ライフサイエンスコーパス: intrinsically disordered protein

1 with the N terminus of CsoS2, a multivalent, intrinsically disordered protein.

2 n the cortactin repeats resemble a coil-like intrinsically disordered protein.

3 )DD) exhibits multiple characteristics of an intrinsically disordered protein.

4 alation of human metallothionein-2A (MT), an intrinsically disordered protein.

5 , a prototypic viral oncoprotein and a model intrinsically disordered protein.

6 rotein is a prime example of a molecular hub intrinsically disordered protein.

7 iled structural ensemble of a membrane-bound intrinsically disordered protein.

8 to conformational biases in the ensembles of intrinsically disordered proteins.

9 etheless poorly understood, particularly for intrinsically disordered proteins.

10 ysis to probe the oligomerization process of intrinsically disordered proteins.

11 us and dynamic complexes in the functions of intrinsically disordered proteins.

12 ecently to be well suited for simulations of intrinsically disordered proteins.

13 g and for the function of the large group of intrinsically disordered proteins.

14 roteins and is prevalent in the sequences of intrinsically disordered proteins.

15 and dynamics of functional de novo designed intrinsically disordered proteins.

16 using an explicit water model optimized for intrinsically disordered proteins.

17 important for the activity and misfolding of intrinsically disordered proteins.

18 etics of proteins as well as the dynamics of intrinsically disordered proteins.

19 We apply our analysis to globular and intrinsically disordered proteins.

20 in the denatured state ensemble (DSE) or in intrinsically disordered proteins.

21 used to study the properties of unfolded and intrinsically disordered proteins.

22 s simulations of three different unfolded or intrinsically disordered proteins.

23 e-induced chain collapse of five unfolded or intrinsically disordered proteins.

24 rning the structure-function relationship of intrinsically disordered proteins.

25 ins fail to properly reproduce properties of intrinsically disordered proteins.

26 define its molecular determinants acting on intrinsically disordered proteins.

27 rging features of binding-induced folding of intrinsically disordered proteins.

28 ted in the liquid-liquid phase separation of intrinsically disordered proteins.

29 lationship between sequence and structure of intrinsically disordered proteins.

30 proteins have some features in common with "intrinsically disordered" proteins.

31 WIP is predicted to be an intrinsically disordered protein, a class of polypeptide

32 enaturants on the dimensions of unfolded and intrinsically disordered proteins: A wide range of exper

33 ded state of the spectrin domain R17 and the intrinsically disordered protein ACTR in two different d

34 guanidinium chloride on the structure of the intrinsically disordered protein ACTR, which can be stud

35 Participation of the small, intrinsically disordered protein alpha-synuclein (alpha-

36 Misfolding and aggregation of the intrinsically disordered protein alpha-Synuclein (alphaS

37 ermination of conformational ensemble of the intrinsically disordered protein alpha-synuclein in the

38 Structural conversion of the presynaptic, intrinsically disordered protein alpha-synuclein into am

39 The formation of amyloid fibrils by the intrinsically disordered protein alpha-synuclein is a ha

40 erns, on the complex structural space of the intrinsically disordered protein alpha-synuclein.

41 ng for analysis by other techniques, such as intrinsically disordered proteins, amyloidogenic protein

42 scussing examples from evolutionary biology, intrinsically disordered proteins and current biomedical

43 of functionally and pathologically important intrinsically disordered proteins and disordered regions

44 Crucially, we show that both intrinsically disordered proteins and highly re-wired pr

45 Intrinsically disordered proteins and intrinsically diso

46 Intrinsically disordered proteins and intrinsically diso

47 ite many previous studies on condensation of intrinsically disordered proteins and low complexity dom

48 ferent epitopes within three disease-related intrinsically disordered proteins and peptides (alpha-sy

49 flexibility and binding properties of these intrinsically disordered proteins and probably exemplifi

50 d recognition of the prevalence and roles of intrinsically disordered proteins and protein regions (I

51 Intrinsically disordered proteins and proteins with intr

52 Intrinsically disordered proteins and regions (IDPs) rep

53 -third of the human proteome is comprised of intrinsically disordered proteins and regions (IDPs/IDRs

54 efore, host cells use numerous advantages of intrinsically disordered proteins and regions to fight f

55 Liquid granules rich in intrinsically disordered proteins and RNA play key roles

56 coupled folding and binding reaction of two intrinsically disordered proteins and the conformational

57 TaFROG is an intrinsically disordered protein, and it localized to th

58 rt the identification of MEG-14 as a classic intrinsically disordered protein, and open the possibili

59 LAT is an intrinsically disordered protein, and these data suggest

60 ted to play a key role in the association of intrinsically disordered proteins, and the observed beha

61 ly, whereas disorder-to-order transitions of intrinsically disordered proteins appear to follow rules

62 Intrinsically disordered proteins are crucial elements o

63 amplitudes of conformational fluctuations of intrinsically disordered proteins are governed, in part,

64 Protein-protein interactions involving intrinsically disordered proteins are important for cell

65 Many intrinsically disordered proteins are promiscuous binder

66 Intrinsically disordered proteins are proteins whose nat

67 Intrinsically disordered proteins are ubiquitous in natu

68 Intrinsically disordered proteins are very common in the

69 tural biology, which include multidomain and intrinsically disordered proteins as well as nucleic aci

70 P granules and stress granules and identify intrinsically-disordered proteins as drivers of RNA cond

71 RNAS PATHWAYS9 (CARP9), a nuclear-localized, intrinsically disordered protein, as a factor promoting

72 rated--functional activation of supercharged intrinsically disordered proteins by low concentrations

73 Thus, an intrinsically disordered protein can tunnel through the

74 Intrinsically disordered proteins can adopt multiple con

75 ditions has led to the realization that such intrinsically disordered proteins can be functional even

76 e of protein-based inheritance through which intrinsically disordered proteins can drive the emergenc

77 how very small structural motifs present in intrinsically disordered proteins can exert a specific f

78 Highly charged intrinsically disordered proteins can form complexes wit

79 Tau, an intrinsically disordered protein confined to neuronal ax

80 Intrinsically disordered proteins control cell elongatio

81 s the activation of nanoscale dynamics of an intrinsically disordered protein, controlling the bindin

82 also the majority of experimental studies of intrinsically disordered protein coupled folding and bin

83 Like other intrinsically disordered proteins, dehydrins can gain st

84 relationships in conformational ensembles of intrinsically disordered proteins derived using experime

85 gment of Msm sigma(A), which may comprise an intrinsically disordered protein domain unique to mycoba

86 Intrinsically disordered protein domains often have mult

87 hese studies were performed on two different intrinsically disordered protein domains, a binding doma

88 The mechanisms by which intrinsically disordered proteins engage in rapid and hi

89 bda serves well to quantify the evolution of intrinsically disordered proteins even though the unstru

90 he case of the Abeta40 peptide, a 40-residue intrinsically disordered protein fragment associated wit

91 probably a common mechanism in molecular hub intrinsically disordered protein function.

92 Intrinsically disordered proteins function as flexible s

93 Dehydrins are intrinsically disordered proteins, generally expressed i

94 The sugar trehalose and hydrophilins (small intrinsically disordered proteins) had also been propose

95 Data indicate that the intrinsically disordered proteins have a similar behavio

96 Intrinsically disordered proteins have been reported to

97 allostery can be facilitated by dynamic and intrinsically disordered proteins have resulted in a new

98 alpha-Synuclein (AS) is an intrinsically disordered protein highly expressed in dop

99 other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues

100 Intrinsically disordered protein (IDP) conformers occupy

101 e than an N-terminal, arginine/glycine rich, intrinsically disordered protein (IDP) domain of LAF-1 i

102 Intrinsically disordered protein (IDP) duplexes composed

103 p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyc

104 The intrinsically disordered protein (IDP), alpha-synuclein

105 Is), those involving a folded protein and an intrinsically disordered protein (IDP), are prevalent in

106 nent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP), regulates cell d

107 elongs to the BH3-only protein family, is an intrinsically disordered protein (IDP).

108 (K(d) approximately 10(-12) M) to become an intrinsically disordered protein (IDP).

109 Intrinsically disordered proteins (IDPs) abound in cellu

110 ed amino acid sequences, monomeric proteins, intrinsically disordered proteins (IDPs) and catalytic r

111 These intrinsically disordered proteins (IDPs) and hybrid prot

112 Intrinsically disordered proteins (IDPs) and IDP regions

113 Dynein light chain 8 (LC8) interacts with intrinsically disordered proteins (IDPs) and influences

114 Intrinsically disordered proteins (IDPs) and intrinsical

115 Intrinsically disordered proteins (IDPs) and membrane-le

116 tigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nucleic aci

117 or the deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of denature

118 These interactions often involve intrinsically disordered proteins (IDPs) and protein bin

119 Many intrinsically disordered proteins (IDPs) and protein reg

120 s requires elucidating the critical roles of intrinsically disordered proteins (IDPs) and regions (ID

121 Intrinsically disordered proteins (IDPs) and their confo

122 Intrinsically disordered proteins (IDPs) are a set of pr

123 Intrinsically disordered proteins (IDPs) are a unique cl

124 Intrinsically disordered proteins (IDPs) are abundant in

125 Intrinsically disordered proteins (IDPs) are characteriz

126 Intrinsically disordered proteins (IDPs) are characteriz

127 Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ens

128 Intrinsically disordered proteins (IDPs) are flexible bi

129 Intrinsically disordered proteins (IDPs) are frequently

130 Intrinsically disordered proteins (IDPs) are functional

131 The functions of intrinsically disordered proteins (IDPs) are governed by

132 Intrinsically disordered proteins (IDPs) are important f

133 Intrinsically disordered proteins (IDPs) are involved in

134 Intrinsically disordered proteins (IDPs) are involved in

135 Intrinsically disordered proteins (IDPs) are known to un

136 Intrinsically disordered proteins (IDPs) are proteins th

137 Intrinsically disordered proteins (IDPs) are proteins th

138 Intrinsically disordered proteins (IDPs) are ubiquitous

139 Intrinsically disordered proteins (IDPs) are well known,

140 Intrinsically disordered proteins (IDPs) are widespread

141 Intrinsically disordered proteins (IDPs) as well as intr

142 Many intrinsically disordered proteins (IDPs) attain a well-d

143 signaling and regulation, are carried out by intrinsically disordered proteins (IDPs) binding to thei

144 cant changes in the structural properties of intrinsically disordered proteins (IDPs) by affecting th

145 The study of intrinsically disordered proteins (IDPs) by NMR often su

146 Intrinsically disordered proteins (IDPs) can display a b

147 Intrinsically disordered proteins (IDPs) can form liquid

148 A subset of these intrinsically disordered proteins (IDPs) can, upon bindi

149 Phase separation of intrinsically disordered proteins (IDPs) commonly underl

150 ular structures that contain phase-separated intrinsically disordered proteins (IDPs) composed of seq

151 Intrinsically disordered proteins (IDPs) constitute an i

152 Intrinsically disordered proteins (IDPs) containing phen

153 The dynamic modes and time scales sampled by intrinsically disordered proteins (IDPs) define their fu

154 aordinary need to describe the structures of intrinsically disordered proteins (IDPs) due to their ro

155 ntitatively reproduce structural behavior in intrinsically disordered proteins (IDPs) has not been es

156 Many intrinsically disordered proteins (IDPs) have been deter

157 Intrinsically disordered proteins (IDPs) have fluctuatin

158 Intrinsically disordered proteins (IDPs) have roles in m

159 Measuring amide hydrogen exchange (HX) of intrinsically disordered proteins (IDPs) in solutions co

160 Liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is a major unde

161 Phase separation of intrinsically disordered proteins (IDPs) is a remarkable

162 Characterization of intrinsically disordered proteins (IDPs) is challenging,

163 eterogeneity, structural characterization of intrinsically disordered proteins (IDPs) is very challen

164 s and mutations that change charge states in intrinsically disordered proteins (IDPs) is well-establi

165 Intrinsically disordered proteins (IDPs) lack stable sec

166 A growing body of literature on intrinsically disordered proteins (IDPs) led scientists

167 Intrinsically disordered proteins (IDPs) often fold into

168 less organelles form via phase separation of intrinsically disordered proteins (IDPs) or regions (IDR

169 Intrinsically disordered proteins (IDPs) or regions (IDR

170 Intrinsically disordered proteins (IDPs) or regions of i

171 Intrinsically disordered proteins (IDPs) perform their p

172 lasm that collectively we term "assemblage." Intrinsically disordered proteins (IDPs) play an importa

173 Intrinsically disordered proteins (IDPs) play central ro

174 lded states of proteins and native states of intrinsically disordered proteins (IDPs) populate hetero

175 Intrinsically disordered proteins (IDPs) present a funct

176 nt (LEA) proteins are mostly predicted to be intrinsically disordered proteins (IDPs) that are induce

177 facile specific recognition is essential for intrinsically disordered proteins (IDPs) that are involv

178 Intrinsically disordered proteins (IDPs) that lack a uni

179 ensemble model from candidate structures for intrinsically disordered proteins (IDPs) that takes full

180 Quantitative comparisons of intrinsically disordered proteins (IDPs) with similar se

181 dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs), adopt in the a

182 s of naturally unstructured proteins, termed intrinsically disordered proteins (IDPs), demonstrates t

183 chnique for studying complex systems such as intrinsically disordered proteins (IDPs), globular prote

184 Many properties of intrinsically disordered proteins (IDPs), or protein reg

185 be significantly more heterogeneous than on intrinsically disordered proteins (IDPs), peptides, and

186 olecular interactions of a set of artificial intrinsically disordered proteins (IDPs), we have create

187 Intrinsically disordered proteins (IDPs), which in isola

188 es in the functional mechanisms exploited by intrinsically disordered proteins (IDPs).

189 o characterizing the structural ensembles of intrinsically disordered proteins (IDPs).

190 s six exciting articles on low complexity or intrinsically disordered proteins (IDPs).

191 argely unknown, in particular in the case of intrinsically disordered proteins (IDPs).

192 mineralization processes and the function of intrinsically disordered proteins (IDPs).

193 interest in understanding the properties of intrinsically disordered proteins (IDPs); however, the c

194 yA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress gr

195 biophysical studies and show that SilE is an intrinsically disordered protein in its free apo-form bu

196 commonly observed in signal transduction by intrinsically disordered proteins in biology.

197 performance of force fields recommended for intrinsically disordered proteins in molecular dynamics

198 between these marginally stable proteins and intrinsically disordered proteins in order to fully unde

199 rs in carbohydrate-active enzymes, which are intrinsically disordered proteins in solution, aid in dy

200 Like some other intrinsically disordered proteins in the solution state

201 P-pRb interactions, or more generally in hub intrinsically disordered protein interaction networks.

202 g dynamic complexes in structural studies of intrinsically disordered protein interactions.

203 Within the intrinsically disordered protein interactome, the alpha-

204 Even in unfolded and intrinsically disordered proteins, internal friction has

205 Liquid-liquid phase separation of intrinsically disordered proteins into mesoscopic, dynam

206 -molecule inhibitors that bind covalently to intrinsically disordered proteins is a promising strateg

207 The function of these intrinsically disordered proteins is the stabilization o

208 A pre-structures motif in the intrinsically disordered proteins is thus important for

209 alpha-Synuclein (alpha-Syn), an intrinsically disordered protein, is associated with Par

210 ollective interactions among multivalent and intrinsically disordered proteins, is thought to mediate

211 Finally, we implicate intrinsically disordered proteins, key components in mRN

212 Intrinsically disordered proteins lack a well-defined fo

213 Intrinsically disordered proteins, like tau, are enriche

214 elay of septum degradation requires Fir1, an intrinsically disordered protein localized to the cytoki

215 ifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-a

216 As an intrinsically disordered protein, monomeric alpha-synucl

217 measuring rapid H/D exchange kinetics by an intrinsically disordered protein, murine CBP(2059-2117)

218 hi-psi dihedral angle space, we used a model intrinsically disordered protein, namely, alpha-synuclei

219 mylin (islet amyloid polypeptide, IAPP), two intrinsically disordered proteins of the calcitonin pept

220 Intrinsically disordered proteins often become structure

221 Intrinsically disordered proteins often play an importan

222 on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist

223 al studies of aggregation of short peptides, intrinsically disordered proteins, or proteins under den

224 As for many intrinsically disordered proteins, order-disorder transi

225 ) interaction thus presents an example of an intrinsically disordered protein/ordered-protein interac

226 Intrinsically disordered proteins organize interaction n

227 electron microscopy, we observed how a model intrinsically disordered protein phase-separates in liqu

228 Intrinsically disordered proteins play crucial roles in

229 Intrinsically disordered proteins play important roles t

230 Example dark-matter species include intrinsically disordered proteins, posttranslational sta

231 ay utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient rep

232 c analysis suggests that HVR-1 is a putative intrinsically disordered protein region.

233 ) and hybrid proteins containing ordered and intrinsically disordered protein regions (IDPRs) constit

234 s) or partially disordered segments known as intrinsically disordered protein regions (IDPRs).

235 id-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA bi

236 Phase transitions driven by intrinsically disordered protein regions (IDRs) have eme

237 Intrinsically disordered protein regions (IDRs) lack a w

238 any cell signaling events are coordinated by intrinsically disordered protein regions (IDRs) that und

239 Intrinsically disordered protein regions are widely dist

240 teractions between prion-related domains and intrinsically disordered protein regions found in SG-nuc

241 atures (MoRFs) provide interaction motifs in intrinsically disordered protein regions to mediate dive

242 Such motifs, which frequently occur in intrinsically disordered protein regions, often bind par

243 ic interactions mediated by self-associating intrinsically disordered protein regions-are thought to

244 Intrinsically disordered proteins/regions (IDPs/IDRs) ar

245 Intrinsically disordered proteins/regions (IDPs/IDRs) co

246 biology, molecular recognition mechanisms in intrinsically disordered proteins remain poorly understo

247 re, we elucidated the mechanistic role of an intrinsically disordered protein, REPETITIVE PRO-RICH PR

248 tions that are close in energy, such as many intrinsically disordered proteins, residues distant from

249 virus-1 viral infectivity factor (Vif) is an intrinsically disordered protein responsible for the ubi

250 hich has acquired a state similar to that of intrinsically disordered proteins, resulting in a predom

251 scriptome-wide analysis of mRNAs that encode intrinsically disordered proteins revealed that each has

252 iquid-liquid phase separation of multivalent intrinsically disordered protein-RNA complexes is ubiqui

253 several well-structured domains connected by intrinsically disordered protein segments are difficult

254 exes, and the roles in the process played by intrinsically disordered protein segments.

255 In intrinsically disordered proteins, slow transverse relax

256 ed simulations of the self-organized polymer-intrinsically disordered protein (SOP-IDP) model of Abet

257 Conformational behavior of intrinsically disordered proteins, such as Phe-Gly repea

258 Intrinsically disordered proteins, such as tau protein,

259 Atg29 has the characteristics of an intrinsically disordered protein, suggesting that it und

260 s (EB1 and PRC1) diffuse more slowly than an intrinsically disordered protein (Tau) on MTs.

261 Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential f

262 These intrinsically disordered proteins tend to fold upon bind

263 approach was applied to alpha-synuclein, an intrinsically disordered protein that aggregates in the

264 It is an intrinsically disordered protein that binds acidic phosp

265 MEG-3 is an intrinsically disordered protein that binds and phase se

266 mutational analyses show APLF is largely an intrinsically disordered protein that binds Ku, Ku/DNA-P

267 PEP-19 is a small, intrinsically disordered protein that binds to the C-dom

268 tems, we introduce a biomimetic, recombinant intrinsically disordered protein that can assemble into

269 alpha-Synuclein is an intrinsically disordered protein that can self-aggregate

270 with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA

271 One of them is COR15A, a small, intrinsically disordered protein that contributes to lea

272 alpha-synuclein is an intrinsically disordered protein that has the capacity t

273 alpha-Synuclein is an intrinsically disordered protein that is associated with

274 ne belonging to the calcitonin family, is an intrinsically disordered protein that is coexpressed and

275 alpha-Synuclein (alphaS) is an intrinsically disordered protein that is water-soluble b

276 the 14-3-3-binding motifs are located, is an intrinsically disordered protein that reduces its flexib

277 complexes (NPCs) contains a high density of intrinsically disordered proteins that are rich in pheny

278 The NPC passageway is lined by intrinsically disordered proteins that contain hydrophob

279 henylalanine-glycine nucleoporins (FG Nups)--intrinsically disordered proteins that facilitate select

280 Dehydrins are a group of intrinsically disordered proteins that protect plants fr

281 naptic protein alpha-synuclein (aSyn) is an 'intrinsically disordered protein' that is highly dynamic

282 globin, on the conformational ensemble of an intrinsically disordered protein, the N protein of bacte

283 s suggested and CD confirmed that P311 is an intrinsically disordered protein, therefore requiring an

284 late folding intermediates but also for some intrinsically disordered proteins-through the eyes of Hs

285 ese fuzzy interactions are characteristic of intrinsically disordered proteins to achieve liquid-liqu

286 this templated folding mechanism may enable intrinsically disordered proteins to achieve specific an

287 The results indicate that, in the case of intrinsically disordered proteins too, the folding mecha

288 Upon analyzing intrinsically disordered proteins, we found a similar pa

289 quences of the proteins are based on a human intrinsically disordered protein, which has been appende

290 indicate that allostery is also manifest in intrinsically disordered proteins, which account for a s

291 are further strengthened by the finding that intrinsically disordered proteins, which have large hydr

292 energy landscape for interactions involving intrinsically disordered proteins, which is likely a res

293 ntrast, it has recently been discovered that intrinsically disordered proteins, which lack a defined

294 ndant (LEA) proteins are hydrophilic, mostly intrinsically disordered proteins, which play major role

295 alpha-synuclein (alphaS) is an intrinsically disordered protein whose fibrillar aggrega

296 alpha-Synuclein is an intrinsically disordered protein whose function in a hea

297 Tau is an intrinsically disordered protein with a central role in

298 Tau is an intrinsically disordered protein with an important role

299 Intrinsically disordered proteins with stickers uniforml

300 ing the detailed mechanism of interaction of intrinsically disordered proteins with their partners is