ライフサイエンスコーパス: intranasally

1 ess to chemical and physical stimuli applied intranasally.

2 ild-type A(H1N1)pdm09 virus was administered intranasally.

3 received a clinical challenge strain of RSV intranasally.

4 t does indeed reach the brain when delivered intranasally.

5 abrogated in Wt mice depleted of macrophages intranasally.

6 he DeltawaaI mutant when it was administered intranasally.

7 n of alpha-galactosylceramide (alpha-GalCer) intranasally.

8 induce significant pneumonia when delivered intranasally.

9 Tpl2(+/+) controls, when challenged with OVA intranasally.

10 ent cell entry and inoculated rhesus monkeys intranasally.

11 s established in C57 (bg+/bg+) mice infected intranasally.

12 r combined with LcrV in adult mice immunized intranasally.

13 f influenza A (H1N1)pdm09 virus administered intranasally.

14 h of the nasal lamina propria when delivered intranasally.

15 ocin (OT) on brain physiology when delivered intranasally?

16 d were randomly administered drug or placebo intranasally 30 min prior to each session.

17 Mice were exposed intranasally, 5 days per week, to liquefied brain tissue

18 Furthermore, in mice infected with AF intranasally, 83% of animals treated with a combination

19 Mice responded to intranasally administered 1018 ISS, a representative B c

20 Two groups of subjects were intranasally administered 160 IU insulin or vehicle afte

21 First, intranasally administered CDG greatly enhances Ag uptake

22 In vivo efficacy of intranasally administered DAS181 was assessed using a co

23 Intranasally administered DFO targets the brain directly

24 ing airways) are pivotal for the efficacy of intranasally administered flagellin-containing vaccines.

25 Here, we intranasally administered fluorescently labeled insulin

26 Intranasally administered HRF recruited inflammatory imm

27 Intranasally administered I-S1 also entered the brain, a

28 ressing either SRV gag or env) vaccines were intranasally administered in 4 RMs, followed by a boost

29 eceptors (bilateral amygdala) in response to intranasally administered insulin (160 IU) compared to s

30 22.2 +/- 0.37 kg/m(2)) aged 22-28 years were intranasally administered insulin (40 IU) or placebo aft

31 Intranasally administered L. rhamnosus GG prevents the d

32 anoparticle formulations increased uptake of intranasally administered nanoparticles in vivo, but the

33 authors examined the acute use of PH94B, an intranasally administered neurosteroidal aerosol, for th

34 exposed to three different blinded doses of intranasally administered nicotine (0, 0.5, 1.0 mg) acro

35 tes in protective immunity induced either by intranasally administered nonreplicating viruslike parti

36 ontrolled, crossover design to determine how intranasally administered oxytocin and vasopressin modul

37 Little is known about how intranasally administered oxytocin reaches the brain and

38 The effects of a single dose of 24 IU intranasally administered oxytocin were tested in a rand

39 satility of the rSeV platform for developing intranasally administered respiratory virus vaccines.

40 WT) and RAGE knockout (RAGE(-/-)) mice, were intranasally administered rIL-5/rIL-13 or rIL-4 alone, a

41 Intranasally administered ST266 accumulated in rodent ey

42 To dampen amygdala reactivity, we intranasally administered the peptide hormone oxytocin t

43 nspired by clinical data in which insulin is intranasally administered to Alzheimer patients.

44 When intranasally administered to an Alzheimer's disease mous

45 800CW-BSA was intranasally administered to the mice in vivo, followed

46 ected mice were solidly protected against an intranasally administered, highly virulent Y. pestis CO9

47 exposure were randomized to receive a single intranasally-administered dose of either trivalent, Russ

48 Intranasally-administered, anti-SP-C-conjugated lipoplex

49 availability of bevacizumab when compared to intranasally administrated free bevacizumab.

50 ) nanoparticles (PLGA NP) were developed and intranasally administrated in CD-1 mice to study their p

51 Ms 30D1 IgG administered intranasally also prevented transmission, suggesting the

52 Animals were infected intranasally and administered ST-246 for 14 days, beginn

53 ucts induce accelerated clearance when given intranasally and induce both immune mechanisms when inje

54 ate study, we administer deuterated oxytocin intranasally and intravenously to rhesus macaques and me

55 noparticle performs better when administered intranasally and intravenously.

56 participants received either AVP or placebo intranasally and made decisions with financial consequen

57 oduced wild-type influenza A(H3N2)2011 virus intranasally and were isolated at the National Institute

58 10(4) IFU of C. trachomatis D was delivered intranasally, and mice were challenged transcervically 6

59 cts, very little of the huge amounts applied intranasally appears to reach the cerebrospinal fluid.

60 on, caudal penetration, and survivability of intranasally applied VSV depends on both innate and adap

61 ug recombinant human IGF-1 were administered intranasally at a 1h interval starting at 0, 2 or 4h aft

62 Minnesota/11/2010 [H3N2 variant]) to ferrets intranasally at a dose of 10(6) 50% tissue culture infec

63 and the H7N1 avian viruses: when inoculated intranasally at a high dose, only the An/13 virus led to

64 cterial shedding is highest in pups infected intranasally at age 4 days and peaks over the first 4 da

65 cell-deficient mice received ovalbumin (OVA) intranasally before mating.

66 Given intranasally before RSV infection, BPZE1 markedly attenu

67 Our data show that intranasally but not subcutaneously administered BCG con

68 and lungs of mice infected intradermally or intranasally, but it is present at lower numbers in thes

69 receive placebo or SynGEM (low or high dose) intranasally by prime-boost administration.

70 tracheal delivery than when it was delivered intranasally by sprayer.

71 ioluminescent strain 536 and received 536_P1 intranasally, ceftriaxone, or control.

72 ficacy, mice were given CR6261 or CR9114 and intranasally challenged 24 h later with lethal doses of

73 so significantly attenuated for virulence in intranasally challenged C57BL/6 mice compared to the wil

74 o measure their enzymatic activities in mice intranasally challenged with a wild-type B anthracis str

75 et v 1 plus aluminium hydroxide adjuvant and intranasally challenged with birch pollen extract.

76 Female Igf1r-deficient and control mice were intranasally challenged with house dust mite (HDM) extra

77 LysM-cre x Stk11fl/fl mice were also intranasally challenged with lipopolysaccharide (LPS).

78 lung homogenates and serum of mice that were intranasally challenged with LPS and received eIF5A siRN

79 Afterward, they were intranasally challenged with MPE (days 13-15) followed b

80 Adult mice were intranasally challenged with PBS or mixed allergen ( Alt

81 Exosomes injected intranasally could also recruit CD11b(+) cells into the

82 The ability of a novel intranasally delivered amnion cell derived biologic to s

83 ely through the gastro-intestinal tract than intranasally delivered antigen and transferrin conjugati

84 Labeled Ag was intranasally delivered into mouse lung to track the migr

85 ptochemogenetic probe luminopsin (LMO3), and intranasally delivered luciferase substrate coelenterazi

86 enicity, and efficacy of an investigational, intranasally delivered norovirus viruslike particle (VLP

87 Although intranasally delivered OT likely affects behavior, there

88 First, the intranasally delivered OT may diffuse directly into the

89 Second, the intranasally delivered OT may trigger increased central

90 shed findings supporting the hypothesis that intranasally delivered oxytocin (OT) can enhance the pro

91 the same genotype as the viruses inoculated intranasally, demonstrating that they are expelled from

92 BALB/c mice were repeatedly intranasally dosed over the course of 5 weeks with cultu

93 C57BL/6 mice were intranasally dosed with fluticasone propionate (1 mg/kg)

94 Lactobacillus rhamnosus was administered intranasally eight times on days 1-4 and 8-11 at 5 x 10(

95 LPS was introduced intranasally either alone or 2 h after pretreatment of m

96 dy responses were analyzed in mice immunized intranasally either with Salmonella enterica serovar Typ

97 lar effects were seen when KGF was delivered intranasally every third day for 15 days, but weight los

98 type H2(b)) mice vaccinated either orally or intranasally exhibited a significant reduction in coloni

99 A group of mice was also intranasally exposed to house dust mite antigen.

100 MPTP mice then received BDNF intranasally followed by multiple unilateral FUS-induced

101 is eliminated and tPA-S478A can be delivered intranasally hours after stroke.

102 Animals were immunized intranasally (i.n.) and/or intramuscularly (i.m.) and su

103 ntigens (Ag) to Fcgamma receptors (FcgammaR) intranasally (i.n.) enhances immunogenicity and protecti

104 nuated in mice; the 50% lethal dose (LD(50)) intranasally (i.n.) is >10,000-fold that of LVS.

105 ups of six guinea pigs (gps) were challenged intranasally (i.n.) or intraperitoneally (i.p.) with 10,

106 mice caused severe disease when administered intranasally (i.n.) or intraperitoneally (i.p.).

107 agellin-modified CS constructs, administered intranasally (i.n.) or subcutaneously (s.c.), developed

108 HIV/SIV) recombinant priming delivered first intranasally (i.n.) plus orally and then intratracheally

109 d parainfluenza virus infection to show that intranasally (i.n.) primed memory CD8+ T cells possess a

110 In vivo, BALB/c mice intranasally (i.n.) treated with poly(I:C) (100 microg/m

111 t (KO) mice infected intradermally (i.d.) or intranasally (i.n.) with LVS succumbed to infection with

112 ous protein delivered subcutaneously (s.c.), intranasally (i.n.), i.m., or transcutaneously (t.c.).

113 When used as a vaccine given intranasally (i.n.), INA-inactivated influenza virus ind

114 r recombinant PspA (rPspA) alone was used to intranasally immunize wild-type (WT) and hFcgammaRI tran

115 tion of IgA and IgG1 in the fecal pellets of intranasally immunized adult mice indicates an induced i

116 We also intranasally immunized groups of mice with a recombinant

117 Additionally, BALB/c mice intranasally immunized with CLH001 in a prime/boost regi

118 Mice and guinea pigs were intranasally immunized with recombinant Bacillus anthrac

119 Mice intranasally immunized with the vesicle preparation deve

120 Mice intranasally immunized with WCV-OVA(1), but not with WCV

121 istered exogenous oxytocin intravenously and intranasally in a triple dummy, within-subject, placebo-

122 It is immunogenic and safe when given intranasally in adult volunteers.

123 cosal adjuvant, respectively, when immunized intranasally in mice.

124 of solution or Kolliphor P 407 gels (KP 407) intranasally in Sprague-Dawley rats.

125 SFV-G-Delta8DR inoculated intramuscularly or intranasally (in a range of 10(2) to 10(4) TCID(50)) pro

126 Three groups of C57BL/6 mice were treated intranasally (IN) and intraperitoneally (IP) daily for 3

127 We infected these mice intranasally (IN) with a wild-type MV expressing green f

128 this end female mice were immunized with CTB intranasally (IN), IP, and subcutaneously (SC).

129 s encoding hMPV F protein, when administered intranasally, induced F-specific virus-neutralizing anti

130 e efficient than those derived from lungs of intranasally infected animals in clearing intestinal inf

131 of orally infected mice and in the lungs of intranasally infected animals.

132 We subcutaneously or intranasally infected bats with TCRV strain TRVL-11573,

133 We intranasally infected C57BL/6 mice with P. aeruginosa an

134 eing largely limited to nasal epithelium for intranasally infected guinea pigs and more widespread in

135 ruitment in vivo To test that hypothesis, we intranasally infected interleukin-8R2 (IL-8R2) (Cxcr2)-d

136 n is induced in the lungs and nasopharynx of intranasally infected mice, and a copA(-) mutant strain,

137 and was associated with higher mortality of intranasally infected mice.

138 o the parental 1918 and LPAI H1N1 viruses in intranasally infected mice.

139 with virus-specific CD8 T cells in lungs of intranasally infected mice.

140 related with diminished virus replication in intranasally infected mice.

141 We intranasally infected Scnn1b-Tg mice and wild-type litte

142 ype and A2AP-deficient (A2AP(-/-)) mice were intranasally infected with B. pseudomallei to induce sev

143 Mice were intranasally infected with bacteria alone or bacteria pl

144 Mice intranasally infected with D39 preincubated with FH had

145 In this study, mice were intranasally infected with either high or low doses of B

146 Mice were intranasally infected with live B. pseudomallei and kill

147 Mice were intranasally infected with S. pneumoniae.

148 a, IRAK-M- deficient and wild-type mice were intranasally infected with S. pneumoniae.

149 eraemia within 24 hours when BALB/c mice are intranasally infected with ST217.

150 Mice were intranasally infected with viable B. pseudomallei and ki

151 Mice were intranasally infected with viable Burkholderia pseudomal

152 were recovered from the intestinal tract of intranasally inoculated ferrets.

153 lls and decreased bacteremia in the lungs of intranasally inoculated mice.

154 Only guinea pigs intranasally inoculated with a live influenza virus or a

155 te SP-D binding in vivo, SP-D(-/-) mice were intranasally inoculated with Alexa Fluor 488-labeled cap

156 irst cell type infected in the lungs of mice intranasally inoculated with F. novicida U112, LVS, or F

157 alveolar lavage fluids and in sera from mice intranasally inoculated with HA-KO/PspA virus, and mice

158 Male Wistar rats were intranasally inoculated with herpes simplex virus 1 (HSV

159 on of IL-6 production in the tonsils of pigs intranasally inoculated with NS4B.VGIv were significantl

160 Wild-type (WT) C57BL/6 mice were intranasally inoculated with S. pneumoniae serotype 6A t

161 CBA/J mice were intranasally inoculated with saline, 1 x 10(6) (BOOP), o

162 Both adult and young chickens intranasally inoculated with the virus became infected a

163 i.p.-sensitization mouse model, Amb-APE was intranasally instilled for 11 consecutive days.

164 ccine candidates, strain 4295 was inoculated intranasally into Hermann's tortoises (Testudo hermanni)

165 n these cultures were harvested and injected intranasally into mice, no bacteria could be recovered f

166 ies presented here show that when inoculated intranasally into mice, rM51R-M virus was cleared from n

167 ng, while clearance of neutrophils delivered intranasally into uninfected mice was reduced in AM depl

168 Mte), lyophilized, pulverized and inoculated intranasally into white-tailed deer once a week for 6 we

169 ALB/c mice with live Deltacps1 spores either intranasally, intraperitoneally, or subcutaneously resul

170 isolated OMVs from A. baumannii cultures and intranasally introduced the OMVs into mice.

171 Delivered by smoking or intranasally, nCB persisted indefinitely in mouse lung,

172 or the major allergen Amb a 1 was instilled intranasally on 1-11 consecutive days, and allergic airw

173 Mice were challenged intranasally on days 0, 3 and 6 with a filtrate of Alter

174 acaques that were immunized mucosally (i.e., intranasally) on days 0 and 14.

175 KO]) mice infected with LVS intradermally or intranasally or anti-IL-6-treated mice, showed greatly r

176 nd transmissibility among animals inoculated intranasally or by aerosols with a human (H3N2) or avian

177 Challenge was subsequently performed intranasally or epicutaneously with ovalbumin and a seco

178 rCK12a delivered intranasally or i.p. stimulates the expression of CD8alp

179 , 0.5, or 1 x 10(6) cell per pup) were given intranasally or i.p. to newborn severe combined immunode

180 highly immunogenic in mice when administered intranasally or intradermally, eliciting serum and fecal

181 were assessed in mice and ferrets inoculated intranasally or intragastrically with virus in liquid.

182 .4 mg/kg) or BSA (vehicle) were administered intranasally or intraperitoneally, followed by either sl

183 of BALB/c female mice were immunized either intranasally or intravaginally with live elementary bodi

184 t was strongly immunogenic when administered intranasally or orogastrically in mice.

185 L-25, or IL-33 signaling were exposed to HDM intranasally or peanut intragastrically, and immune infl

186 When they were administered intranasally or subcutaneously in cotton rats, the candi

187 atment of mice with antibiotics administered intranasally or subcutaneously significantly reduced lun

188 creased the virulence of spores administered intranasally or subcutaneously to C57BL/6 mice but not t

189 an when the virus was used to vaccinate mice intranasally or subcutaneously.

190 V F was equally protective when administered intranasally or subcutaneously.

191 ld-type and ILC2-deficient mice were exposed intranasally or systemically to the TH2-inducing antigen

192 1:1 ratio to davunetide (30 mg twice daily, intranasally) or placebo for 52 weeks at 48 centres in A

193 in mice challenged with WEEV subcutaneously, intranasally, or via mosquito.

194 Mice were challenged with LPS/elastase intranasally over 4 weeks, resulting in a chronically in

195 Mice were exposed to 5 doses of HDM intranasally over a 16-day period.

196 e experimental asthma, and IL-37 was applied intranasally prior to each OVA challenge.

197 The conjugate administered intranasally protected mice against experimental NP colo

198 n, that fusion-inhibitory peptides delivered intranasally provide effective prophylaxis against MV in

199 wn that fusion-inhibitory peptides delivered intranasally provide effective prophylaxis against MV in

200 When administered to mice intranasally, they preferentially accumulate in the lung

201 Given to mice intranasally, this vaccine elicits antibody-independent,

202 A/chicken/Hong Kong/G9/97 were administered intranasally to 50 adults in isolation; 41 participants

203 Naive mice were exposed intranasally to a combination of common airborne allerge

204 hagocytic cell labeling dye was administered intranasally to label resident alveolar macrophages (AMs

205 A lethal dose of ST615 administered intranasally to mice led to the rapid onset of disease s

206 nd poly(inosinic-cytidylic) acid was applied intranasally to mice with already established experiment

207 ding protein (MBP::VP6) and was administered intranasally to mice.

208 s) specific for IL-4Ralpha were administered intranasally to neonatal mice at the time of primary inf

209 des pteronyssinus (rDer p)2 and then exposed intranasally to the allergen.

210 Mice were intranasally treated with apoBLG versus holoBLG and anal

211 Non-diabetic and diabetic rats were intranasally treated with saline, isoproterenol (to incr

212 carcinogens and inflammation, A/J mice were intranasally treated with the tobacco carcinogen 4-(meth

213 aureus (MSSA) were asked to apply mupirocin intranasally twice daily for up to 5 days and to bathe d

214 y replicated in the lungs of mice inoculated intranasally under anesthesia to cause significant morbi

215 e bioavailability of insulin co-administered intranasally using PTD4, 16 mg/mL glycerin and 100 mM Ar

216 challenge studies where they were challenged intranasally using the identical influenza A(H1N1)pdm09

217 85 (LepNP85) and administered this conjugate intranasally using the nose-to-brain (INB) route to bypa

218 BALB/c or C57BL/6 mice that were intranasally vaccinated with 10(8) CFU of FTT1103 mutant

219 Mice intranasally vaccinated with a site-directed (indicated

220 In a series of experiments, animals were intranasally vaccinated with dscCfaE alone, dscCfaE with

221 Mice intranasally vaccinated with M2KO virus developed protec

222 anate (FITC)-labeled control siRNA delivered intranasally was found in the cytoplasm of neurons and g

223 T) and wild-type (WT) controls were infected intranasally with 10 000 focus-forming units of influenz

224 Twenty-one healthy adults were inoculated intranasally with 10(6) plaque-forming units of rHMPV-SH

225 iprocal bone marrow transfer were inoculated intranasally with 10,000 PFU/mouse influenza A/WSN/33 (H

226 Moreover, OVA-sensitized mice treated intranasally with 20 ng/kg of IRL201104 show a significa

227 h PGE(2)-sufficient controls when challenged intranasally with a house dust mite extract.

228 a parallel experiment, mice were challenged intranasally with a lethal dose of S. pneumoniae D39.

229 Newborn mice primed intranasally with a single dose of S. Typhi(F1) elicited

230 C57BL/6 mice were challenged intranasally with A. fumigatus conidia weekly, and leuko

231 nitial infection, all horses were challenged intranasally with Ab4.

232 groups of horses (n = 8 each) were infected intranasally with Ab4DeltaORF2 or the parent Ab4 virus o

233 r-deficient (ST2(-/-) ) mice were challenged intranasally with Alt-Ext or vehicle once or twice to ev

234 WT and IP(-/-) mice were challenged intranasally with Alternaria alternata extract for 4 con

235 deficient (TSLPR(-/-) ) mice were challenged intranasally with Alternaria extract (Alt-Ext) or PBS fo

236 cin, flurbiprofen, or vehicle and challenged intranasally with Alternaria extract for four consecutiv

237 ive wild-type (WT) mice were challenged once intranasally with Alternaria.

238 x/flox)] littermates (+/+ mice) when treated intranasally with an extract of the dust mite Dermatopha

239 toneally with ovalbumin (OVA) and challenged intranasally with antigen.

240 Mice inoculated intranasally with any of these live recombinant viruses

241 Mice were then challenged intranasally with BALB/c-adapted A/New Caledonia influen

242 thout LTR192G as the adjuvant and challenged intranasally with C. jejuni 81-176 or CG8486.

243 a negative control, and mice were inoculated intranasally with C. muridarum as positive controls.

244 t also lacked TLR2, TLR4, MyD88, or LXRalpha intranasally with C. pneumoniae followed by feeding of a

245 regimen, in which animals were boosted twice intranasally with C.1086 gp120 and the TLR 7/8 agonist R

246 When given intranasally with cholera toxin adjuvant, the fusion con

247 o yeast glucan particles and then challenged intranasally with Coccidioides showed early lung infiltr

248 Mice were immunized intranasally with each protein with or without LTR192G a

249 Mice were inoculated intranasally with each virus and monitored for morbidity

250 Ten days later, mice were infected intranasally with either RSV or UV-inactivated RSV.

251 Mice immunized intranasally with Gag-Fc plus CpG adjuvant developed loc

252 Pigs either were vaccinated intranasally with GII.4/1997 NoV (VA387)-derived P parti

253 MX001 to acyclovir in BALB/c mice inoculated intranasally with HSV types 1 or 2.

254 basophils from atopic asthmatics challenged intranasally with human rhinovirus 16 were monitored dir

255 als) held in individual pens were inoculated intranasally with IDV strain D/bovine/Mississippi/C00046

256 We treated BALB/c mice intranasally with IL-13 or IL-17 alone or in combination

257 lled study, healthy subjects were inoculated intranasally with influenza virus (A/Perth/16/2009 H3N2)

258 Vaccination of TRP-SIY mice intranasally with influenza virus that expresses the SIY

259 oked and on going pain whereas animals dosed intranasally with LENK alone were unresponsive.

260 of those with carriage, 10 were rechallenged intranasally with live 6B Streptococcus pneumoniae up to

261 d with unvaccinated controls, mice immunized intranasally with live D27-pLpxL exhibit a decreased bac

262 d wild-type C57BL/6 controls were challenged intranasally with low doses of an extract derived from t

263 D) in both uninfected mice and mice infected intranasally with murine cytomegalovirus (MCMV).

264 ch interferon (IFN)gammaR(-/-) mice infected intranasally with murine gammaherpesvirus 68 (MHV68) dev

265 ath of A/J mice inoculated subcutaneously or intranasally with mutant spores was lower than that for

266 G concentration of <20 IU/ml were inoculated intranasally with non-attenuated, wild type Bordetella p

267 f <20 international units/ml were inoculated intranasally with nonattenuated, wild-type Bordetella pe

268 e responses in adult B6 and Bc mice infected intranasally with NSV.

269 rch pollen allergic subjects were challenged intranasally with omalizumab, placebo or birch pollen al

270 zed to ovalbumin (OVA), bred, and challenged intranasally with OVA on gestational day 15, which produ

271 ance and increased mortality when challenged intranasally with P. aeruginosa.

272 ccus pneumoniae and treated intravenously or intranasally with P4 and intravenous immunoglobulin (IVI

273 S100a9(-/-) mice that were infected intranasally with pneumococci rapidly succumbed, with 80

274 infection, we treated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid conden

275 Mice were infected intranasally with rhinovirus (RV) immediately after O2 e

276 Mice immunized intranasally with rM51R vectors expressing vaccinia viru

277 to moderate asthma (n = 20) were challenged intranasally with RV16.

278 ild-type and CXCR2(-/-) mice were inoculated intranasally with RV1B or sham HeLa cell supernatant.

279 ng RNA knockdown of lung MD2 were challenged intranasally with RWPE or CDE, and innate and allergic i

280 ce and wild-type (WT) controls were infected intranasally with S pneumoniae.

281 re significantly attenuated in mice infected intranasally with S. aureus deficient in beta-toxin comp

282 evel controlled cortical impact and infected intranasally with S. pneumoniae (1,500 colony-forming un

283 nized intraperitoneally with purified Shr or intranasally with Shr-expressing Lactococcus lactis.

284 nd mortality were monitored in mice infected intranasally with SPBNgamma or SPBN(-) control virus to

285 We then infected A/J mice intranasally with spores that harbored the germination r

286 esus monkeys (Macaca mulatta) was inoculated intranasally with STAT1-blind MV, viremia was short-live

287 When mice were challenged intranasally with Streptococcus pneumoniae 7 d postinfec

288 ND4-SW mice were infected intranasally with Streptococcus pneumoniae serotype 3 (W

289 as induced in mice, and animals were treated intranasally with TGA either simultaneously with treatme

290 Mice were immunized intranasally with the combined conjugates consisting of

291 Mice infected intranasally with the Deltactu mutant showed significant

292 esus monkeys (Macaca mulatta) was inoculated intranasally with the SLAM-blind virus, no clinical symp

293 Mice infected intranasally with the SPD0420 and SPD1774 mutants surviv

294 In this work, mice were infected intranasally with transcriptional regulator mutants of t

295 Mice immunized intranasally with Ty21a-AR-Ss produced antibodies agains

296 th live attenuated Y. pestis and challenging intranasally with virulent plague, nearly 20% of pulmona

297 urden and increased survival when challenged intranasally with virulent Y. pestis.

298 d T cell-mediated defense in mice challenged intranasally with Y. pestis.

299 e obtained when the vaccine was administered intranasally, with the i.d. route requiring 25-40 times

300 ystemic antibody responses when administered intranasally without additional adjuvants.