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1 ant presence of anti-B. burgdorferi antibody intrathecally.
2 of 0.027 microg in the rat when administered intrathecally.
3 cacy than AAV2, 5, 6, 8, and 9 when injected intrathecally.
4 f chronic and thermal pain when administered intrathecally.
5 d CFA pain in the Pi16(-/) when administered intrathecally.
6 localized delivery either intracerebrally or intrathecally.
7 t AM630, administered either systemically or intrathecally.
8 s (MM-ODNs) for PKCepsilon were administered intrathecally.
9 esia was blocked by minocycline and SB203580 intrathecally.
10  nociception was eliminated by CTAP injected intrathecally.
11 ord were stained by sodium selenite injected intrathecally.
12 ACEA-1021 intraperitoneally (1-60 mg/kg), or intrathecally (1-40 micrograms/mouse), and tested for an
13 ine, BNI) opioid receptors were administered intrathecally 10 min before each of two EA treatments at
14 (ODN) to the cloned rat KOR was administered intrathecally (12.5 microg, twice daily for 4 d) to spec
15 es to determine the relative contribution of intrathecally activated and peripheral LGI1-specific B c
16                                              Intrathecally administered 8d significantly reduced pain
17                                 he effect of intrathecally administered [D-Ala2,N-Me-Phe4,Gly5-ol]-en
18 press such pain, we evaluated the effects of intrathecally administered A(2A)R agonists on neuropathi
19              Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonist
20 ing the silencing of FUS expression using an intrathecally administered antisense oligonucleotide.
21 investigations to enhance bioavailability of intrathecally administered ASOs.FUNDINGSMA Foundation, S
22 agents (alcohol, phenol, botulinum toxin A), intrathecally administered drugs (baclofen), and surgery
23 he cerebrospinal fluid (CSF), while allowing intrathecally administered drugs free passage out of tha
24 eases brain and spinal cord drug exposure of intrathecally administered drugs in mice and rats.
25 paces of the brain, to enhance the uptake of intrathecally administered drugs.
26 ere we describe the clinical experience with intrathecally administered elsunersen, a gapmer antisens
27 o effect on abrupt or sustained neurons, but intrathecally administered fedotozine inhibited the evok
28                            We also show that intrathecally administered GDNF increases the amplitudes
29                      The analgesic effect of intrathecally administered morphine was also profoundly
30 ia when it was coinjected with TNFalpha, but intrathecally administered SB- 366791 attenuated bilater
31 relevance to mutant Huntington retention and intrathecally administered therapeutics responsiveness.
32 clinic to improve the efficacy and safety of intrathecally administered therapeutics.
33 has a distinct impact on the distribution of intrathecally administered therapeutics.
34 and observed heterogeneous responsiveness to intrathecally administered therapies.
35                                              Intrathecally administered U50488H had no effect on abru
36 rified NgR(310)ecto-Fc protein was delivered intrathecally after midthoracic dorsal over-hemisection.
37 ive to spinal GABA levels, GABA was injected intrathecally after nerve injury and sensory behaviors w
38  when compounds 1 and 5a,b were administered intrathecally, all produced analgesia in the tail-flick
39 w describes recent insights into the fate of intrathecally and epidurally administered opioids.
40 horylation in spinal microglia when injected intrathecally and in the BV-2 microglial cell line when
41 improve the therapeutic index when delivered intrathecally and lead to sustained drug retention in th
42 ecruited from the blood, have been activated intrathecally and leave the CNS after performing effecto
43 en-reactive cells had acquired few mutations intrathecally and showed minimal variation in autoantige
44 d U50488H were administered intravenously or intrathecally, and antagonists were used.
45 cluster also blocked the analgesic effect of intrathecally applied bovine adrenal medulla peptide 8-2
46 ntify underlying E2 signaling mechanisms, we intrathecally applied BSA-conjugated E2 over the spinal
47              Consistent with these findings, intrathecally applied CGRP caused a long-lasting, dose-d
48 anisms regulating analgesic effectiveness of intrathecally applied EM2 also pertain to endogenous EM2
49 nd 5HT(7) (AS-19) agonists were administered intrathecally at C4 (three injections, 5-min intervals)
50 strates that AQP4-specific Ig is synthesized intrathecally at disease onset and directly contributes
51  altered only modestly by morphine delivered intrathecally at spinal cord segment S1-S2.
52                  All drugs were administered intrathecally at the L(6)-S(1) segmental level of spinal
53                      Treatment was initiated intrathecally at the time of injury or 3 days after inju
54 modified stereotaxic frame and then injected intrathecally, at the level of the cisterna magna, with
55 TLR4), and AS-ODN for TLR4 mRNA administered intrathecally, attenuated HMWH-induced antihyperalgesia.
56 against TLR4 and RAGE mRNA were administered intrathecally before ('prevention protocol') or 3 days a
57 when chelerythrine chloride was administered intrathecally before CAP injection.
58 ptor antagonist (NBQX, 20 nmol) was injected intrathecally before low-pH injections.
59 gonists olcegepant and CGRP(8-37) both given intrathecally, blocked, and reversed hyperalgesic primin
60 ed mechanical hypersensitivity when injected intrathecally, but not intraplantarly.
61 8 microg kg(-1), 12 microl) was administered intrathecally (C4) to anaesthetized, vagotomized and ven
62   These data support a key role for chronic, intrathecally compartmentalized inflammation in specific
63 g method of delivery, doses, tolerability of intrathecally delivered antisense drugs, and the biodist
64                                           An intrathecally delivered antisense oligonucleotide that a
65 (18)F]BIO-687 could show the distribution of intrathecally delivered ASOs in the rat and NHP brains.
66 ents with rGBM treated in a phase 1 trial of intrathecally delivered bivalent chimeric antigen recept
67                                              Intrathecally delivered chondroitinase ABC (C'ase) impro
68 r example, by improving the effectiveness of intrathecally delivered drugs.
69 g SMA and recently led to FDA approval of an intrathecally delivered SMN-enhancing oligonucleotide cu
70                                              Intrathecally delivering an adeno-associated virus vecto
71 rrier can be bypassed by administering drugs intrathecally directly to the cerebrospinal fluid (CSF).
72 arabine administered either intravenously or intrathecally does not improve the prognosis of HIV-infe
73 bitors of PKCbetaII, PKCdelta, and PKC given intrathecally dose-dependently attenuated paclitaxel-ind
74                                         This intrathecally evoked release of spinal PGE(2) was dimini
75 uction in the DRG, whereas administering BH4 intrathecally exacerbated pain.
76 e doses of tofersen or placebo, administered intrathecally for 12 weeks.
77 irus (AAV)-based PPT1 gene therapy delivered intrathecally has been tested in mouse models but has sh
78 ntagonist, at doses of 0.001 and 0.003 nmol, intrathecally (i.t.) blocked the hyperalgesia induced by
79 oc-D-fluoromethylketone (BDFMK) administered intrathecally (i.t.) in a reversible spinal cord ischemi
80 valuate efficacy in vivo, Ap4m1-KO mice were intrathecally (i.t.) injected with 5 x 1011, 2.5 x 1011,
81                            When administered intrathecally (i.t.) to the lumbar spinal cord, GSK18925
82                   Administration of A-134974 intrathecally (i.t.) was more potent (ED(50)=10 nmol) in
83 red to Aga(-/-) mice intravenously (i.v.) or intrathecally (i.t.), at a range of doses, either before
84  of AAVrh8-HEXA and AAVrh8-HEXB administered intrathecally (i.t.), with 75% of the total dose (1 x 10
85 iven into the rostral-ventral medulla (RVM), intrathecally (i.th.) or simultaneously into both the RV
86 directly to the spinal cord (10 or 25 microg intrathecally [i.t.] in 5 microl saline) induced pupilla
87 During studies in which drugs were delivered intrathecally in a volume sufficiently large to distribu
88 ma (horseradish peroxidase) was administered intrathecally in cats, which were then subjected to mode
89 nal cord, we have synthesized and evaluated (intrathecally in mice) a series of bivalent ligands (KDN
90  the SP(1-7) antagonist, D-SP(1-7), injected intrathecally in mice, on two nociceptive assays that ar
91 is that neuroactive metabolites are produced intrathecally in neuropsychiatric lupus erythematosus.
92 B receptor antagonist CGP 35348 was injected intrathecally in rats pretreated 24 min earlier with 1 o
93 ors (emetine or cycloheximide) were injected intrathecally in the cervical spinal cord of anesthetize
94 pb triggered potent scratching when injected intrathecally in wild-type and Nppb(-/-) mice, showing t
95  and Kir6.2, through an adenovirus delivered intrathecally, increased morphine antinociception in HFD
96                                         Rats intrathecally infused with IL-6 developed progressive we
97                                              Intrathecally-infused antibodies exhibited size-dependen
98 tihyperalgesic action, which was mimicked by intrathecally injected AM 404.
99                                              Intrathecally injected GABA receptor agonists after intr
100 absence of intraplantar capsaicin injection, intrathecally injected GABA receptor antagonists allowed
101  HSV carrying PDGF siRNA was established and intrathecally injected into the cavum subarachnoidale of
102 al hyperalgesia (von Frey fibres) induced by intrathecally injected NMDA in mice were inhibited by th
103  the importance of PIP(2) in nociception, we intrathecally injected PIP(2) into mice.
104 t-Marie-Tooth Disease (CMT1X), was delivered intrathecally into adult Gjb1-null mice, a genetically a
105 ry (SNI) model male donor mice were injected intrathecally into naive male recipient mice.
106 ivered chronically via fibroblasts implanted intrathecally into neonatal rats, can facilitate synapti
107 with more advanced disease were transplanted intrathecally (IT).
108                 Prophylaxis was administered intrathecally(IT) in 894 (77%) and using systemic high-d
109         Liposomal cytarabine 50 mg was given intrathecally on days 2 and 15 of hyper-CVAD and day 10
110 sient effect of both CGRP antagonists, given intrathecally, on mechanical hypersensitivity in female
111 ttenuated hypersensitivity when administered intrathecally or into the hindpaw.
112                                 We show that intrathecally or intracerebroventricularly delivered C16
113 show that proteasome inhibitors administered intrathecally or subcutaneously prevented the developmen
114 that administration of the neurotrophin NT-3 intrathecally or to the proximal stump can prevent axoto
115 are known to alter nociception when injected intrathecally or when released in response to capsaicin.
116 ghest concentration of tofersen administered intrathecally over a period of 12 weeks.
117 tients compared with 60% of patients treated intrathecally (P = .3).
118 esis inhibitor Cycloheximide (CXM) or saline intrathecally prior to, or immediately after, nonconting
119                         However, C5a applied intrathecally produces a dose-dependent, slow-onset cold
120 plantation of lentivirus-loaded biomaterials intrathecally provides the opportunity to induce the exp
121 imals, 7-NI (1-100 micrograms), administered intrathecally, strongly inhibited the NMDA receptor medi
122                         Increased amounts of intrathecally synthesized IgG and oligoclonal bands have
123                             For example, the intrathecally synthesized oligoclonal bands (OGBs) in di
124                             For example, the intrathecally synthesized oligoclonal bands in diseases
125         Thus, our preclinical study supports intrathecally targeting sTNFalpha as a viable strategy t
126  (intracerebroventricularly) or spinal cord (intrathecally) than when given systemically (intravenous
127 ne was created and successfully administered intrathecally to a 4-year-old patient within 3 years of
128 provide evidence that the drugs administered intrathecally to either enlargement do not spread to the
129 ur hypothesis by administering HUP-A i.p. or intrathecally to female Sprague-Dawley rats (200-235 g b
130  oligodeoxynucleotide (ODN) was administered intrathecally to L5 spinal nerve injured rats to reduce
131                                When injected intrathecally to mice, CGRP8-37-cholestanol inhibited no
132  gliosarcoma cells, 125IUdR was administered intrathecally to rats as: (a) a single injection (500 mi
133           We delivered recombinant sialidase intrathecally to rats following a spinal cord contusive
134 ha 2C-adrenergic receptors were administered intrathecally to reduce the expression of these receptor
135 f adrenal medullary tissue were transplanted intrathecally to relieve intractable cancer pain, patien
136                                When injected intrathecally to target spinal NK(1)R+ve neurons in knoc
137 ier (BBB) and therefore need to be delivered intrathecally to the central nervous system (CNS).
138 tor terminals, but also when it is presented intrathecally to the central terminals in the spinal cor
139                   However, when administered intrathecally, to the central terminal, it attenuated hy
140   Neutralizing IL-10 antibodies administered intrathecally transiently abolished the effect of ATL313
141            This study provides evidence that intrathecally transplanted NPCs interfere with the CNS-r
142 ole (a positive GT activity regulator) given intrathecally twice a day for postoperative days 1-4.
143  a GR antisense oligonucleotide administered intrathecally twice daily for postoperative days 1-6.
144 glycan using monoclonal antibodies delivered intrathecally via osmotic mini-pumps after spinal cord i
145 y of icilin applied topically to the paws or intrathecally was tested in rats after spinal nerve liga
146 n that any opioid administered epidurally or intrathecally will produce analgesia by a selective spin
147 zin-5-ylamino]ethyl)ph enol)] coadministered intrathecally with ATL313 abolished the action of ATL313
148 paw were measured in rats that were injected intrathecally with either an NMDA (MK-801) or an NK-1 (L
149                        Animals were injected intrathecally with either Na(v)1.8 antisense or mismatch
150 DRG) of rhesus macaques that were inoculated intrathecally with live B. burgdorferi and either treate
151 ntisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation o

 
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