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1 ither the substrate entry pore or the distal intrinsically disordered region.
2 1 phosphorylates ORE1 at a hotspot within an intrinsically disordered region.
3 to a rigidly structured region and a smaller intrinsically disordered region.
4 ular condensation even in the absence of its intrinsically disordered region.
5 eron as PcoB, highlighting a new role for an intrinsically disordered region.
6 X-isoleucine-proline) which exists within an intrinsically disordered region.
7 transmembrane domains (TMDs) with or without intrinsically disordered regions.
8 ch has general applicability to the study of intrinsically disordered regions.
9 egions (PFRs), including protein domains and intrinsically disordered regions.
10 ar interactions in multidomain proteins with intrinsically disordered regions.
11 t are multivalent or contain low-complexity, intrinsically disordered regions.
12 eir structure, possibly by intercalating its intrinsically disordered regions.
13 Both contain three folded domains and ~70% intrinsically disordered regions.
14 w that 21.7% of them are located within such intrinsically disordered regions.
15 ic, multidomain proteins with structured and intrinsically disordered regions.
16 taining BRD4 and MED1 via histidine-enriched intrinsically disordered regions.
17 lly proteins that include folded domains and intrinsically disordered regions.
18 thin IDPConformerGenerator for proteins with intrinsically disordered regions.
19 in partners through interactions mediated by intrinsically disordered regions.
20 ntrations, using both structured domains and intrinsically disordered regions.
21 d, highlighting the feasibility of targeting intrinsically disordered regions.
22 nce motifs found in numerous proteins within intrinsically disordered regions.
23 ion motifs, two zinc-finger motifs, and four intrinsically disordered regions.
24 tein complexes whose members are enriched in intrinsically disordered regions.
25 and sheds light on the in situ prevalence of intrinsically disordered regions.
26 contain BAR domains often also contain large intrinsically disordered regions.
27 nteractions, often mediated by proteins with intrinsically disordered regions.
28 d in the amino acid sequences of orthologous intrinsically disordered regions.
29 sperse oligomeric ensembles and contain long intrinsically disordered regions.
30 erent interacting partners that bind through intrinsically disordered regions.
31 er DMS reactivity than regions that code for intrinsically disordered regions.
32 condary structure and natively unstructured (intrinsically disordered) regions.
33 LLPS are mediated via the negatively charged intrinsically disordered region 1 (IDR1) of the protein,
37 ically disordered proteins and proteins with intrinsically disordered regions, although extremely imp
38 yltransferase activity and is composed of an intrinsically disordered region and a folded segment.
39 assembled condensates through its C-terminal intrinsically disordered region and facilitates SHANK3 c
40 Exon 14 encodes 10 amino acids within an intrinsically disordered region and includes at least on
41 scattering, we show that the long N-terminal intrinsically disordered region and the linker connectin
42 ation, a framework for examining function in intrinsically disordered regions and a predictive model
43 s of VP30 with sequence features that typify intrinsically disordered regions and a putative RNA bind
45 RD4S nuclear condensation is mediated by its intrinsically disordered regions and binding of its brom
46 y motor and structural proteins that contain intrinsically disordered regions and coiled coil domains
47 ing lower inclusion levels, and overlap with intrinsically disordered regions and disease-associated
48 re of the Pih1 C terminus and identified two intrinsically disordered regions and five hydrophobic cl
49 and MIP-2 each contain two LOTUS domains and intrinsically disordered regions and form homo- and hete
50 r proteins, however 14-3-3 complexes feature intrinsically disordered regions and often a transient t
51 erging methods for the quantitative study of intrinsically disordered regions and refined models for
52 that are able to undergo LLPS often contain intrinsically disordered regions and remain dynamic in s
53 ss than ten residues in length, occur within intrinsically disordered regions, and are recognized and
55 t bind to microtubule ends and shafts, carry intrinsically disordered regions, and form complex multi
56 -pathogen interactions, interactions between intrinsically disordered regions, and interactions relat
57 Nonoptimal codons are preferentially used in intrinsically disordered regions, and more optimal codon
58 ements in client proteins stabilizes Hsp33's intrinsically disordered regions, and this stabilization
63 udies have shown that LCRs may co-occur with intrinsically disordered regions, are highly conserved i
64 bacterial ParB forms an elongated dimer with intrinsically disordered regions as well as folded domai
66 arly at residues Ser226 and Ser255 within an intrinsically disordered region, as critical determinant
68 t a conserved Ser-46 site in the N-terminal "intrinsically disordered" region by IkappaB kinase epsil
70 e features of FoxP1 provide a glimpse of how intrinsically disordered regions can facilitate domain s
72 ition, we obtained compound A6 that mediates intrinsically disordered region conformational changes t
74 in the condensate-forming protein(s) and the intrinsically disordered region-containing proteins, res
75 d and cdk-dependent phosphorylation of these intrinsically disordered regions contributes to Ngn2 reg
76 the two domains, along with the presence of intrinsically disordered regions, controls this process.
77 ersely, an NSUN2 variant lacking an internal intrinsically disordered region (DeltaIDR-NSUN2) can ins
78 n, mutagenesis and replacement assays of the intrinsically disordered region demonstrate a critical r
79 minal domain of kazrin C, predicted to be an intrinsically disordered region, directly interacts with
80 ransmembrane domain and other regions of the intrinsically disordered region do not cause gain of fun
81 t MLL1/KMT2A methylates Borealin K143 in the intrinsically disordered region essential for liquid-liq
82 Collectively, this work demonstrates that intrinsically disordered regions exhibit distinct confor
83 hydrogen-bonded structure and may provide an intrinsically disordered region for chaperone interactio
84 nteracting with a previously uncharacterized intrinsically disordered region found in many T7SS toxin
87 idated the molecular principles by which its intrinsically disordered region (IDR) at the carboxyl-te
89 polypeptide's N-terminal end, composed of an intrinsically disordered region (IDR) followed by a high
90 CTD interaction with MED relates to a large intrinsically disordered region (IDR) in CKM subunit MED
92 either directly recognizes a site within an intrinsically disordered region (IDR) of a client protei
94 multiple-chain simulations of the N-terminal intrinsically disordered region (IDR) of DEAD-box helica
95 re, we show that condensates composed of the intrinsically disordered region (IDR) of MED1 selectivel
96 erved ATM/ATR consensus SQ motifs within the intrinsically disordered region (IDR) of mouse RIF1 that
97 actions between unphosphorylated PhyR and an intrinsically disordered region (IDR) of the anti-sigma
100 Met4 variant with a partial truncation of an intrinsically disordered region (IDR) shows less puncta
101 found that its N-terminal half comprises an intrinsically disordered region (IDR) that facilitates i
102 sor of yeast profilin 1 (Syp1)/FCHo uses its intrinsically disordered region (IDR) to directly bind a
104 lent interactions mediated by its N-terminal intrinsically disordered region (IDR) to orchestrate enh
105 resents a confinement state that requires an intrinsically disordered region (IDR), implicated in liq
106 he C-terminal (Ct-) tail is classified as an intrinsically disordered region (IDR), the N-terminal (N
107 CA512 RESP18HD residues 91-131 encode for an intrinsically disordered region (IDR), which in vitro ac
108 In eukaryotic cells, most TFs contain an intrinsically disordered region (IDR), which is commonly
109 at the conserved residues of CBX2 within the intrinsically disordered region (IDR), which is the regi
117 es in vitro, and truncation mutations in the intrinsically disordered regions (IDR) of EloA interfere
119 ted mutagenesis indicated that one predicted intrinsically disordered region IDR2 is involved in Tah1
120 at histone chaperones are highly enriched in intrinsically disordered regions (IDRs) and acidic stret
121 certain sequence characteristics, including intrinsically disordered regions (IDRs) and prion-like d
124 to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for
128 ependent interactions for protein functions, intrinsically disordered regions (IDRs) are often overlo
136 hted how interspersed structural domains and intrinsically disordered regions (IDRs) could influence
137 The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of
138 ins are composed of both modular domains and intrinsically disordered regions (IDRs) having low amino
140 ning and yeast one-hybrid assay identify two intrinsically disordered regions (IDRs) in CgPho4 that b
142 e show that interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulat
144 Liquid-liquid phase separation (LLPS) of intrinsically disordered regions (IDRs) in proteins can
146 r predictors have been developed to identify intrinsically disordered regions (IDRs) in proteins, ach
147 iochemical evidence that SLC26 proteins have intrinsically disordered regions (IDRs) in their C-termi
150 ically disordered proteins (IDPs) as well as intrinsically disordered regions (IDRs) of complex prote
157 xes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or b
158 re enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in
159 ic multivalent interactions, often involving intrinsically disordered regions (IDRs) of proteins, yet
160 RM2 or depletion of SON in a cell-line where intrinsically disordered regions (IDRs) of SRRM2 are gen
161 inherited human disorders, and many occur in intrinsically disordered regions (IDRs) of transcription
162 mains, about half of the protein consists of intrinsically disordered regions (IDRs) of varying lengt
167 disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) possess low sequ
170 ng phase-separating (PS) proteins, many have intrinsically disordered regions (IDRs) that are needed
171 stantial portion of the proteome consists of intrinsically disordered regions (IDRs) that do not fold
172 We find that ORC, Cdc6, and Cdt1 contain intrinsically disordered regions (IDRs) that drive LLPS
173 c transcription factors is that they contain intrinsically disordered regions (IDRs) that often arise
174 s targeting CD19, CD22 and HER2 by including intrinsically disordered regions (IDRs) that promote sig
175 es of full-length kinases and to address the intrinsically disordered regions (IDRs) that typically f
176 res (MoRFs) are a commonly occurring type of intrinsically disordered regions (IDRs) that undergo dis
177 T, TGF-beta, and JAK/STAT pathways use their intrinsically disordered regions (IDRs) to enter and con
178 any aspects of RNA metabolism, often contain intrinsically disordered regions (IDRs) whose functions
181 we analyze the primary sequence features of intrinsically disordered regions (IDRs) within SG-reside
183 s are often made up of proteins that contain intrinsically disordered regions (IDRs), form phase-sepa
185 By fusing transcription factors (TFs) to intrinsically disordered regions (IDRs), we drive the fo
186 able fraction of eukaryotic proteins contain intrinsically disordered regions (IDRs), which act in un
187 he identification of proteins with extensive intrinsically disordered regions (IDRs), which are confo
188 nd other PRC2-colocalised caRBPs are rich in intrinsically disordered regions (IDRs), which could con
189 the majority of human proteins that contain intrinsically disordered regions (IDRs), which do not ad
197 cs, and more likely to contain proteins with intrinsically disordered regions, implying that environm
198 hose functions are not well characterized.An intrinsically disordered region in TCF-1 has now been fo
200 in K7 from vaccinia virus, which binds to an intrinsically disordered region in the N-terminus of DDX
202 ven by RNA-binding proteins that harbor long intrinsically disordered regions in addition to folded R
203 ild, aided by AlphaFold predictions, several intrinsically disordered regions in different APC/C subu
204 they highlight the functional importance of intrinsically disordered regions in modulating host-viru
205 Our study establishes the importance of intrinsically disordered regions in p47 for the formatio
207 , little is known about the functionality of intrinsically disordered regions in plant proteins.
211 o inactive, liquid-like droplets through its intrinsically disordered regions in the N-terminal domai
212 rties to protein structural properties, i.e. intrinsically disordered regions in the protein chain.
214 rization of modular proteins containing long intrinsically disordered regions intercalated with folde
215 ORC1 RNA binding activity resides in its intrinsically disordered region, involved in intra- and
216 K1 uses an N-terminal extension and a large, intrinsically disordered region juxtaposed to a stable s
219 the inhibitory activity and suggest that the intrinsically disordered region makes its inhibitory pot
220 ions that encode protein domain junctions or intrinsically disordered regions may reflect increased R
221 anisms may therefore help us to decipher how intrinsically disordered regions mediate functional effe
223 his study reveals the mechanistic role of an intrinsically disordered region of a transmembrane recep
224 ring in condensates formed by the C-terminal intrinsically disordered region of CAPRIN1, an RNA-bindi
228 nd tightly to a long acidic tract within the intrinsically disordered region of NPM1, altering its ph
230 ined secondary structural elements and is an intrinsically disordered region of the channel protein.
233 Multiple O-GlcNAc modified amino acids in intrinsically disordered regions of A4 were identified b
234 eracts with short linear motifs found within intrinsically disordered regions of ERK substrates and r
235 supporting interesting parallels between the intrinsically disordered regions of histones and this po
236 linear motifs found in unstructured loops or intrinsically disordered regions of many autophagy-relat
237 ediated by NPCs are focused on properties of intrinsically disordered regions of nucleoporins that bi
239 lignment between exons and the boundaries of intrinsically disordered regions of proteins is not a ge
245 play (ProP-PD) to identify peptides from the intrinsically disordered regions of the human proteome t
246 Tmod1-TM complex formation, indicating that intrinsically disordered regions of the two proteins bec
247 e of cysteine reactive inhibitors, targeting intrinsically disordered regions of transcription factor
248 ite on Hsf1 represses clustering, whereas an intrinsically disordered region on Hsf1 promotes condens
250 those differences, focusing on the impact of intrinsically disordered regions on the thermodynamic an
251 tal approaches identified several conserved, intrinsically disordered regions outside the homeodomain
252 a bipartite nuclear localization signal, an intrinsically disordered region overlapping arginine-ric
253 ences of charge patterning on the C-terminal intrinsically disordered region (p27 IDR) of the cell cy
255 esis and chimaera assays demonstrate that an intrinsically disordered region promotes oligomerization
256 cause RPs are often highly basic and contain intrinsically disordered regions prone to nonspecific in
257 cal doctrine, in which phosphorylation of an intrinsically disordered region/protein confers affinity
259 study shows that the self-association of the intrinsically disordered region, QPGY domain, leads to l
260 tion of intrinsically disordered proteins or intrinsically disordered regions regulates many cellular
261 y between folded domains, linear motifs, and intrinsically disordered regions regulates the formation
262 cular Cell,(1) Struhl reasons that the term "intrinsically disordered regions" represents a vague and
264 secondary structure, transmembrane helices, intrinsically disordered regions, signal peptides and ot
265 s (GPCRs); however, much less is known about intrinsically disordered regions such as the carboxyl te
266 ate that the N-terminus of Kdm1a contains an intrinsically disordered region that is essential to seg
267 t this linker segment harbors a lysine-rich, intrinsically disordered region that is necessary and su
268 t amino acid motif within the ALTO protein's intrinsically disordered region that is required for thi
269 he scaffold protein Lge1, which possesses an intrinsically disordered region that phase-separates via
270 nally, the eIF4E4 N-terminal extension is an intrinsically disordered region that transitions to a pa
271 FLs) are abundant and functionally important intrinsically disordered regions that connect protein do
272 i-domain protein is sparse, not least due to intrinsically disordered regions that elude high-resolut
273 al membrane proteins with negatively charged intrinsically disordered regions that flank positively c
274 provides a new window into exploring dynamic intrinsically disordered regions that previously were de
276 tructural evidence that Ngn2 contains large, intrinsically disordered regions that undergo phosphoryl
277 xperiments show that despite being within an intrinsically disordered region, the hinge E7 epitope ha
278 ronmentally sensitive folding pathway and an intrinsically disordered region, the yeast prion protein
279 two FBF-2 molecules via motifs in the LST-1 intrinsically-disordered region; the gld-1 FBE pair incl
280 e mass spectrometry data, and on the role of intrinsically disordered regions to control protein moti
282 t of transcription regulators that use their intrinsically disordered regions to remodel transcriptio
283 the protein's functional regions (domains or intrinsically disordered regions) to find those that sho
284 y motifs (alpha-helixes and beta-sheets) and intrinsically disordered regions), to function (activity
285 Nearly half of the RNA-binding sites map to intrinsically disordered regions, uncovering unstructure
287 restin's C-terminal, specifically within the intrinsically disordered region, we sought to delete the
288 determine whether these C-terminal tails are intrinsically disordered regions, we conducted a battery
291 in vitro, the contributions of its different intrinsically disordered regions, which includes a centr
294 rescue function in vivo, and that groups of intrinsically disordered regions with similar evolutiona
295 ment structural transitions occurring within intrinsically disordered regions, with regions involved
297 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions within proteins (IDRs)
300 le site within MYC and indicate that certain intrinsically disordered regions within transcription fa