ライフサイエンスコーパス: invariant NKT cell

1 nd an invariant T-cell receptor-alpha chain (invariant NKT cells).

2 ent and effector functions of T1D-protective invariant NKT cells.

3 those of conventional NK cells, T cells, and invariant NKT cells.

4 ionally similar to mammalian CD1d-restricted invariant NKT cells.

5 features with both the gammadelta T and the invariant NKT cells.

6 nhanced capacity to activate CD1d-restricted invariant NKT cells.

7 y impaired in the intrathymic development of invariant NKT cells.

8 lls have an innate-like phenotype similar to invariant NKT cells.

9 te CD8(+) T cell pool and the development of invariant NKT cells.

10 y stimulated alpha-galactosylceramide-primed invariant NKT cells.

11 FN-alpha was at least partially dependent on invariant NKT cells.

12 d for presentation of autoantigens to murine invariant NKT cells.

13 s have been silenced, are unable to activate invariant NKT cells.

14 D56(+) T cells, and small numbers of classic invariant NKT cells.

15 to explain some of the unusual properties of invariant NKT cells.

16 cytokine GM-CSF in the thymic development of invariant NKT cells, a role that licenses these cells to

17 e protective later during infection than the invariant NKT cell agonist alpha-galactosylceramide.

18 wo potent variants of the highly stimulatory invariant NKT cell agonist alpha-galactosylceramide.

19 that innate T cells such as CD1d-restricted invariant NKT cells all underwent a phase of intense int

20 In contrast to invariant NKT cells and MAIT cells, this population has

21 ein (SAP) is required for the development of invariant NKT cells and mediates signals from signaling

22 s that guide the development and function of invariant NKT cells and we highlight related mechanisms

23 genic milieu through the interplay of Tregs, invariant NKT cells, and plasmacytoid dendritic cells, w

24 Moreover, CD1d tetramer staining shows that invariant NKT cells are activated in response to oral Sa

25 Although invariant NKT cells are also innate T cells, they are se

26 In this study we show that invariant NKT cells are also recruited to CCL22-expressi

27 V alpha 24+V beta 11+ invariant NKT cells are detectable in the blood and tumo

28 cellular mechanism by which IL-4(+)IL-13(+) invariant NKT cells are necessary for IL-4Ralpha signali

29 Invariant NKT cells are present in ACD, regardless of th

30 ciprocal interactions between CD8(+) DCs and invariant NKT cells are required for tolerance induction

31 Semi-invariant NKT cells are thymus-derived innate-like lymph

32 s, effector T cells, regulatory T cells, and invariant NKT cells, as well as its impact on immune dis

33 dentified within GBM were not canonical, or "invariant," NKT cells, as they demonstrated diverse TCR

34 reveal that CCR7 controls the development of invariant NKT cells by enabling their access to IL-15 tr

35 ructing the function of the immunoregulatory invariant NKT cells can affect tumor cell survival is no

36 Invariant NKT cell (CD3(+)Valpha24(+)) proportions were

37 an anti-Valpha24-Jalpha18 Ab, human primary invariant NKT cells could be divided into Valpha24 low-

38 ory T cell development and the completion of invariant NKT cell development.

39 Invariant NKT cells differentiate into three predominant

40 gesting that both Ag-specific CD4 T cell and invariant NKT cell effector responses to Salmonella-OVA

41 Hepatic invariant NKT cells expressed distinct proinflammatory c

42 To address this issue, we examined invariant NKT cells in Itk-/- and Itk/Rlk-/- mice.

43 Valpha24-invariant NKT cells inhibit tumor growth by targeting tu

44 Type I invariant NKT cells (iNKT cells) are a subset of alphabe

45 Invariant NKT cells (iNKT cells) are a unique subset of

46 Invariant NKT cells (iNKT cells) are innate lymphocytes

47 Invariant NKT cells (iNKT cells) are innate T lymphocyte

48 Invariant NKT cells (iNKT cells) have been reported to p

49 w that regulatory T cells (T(reg) cells) and invariant NKT cells (iNKT cells) perceived stronger TCR

50 Invariant NKT cells (iNKT cells) play a pivotal role in

51 Invariant NKT cells (iNKT cells) recognize CD1d/glycolip

52 Peripheral invariant NKT cells (iNKT) and CD8(+) tissue-resident me

53 Invariant NKT cells (iNKT) are potent immunoregulatory T

54 CD1d-reactive invariant NKT cells (iNKT) play a vital role in determin

55 populations of innate-like T cells including invariant NKT cells (iNKT), CD8alphaalphaTCRalphabeta sm

56 In recipients specifically lacking host invariant NKT cells (iNKTs), RLI did not induce an antit

57 We found not only that mice deficient in invariant NKT cells (Jalpha18(-/-)) had a marked attenua

58 In contrast, the skins of UVB-irradiated invariant NKT cell-knockout (Jalpha18(-/-)) and NKT cell

59 sistant to immunopathologies associated with invariant NKT cell-mediated hepatitis and colitis.

60 ate T cells such as gammadelta TCR(+) cells, invariant NKT cells, mucosal-associated invariant T cell

61 Tumor infiltration with Valpha24-invariant NKT cells (NKTs) associates with favorable out

62 and IL-22 production correlated with reduced invariant NKT cell numbers as well as lower IL-23 levels

63 tk and Rlk, leading to a 7-fold reduction in invariant NKT cell numbers in the thymus of Itk/Rlk-/- m

64 ant in this disease but does not involve the invariant NKT cell often associated with CD1d-restricted

65 dings suggest that the activation of hepatic invariant NKT cells plays a critical role in regulating

66 Innate T cells such as invariant NKT cells provide immediate immune defense, wh

67 became clear that this cell does not express invariant NKT cell receptors characteristic of most NKT

68 Invariant NKT cells respond to IL-1beta and IL-23 provid

69 gning therapeutic glycolipids for modulating invariant NKT cell responses.

70 Upon activation by alpha-GalCer, invariant NKT cells secrete multiple cytokines and confe

71 Similar to polyclonal T-CD4 T cells and also invariant NKT cells, T3 CD4 T cell development is contro

72 Utilizing induced expression of the semi-invariant NKT cell TCR on double positive thymocytes, an

73 itic cells are more efficient in stimulating invariant NKT cells than untreated controls.

74 18-deficient mice, which lack only type 1 or invariant NKT cells, the increase in the numbers of lung

75 d on a subset with semi-invariant TCR termed invariant NKT cells, the majority of CD1d-restricted lip

76 nd that, as has been suggested for mammalian invariant NKT cells, they may serve as immune regulators

77 The expression of PLZF, the signature invariant NKT cell transcription factor, in these innate

78 Furthermore, increased numbers of invariant NKT cells were detected in Ly9-deficient thymi

79 Invariant NKT cells were identified in all the 10 skin b

80 bers of cotransferred gammadelta T cells and invariant NKT cells, whereas either cell type alone was

81 nd activation of a unique subset of T cells, invariant NKT cells, which express limited TCR diversity

82 pose tissue DPs resided in close vicinity to invariant NKT cells, which they could activate in vitro.

83 largely absent in mice lacking CD1d-specific invariant NKT cells, with no effect on innate itk(-/-) C