ライフサイエンスコーパス: intrathymic

1 One intrathymic (25%) and three perithymic (75%) BM recipien

2 Intrathymic AAV-transduced progenitors promote a rapid r

3 a limits thymocyte emigration, leading to an intrathymic accumulation of mature thymocytes within med

4 oth the generation of invariant TCRs and the intrathymic acquisition of effector functions were due t

5 We sought to determine the efficacy of intrathymic adeno-associated virus (AAV) serotypes to tr

6 ditioning resulted in a reduced expansion of intrathymic-administered donor ETPs.

7 We previously showed that the forced intrathymic administration of histocompatible HSCs can s

8 opoiesis of aged mice improved with a single intrathymic administration of low-dose keratinocyte grow

9 ical to transplantation tolerance induced by intrathymic Ag inoculation.

10 Allele-specific quantification of intrathymic AIRE showed that despite its lower expressio

11 Thus, androgen control of an intrathymic Aire-mediated tolerance mechanism contribute

12 CsA can prevent the induction of intrathymic alloantigen tolerance.

13 l host alloreactive CD8+ T cells and nascent intrathymic alloreactive CD8+ T cells.

14 , by creating thymic space and/or overcoming intrathymic alloresistance.

15 therefore represents a general phenomenon in intrathymic alphabeta T lymphocyte development.

16 rradiated Ly 5 congenic mice by quantitative intrathymic and intravenous bone marrow (BM) adoptive tr

17 factor and essential regulator of late-stage intrathymic and post-thymic T cell maturation.

18 thymocyte depletion was occurring through an intrathymic apoptosis mechanism, also prevented by admin

19 This study describes the successful intrathymic autotransplantation of isolated islets using

20 Distinct intrathymic B cell subpopulations were identified, namel

21 These intrathymic B cells engender Tregs.

22 of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 i

23 Thus, we present a mechanism whereby intrathymic B cells, through the provision of cognate he

24 vations demonstrate a specific inhibition of intrathymic B lymphopoiesis, which in turn may explain w

25 Despite the fact that intrathymic B-cell progenitors are bone marrow-derived c

26 Three intrathymic BM recipients rejected after 27, 32, and 54

27 Polymerase chain reaction detected intrathymic but not hematopoietic chimerism in sex-misma

28 ) as their sole antigenic disparity and that intrathymic but not i.v. inoculation of TS1 mice with S1

29 s also been implicated in the development of intrathymic, but not extrathymic, intestinal intraepithe

30 rs was detected in mice transplanted via the intrathymic, but not the intravenous, route.

31 BMT can tolerize preexisting peripheral and intrathymic CD4 cells to xenoantigens.

32 c transcription factor Thpok is required for intrathymic CD4(+) T cell differentiation and, together

33 CD40L, with analysis of distinct subsets of intrathymic CD4(+) T cells revealing a differential cont

34 demethylases, Jmjd3 and Utx, in non-dividing intrathymic CD4(+) T-cell precursors.

35 Precise intrathymic cell migration is important for thymocyte ma

36 antigen presentation and the coordination of intrathymic cell migration: for example, major histocomp

37 a surface density similar to that on mature intrathymic cells and peripheral splenic T cells.

38 only marker on emigrants not found on either intrathymic cells or mature spleen T cells was CTLA-4, w

39 cellular expansion to ensure that sufficient intrathymic cellular niches are available to support the

40 An in situ intrathymic CFSE injection labeled developing thymocytes

41 ance of regulatory mechanisms in addition to intrathymic clonal deletion for the maintenance of toler

42 ion declines, and is most likely mediated by intrathymic clonal deletion of T cells that recognize an

43 tive T-cell elimination, alloreactive T-cell intrathymic clonal deletion, and suppressor T-cell induc

44 Our data imply that intrathymic clonal fitness is important during T-cell de

45 loped normally in the thymus, because of low intrathymic complement activity.

46 nt on the functional outcomes imposed by the intrathymic constraints of differentiation and self-tole

47 also by closely regulated responsiveness to intrathymic cytokines such as IL7.

48 positive selection and become responsive to intrathymic cytokines such as interleukin 7 (IL-7).

49 hymocytes, but it is subsequent signaling by intrathymic cytokines that specifies CD8 lineage choice

50 d the development of autoreactive T cells by intrathymic deletion and protected the mice from the dev

51 h the avidity of the interaction involved in intrathymic deletion is significantly lower than that in

52 transplantation antigens is achieved through intrathymic deletion of donor-reactive T cells in mixed

53 more than 145 days) and demonstrated ongoing intrathymic deletion of donor-reactive T cells.

54 d by a xenogeneic MHC, as well as incomplete intrathymic deletion of thymocytes recognizing host tiss

55 e Ealpha52-68:I-A(b) complex display drastic intrathymic deletion.

56 ewise mild phenotype seen after conditional (intrathymic) deletion of Notch1.

57 at Mtv-17 Sag causes peripheral, rather than intrathymic, deletion of T cells.

58 T cell development, only one contributed to intrathymic dendritic cell (DC) differentiation, predomi

59 thymocytopoiesis is accompanied by a wave of intrathymic dendritic cell formation, these coordinated

60 ce by regulating the frequency and makeup of intrathymic dendritic cells (DCs) required for effective

61 ially, we examined whether AHR activation in intrathymic dendritic cells could mediate TCDD-induced t

62 lasmacytoid dendritic lineage, suggesting an intrathymic dendritic specification pathway.

63 he enhanced reconstitution capacity of these intrathymic-derived ETPs was corroborated by their signi

64 t for some T-cell functions, but its role in intrathymic development is unclear.

65 transcription factors, is essential for the intrathymic development of CD4+ T cells and for the diff

66 These animals exhibited normal intrathymic development of conventional T cells, but the

67 sly unknown function of costimulation in the intrathymic development of iNKT cells, distinct from tha

68 ls, but they were profoundly impaired in the intrathymic development of invariant NKT cells.

69 MHC class II interaction(s) required for the intrathymic development of long-lived CD4(+) SP cells oc

70 s after in vivo depletion of DCs resulted in intrathymic development of non-T-lineage cells.

71 vities of specific genomic loci during early intrathymic development to establish T cell lineage iden

72 Intrathymic development was blocked within the CD4- CD8-

73 After intrathymic development, T cells exit the thymus and joi

74 SP differentiation of thymocytes during late intrathymic development.

75 a mystery, particularly given the rigors of intrathymic developmental checkpoints, successfully trav

76 and MHC class II-induced TCR signals direct intrathymic developmental decisions.

77 on and multiple pre- and post-beta-selection intrathymic developmental defects.

78 ased overall thymic cellularity and impaired intrathymic differentiation at the CD4(-)CD8(-)CD44(+)CD

79 he signal pathways that activate them during intrathymic differentiation from pluripotent precursors.

80 on factors GATA-3 and ThPOK are required for intrathymic differentiation of CD4(+) T cells, but their

81 ly received much attention, but the earliest intrathymic differentiation steps in adult mice have rem

82 eptor (TCR) gene rearrangements during their intrathymic differentiation to become T cells.

83 ction was apparent at the earliest stages of intrathymic differentiation.

84 nd the timing of TCR signaling contribute to intrathymic differentiation.

85 a thymocytes have hampered analyses of their intrathymic differentiation.

86 Persistence of intrathymic donor cells was associated with intrathymic

87 total lymphoid irradiation and perithymic or intrathymic donor-specific BM induced tolerance to renal

88 d examines why autoantibodies after a single intrathymic drug injection were much more limited in iso

89 anscription in vivo reduced the frequency of intrathymic early T cell progenitors (ETP), but not CTP,

90 ive, c-kit high progenitor cells differ from intrathymic early T cell progenitors (ETPs) by functiona

91 ulatory T (T(reg)) cell lineage is driven by intrathymic encounter of agonist self-antigens in a simi

92 splantation of limited numbers of HSC but to intrathymic events.

93 , but exerts its influence on the subsequent intrathymic expansion and differentiation of iNKT cells.

94 ZF-deficient NKT cells failed to undergo the intrathymic expansion and effector differentiation that

95 dependent, active regulatory mechanism after intrathymic exposure to donor-specific alloantigen and d

96 e show that LTbetaR differentially regulates intrathymic expression of adhesion molecules known to pl

97 Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral s

98 Intrathymic expression of tissue-specific antigens (TSAs

99 henotype, as do adult CD8+ RTE identified by intrathymic FITC injection.

100 -deficient (Tnfrsf11b(-/-)) mice impacts the intrathymic Foxp3(+) Treg pool by enhancing peripheral T

101 C homeostasis is not a rate-limiting step in intrathymic Foxp3(+) Treg production.

102 ase into the blood approximately 1 wk before intrathymic gate opening.

103 An innovative intrathymic gene therapy approach that directly targets

104 c medulla plays an important role during the intrathymic generation of distinct alphabetaT-cell subty

105 atal periods, the medulla is involved in the intrathymic generation of multiple alphabetaT cell linea

106 use models that GVHD results in depletion of intrathymic group 3 innate lymphoid cells (ILC3s) necess

107 us in this model, we examined the effects of intrathymic (i.t.) injection of P5-primed alloreactive T

108 These studies suggest that intact intrathymic IL-12 production is necessary for the negati

109 nitial studies we demonstrated that abundant intrathymic IL-12 synthesis occurs during OVA peptide-in

110 mice, and it is hypothesized that decreased intrathymic IL-7 is involved in age-related thymic invol

111 Thus, intrathymic IL-7 was required for development of thymic

112 KGF treatment caused increased production of intrathymic IL-7, and the thymopoietic effects of KGF re

113 tered activation of the Th1 response in this intrathymic immune modulation model.

114 B7 T-cell co-stimulation in conjunction with intrathymic immunomodulation on cellular and humoral imm

115 gen, RT.1Aa, we previously demonstrated that intrathymic immunomodulation with donor antigens resulte

116 However, intrathymic injection and bone marrow chimera experiment

117 lf-antigen, whereas increasing CS content by intrathymic injection inhibited thymic selection, indica

118 We have recently shown that intrathymic injection of a combination of immunogenic WA

119 protein tyrosine kinase, ZAP-70, with direct intrathymic injection of a ZAP-70-expressing T cell-spec

120 We conclude that intrathymic injection of Ag induces apoptosis of immatur

121 This hypothesis is based on the finding that intrathymic injection of allopeptides in the adult anima

122 1a) donors were pretreated (day -14) with an intrathymic injection of alpha(1h)l58-80-RT1.Aa, alpha(1

123 Intrathymic injection of an AAV8-ZAP-70 vector into ZAP-

124 wk-old mice developed thymic chimerism after intrathymic injection of BM cells, and that the levels o

125 n whom gating was synchronized by an initial intrathymic injection of BM cells.

126 on an interventional radiology technique for intrathymic injection of cells or drugs.

127 of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small

128 estine, a pattern of migration visualized by intrathymic injection of FITC and subsequent accrual of

129 The intrathymic injection of interleukin-7 prior to irradiat

130 We show that intrathymic injection of multipotent hematopoietic stem/

131 hase of acquired thymic tolerance induced by intrathymic injection of myelin Ags.

132 T-cell-mediated antitumor immunity following intrathymic injection of progenitor cells harboring a tr

133 (n=4) injection of donor bone marrow (BM) or intrathymic injection of saline (n=5).

134 ins, and NK1.1(+) cells can be obtained upon intrathymic injection of sorted PLZF(+) cells, thus indi

135 Intrathymic injection of these progenitors, however, yie

136 After intrathymic injection, donor-derived cells phenotypicall

137 Upon intrathymic injection, IL-7R(neg-lo) pro-T cells generat

138 Intrathymic injections of DNMAML(-) or DNMAML(+) DN thym

139 Two intrathymic injections of procainamide-hydroxylamine (PA

140 In conclusion, mTEC specialization controls intrathymic iNKT cell development and function, and dete

141 Collectively, our findings demonstrate that intrathymic iNKT cell development requires stepwise inte

142 The finding that intrathymic inoculation of an immunodominant WF major hi

143 imed thymic DCs isolated from ACI rats given intrathymic inoculation of P5 for 2 days were capable of

144 Intrathymic inoculation of splenic T-cells obtained from

145 d reliably in experimental animals following intrathymic inoculation with the relevant donor strain A

146 of studies, we showed that intravenous-like intrathymic-inoculation of in vitro P5-pulsed host myelo

147 ss of thymic ILC3s resulted in deficiency of intrathymic interleukin-22 (IL-22) compared with transpl

148 KGF induced increased numbers of TECs and intrathymic interleukin-7 (IL-7) production and reorgani

149 ted in rodents, and more significantly, such intrathymic islet allografts have been shown to induce r

150 Intrathymic islet autotransplantation has been pursued,

151 nine thymus and establish the feasibility of intrathymic islet transplantation in a phylogenetically

152 Intrathymic (IT) alloantigen combined with administratio

153 parenchymal fibrosis; isograft controls and intrathymic (IT) animals failed to develop this lesion.

154 ACI recipients were pretreated with intrathymic (IT) injection of 300 microg of the individu

155 e this hypothesis, we studied the effects of intrathymic (IT) injection of a single immunodominant Wi

156 The finding that intrathymic (IT) injection of an immunodominant peptide

157 transcriptional checkpoints that control the intrathymic journey of T cell precursors.

158 Intrathymic levels of IL-22 were increased after thymic

159 t alphabeta-lineage thymocytes contribute to intrathymic levels of KGF.

160 re signaled by alpha beta TCR engagements of intrathymic ligands.

161 Importantly, FGF21 overexpression reduced intrathymic lipid, increased perithymic brown adipose ti

162 ell integrity and reducing the generation of intrathymic lipid.

163 inguished by their TCR-signaling pattern and intrathymic location and provide a framework for underst

164 d T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice.

165 re CD8(lo)CD4(hi) cells could complete their intrathymic maturation and populate the peripheral lymph

166 aracterized block in post-positive selection intrathymic maturation of CD4 T cells.

167 n of the mouse gimap5 gene impairs the final intrathymic maturation of CD8 and CD4 T cells and compro

168 binding gradually decreased with increasing intrathymic maturation.

169 While intrathymic MHC expression influences the specificity of

170 d, the premature TCR alpha beta contact with intrathymic MHC molecules further pronounces the block i

171 e phenotypic changes, calcium signaling, and intrathymic migration in a synchronized cohort of MHC cl

172 Here, we examined the intrathymic migration of human thymocytes in both mouse

173 entifying the chemokine signals that control intrathymic migration patterns.

174 tional knockout mice do not have a defect in intrathymic migration, thymic egress, T cell survival, o

175 Therefore, we propose that intrathymic miR-181a/b-1 controls development of Treg ce

176 e 6th fraction permitted perithymic (n=4) or intrathymic (n=4) injection of donor bone marrow (BM) or

177 es of autoeffector T cells that have escaped intrathymic negative selection for self-MHC class II Ag

178 Despite the demonstration of functional intrathymic negative selection in I-A(12%) mice, transfe

179 A profound intrathymic negative selection occurs in 1H3.1 TCR trans

180 Here, we show the increase in intrathymic niches caused by the proliferation of the ep

181 lobes; gate opening occurred only after most intrathymic niches for prothymocytes had emptied; and th

182 iment as being the result of competition for intrathymic niches specifically supporting the DN3 stage

183 by the thymus; 3) competitive antagonism for intrathymic niches; 4) temporally linked generation of t

184 The relative number of intrathymic NK T cell precursors decline in a linear man

185 nown NKT regulators, CYLD is dispensable for intrathymic NKT cell maturation but is obligatory for th

186 cription factors, mobilized and modulated by intrathymic Notch signaling.

187 The cDCs of intrathymic origin were mostly Sirpalpha(-) CD11b(-) CD8

188 that chromatin-reactive T cells produced by intrathymic PAHA created a B cell population primed to s

189 Mice subjected to a single intrathymic PAHA injection after receiving splenic B cel

190 anti-chromatin Abs developed after a single intrathymic PAHA injection in Fas-deficient C57BL/6-lpr/

191 milarly primed T cells or of B cells without intrathymic PAHA injection of the recipient failed to pr

192 tion after receiving splenic B cells from an intrathymic PAHA-injected syngeneic donor also developed

193 Furthermore, data suggest an intrathymic pathway of CD4+ Valpha24 NK T cell developme

194 Intrathymic peptide inoculation was associated with a do

195 R with an optimal affinity for the selecting intrathymic peptide-MHC complexes.

196 tiated NZB T cell precursors included in the intrathymic pool of CD4(-)CD8(-) cells also exhibited no

197 rrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous

198 Compensatory expansion of intrathymic populations can account for at least a part

199 CXCR4 is dispensable for the maintenance and intrathymic positioning of CD4(+)CD8(+) thymocytes, and

200 Intrathymic positive selection matches CD4-CD8 lineage d

201 ce self-peptides play a critical role in the intrathymic positive selection of the mature TCR reperto

202 a consequence of the peptide specificity of intrathymic positive selection, mice transgenic for a re

203 These observations suggest that, similar to intrathymic positive selection, the maintenance of the m

204 rtoire diversification occurred by a gain in intrathymic positive selection.

205 al persistence in irradiated hosts and their intrathymic positive selection.

206 Whether intrathymic-positive and -negative selection of conventi

207 ion of newly formed T cells does not require intrathymic preactivation, is cell-intrinsic, and correl

208 itor (ETP), which appears to be the earliest intrathymic precursor defined to date.

209 ors constraining new progenitor recruitment, intrathymic precursor expansion, and thymus size remain

210 t was disturbed with a block at the earliest intrathymic precursor stage.

211 Intrathymic precursor transfer experiments and the ident

212 The earliest intrathymic precursors were CD4(lo)CD8(-)CD25(-)CD44(+)c

213 Immature intrathymic precursors were insensitive to an emigration

214 We have investigated the effects of flt3L on intrathymic precursors.

215 ceptibility to type 1 diabetes by regulating intrathymic preproinsulin expression.

216 intrathymic donor cells was associated with intrathymic presence of cells resembling long-term hemat

217 se chain reaction analyses demonstrated that intrathymic production of IL-7 was significantly decreas

218 ipotent progenitors (MPPs), and the earliest intrathymic progenitor (DN1), using 2 in vitro assays an

219 ly in the CD4(-)CD8(-)CD3(-) triple-negative intrathymic progenitor cell population 24 h after exposu

220 mo-2'-deoxyuridine incorporation in specific intrathymic progenitor cell populations.

221 These data indicate that intrathymic progenitor cells are direct targets of TCDD

222 with reduced progenitor input to the thymus, intrathymic progenitor niches remain unsaturated for at

223 ing experiments using RNA isolated from four intrathymic progenitor populations in which the AHR was

224 e, we study the subpopulation of early human intrathymic progenitors expressing the type IA BMP recep

225 ch1 and Notch3 are coexpressed on some early intrathymic progenitors, the relatively mild phenotype s

226 e compelling evidence that c-Myc mediates an intrathymic proliferation wave immediately after agonist

227 t NKT cells all underwent a phase of intense intrathymic proliferation, whereas adaptive CD4(+) and C

228 populations are efficiently expanded through intrathymic proliferation.

229 on of the cortex for about the first 10 d of intrathymic residence; this region virtually overlaps th

230 he CXCR4-mediated chemorepellent activity of intrathymic SDF-1 contributes to SP thymocyte egress fro

231 the alphabeta fate upon separation from the intrathymic selecting environment, those that express CD

232 nce between these two lineages occurs during intrathymic selection and is thought to be irreversible

233 sary for T cell function is a consequence of intrathymic selection during which T cell antigen recept

234 changes in CXCR4 expression as a marker for intrathymic selection events, and show its role in T-cel

235 s that a reciprocal loss-and-gain pattern of intrathymic selection exists between H-2Kb and H-2Kbm8.

236 Intrathymic selection generates a peripheral repertoire

237 multiple self-peptide/MHC complexes directs intrathymic selection of T cells.

238 lly autoreactive CD8 cells that have escaped intrathymic selection.

239 t relied on coexpression of a second TCR for intrathymic selection.

240 nue to express Fezf2 and Aire, regulators of intrathymic self-antigens, and support T-reg development

241 Intrathymic self-peptide-major histocompatibility comple

242 role for CD4(+)3(-)RANKL(+) inducer cells in intrathymic self-tolerance.

243 tudy identifies costimulation by CD28 as the intrathymic signal required for clonal deletion and iden

244 TCR on DP thymocytes appears to result from intrathymic signaling, as in vitro culture of these cell

245 ate into CD4+ or CD8+ T cells in response to intrathymic signals that extinguish transcription of the

246 tes is important for self-tolerance, but the intrathymic signals that induce clonal deletion have not

247 tenin expression is stringently regulated by intrathymic signals, it is expressed at the highest leve

248 regulated NF-kappaB DNA binding activated by intrathymic signals.

249 ong five distinct components of the earliest intrathymic stage (DN1, CD25(-)44(+)).

250 and influences the balance of early and late intrathymic stages of Foxp3(+) regulatory T cell develop

251 up-regulated between the first two stages of intrathymic T cell development (double negative 1 and do

252 ecause thymocytes are seemingly short-lived, intrathymic T cell development depends on continuous imp

253 Intrathymic T cell development depends on signals transd

254 o a nonredundant cytokine network supporting intrathymic T cell development emerged as a consequence

255 hymocytes, the possible role of CD205 during intrathymic T cell development has not been studied.

256 Intrathymic T cell development is a complex process that

257 Intrathymic T cell development is predicated on the Notc

258 ur data identify novel roles for CCR7 during intrathymic T cell development, highlighting its importa

259 With respect to intrathymic T cell development, il7 deficiency is associ

260 nation according to distinct programs during intrathymic T cell development.

261 additional, as-yet unidentified cytokines to intrathymic T cell development.

262 ic beta chain, we address several aspects of intrathymic T cell development.

263 Understanding intrathymic T cell differentiation has been greatly aide

264 s, there is a severe block in all aspects of intrathymic T cell maturation, although both positive an

265 recapitulates critical intermediary steps in intrathymic T cell maturation.

266 Decreased intrathymic T cell precursors and decreased generation o

267 genes that are specifically up-regulated in intrathymic T cell precursors as compared with myeloid p

268 pose that intrinsic developmental defects in intrathymic T cell precursors do not contribute to age-r

269 After our observation that intrathymic T cell precursors expressing a human CD25 re

270 nt models postulate that irradiation affects intrathymic T cell precursors.

271 e influence of MHC molecules, key drivers of intrathymic T cell selection and naive peripheral T cell

272 While analyzing gene expression during intrathymic T cell selection, we found that Zfp67, encod

273 ell receptor (TCR) signals are essential for intrathymic T cell-positive selection, it remains contro

274 elopmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important

275 as seen on double negative thymocytes and on intrathymic T progenitor cells.

276 (extrachromosomal DNA circles formed during intrathymic T-cell development) to assess thymus-depende

277 hematopoietic system, HH signaling regulates intrathymic T-cell development, and it is one of the sur

278 egulation of signaling pathways that control intrathymic T-cell development.

279 d joining gene segments, suggesting abnormal intrathymic T-cell development.

280 at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development.

281 ) homozygotes were fertile, and no defect in intrathymic T-cell differentiation was detected.

282 ages, including T cells, but its function in intrathymic T-cell precursors has been poorly defined.

283 T-cell progenitors (ETPs), the most immature intrathymic T-cell precursors, harvested from the involu

284 Thus, intrathymic T-cell production is intimately linked to th

285 n elevated because PI-resistant virus spares intrathymic T-cell production.

286 Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing

287 Intrathymic tolerance to vascularized grafts in large an

288 leading to permanent marrow engraftment and intrathymic tolerization of T cells that develop subsequ

289 -specific generation of Foxp3(+) cells using intrathymic transfer of TCR-transgenic thymocytes expres

290 By using intrathymic transfer, we found that the CD25hi subset is

291 Using intrathymic transfer, we show that the immature CD8(lo)C

292 In contrast, intrathymic transfers after in vivo depletion of DCs res

293 ular barcoding and reporter mice, as well as intrathymic transfers coupled with DC depletion.

294 However, intrathymic transfers into nonmanipulated mice, as well

295 Intrathymic transplantation and in vitro colony-forming

296 on of specific unresponsiveness secondary to intrathymic transplantation will not be impaired or limi

297 In intrathymic-transplanted mice, ongoing thymopoiesis was

298 Intrathymic TSHR expression was decreased in individuals

299 A majority of intrathymic Valpha24 NK T cell progenitors are CD4+, whe

300 histocompatibility barriers is modulated by intrathymic vs intravenous administration of HSCs.