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1 ation, the sporophyte dries from the outside inwardly and continues to do so after guard cells die an
3 transmembrane cargo can be sequestered into inwardly budding vesicles for degradation, or can exit t
4 s thaliana) plasma membrane Ca(2+)-permeable inwardly conducting ion channel impairs HR and that this
5 ear-UV photon drives the complex back to the inwardly connected conformer in the repellent signaling
7 auses a Schiff base connectivity switch from inwardly connected to outwardly connected states in the
12 ntaining electron-rich aromatic walls and an inwardly directed carboxylic acid displayed the necessar
15 tion of a substrate, SERT and DAT display an inwardly directed current comprised of a peak and a stea
16 around the guest species; presents them with inwardly directed functionality; and provides a generall
17 esicles, melibiose efflux is inhibited by an inwardly directed gradient of Na(+) or Li(+) and stimula
20 rotein- and energy-dependent pathway for the inwardly directed transbilayer movement of lipids other
23 to alternate between "outwardly facing" and "inwardly facing" conformations of the transmembrane subs
26 sporter: the changes from an outwardly to an inwardly open conformation during the transport cycle us
35 er concentration of cGMP and manifests as an inwardly rectified, K+-specific current with a 10.8 pS u
37 ed K(+) channel (KACh) conducts current that inwardly rectifies when activated by some ligands (such
38 ether their macroscopic current outwardly or inwardly rectifies, whereby rectification refers to a ch
39 h that GABABR activation shifts from opening inwardly rectifiying potassium channels (Kir/GIRK) to in
40 ents here, functional voltage-gated (Kv) and inwardly rectifying (Kir) K(+) channel remodeling was ex
41 e concurrent inhibition of barium-sensitive, inwardly rectifying (Kir) potassium channels and activat
43 ious results, whole-cell recordings revealed inwardly rectifying AMPAR EPSCs, a hallmark of CP-AMPARs
45 clic monophosphate showed the presence of an inwardly rectifying and TRAM-34-sensitive K(+) channel i
48 -expressed with STIM1, Orai1 induced a large inwardly rectifying Ca(2+)-selective current with Ca(2+)
49 d orai-1 cDNAs in HEK293 cells induces large inwardly rectifying cation currents activated by ER Ca(2
50 [sulfonylurea receptor (SUR) 1 and potassium inwardly rectifying channel (Kir) 6.1] were expressed se
51 3, member 13 of subfamily J of the potassium inwardly rectifying channel family in all affected indiv
55 Like human CFTR, ovine CFTR formed a weakly inwardly rectifying Cl(-) channel regulated by PKA-depen
56 of multiple Kir2 family paralogues, and the inwardly rectifying conductance contributes to the regul
57 izing mutants in the same loop express large inwardly rectifying CRAC current, and two of these exhib
58 ) and (I362T+A419P) generated a constitutive inwardly rectifying current that suggests a sensitivity
59 I-AMPARs as evidenced by polyamine-dependent inwardly rectifying current-voltage (I-V) relationships,
62 potassium (ROMK) channel is a member of the inwardly rectifying family of potassium (Kir, Kir1.1) ch
63 hus the SNr receives direct projections from inwardly rectifying gamma-aminobutyric acid (GABA)-ergic
66 is a critical determinant of G-protein-gated inwardly rectifying K(+) (GIRK) channel activation and u
68 omplexes from Gi/o-gated G protein-regulated inwardly rectifying K(+) (GIRK) channels and delayed GIR
69 ing cascade that activates G-protein-coupled inwardly rectifying K(+) (GIRK) channels and small condu
70 Here we demonstrate that G protein-regulated inwardly rectifying K(+) (GIRK) channels can operate as
71 ate a shared pool of cardiac G protein-gated inwardly rectifying K(+) (GIRK) channels in SAN cells fr
72 hibitory signaling involving G-protein-gated inwardly rectifying K(+) (Girk) channels in VTA DA neuro
75 , including that mediated by G protein-gated inwardly rectifying K(+) (GIRK) channels, has been impli
76 nhibit neurons by activating G protein-gated inwardly rectifying K(+) (GIRK) channels, thereby modera
84 ified in mouse macrophages: Ba(2+)-sensitive inwardly rectifying K(+) (Kir) channels and 4-aminopyrid
87 shown that capillary endothelial cell (cEC) inwardly rectifying K(+) (Kir) channels can sense neuron
91 increase in membrane cholesterol suppresses inwardly rectifying K(+) (Kir2) channels that are respon
94 2 receptors activates atrial G protein-gated inwardly rectifying K(+) (Kir3) channels via the betagam
96 hannels are present in the lumen or when the inwardly rectifying K(+) channel blocker BaCl(2) is pres
97 perpolarization, increased G-protein-coupled inwardly rectifying K(+) channel current, and attenuated
98 rant localization, and enhanced block of the inwardly rectifying K(+) channel Kir2.1, compared with t
99 18, which encodes a skeletal muscle-specific inwardly rectifying K(+) channel Kir2.6, were reported i
100 etic neuralgia through downregulation of the inwardly rectifying K(+) channel Kir4.1 in satellite gli
101 ia development through downregulation of the inwardly rectifying K(+) channel Kir4.1 in satellite gli
103 age-gated potassium channel (Kv), as well as inwardly rectifying K(+) channel remodeling, were invest
105 t DNA sequencing of KCNJ10, which encodes an inwardly rectifying K(+) channel, identifies previously
106 at the CaR interacts with and inactivates an inwardly rectifying K(+) channel, Kir4.1, which is expre
107 naptic inhibition in the brain by activating inwardly rectifying K(+) channels (GIRKs) and inhibiting
109 most circumstances, outward currents through inwardly rectifying K(+) channels are reduced at more de
110 e that this inhibition requires one of three inwardly rectifying K(+) channels encoded by the C. eleg
111 lial cell Ca(2+)-activated K(+) channels and inwardly rectifying K(+) channels in arterial myocytes.
112 ABA(B)) receptors from their G-protein-gated inwardly rectifying K(+) channels in hypothalamic neuron
113 Comparison of high-resolution structures of inwardly rectifying K(+) channels suggests a model for a
121 does not act via either G-protein-activated inwardly rectifying K(+) conductance (G(IRK)) or hyperpo
122 y is that ICC express the Ba(2+) -sensitive, inwardly rectifying K(+) conductance in colonic muscles.
123 tence of I(OMMKi), a novel voltage-dependent inwardly rectifying K(+) conductance located in the OMM.
125 we pinpointed the lack of the Kir2.1-encoded inwardly rectifying K(+) current (I(K1)) as the single m
127 kephalin (DAMGO) and endomorphin-2 activated inwardly rectifying K(+) current in a concentration-depe
135 (KATP) is formed by the association of four inwardly rectifying K+ channel (Kir6.x) pore subunits wi
137 e frequency, increased GIRK (G-protein-gated inwardly rectifying K+ channel) current, and attenuated
139 however, it requires synaptic activation of inwardly rectifying KARs and release of Ca(2+) from stor
140 hannels are heteromultimeric complexes of an inwardly rectifying Kir channel (Kir6.x) and sulfonylure
142 had depolarized resting potentials due to an inwardly rectifying leak conductance formed by the mutan
143 s, including the hyperpolarization-activated inwardly rectifying non-specific cation current (I(h)),
144 polarized potential (e.g. cells with a large inwardly rectifying or Ca(2+)-activated K(+) current), a
146 that alcohol activation of a G-protein-gated inwardly rectifying potassium (GIRK or Kir3) channel is
147 lular pathways that regulate G protein-gated inwardly rectifying potassium (GIRK or Kir3) channels ar
149 etween GPCRs, G proteins and G protein-gated inwardly rectifying potassium (GIRK or Kir3) channels.
150 REM sleep; likewise, with G-protein-coupled inwardly rectifying potassium (GIRK) channel blockade.
151 Tertiapin Q (TPQ), a G protein-dependent inwardly rectifying potassium (GIRK) channel inhibitor,
154 iously, we demonstrated that G-protein-gated inwardly rectifying potassium (GIRK) channels are expres
157 the effect of cholesterol on G protein-gated inwardly rectifying potassium (GIRK) channels expressed
158 onist baclofen to activate G protein-coupled inwardly rectifying potassium (GIRK) channels in hypotha
159 rnalization of M(2)R and G-protein-activated inwardly rectifying potassium (GIRK) channels in neurona
160 s revealed the expression of G protein-gated inwardly rectifying potassium (GIRK) channels in these c
161 latonin receptors activate G-protein-coupled inwardly rectifying potassium (GIRK) channels in Xenopus
164 jor subunits of neuronal G protein-activated inwardly rectifying potassium (GIRK) channels that media
165 eurons by avidin-mediated cross-linking, and inwardly rectifying potassium (GIRK) channels were used
166 d a photochromic opener of G protein-coupled inwardly rectifying potassium (GIRK) channels, termed CL
172 oltage clamp, Dyn-A opened G-protein-coupled inwardly rectifying potassium (GIRK)-like channels on PO
174 ted by GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK/Kir(3)) channels, ho
176 es D2-receptors on MSNs, G protein activated inwardly rectifying potassium (GIRK2; Kir 3.2) channels
184 via the activation of Na(+)/K(+)-ATPase and inwardly rectifying potassium (K(IR)) channels in humans
186 nted during exercise following inhibition of inwardly rectifying potassium (KIR ) channels and Na(+)
187 ilatation that is dependent on activation of inwardly rectifying potassium (KIR ) channels, with a mo
189 ics simulations containing >100 copies of an inwardly rectifying potassium (Kir) channel which forms
190 in human sequence databases) that encodes an inwardly rectifying potassium (Kir) channel, Kir2.6.
191 ypothesized that RH occurs via activation of inwardly rectifying potassium (KIR) channels and Na(+)/K
192 llular polyamines are endogenous blockers of inwardly rectifying potassium (Kir) channels and underli
200 annels are prokaryotic homologs of mammalian inwardly rectifying potassium (Kir) channels, and recent
204 , we show that the voltage dependence of the inwardly rectifying potassium (KIR) conductance activate
205 ular complexes with neuronal G protein-gated inwardly rectifying potassium (Kir3 or GIRK) channels.
208 crystallization conditions for a prokaryotic inwardly rectifying potassium channel (>130 different co
209 xpressing rat MOR1 as well G protein-coupled inwardly rectifying potassium channel (GIRK) channel sub
210 ce that reversed at -93 mV, indicative of an inwardly rectifying potassium channel (GIRK) mechanism.
211 KOR-induced tyrosine phosphorylation of the inwardly rectifying potassium channel (GIRK) subunit Kir
212 -MSN hyperexcitability mediated by decreased inwardly rectifying potassium channel (IRK) function.
214 r-mediated activation of G-protein-activated inwardly rectifying potassium channel (Kir3.X) (GIRK) co
215 multimeric protein complex composed of four inwardly rectifying potassium channel (Kir6.2) and four
216 mutations in KCNJ6 (GIRK2), which encodes an inwardly rectifying potassium channel and maps to the Do
217 ings of ligand activated G-protein-activated inwardly rectifying potassium channel currents in mouse
218 mutation in the gene encoding the G-protein inwardly rectifying potassium channel Girk2, exhibits a
219 specific amino acid mutations in the Kir2.1 inwardly rectifying potassium channel have been found to
220 Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2.1 are associa
221 use visual system to ectopically express the inwardly rectifying potassium channel Kir2.1 in individu
222 us activity due to the overexpression of the inwardly rectifying potassium channel Kir2.1 in the olfa
224 iesterase (PDE) 1C, and PDE9A; and channels: inwardly rectifying potassium channel Kir2.4, transient
225 mediated via the G protein-coupled receptor inwardly rectifying potassium channel Kir3.Our findings
228 stal convoluted tubule (DCT), comprising the inwardly rectifying potassium channel Kir4.1/Kir5.1 hete
232 ng the sulfonylurea receptor 1 (SUR1) or the inwardly rectifying potassium channel Kir6.2, respective
233 P(a) < 0.08), as well as with ATP-sensitive inwardly rectifying potassium channel subunit Kir6.2 (KC
235 TA neurons, NK receptor activation closes an inwardly rectifying potassium channel, and moreover inhi
236 l, cytoplasmic domain of the G-protein-gated inwardly rectifying potassium channel, K(ir)3.1 facilita
241 larke et al. now present 11 structures of an inwardly rectifying potassium channel, providing evidenc
243 d postsynaptic activation of G-protein-gated inwardly rectifying potassium channels (GIRKs) electroph
244 ought to determine whether G protein-coupled inwardly rectifying potassium channels (GIRKs) modulate
245 ty of effectors, including G-protein-coupled inwardly rectifying potassium channels (GIRKs)(1,2).
246 ave investigated the role of G-protein-gated inwardly rectifying potassium channels (GIRKs), a recent
247 trimers to interact with G-protein regulated inwardly rectifying potassium channels (GIRKs), and we s
250 ated vasodilatation occurs via activation of inwardly rectifying potassium channels (KIR ), and synth
251 consequent upon loss or reduced function of inwardly rectifying potassium channels affecting various
252 ha(i/o)-coupled receptors, G protein-coupled inwardly rectifying potassium channels and adenylate cyc
253 We tested the hypothesis that activation of inwardly rectifying potassium channels and the sodium-po
256 hloroquine and related compounds can inhibit inwardly rectifying potassium channels by multiple poten
258 ore, whether Cav-1 regulates the function of inwardly rectifying potassium channels Kir2.1 that play
259 r and its downstream GIRK (G protein-coupled inwardly rectifying potassium channels) channels (IK,Ado
260 -THCs enable CB1-mediated optical control of inwardly rectifying potassium channels, as well as adeny
261 er L-glutamate or expressing G-protein-gated inwardly rectifying potassium channels, hepatic lineage
264 In the striatum, light delivery activated an inwardly rectifying potassium conductance and biased rot
265 iated by the mGlu2 subtype that activates an inwardly rectifying potassium conductance in the dendrit
266 ine-mediated activation of G protein-coupled inwardly rectifying potassium conductance was measured u
269 es have postulated an important role for the inwardly rectifying potassium current (I(K1)) in control
270 wo critical ionic current mechanisms are the inwardly rectifying potassium current (I(K1)), which is
271 sarcoplasmic reticulum Ca2+ concentrations, inwardly rectifying potassium current (IK1) density, and
274 ors by (1) activation of a G protein-coupled inwardly rectifying potassium current, (2) inhibition of
275 potential from resting value, mediated by an inwardly rectifying potassium current, resulting in redu
276 types of TH neuron through G-protein coupled inwardly rectifying potassium currents mediated by delta
277 nist baclofen both elicited increases of the inwardly rectifying potassium currents that could be blo
279 he Kir7.1 subunit that acts as a tetrameric, inwardly rectifying potassium ion channel in the retinal
280 ltage-dependent inward rectification of Kir (inwardly rectifying potassium) channels arises from bloc
281 receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heterome
283 by submicromolar concentrations of 5-HT, is inwardly rectifying with a reversal potential near the e
284 he current-voltage relationship was slightly inwardly rectifying with a reversal potential of -52 +/-
285 ons from refractory and late SE animals were inwardly rectifying, and philanthotoxin-sensitive; simil
286 itions are associated with shifts from CI to inwardly rectifying, GluA2-lacking, Ca(2+)-permeable (CP
287 of capsaicin-induced mEPSCs, from linear to inwardly rectifying, indicating an increased prevalence
289 and TRPML3 to be measured and identified as inwardly rectifying, proton-impermeant, Ca(2+)-permeant
294 potassium, which are largely mediated by the inwardly-rectifying potassium channel Kir4.1, and to tak
295 -targeted CaMKII directly phosphorylates the inwardly-rectifying potassium channel, Kir6.2 (alpha sub
296 e desensitization of the G protein-activated inwardly-rectifying potassium current evoked by receptor
297 of each individual cell protruding from the inwardly regressive arm of the cell-cell interface, and
298 l periphery from where activation propagates inwardly through Ca(2+)-induced Ca2+ release (CICR) from