ライフサイエンスコーパス: involution

1 ive phase is followed by a regression phase (involution).

2 nent of the mechanism regulating age-related involution.

3 growth phases and do not undergo spontaneous involution.

4 implications for the role of FOXN1 in thymic involution.

5 hannels; 1 showed advanced fibrotic vascular involution.

6 volume is important in assessing growth and involution.

7 ptosis normally initiated by oncoprotein and involution.

8 is that it undergoes profound age-associated involution.

9 enitor cells underlies the process of thymic involution.

10 erative potential of cTECs to counter thymic involution.

11 ne of cTECs is a prominent feature of thymic involution.

12 death during normal postpartum mammary gland involution.

13 sfunction postpartum resulting in precocious involution.

14 nflammatory drugs (NSAIDs) during postpartum involution.

15 ally declines by puberty, a result of thymic involution.

16 and confers resistance to castration-induced involution.

17 ing downregulated during lactation and early involution.

18 cytokines IL-4 and IL-13 also peaked during involution.

19 central tolerance that occur owing to thymic involution.

20 al cells during the onset of postlactational involution.

21 diversity by accelerating age-related thymic involution.

22 cell generation by inducing premature thymic involution.

23 eriods including puberty and postlactational involution.

24 aired and EZH2 overexpression caused delayed involution.

25 y ERalpha and unique to the phase of mammary involution.

26 uption marks an early stage of mammary gland involution.

27 de, can partially reverse age-related thymic involution.

28 during aging contribute to the mechanism of involution.

29 ice displayed enhanced age-associated thymic involution.

30 ance of apoptotic cells during mammary gland involution.

31 environment during pregnancy, lactation, and involution.

32 e with age is largely attributable to thymic involution.

33 plantation tolerance after the age of thymic involution.

34 ting the epithelial movements of epiboly and involution.

35 well as their requirement for embryonic head involution.

36 leading to the appearance of nevi and their involution.

37 s nor in recipients beyond the age of thymic involution.

38 le to protect the thymus from stress-induced involution.

39 ent inability to release milk, and premature involution.

40 cleaved form of TWEAK is upregulated during involution.

41 postnatal skeletal development and skeletal involution.

42 th mammary glands undergoing weaning-induced involution.

43 odulating Stat3 activity before the onset of involution.

44 ndent rise in p21Waf1 levels around day 3 of involution.

45 ir synergistic physiological roles in normal involution.

46 cts of developmental programming upon thymic involution.

47 cteristic sequence of growth and spontaneous involution.

48 response to a full pregnancy, lactation and involution.

49 lliparous, mid gestation, lactation and post involution.

50 erate systemic GR-effect, assessed as thymic involution.

51 I dose, accelerating aging-associated thymic involution.

52 of mTORC1 in adult mice caused severe thymic involution.

53 sue expansion in pregnancy and regression in involution.

54 mmary gland during pregnancy, lactation, and involution.

55 AK1 target genes that are upregulated during involution.

56 f the progeny and is followed by a period of involution.

57 and Zn in lysosomes and activated premature involution.

58 stologic and biochemical signs of precocious involution.

59 a, a well-characterized regulator of mammary involution.

60 gulated during weaning-induced mammary gland involution.

61 l growth and discuss their automorphisms and involutions.

62 romal wound-healing events during postpartum involution, a dynamic process characterized by widesprea

63 these individuals, who are well into thymic involution, a substantial number of clonotypes were stab

64 an important regulator of mammary epithelial involution after pregnancy.

65 /503 as an important regulator of epithelial involution after pregnancy.

66 during pregnancy, and delayed mammary gland involution after weaning.

67 Activation of MDM2 delayed mammary gland involution and accelerated tumor progression in mouse ma

68 epithelial cells results in impaired thymic involution and blunted expansion of natural regulatory T

69 ion between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant

70 Rapid involution and contraction of neovascular tissue adheren

71 Thus, the RB family promotes thymic involution and controls T cell production via a bone mar

72 ced hematopoietic stem cell function, thymic involution and decreased lymphoid output with a skewing

73 No association was seen between involution and dense area (P trend = .56).

74 We examined the involution and density association in a large benign bre

75 to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan

76 Lack of Mkl1 causes premature involution and impairs expression of Srf-dependent genes

77 KMT2D deficiency also delays germinal center involution and impedes B cell differentiation and class

78 as a critical mediator of cell death during involution and importantly, that as an initial involutio

79 ated the mechanisms underlying the choroidal involution and its long-term impact on retinal function.

80 loss of Mnt severely disrupts mammary gland involution and leads to hyperplastic ducts associated wi

81 nt > or = 380 days), and correlated with the involution and loss of Tg skin grafts.

82 t evidence of an inverse association between involution and mammographic density.

83 rucial role of N-cadherin regulation for the involution and migration of cells beyond the gradient of

84 abeta protects against homeostatic premature involution and orchestrates thymic regeneration followin

85 that promotes apoptosis during mammary gland involution and p53-independent apoptosis.

86 dy, there was an inverse association between involution and PD (mean PD, 22.4%, 21.6%, 17.2%, for no,

87 derm within the DMZ, which is independent of involution and prior to the formation of the dorsal blas

88 Thymic involution and proliferation of naive T cells both contr

89 through cycles of proliferation, branching, involution and remodeling.

90 ical insults also induced significant thymic involution and rendered serum immunosuppressive.

91 b family genes in young mice prevents thymic involution and results in an enlarged thymus competent f

92 Both thymic involution and serum-derived immunosuppression were reve

93 cumulation of Dab2 correlated with prominent involution and the loss of normal positioning of the int

94 ken together, these findings identify thymic involution and the persistent activation of autoreactive

95 Thymic involution and the subsequent amplified release of autor

96 thymic physiology and age-associated thymic involution and their potential use in the restoration of

97 left by infantile hemangiomas after natural involution and to identify clinical characteristics that

98 Periglacial involutions and modest geochemical differentiation of th

99 otent luminal stem cells survive consecutive involutions and retain their identity throughout adult l

100 nal movements of cells that include epiboly, involution, and convergence and extension (C&E).

101 nd proteolysis increased dramatically during involution, and denatured collagen I acted as a strong c

102 diated regeneration after castration-induced involution, and depleted smooth muscle cells are mainly

103 nderstanding of mechanisms that drive thymic involution, and develop safe and effective strategies to

104 in mammary epithelial cell proliferation and involution, and provide the first in vivo evidence of a

105 ous mechanical stresses attributable to head involution, another developmental process that occurs co

106 Mammographic density and lobular involution are both significant risk factors for breast

107 model in which thymic growth and subsequent involution are driven by cell-intrinsic changes in the p

108 namics of clonal emergence, persistence, and involution are sufficiently complex that in the individu

109 w estrogen and neutrophils influence mammary involution are unknown.

110 breast cancer that identifies mammary gland involution as a driving force of tumor progression.

111 R(+) macrophages resulted in delayed mammary involution as evidenced by loss of lysosomal-mediated an

112 of putative biomarkers for proliferation and involution as well as a small set of putative biomarkers

113 the collagen fibrillogenesis associated with involution, as well as tumor growth and tumor cell infil

114 Chronic thymus involution associated with aging results in less efficie

115 hat PMCA2 is down-regulated early in mammary involution associated with changes in MEC shape.

116 in pre-established tumors caused rapid tumor involution associated with pervasive morphological chang

117 vity can be a strategy for preventing thymic involution/atrophy.

118 Following pregnancy and involution, beta Gal+ mammary epithelial cells were foun

119 ll shape change drives epithelial cell sheet involution between the oocyte and nurse cell complex whi

120 hibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog-defici

121 ted to wave functions fixed by Wilson's sign involution but is violated in general.

122 ndent mammary tumors that regress upon gland involution but progress to nonregressing, invasive adeno

123 grity, and sustained 5-HT7 activation drives involution by disrupting tight junctions.

124 in BALB/c mice showed that estrogen promotes involution by exacerbating inflammation, cell death and

125 zed, prospective data have shown that thymic involution can be pharmacologically reversed in humans,

126 h phase (anagen) to a rapid apoptosis-driven involution (catagen) and finally a relative quiescent ph

127 ated cycles of active regeneration (anagen), involution (catagen), and relative quiescence (telogen).

128 s repeatedly interrupted by apoptosis-driven involution (catagen).

129 t postpartum breast tissue remodeling during involution coincides with inflammatory lymphangiogenesis

130 in ductal branching and abnormal age-related involution compared to littermate controls.

131 r cells, and failed to undergo age-dependent involution compared with wild-type animals.

132 ophages during weaning-induced mammary gland involution, conditional systemic deletion of macrophages

133 F4/80 were examined across the pregnancy and involution cycle in rodent and human mammary tissues.

134 e hair follicles go through regeneration and involution cycles.

135 Using parabiosis we report that thymic involution, declines in peripheral T-cell counts, and re

136 d several aging phenotypes, including thymic involution, decreased production of naive T cells, reduc

137 und this mutation to be a new allele of head involution defective (hid) and showed that hid expressio

138 geted expression of the cell death gene head involution defective (hid) in combination with cryGal80

139 can suppress the apoptotic activity of Head involution defective (Hid) in the developing eye.

140 cade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspa

141 ed repression of the pro-apoptotic gene head involution defective (hid) is required to maintain a bal

142 s on the IAP antagonists, Reaper (Rpr), Head involution defective (Hid), and Grim.

143 the proapoptotic genes reaper (rpr) and head involution defective (hid), which are directly regulated

144 ression of a proapoptotic gene, such as head involution defective (hid).

145 of cell death produced by a heat shock-head involution defective (hs-hid) transgene, the inhibition

146 increased apoptosis is mediated by the head involution defective (Wrinkled) gene product.

147 subsequent ecdysone-induced reaper and head involution defective death activator expression and tiss

148 opically express the pro-apoptotic gene head involution defective, activate caspase-3 and are positiv

149 duced by the proapoptotic genes reaper, head involution defective, and grim.

150 by regulating the expression of cut and head involution defective.

151 translation of caudal mRNA and exhibit head involution defects.

152 T3 and p53 therefore results in hyperdelayed involution, demonstrating their synergistic physiologica

153 expressing mammary glands exhibit a delay in involution despite induction of proapoptotic signaling e

154 Estrogen exposure during mammary involution drives tumor growth through neutrophils' acti

155 Thymic involution during aging is a major cause of decreased pr

156 th during the first year of life followed by involution during early childhood.

157 BMDMs exposed to the postpartum mammary involution environment upregulated the M2 markers argina

158 nvade metanephric mesenchyme which undergoes involution, events replicated in organ culture.

159 identified a role for this gene during gland involution; excision of the Fog2 gene leads to the accel

160 Breast involution following pregnancy has been implicated in th

161 e because loss of Rac1 disrupts clearance in involution following the first lactation.

162 as no (0%), partial (1% to 74%), or complete involution (>or= 75%).

163 artial (odds ratio, 1.3; 95% CI, 1.0 to 1.6) involution had greater odds of high density (DY pattern)

164 erse repertoire is maintained despite thymic involution; however, peripheral fitness selection of T c

165 can substantially reverse age-related thymic involution, identifying FOXN1 as a specific target for i

166 occurs during this period followed by their involution immediately following weaning.

167 During breast involution, immune avoidance, increased lymphatic networ

168 E(T74A T393A) mutation delayed mammary gland involution, implicating cyclin E degradation in this ant

169 f IGFBP5 in normal mammary glands undergoing involution, implying an acceleration of the involution p

170 nvolution, which suggests that neuroectoderm involution in C. elegans is potentially homologous with

171 White matter involution in HD is thus a product of the cell-autonomou

172 d Zn transport is critical for mammary gland involution in mice.

173 eration in virgin glands, while accelerating involution in postlactation glands.

174 ing IH and appears to stop growth and hasten involution in proliferative and plateau phase IH.

175 leading to normal epithelial cell apoptosis/involution in Shp2-deficient mammary gland.

176 endent kinase inhibitor p21Waf1 at 3 days of involution in STAT3 null glands was abolished in STAT3-p

177 tosis persisted at days 6, 17 and 4 weeks of involution in STAT3-p53 doubly null mammary glands.

178 ating that neither is sufficient to initiate involution in the absence of CSF1R(+) macrophages.

179 that the critical factor triggering delayed involution in the STAT3 null gland is a p53-dependent ri

180 beta Gal) expression following pregnancy and involution in whey acidic protein promoter (WAP)-Cre/Ros

181 Long-term effects on choroidal involution included a hypoxic outer neuroretina, associa

182 eted mammary glands was sufficient to rescue involution, including apoptosis, alveolar regression and

183 ompetent mice, we discovered that postpartum involution increases mammary tumor metastasis.

184 In vivo, MMTV infection delayed involution-induced apoptosis in the mouse mammary gland.

185 We hypothesize that postpartum mammary involution induces metastasis through wound-healing prog

186 eta-catenin in thymocytes resulted in thymic involution instead of lymphomagenesis.

187 ion of TNFalpha, a potent activator of early involution, into the mammary gland fat pads of lactating

188 Although thymic involution is a primary driver of this naive T cell loss

189 Thymic involution is central to the decline in immune system fu

190 Postpartum involution is characterized by wound healing-like events

191 Transient thymic involution is frequently found during inflammation, yet

192 sts, which, if true, would imply that thymic involution is not an intrinsic property of thymic tissue

193 e dominant plasminogen activator for mammary involution is PKal, a serine protease that participates

194 Mammary gland involution is the most dramatic example of physiological

195 d growth in infancy, followed by a period of involution, leading to complete regression.

196 was slightly up-regulated shortly before/at involution, leading to normal epithelial cell apoptosis/

197 These results suggest that this defect in involution leads to an increase in the number of suscept

198 We found that thymic involution leads to T cell activation shortly after thym

199 To determine how thymic involution leads to the persistent release and activatio

200 The involution macrophages exhibit an M2 phenotype as determ

201 Conversely, involution matrix failed to support ductal development i

202 ung, liver, and kidney were increased in the involution matrix group, and correlated with a twofold i

203 emixed with Matrigel, nulliparous matrix, or involution matrix, were injected into mammary fat pads o

204 Cyst sclerosis with stabilization (n = 1) or involution (n = 13) was achieved following 1 (n = 10), 2

205 romal cysts is safe and effective, with cyst involution obtained in 93% (14 of 15) of patients.

206 Failure to execute involution occurred in the presence of milk stasis and S

207 We have recently demonstrated that choroidal involution occurs early in retinopathy.

208 he first reported case, to our knowledge, of involution of BRAF inhibitor-induced EMN following the c

209 to the clear fiber state and to the improper involution of cells from the anterior epithelium directl

210 f the polycystin proteins and the subsequent involution of cilia.

211 Our case report describing the involution of EMN supports data from previous clinical t

212 ease progression upon infection exhibited an involution of GCs without local IL-21 production in GCs.

213 lation in proliferating populations, and the involution of germ layer cells induced by a diffusing mo

214 ter, coinciding with the previously observed involution of germinal centers.

215 The mechanisms that trigger involution of hemangioma into fibro-fatty tissue remain

216 primary vitreus (PHPV), attributed to failed involution of hyaloid vessels.

217 thermography to assess the proliferation and involution of IHs compared with a visual analog scale.

218 an antagonist of IGF signaling that mediates involution of mammary gland in females after offspring a

219 Within months, we noted clinical involution of many of her EMN.

220 To follow the kinetics of induction and involution of mitochondria, we determined the expression

221 tive ductal development, in pregnancy and in involution of mouse mammary gland.

222 ptotic stimuli and occurs in vivo during the involution of mouse mammary tissues, a morphogenic proce

223 cent (62 of 132) of respondents had observed involution of Spitz nevi.

224 onstriction in the retracting pharynx drives involution of the adjacent neuroectoderm.

225 Postpartum involution of the breast has been identified as a key me

226 NAI2 was required for proper postlactational involution of the breast.

227 progesterone (P4) concentrations and caused involution of the CL.

228 hese compartments formed by FtsZ-independent involution of the cytoplasmic membrane (CM) rather than

229 on of the Fog2 gene leads to the accelerated involution of the gland despite diminished levels of the

230 Bin1 loss delayed the outgrowth and involution of the glandular ductal network during pregna

231 g that mechanical forces attributable to the involution of the infarct contributed to the changes in

232 gen, consisting of a swift, apoptosis-driven involution of the lower half of the follicle.

233 ction and either failed to develop a UB with involution of the mesenchyme, or developed small kidneys

234 Finally, Bmf is expressed during involution of the mouse mammary gland, suggesting that B

235 It results in involution of the normal gland to ~90% of its original s

236 least one other characteristic indicative of involution of the retinal pigment epithelium (i.e., shar

237 Involution of the thymus is accompanied by a decline in

238 Involution of the thymus results in reduced production o

239 mune system is the structural and functional involution of the thymus, and the associated decline in

240 SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta

241 The age-dependent involution of this organ leads to decreasing production

242 capillaries revealed that diabetes promotes involution of tight junctions, fenestration of endotheli

243 y collapse of the tumor microenvironment and involution of tumor vasculature.

244 with reduced expression, within 24 hours of involution, of the death receptor (DR) ligand TNF and it

245 ips may include effects of disordered breast involution on inflammatory milieu in the breast as well

246 ensity (DY pattern) than those with complete involution (P trend < .01).

247 Upon lactation and continuing into the involution phase, these patterns reverse with a dramatic

248 xperimental evidence indicates that improper involution plays a role in the development of this malig

249 th adverse pregnancy outcomes, such as fetal involution, prematurity, and low birth weight, and with

250 Sox10 also plays a role during the involution process at the end of the lactation period.

251 involution, implying an acceleration of the involution process by inhibition of Wnt signaling.

252 e that thymus tissue is plastic and that the involution process might be therapeutically halted or re

253 microenvironment during post-partum mammary involution promotes parity-associated breast cancer.

254 , cyclooxygenase-2 (COX-2) inhibition during involution reduced the risk of cancer metastasis and cor

255 wth in the brain induced significant splenic involution, reductions in peripheral T cells, reduced MH

256 and they suggest that onset of human thymus involution relates to decreased colonization by prothymo

257 anisms responsible for age-associated thymic involution remain unknown, a variety of theories have be

258 tical roles in mammopoiesis/lactogenesis and involution, respectively, in the mammary gland.

259 used apoptosis and accelerated mammary gland involution, respectively, with increased Bim levels.

260 during pregnancy, hormonal withdrawal during involution resulted in complete remodeling and the resto

261 NA sequencing of ST18-depleted tumors before involution revealed down-regulation of inflammatory resp

262 For instance, age-associated thymic involution seems to occur in all species that possess a

263 land microenvironment during postlactational involution shares similarities with inflammation, includ

264 The rate of involution shown by our model is compatible with indepen

265 volution and importantly, that as an initial involution signal, TNFalpha redistributes ZnT2 to lysoso

266 l between tumor regression and mammary gland involution suggests that Wnt-driven mammary tumors use t

267 In general, these proteins lack surface involutions suitable for high-affinity binding by small

268 henotype to accelerated aging-related thymic involution support the possibility that changes in Foxn1

269 mmary gland homeostasis and the lactation-to-involution switch are regulated by serotonin (5-hydroxyt

270 the first months of life and the spontaneous involution that follows throughout the course of years r

271 tic region also regulates the rate of thymic involution that is accelerated in NOD mice.

272 At 3 days post lactational involution, the mammary glands of Snai2-deficient mice e

273 Despite thymic involution, the number of naive CD4(+) T cells diminishe

274 s have been implicated in age-related thymic involution, their relative contributions are not known.

275 e as a means to reverse age-dependent thymic involution, thereby enhancing immune function and decrea

276 At the end of involution, these patterns return to that of the adult n

277 es and maintain STAT5 activation even during involution, thus preventing the apoptosis normally initi

278 motional for tumor cell dissemination during involution, thus providing a plausible mechanism to expl

279 --the formation of blood vessels followed by involution to fatty tissue.

280 that widespread cell death during postpartum involution triggers efferocytosis-induced wound-healing

281 nd provide a link between mammary epithelial involution, tumorigenesis, and the phenomenon of chemore

282 pregulated after castration-induced prostate involution-two characteristics consistent with that of a

283 birth to a peak at 1 year, followed by rapid involution until approximately 8 years, and then a more

284 Cyst involution, visual acuity, and treatment complications.

285 he average age at which hemangioma completed involution was 3.5 years.

286 We determined that thymic involution was a hallmark feature of immunosuppression i

287 This failure to induce involution was associated with reduced expression, withi

288 Thymic involution was prevented in genetically manipulated mice

289 In addition to thymic involution, we determined that tumour growth in the brai

290 tructural alterations associated with thymic involution were diminished in aged Foxn1 Tg.

291 The most common sequelae after involution were telangiectasias (145, 84.3%), fibrofatty

292 this is not the case for its function during involution where Sox10 seems to work at least in part th

293 action, segmental groove retraction and head involution, whereas it is dispensable for other morphoge

294 ghtfold increase in macrophage number during involution, which returned to nulliparous levels with fu

295 ology and gene expression in tissues driving involution, which suggests that neuroectoderm involution

296 mouse model that induces accelerated thymic involution while maintaining a young periphery.

297 clooxygenase-2 (COX-2) inhibition during the involution window decreased normal mammary gland lymphan

298 The hallmarks of skeletal involution with age, on the other hand, are decreased bo

299 in mice protects against age-related thymic involution with an increase in earliest thymocyte progen

300 = .04) and a strong positive association of involution with nondense area (P trend < .01).