ライフサイエンスコーパス: intrathecal

1 ss of the larger antibody from the CSF, with intrathecal 0.75 m mannitol increasing the number of per

2 In anesthetized rats pretreated with intrathecal A2A receptor antagonist injections before mA

3 of GLD that presymptomatic monotherapy with intrathecal AAV9 encoding canine GALC administered into

4 Using intrathecal adeno-associated virus serotype 9-based deli

5 tio to receive HTT(Rx) or placebo as a bolus intrathecal administration every 4 weeks for four doses.

6 y, and pharmacokinetics of ISIS 333611 after intrathecal administration in patients with SOD1-related

7 Intrathecal administration is of growing interest for dr

8 Intrathecal administration of a Ca(2+)-permeable AMPAR s

9 though KV1.3 is not expressed in CNS tissue, intrathecal administration of a KV1.3 channel blocker or

10 Intrathecal administration of a palmitoylated peptide co

11 Intrathecal administration of AM1710 also attenuated pac

12 Targeting the spinal cord via intrathecal administration of an adeno-associated virus

13 Here, we report that commencing intrathecal administration of an inhibitor of the proinf

14 ely ablated Y1R-expressing interneurons with intrathecal administration of an NPY-conjugated saporin

15 Intrathecal administration of an oligodeoxynucleotide an

16 Intrathecal administration of BzATP resulted in ROS prod

17 OIH was reversed, in vivo, by intrathecal administration of cordycepin, a protein tran

18 Background The use of MR cisternography with intrathecal administration of gadolinium-based contrast

19 The overall rate of adverse events after intrathecal administration of GBCA was 13% (95% confiden

20 Conclusion Overall, intrathecal administration of GBCAs at doses greater tha

21 Intrathecal administration of HTT(Rx) to patients with e

22 Intrathecal administration of IL4-10 dose-dependently in

23 Intrathecal administration of lentivirus containing the

24 Intrathecal administration of MRP14 before infection rev

25 pregnancy-related analgesia is reversible by intrathecal administration of naloxone, suggesting an op

26 Moreover, intrathecal administration of rapamycin, a selective inh

27 The intrathecal administration of small interfering RNAs aga

28 Similarly, intrathecal administration of the IL-1 receptor antagoni

29 Intrathecal administration of tofersen is being studied

30 Intrathecal administration of vasodilators or fibrinolyt

31 Here, we report that commencing intrathecal administration of XPro1595, an inhibitor of

32 tor activation and this could be reversed by intrathecal administration of yohimbine (alpha-2-adrenoc

33 Upon intrathecal administration the elimination rate constant

34 Following intrathecal administration, beta-endorphin (10-100 nmol)

35 Moreover, when FXN LNPs were delivered by intrathecal administration, we detected recombinant huma

36 ovide radiation safety estimates specific to intrathecal administration.

37 etry estimation for regions most relevant in intrathecal administration.

38 Finally, spinal (intrathecal) administration of IFN-alpha reduced inflamm

39 Subcutaneous, but not intrathecal, administration of APAP elicited a dose depe

40 (ALL) therapy and provide data on safety of intrathecal and high-dose MTX rechallenge in patients wi

41 rmacokinetics of ziconotide in CSF following intrathecal and intravenous (i.v.) administration of zic

42 Here, we provide evidence that chronic intrathecal and intravenous administration of NgR1-Fc to

43 in lower absorbed dose estimates for several intrathecal and nonintrathecal regions.

44 , revealed physiological differences between intrathecal and systemic immunity, irrespective of final

45 Of 13 patients rechallenged with intrathecal and/or high-dose MTX, 12 did not experience

46 ckade of the anti-inflammatory activity with intrathecal anti-IL10 unmasks neuropathic pain behavior

47 e reproduced in a therapeutic approach using intrathecal anti-Nogo-A antibodies; such a therapy is cu

48 In contrast, 2 weeks of intrathecal anti-Nogo-A antibody treatment led to signif

49 ases in peripheral CD4+ T cells and JC virus intrathecal antibodies were observed.

50 ll LNB cases verified by a positive Borrelia intrathecal antibody index test performed at the Departm

51 oglobulin G at the time of positive Borrelia intrathecal antibody index test were negative in 67 pati

52 hese assays do not establish the presence of intrathecal antibody production to B. burgdorferi and th

53 Our findings emphasize that intrathecal antibody synthesis does not necessarily refl

54 re autoimmune disorder characterized by high intrathecal antibody synthesis.

55 osorbent assays, surgical interventions, and intrathecal antisense treatments.

56 ocused on intravenous magnesium sulphate and intrathecal antitoxin administration as methods of spasm

57 ease controls (n = 58) were investigated for intrathecal antiviral antibodies, using a phage display

58 We previously showed that intrathecal application of endomorphin 2 [EM2; the highl

59 In vivo, neither topical (10-200microM) nor intrathecal application of icilin (0.1nM to 1microM) aff

60 Intrathecal application of morphine (5 ng/50 mul) signif

61 itting information underlying itch caused by intrathecal application of morphine have not been identi

62 We found that intrathecal application of morphine increased ongoing ac

63 In addition, intrathecal application of morphine increased responses

64 In vivo, intrathecal application of Nogo-A-blocking Abs resulted

65 Intrathecal applications of BC-1215 (a Fbxo3 activity in

66 ricular and intraparenchymal, intranasal and intrathecal) are discussed along with key barriers to CN

67 In addition, intrathecal as well as intraperitoneal pretreatment with

68 and TH17) and regulatory T cells, as well as intrathecal B-cell differentiation resulting in the gene

69 one (cohorts 1 and 2) or GCIPL corrected for intrathecal B-cell frequencies (cohort 1) were tested fo

70 GCIPL volumes were associated with increased intrathecal B-cell frequencies (median, 1.96% [IQR, 1.45

71 Loss of GCIPL is associated with intrathecal B-cell immunity and constitutes an independe

72 versification could be observed, and whether intrathecal B-cell repertoires, if present, were related

73 GAS T score at 3 months was 38.9 (13.2) for intrathecal baclofen and 21.0 (4.6) for placebo (regress

74 Neuromodulation interventions, such as intrathecal baclofen and deep brain stimulation, are pro

75 alysis were available for 17 patients in the intrathecal baclofen group and 16 in the placebo group.

76 block randomization (2:2) for treatment with intrathecal baclofen or placebo for 3 months via an impl

77 Intrathecal baclofen treatment is superior to placebo in

78 Intrathecal baclofen treatment is used for the treatment

79 dy was to provide evidence for the effect of intrathecal baclofen treatment on individual goals in pa

80 -V) aged 4 to 24 years who were eligible for intrathecal baclofen were included.

81 Also, intrathecal bumetanide significantly attenuated hyperalg

82 Intrathecal, but not systemic, administration of the Hsp

83 S pathway contributions to enhanced pLTF via intrathecal (C4) delivery of small interfering RNAs targ

84 tenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity throug

85 spinal fluid samples were collected using an intrathecal catheter at defined times to compare cerebra

86 n of a headache is not of value, although an intrathecal catheter may prove to be the best method for

87 e specific Kir6.2-siRNA were injected via an intrathecal catheter.

88 The use of intrathecal catheters for the prevention of a headache i

89 L volumes correlated with the frequencies of intrathecal CD56bright natural killer cells (r = 0.28; P

90 e dose of etoposide (950 to 450 mg/m(2)) and intrathecal central nervous system prophylaxis while omi

91 stem leukemia can be adequately managed with intrathecal chemotherapy and rarely requires radiotherap

92 ases, prophylactic CNS-directed conventional intrathecal chemotherapy is required for relapse-free su

93 cts of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with au

94 b 140 mg/day (100 mg/day over 70 years) with intrathecal chemotherapy, vincristine, and dexamethasone

95 sed for various combinations of systemic and intrathecal chemotherapy, whole-brain radiotherapy, and

96 te, capped vincristine, and used combination intrathecal chemotherapy.

97 une surveillance, as well as several ongoing intrathecal clinical trials.

98 high-risk patients received six cycles with intrathecal CNS prophylaxis or extended intrathecal trea

99 tion of full-length IgG could be enhanced by intrathecal co-infusion of hyperosmolar mannitol.

100 of studying immune responses directly in the intrathecal compartment.

101 Intrathecal cordycepin, which reverses Type I priming, o

102 AP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related mi

103 21-5p is upregulated in DRG neurons and both intrathecal delivery of a miR-21-5p antagomir and condit

104 nduced pMF required spinal aPKC activity, as intrathecal delivery of a zeta-pseudosubstrate inhibitor

105 icantly rescues human SOD1(+/L144F) MNs, and intrathecal delivery of adeno-associated virus (AAV)9-mi

106 This trial is the first clinical study of intrathecal delivery of an antisense oligonucleotide.

107 We validate intrathecal delivery of EPHA2, HER2 and interleukin 13 r

108 In contrast, intrathecal delivery of glibenclamide, a KATP channel bl

109 This report investigates the intrathecal delivery of lentiviruses for long-term expre

110 Intrathecal delivery of MT-I/II to adult DRGs also promo

111 Using intrathecal delivery of scAAV9 expressing an shRNA targe

112 Moreover, intrathecal delivery of TGF-beta2 during the effector ph

113 Intrathecal delivery of the S1PR1 antagonist W146 reduce

114 antisense drugs, and the biodistribution of intrathecal dosed antisense drugs.

115 okinetics, and clinical efficacy of multiple intrathecal doses of nusinersen (6 mg and 12 mg dose equ

116 Administration of multiple intrathecal doses of nusinersen showed acceptable safety

117 rategy in patients with suspected failure of intrathecal drug administration systems.

118 Implantable intrathecal drug delivery systems (IDDS) are basic tool

119 r) was the most potent member of the series (intrathecal ED50 approximately 9 fmol per mouse), wherea

120 cells potentially favoring a proinflammatory intrathecal environment in HTT gene expansion carriers.

121 oth under control conditions and with lumbar intrathecal fentanyl impairing feedback from mu-opioid r

122 er control conditions (CTRL) and with lumbar intrathecal fentanyl impairing lower limb muscle afferen

123 group III/IV afferent inhibition via lumbar intrathecal fentanyl on peak exercise capacity ( VO2 pea

124 exhaustion to determine VO2 peak with lumbar intrathecal fentanyl or placebo.

125 exhaustion to determine VO2 peak with lumbar intrathecal fentanyl or placebo.

126 e, 4 min each) either with or without lumbar intrathecal fentanyl to attenuate group III/IV afferent

127 Lumbar intrathecal fentanyl was used to attenuate the central p

128 n the past few years we and others have used intrathecal fentanyl, a mu-opiate receptor agonist, in h

129 oride (a non-specific PKC inhibitor, 10nmol, intrathecal) for 14 days.

130 h GAD autoimmunity requires demonstration of intrathecal GAD antibody synthesis.

131 of understanding of the relationship between intrathecal GBCA exposure and dose-related adverse event

132 d on rates and types of adverse events after intrathecal GBCA exposure.

133 atabases were searched for studies reporting intrathecal GBCA use.

134 tanding of the dose-response relationship of intrathecal GBCAs and to characterize related adverse ev

135 Intrathecal gene delivery after the onset of peripheral

136 altered exocytotic dynamics, which involved intrathecal granule swelling that was abruptly followed

137 rolled at RUMC, and were assigned to receive intrathecal HPbetaCD at a starting dose of 200 mg every

138 nrolled and sequentially assigned to receive intrathecal HPbetaCD at a starting dose of 50 mg per mon

139 cohorts of three to receive monthly initial intrathecal HPbetaCD at doses of 50, 200, 300, or 400 mg

140 ERPRETATION: Patients with NPC1 treated with intrathecal HPbetaCD had slowed disease progression with

141 escalation phase 1-2a study, we gave monthly intrathecal HPbetaCD to participants with NPC1 with neur

142 ltinational, randomised, controlled trial of intrathecal HPbetaCD.

143 to assess the safety and efficacy of lumbar intrathecal HPbetaCD.

144 nce following repeated bolus i.p. or chronic intrathecal HUP-A dosing.

145 Here, we demonstrate that a local, intrathecal (i.t.) injection of bone marrow stromal cell

146 tinociception was sensitive to antagonism by intrathecal (i.t.) pretreatment with the kappa- and mu-s

147 In a model of peripheral neuropathy, intrathecal (i.th.) administration of ligand 14 reversed

148 ery into the lumbosacral subarachnoid space (intrathecal; i.t.).

149 ammation, blood-brain barrier breakdown, and intrathecal Ig synthesis.

150 disease multiple sclerosis correlating with intrathecal IgG production, as well as in the serum of t

151 ncies (median, 1.96% [IQR, 1.45%-4.20%]) and intrathecal IgG synthesis (median cerebrospinal fluid/se

152 Whereas the extent of intrathecal IgG synthesis varies largely between patient

153 RS-CoV-2 RNA in the cerebrospinal fluid, nor intrathecal IgG synthesis, but did observe signs of bloo

154 The effects of intrathecal IL-35 therapy were Treg-cell dependent and a

155 d be taken into consideration when designing intrathecal imaging studies.

156 n of clonally related B cells that shape the intrathecal immune repertoire.

157 consistent with a model where the CNS shapes intrathecal immune responses to provide effective protec

158 insight about disease-specific phenotypes of intrathecal immune responses.

159 Intrathecal inflammation correlates with the grey matter

160 The cell-specific biomarkers of intrathecal inflammation may improve diagnosis and manag

161 re therapeutic developments in patients with intrathecal inflammation that is not captured by imaging

162 hindered by an inability to reliably measure intrathecal inflammation.

163 strate poor correlation between systemic and intrathecal inflammatory biomarkers in patients with neu

164 mmunophenotyping captures the biology of the intrathecal inflammatory processes, it has the potential

165 whole brain in a size-dependent manner after intrathecal infusion in rats using ex vivo fluorescence

166 ismutase 1 (SOD1) were treated with a single intrathecal infusion of adeno-associated virus encoding

167 Transection of the L4 dorsal root or intrathecal infusion of aminobutyrate aminotransferase i

168 Intrathecal infusion of the PACAP antagonist PACAP(6-38)

169 cerebrospinal fluid drains, implantation of intrathecal infusion pumps, implantation of deep brain s

170 , phase 1 trial, we delivered ISIS 333611 by intrathecal infusion using an external pump over 11.5 h

171 In adult animals, chronic intrathecal infusions of antibodies also induced the los

172 ects of Hsp90 inhibition were abolished upon intrathecal inhibition of ERK, RSK, or protein synthesis

173 ed a lentiviral vector using a single lumbar intrathecal injection and a myelin-specific promoter.

174 ongly attenuates chronic pain by systemic or intrathecal injection and completely blocks the second p

175 red into 3-week-old Sh3tc2-/- mice by lumbar intrathecal injection and gene expression was assessed 4

176 Overall, intrathecal injection appeared to be the optimal adminis

177 ry methods of direct intra-DRG injection and intrathecal injection have several disadvantages, includ

178 pz.GJB1 lentiviral vector by a single lumbar intrathecal injection into 6-month-old Gjb1-null mice, w

179 Following intrathecal injection into rodents, the nanoparticles, c

180 After intrathecal injection of a gene-specific antisense oligo

181 re, systemic administration of gabapentin or intrathecal injection of alpha2delta-1Tat peptide revers

182 Scratching behavior was also induced by the intrathecal injection of an Akt activator.

183 Since intrathecal injection of an alpha(2A)-adrenoceptor antag

184 In addition, intrathecal injection of an NMDAR antagonist or systemic

185 Inhibition of endogenous IL-10 signaling by intrathecal injection of anti-IL-10 to WT mice or Rag1(-

186 Intraplantar and intrathecal injection of bile acids caused analgesia to

187 We found that, following intrathecal injection of capsaicin to eliminate the cent

188 ous studies, neither dorsal rhizotomy nor an intrathecal injection of capsaicin, which completely eli

189 In contrast, intrathecal injection of CSF1 induced mechanical hyperse

190 Intrathecal injection of CXCL13 was sufficient to induce

191 Finally, intrathecal injection of CXCL13-activated astrocytes ind

192 strated a short-onset vasoconstriction after intrathecal injection of either PDPs or BOXes.

193 Furthermore, healthy mice subjected to intrathecal injection of G-CSF exhibit pronounced viscer

194 pothesis, we used a mouse model generated by intrathecal injection of gp120 and compared the patholog

195 The intrathecal injection of GRP led to intense scratching,

196 Consistent with these observations, intrathecal injection of IL-33 enhanced CCI hyperalgesia

197 Moreover, intrathecal injection of MRP14 alone was sufficient to i

198 Intrathecal injection of oxytocin receptor antagonist no

199 Intrathecal injection of PDGF siRNA and morphine reverse

200 Intrathecal injection of pinacidil, a KATP channel opene

201 G neurons occurring in rats with CIPN, while intrathecal injection of ProTx II significantly attenuat

202 h recombinant TNFalpha in vitro and repeated intrathecal injection of recombinant TNFalpha in naive r

203 combinant TNFalpha in vitro, and by repeated intrathecal injection of recombinant TNFalpha in naive r

204 ats, as well as rats with Slack knockdown by intrathecal injection of short interfering RNA, exhibite

205 Intrathecal injection of the mu-opioid receptor agonist

206 Furthermore, intrathecal injection of the Panx1 blockers or Panx1-spe

207 Intraplantar and intrathecal injection of the TLR9 agonist ODN 1826 induc

208 ple for developing a possible alternative to intrathecal injection of ziconotide using a tunable VLP

209 revealed that, following intraganglionic or intrathecal injection, recombinant adeno-associated viru

210 0.82) but much higher than those obtained by intrathecal injection.

211 itoneal and intravenous injection as well as intrathecal injection.

212 to 8.1% ID/g, was recorded followed a single intrathecal injection.

213 Spinal (intrathecal) injection of carbenoxolone (a non-selective

214 Cutaneous and intrathecal injections of IL-31 evoked intense itch, and

215 C57Bl6 mice were given intrathecal injections of small interfering RNAs to redu

216 brain and spinal cord when intracranial and intrathecal injections of the same AAV vector were combi

217 ive tissues when comparing intracranial with intrathecal injections.

218 nistration: intravenous, intraperitoneal, or intrathecal injections.

219 Since the late 1950s, intrathecal (IT) amphotericin B deoxycholate (AmBd) has

220 However, few intrathecal (IT) therapies have reached the clinic due,

221 rage of synaptic events that were blocked by intrathecal kynurenate.

222 This study demonstrates that a single intrathecal lentiviral gene delivery can lead to Schwann

223 Intrathecal lidocaine in the lithotomy position carries

224 d eight doses of rituximab and four doses of intrathecal liposomal cytarabine.

225 7 mg/kg/day of NgR1-Fc (n = 8) delivered via intrathecal lumbar catheter and osmotic minipump for 4 m

226 ar disease-free survival (DFS) compared with intrathecal methotrexate (IT MTX), when given on a modif

227 ine, and prednisone given every 21 days with intrathecal methotrexate and locoregional RT is the curr

228 dose >/=8000 mg/m(2) with hand weakness, and intrathecal methotrexate dose >/=225 mg with dorsiflexio

229 This study showed that intrathecal microRNA can be used as a potential treatmen

230 Intrathecal Mito-tempol (a mitochondria-targeted O2(.-)s

231 at spinal dorsal horn neurons after repeated intrathecal morphine injections.

232 fectively prevented by either intravenous or intrathecal MSC transplantation (MSC-TP), which was perf

233 nificantly reversed by either intravenous or intrathecal MSCs when cells were transplanted after repe

234 ymphoma refractory to high-dose systemic and intrathecal MTX plus IV rituximab.

235 r, CD56(bright) NK cells represent the major intrathecal NK-cell subset in both MS patients and healt

236 (P = .003), clinical relapses (P = .03), and intrathecal NMDAR-antibody synthesis (P < .001).

237 SF CXCL13 concentration that correlated with intrathecal NMDAR-antibody synthesis.

238 his neuronal population remains sensitive to intrathecal NPY after nerve injury.

239 mechanical hyperalgesia that is prevented by intrathecal oligodeoxynucleotide antisense to CD44 mRNA,

240 peripherally induced priming is prevented by intrathecal oligodeoxynucleotide antisense to the nuclea

241 Intrathecal oligodeoxynucleotide antisense to TLR4 mRNA

242 role for spinal 5-HT(3) serotonin receptors, intrathecal ondansetron administration after TBI dose-de

243 s analgesic effects produced by systemic and intrathecal opioid agonists and abolishes chronic opioid

244 e prediction of IgG brain distribution after intrathecal or intracerebroventricular infusion into the

245 al disorders (enzyme replacement therapy via intrathecal or intracerebroventricular routes or with fu

246 fects after systemic (subcutaneous), spinal (intrathecal) or hindpaw (intraplantar) injections of tes

247 However, intrathecal PACAP did not show additive effects, suggest

248 In intrathecal PACAP-antagonist-treated rats, both BP and H

249 -ISF exchange across the rat brain following intrathecal paramagnetic contrast agent administration.

250 n both males and females, while both paw and intrathecal PGE(2) hypersensitivity was more persistent

251 l cord (as prolonged hyperalgesia induced by intrathecal PGE2), but only when the mechanical stimulus

252 stems (IDDS) are basic tool enabling chronic intrathecal pharmacotherapy.

253 Intrathecal post-treatment of NPD1/PD1 also effectively

254 Meanwhile, intrathecal pretreatment with naloxone, non-selective op

255 The preferred test to detect intrathecal production of antibodies to B. burgdorferi i

256 To define the role of radiotherapy and intrathecal prophylaxis in extralymphatic craniofacial i

257 This retrospective analysis does not support intrathecal prophylaxis or radiotherapy to ECFI patients

258 In 88 ECFI patients who received intrathecal prophylaxis with methotrexate, the 2-year ra

259 nophen also reversed hyperalgesia induced by intrathecal prostaglandin E2 To distinguish between a pe

260 icrospheres, obviating the need for invasive intrathecal pumps or catheters.

261 Silencing endogenous Rab7 with intrathecal Rab7-siRNA or, indirectly, by reversing nerv

262 transfected macrophages administered through intrathecal route provided significant increases of GDNF

263 ecules to the central nervous system via the intrathecal route.

264 oglial function with systemic minocycline or intrathecal SB203580 at the time of neonatal incision an

265 aches have been restricted to using invasive intrathecal single-stranded oligonucleotide delivery.

266 human soluble TNF receptor 1 (sTNFR1) in the intrathecal space at the level of the phrenic motor nucl

267 , antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neur

268 ivirus-filled sponges were inserted into the intrathecal space surrounding the spinal cord, with tran

269 dies into the mouse cerebral ventricle(s) or intrathecal space.

270 ose was estimated for each subject using the intrathecal-specific dosimetry application.

271 The intrathecal-specific VIDA implementation enables tailore

272 cytosis, elevated protein concentration, and intrathecal synthesis of borrelial immunoglobulin M and

273 n = 1) cerebrospinal fluid levels; there was intrathecal synthesis of glycine receptor antibodies in

274 inal fluid and serum samples demonstrated an intrathecal synthesis of IgG antibodies to the NR1 subun

275 c B cells that are likely to account for the intrathecal synthesis of these autoantibodies.

276 atients have comparable numbers of activated intrathecal T and B cells, which are preferentially embe

277 on, soluble CD27 is a validated biomarker of intrathecal T-cell activation, with an area under the re

278 sCD27, known to best predict the presence of intrathecal T-cell mediated inflammation.

279 The frequency of intrathecal Th17.1 cells correlated negatively with prog

280 In a multivariable analysis, more intrathecal therapy (IT) predicted fewer reactions (P =

281 se failed to improve outcome, but additional intrathecal therapy during early induction seemed to con

282 k of CNS relapse received two extra doses of intrathecal therapy during the first 2 weeks of remissio

283 raginase and early intensification of triple intrathecal therapy would improve systemic and CNS contr

284 de, ifosphamide, corticosteroids, and triple intrathecal therapy.

285 f high-dose MTX and 13 to 25 doses of triple intrathecal therapy.

286 Intrathecal TNF soluble receptor I (functionally blockin

287 bitory peptide (PKCzeta-PS) 35 min following intrathecal TNFalpha arrested TNFalpha-induced pMF (28 +

288 Intrathecal TNFalpha without neural apnoea was sufficien

289 of the non-GAD antibodies and peripheral and intrathecal transfer protocols, combined with adsorption

290 Here, we found that intrathecal transplantation of neural stem/precursor cel

291 with intrathecal CNS prophylaxis or extended intrathecal treatment if leptomeninges were involved.

292 Intrathecal treatment of WT mice with soluble IL-33 rece

293 Intrathecal treatment with antisense directed to IL-6 re

294 itionally, inhibition of the ATF6 pathway by intrathecal treatment with ATF6 siRNA reduced pain behav

295 Intrathecal treatment with l-THP combined with the Sig-1

296 id or did not receive the two extra doses of intrathecal treatment.

297 patients with CNS3 status received two extra intrathecal treatments during induction and augmented po

298 esis that postinduction CNS prophylaxis with intrathecal triple therapy (ITT) including methotrexate,

299 l layer volumes alone or in combination with intrathecal variables are associated with worsening of d

300 IP3R inactivation by intrathecal xestospongin C attenuated the female-specifi