

5 se-induced fat oxidation, leading to reduced intramyocellular and liver triglyceride content.

6 Intramyocellular and visceral lipid contents were invers

7 de that obesity is associated with increased intramyocellular ceramide content.

8 We report that both the intramyocellular circadian clock and diurnal variations

9 Intramyocellular content of lipid (IMCL) and fiber-type

10 not attenuate PA-induced increases in total intramyocellular diacylglycerol and ceramide.

11 2 diabetes patients have higher unsaturated intramyocellular fat and blunted palmitate and linoleate

12 nsulin resistance in muscle by conversion of intramyocellular fat into thermal energy.

13 We show that athletes have higher intramyocellular fat saturation with very high palmitate

14 However, exercise increases both intramyocellular fat stores and insulin sensitivity, a p

15 The amount of intrahepatic fat and intramyocellular fat was measured with (1)H-magnetic res

16 ffspring is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because

17 diabetes is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because

18 ugh increased contributions of the saturated intramyocellular fatty acid pools.

19 There were no differences between groups in intramyocellular glucose, as measured by biochemical ass

20 Intramyocellular (IMCL) triglyceride stores are an acces

21 Intramyocellular levels of lipid intermediates, includin

22 skeletal muscle as a predisposing factor for intramyocellular lipid (IMCL) accumulation and muscle in

23 To examine the role of intramyocellular lipid (IMCL) accumulation as well as ci

24 Intramyocellular lipid (IMCL) accumulation is postulated

25 Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are

26 scle fibers would exhibit similar changes in intramyocellular lipid (IMCL) and extramyocellular lipid

27 resistance correlates more tightly with the intramyocellular lipid (IMCL) concentration than with an

28 This study compared soleus intramyocellular lipid (IMCL) concentrations after consu

29 Intrahepatic lipid (IHL) and intramyocellular lipid (IMCL) concentrations were determ

30 onal studies have shown correlations between intramyocellular lipid (IMCL) content and muscle strengt

31 mass, fiber type, cross-sectional area, and intramyocellular lipid (IMCL) content.

32 ABSTRACT: Intramyocellular lipid (IMCL) hampers insulin sensitivit

33 Excessive intramyocellular lipid (IMCL) storage exceeds intracellu

34 ydrate and fat as precursors of glycogen and intramyocellular lipid (IMCL) synthesis.

35 The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxid

36 he expression of BMPs, inflammation, HO, and intramyocellular lipid accumulation in both skeletal and

37 itivity, mitochondrial function, hepatic and intramyocellular lipid accumulation, cardiac energy stat

38 function, which predisposes IR offspring to intramyocellular lipid accumulation, which in turn activ

39 rate that burn injury results in a localized intramyocellular lipid accumulation, which in turn is ac

40 ed by etomoxir, in the presence of increased intramyocellular lipid accumulation.

41 In addition, intramyocellular lipid and HTG contents were measured by

42 ectroscopy studies were performed to measure intramyocellular lipid and intrahepatic triglyceride con

43 Increased intramyocellular lipid concentrations are thought to pla

44 s with impaired glucose tolerance had higher intramyocellular lipid content (3.04 [0.43] vs 1.99 [0.1

45 Intramyocellular lipid content (IMCL) can be elevated in

46 Intramyocellular lipid content (IMCL) is elevated in ins

47 increased intrahepatic lipid content (IHL), intramyocellular lipid content (IMCL), and low circulati

48 me (P = .9), myocardial TG content (P = .9), intramyocellular lipid content (P = .3), or cardiac func

49 increase of approximately 80 percent in the intramyocellular lipid content (P=0.005).

50 es and is strongly associated with increased intramyocellular lipid content and inflammation.

51 ed with an approximately 60% increase in the intramyocellular lipid content as assessed by H magnetic

52 This increase in intramyocellular lipid content was most likely attributa

53 iated with increases in hepatic (HTG) and/or intramyocellular lipid content, little is known about th

54 tion this is avoidable, given that causes of intramyocellular lipid deposition are predominantly life

55 Persistent elevation of intramyocellular lipid intermediates, likely resulting f

56 Abdominal adipose tissue volume and intramyocellular lipid levels were comparable between 8-

57 scriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be

58 es were to examine saturated and unsaturated intramyocellular lipid pool turnover.

59 conclude that insulin-resistant, maladapted intramyocellular lipid storage and turnover in patients

60 KEY POINTS: Intramyocellular lipid storage is negatively associated

61 The primary outcomes were to assess intramyocellular lipid storage of the vastus lateralis i

62 Intramyocellular lipid was assessed by proton nuclear ma

63 esonance imaging, and intrahepatic lipid and intramyocellular lipid were assessed by proton magnetic

64 magnetic resonance imaging and muscle lipid (intramyocellular lipid) by proton magnetic resonance spe

65 Recent studies have demonstrated increased intramyocellular lipid, decreased mitochondrial ATP synt

66 A levels of regulatory components related to intramyocellular lipid, glucose metabolism and fiber siz

67 ance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG)

68 taneous (SAT) adipose tissue, liver fat, and intramyocellular lipids (IMCL) in 101 Chinese, 82 Malays

69 one marrow fat content, of soleus muscle for intramyocellular lipids (IMCL), and liver for intrahepat

70 metabolism, resulting in increased levels of intramyocellular lipids (IMCLs) and lipid intermediates,

71 lin resistant, demonstrated higher levels of intramyocellular lipids (IMCLs), and expressed approxima

72 ent understanding of the effects of elevated intramyocellular lipids on insulin signaling and how the

73 ut exercise on skeletal muscle mitochondria, intramyocellular lipids, and insulin sensitivity index (

74 s between BMI and unsaturated fatty acids in intramyocellular lipids, and methylene groups in extramy

75 fetuin-A, body composition, pancreatic fat, intramyocellular lipids, fecal SCFAs, blood pressure, or

76 pecific skeletal muscle proteins involved in intramyocellular lipids, mitochondrial oxidative capacit

77 by a high oxidative capacity, have elevated intramyocellular lipids, yet are highly insulin sensitiv

78 ulin in adipocytes may be inhibited, whereas intramyocellular lipogenesis via the MAP kinase pathway

79 atty acids (NEFA) are trafficked directly to intramyocellular long-chain acylcarnitines (imLCAC) rath

80 Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) hav

81 P-MRS to measure changes in cytosolic [ADP] (intramyocellular marker of oxidative metabolism), oxidat

82 ed circulating fatty acid levels and reduced intramyocellular or liver triglyceride content.

83 balance (NBphe) was the primary outcome and intramyocellular signals were assessed.

84 PLIN2 overexpression in vitro increased intramyocellular TAG storage paralleled with improved in

85 n of FIT2 (CKF2) had significantly increased intramyocellular triacylglyceride and complete protectio

86 Intramyocellular triacylglycerol (IMTG) accumulation is

87 reased energy metabolism and accumulate more intramyocellular triacylglycerol but have normal glucose

88 Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations are asso

89 In muscle, diacylglycerol (DAG) and intramyocellular triacylglycerol were increased.

90 To this end, we have determined intramyocellular triglyceride (IMCL-TG) content with pro

91 milar amount of readily accessible energy as intramyocellular triglyceride (imTG).

92 Hepatic, myocardial, and intramyocellular triglyceride (TG) content relative to w

93 The athlete's paradox states that intramyocellular triglyceride accumulation associates wi

94 bolic response in diabetes, characterized by intramyocellular triglyceride accumulation.

95 Mitochondrial respiration and intramyocellular triglyceride, sphingolipid, and diacylg

96 Intramyocellular triglycerides (imcTG) of skeletal muscl

97 tant muscle and that the association between intramyocellular triglycerides (IMTG) and insulin resist

98 ylcarnitines (imLCAC) rather than transiting intramyocellular triglycerides (imTG) on the way to rest

99 Chronic exercise and obesity both increase intramyocellular triglycerides (IMTGs) despite having op

100 High levels of intramyocellular triglycerides are linked to insulin res

101 ion, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with